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Suprax (cefixime) vs. Augmentin: What's the difference?
- Suprax (cefixime) and Augmentin (amoxicillin and clavulanic acid) are antibiotics used to treat middle ear infections (otitis media), tonsillitis, throat infections (pharyngitis), laryngitis, bronchitis, pneumonia, and urinary tract infections (UTIs).
- Suprax is also used to treat gonorrhea and acute bacterial bronchitis in patients with chronic obstructive pulmonary disease (COPD).
- Suprax and Augmentin are different types of antibiotics. Suprax is a cephalosporin antibiotic and Augmentin is a combination of a penicillin-type antibiotic and a beta-lactamase inhibitor.
- Suprax is a brand name for cefixime.
- Augmentin is a brand name for amoxicillin and clavulanic acid.
- Side effects of Suprax and Augmentin that are similar include diarrhea, nausea, vomiting, abdominal pain or discomfort, skin rash, and headache.
- Side effects of Suprax that are different from Augmentin include fever, joint pain, abnormal liver tests, vaginitis, itching, and dizziness.
- Side effects of Augmentin that are different from Suprax include bloating, gas, and heartburn.
What are Suprax and Augmentin?
Suprax is a cephalosporin antibiotic used to treat middle ear infections (otitis media), tonsillitis, throat infections (pharyngitis), laryngitis, pneumonia, bronchitis, urinary tract infections (UTIs), gonorrhea, and acute bacterial bronchitis in patients with chronic obstructive pulmonary disease (COPD). Other drugs in the cephalosporin class include cephalexin (Keflex), cefaclor (Ceclor), cefuroxime (Zinacef), cefpodoxime (Vantin), cefprozil (Cefzil), and injectable forms. Cephalosporins stop bacteria from multiplying by preventing bacteria from forming the walls that surround and protect them from their environment and keep the contents of the bacterial cell together; bacteria typically cannot survive without a cell wall. Suprax is effective against a wide spectrum of bacteria including Streptococcus pneumoniae, Streptococcus pyogenes, Hemophilus influenzae, Staphylococcus aureus, E. coli, Moraxella catarrhalis, Klebsiella, Proteus mirabilis, Salmonella, Shigella, and Neisseria gonorrhoeae.
Augmentin (amoxicillin and clavulanic acid) is a combination of a penicillin-type antibiotic and a beta-lactamase inhibitor used to treat middle ear infections (otitis media), tonsillitis, throat infections (pharyngitis), laryngitis, bronchitis, sinusitis, pneumonia, urinary tract infections (UTIs), and skin infections. Augmentin is effective against some bacteria such as H. influenzae, N. gonorrhoeae, E. coli, Pneumococci, Streptococci, and certain strains of Staphylococci. Amoxicillin stops bacteria from multiplying by preventing bacteria from forming the walls that surround them. The walls are necessary to protect bacteria from their environment and to keep the contents of the bacterial cell together. Bacteria cannot survive without a cell wall. Clavulanic acid enhances the effectiveness of amoxicillin against bacteria that are ordinarily resistant to amoxicillin alone.
What are the side effects of Suprax and Augmentin?
Common side effects of Suprax include:
Other side effects include:
Common side effects are:
Other important side effects include:
- bloody or prolonged diarrhea,
- easy bruising or bleeding,
- reversible hepatitis,
- rash, and
- allergic reactions.
Serious but rare reactions include seizures, severe allergic reactions (anaphylaxis), and low platelet or red blood cell count. Antibiotics can alter the normal bacteria in the colon and encourage overgrowth of some bacteria such as Clostridium difficile, which causes inflammation of the colon (pseudomembranous colitis). Patients who develop signs of pseudomembranous colitis after starting Augmentin (diarrhea, fever, abdominal pain, and possibly shock) should contact their physician immediately. Persons who are allergic to the cephalosporin class of antibiotics, which are related to the penicillins, for example, cefaclor (Ceclor), cephalexin (Keflex), and cefprozil (Cefzil), may or may not be allergic to penicillins.
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What is the dosage of Suprax vs. Augmentin?
- The recommended adult dose for otitis media, tonsillitis, pharyngitis, and urinary tract infections is 400 mg once daily or divided and given as 200 mg every 12 hours.
- Pediatric patients (6 months and older) have a recommended dose of 8 mg/kg/day once daily or in two doses of 4/mg/kg every 12 hours.
- Augmentin should be taken on a full stomach to reduce stomach upset. No more than one tablet should be taken at a time since the extra clavulanic acid can cause stomach upset.
- Recommended adult doses are 500 mg every 8-12 hours, 250 mg every 8 hours, 875 mg every 12 hours, or 2000 mg every 12 hours.
- Dosing is based on the amoxicillin component.
- Pediatric patients weighing more than 40 kg should receive adult doses.
- Pediatric patients weighing less than 40 kg should receive 20 to 45 mg/kg every 8 or 12 hours.
What drugs interact with Suprax and Augmentin?
- Probenecid (Benemid) may increase the blood concentration of Suprax by decreasing removal of Suprax by the kidney. This interaction sometimes is used to enhance the effect of cephalosporins.
- Combining Suprax with aminoglycosides -- for example, tobramycin (Tobradex) -- produces additive bacterial killing effects but also may increase the risk of harmful effects to the kidney.
- Exenatide (Byetta) may delay or reduce the absorption of cephalosporins. Cephalosporins should be administered one hour before exenatide.
- Suprax may cause a false positive urine ketone test.
- Co-administration of probenecid, a drug used for treating gout, prevents the normal elimination of amoxicillin by the kidneys and can cause high, toxic blood levels of amoxicillin.
- Augmentin may decrease the effectiveness of birth control pills, increasing the risk of unexpected pregnancies.
- Combining Augmentin and allopurinol (Zyloprim, Aloprim) may increase the occurrence of skin rash.
Are Suprax and Augmentin safe to use while pregnant or breastfeeding?
Use of Augmentin in pregnant women has not been well studied. Penicillins are generally considered safe for use by pregnant women who are not allergic to penicillin.
Augmentin is excreted in breast milk and may cause diarrhea in the infant.
Suprax (cefixime) and Augmentin (amoxicillin and clavulanic acid) are antibiotics used to treat infections of the middle ear (otitis media), tonsillitis, throat infections (pharyngitis), laryngitis, bronchitis, pneumonia, and urinary tract infections (UTIs).
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Related Disease Conditions
Laryngitis is an inflammation of the voice box (vocal cords). The most common cause of acute laryngitis is an infection, which inflames the vocal cords. Symptoms may vary from the degree of laryngitis and age of the person (laryngitis in infants and children is more commonly caused by croup).
Urinary Tract Infection (UTI)
A urinary tract infection (UTI) is an infection of the bladder, kidneys, ureters, or urethra. E. coli, a type of bacteria that lives in the bowel and near the anus, causes most UTIs. UTI symptoms include pain, abdominal pain, mild fever, urinary urgency, and frequency. Treatment involves a course of antibiotics.
Tonsillitis is a contagious infection with symptoms of bad breath, snoring, congestion, headache, hoarseness, laryngitis, and coughing up blood. Tonsillitis can be caused by acute infection of the tonsils, and several types of bacteria or viruses (for example, strep throat or mononucleosis). There are two types of tonsillitis, acute and chronic. Acute tonsillitis lasts from 1-2 weeks while chronic tonsillitis can last from months to years. Treatment of tonsillitis and adenoids include antibiotics, over-the-counter medications, and home remedies to relieve pain and inflammation, for example, saltwater gargle, slippery elm throat lozenges, sipping warm beverages and eating frozen foods (ice cream, popsicles), serrapeptase, papain, and andrographism Some people with chronic tonsillitis may need surgery (tonsillectomy or adenoidectomy).
Staph (Staphylococcus) Infection
Staphylococcus or staph is a group of bacteria that can cause a multitude of diseases. Staph infections can cause illness directly by infection or indirectly by the toxins they produce. Symptoms and signs of a staph infection include redness, swelling, pain, and drainage of pus. Minor skin infections are treated with an antibiotic ointment, while more serious infections are treated with intravenous antibiotics.
Middle Ear Infection (Otitis Media)
A middle ear infection (otitis media) can cause earache, temporary hearing loss, and pus drainage from the ear. It is most common in babies, toddlers, and young children. Learn about causes and treatment.
Gonorrhea In Women
Gonorrhea is a bacterial infection transmitted during sexual contact. In women, symptoms include a yellow vaginal discharge, burning or frequent urination, and redness, swelling, burning, and itching of the vaginal area. Gonorrhea can be treated with injectable (penicillin) or oral medications.
Sore throat (throat pain) usually is described as pain or discomfort in the throat area. A sore throat may be caused by bacterial infections, viral infections, toxins, irritants, trauma, or injury to the throat area. Common symptoms of a sore throat include a fever, cough, runny nose, hoarseness, earaches, sneezing, and body aches. Home remedies for a sore throat include warm soothing liquids and throat lozenges. OTC remedies for a sore throat include OTC pain relievers such as ibuprofen or acetaminophen. Antibiotics may be necessary for some cases of sore throat.
Pneumonia is inflammation of the lungs caused by fungi, bacteria, or viruses. Symptoms and signs include cough, fever, shortness of breath, and chills. Antibiotics treat pneumonia, and the choice of the antibiotic depends upon the cause of the infection.
Bronchitis is inflammation of the airways in the lung. Acute bronchitis is short in duration (10-20 days) in comparison with chronic bronchitis, which lasts for months to years. Causes of acute bronchitis include viruses and bacteria, which means it can be contagious. Acute bronchitis caused by environmental factors such as pollution or cigarette smoke is not contagious. Common symptoms for acute bronchitis include nasal congestion, cough, headache, sore throat, muscle aches, and fatigue. Acute bronchitis in children also my include runny nose, fever, and chest pain. Treatment for acute bronchitis are OTC pain relievers, cough suppressants (although not recommended in children), and rest. Infrequently antibiotics may be prescribed to treat acute bronchitis.
E. coli (0157:H7) Infection
There are many types of E. coli (Escherichia coli). E. coli can cause urinary tract and bladder infections, or lead to sepsis. E coli O157:H7 (EHEC) causes bloody diarrhea and colitis. Complications of E. coli infection include hemorrhagic diarrhea, hemolytic-uremic syndrome, and thrombotic thrombocytopenic purpura. Symptoms include severe abdominal pain and bloody diarrhea. E coli O157:H7 commonly is due to eating raw or undercooked hamburger or raw milk or dairy products.
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Group A Streptococcal Infections
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Chronic bronchitis is a cough that occurs daily with production of sputum that lasts for at least 3 months, 2 years in a row. Causes of chronic bronchitis include cigarette smoking, inhaled irritants, and underlying disease processes (such as asthma, or congestive heart failure). Symptoms include cough, shortness of breath, and wheezing. Treatments include bronchodilators and steroids. Complications of chronic bronchitis include COPD and emphysema.
COPD (Chronic Obstructive Pulmonary Disease)
COPD or chronic obstructive pulmonary disease is a lung condition caused by smoking tobacco, exposure to secondhand smoke, and/or air pollutants. Conditions that accompany COPD include chronic bronchitis, chronic cough, and emphysema. Symptoms of COPD include shortness of breath, wheezing, and chronic cough. Treatment of COPD includes GOLD guidelines, smoking cessation, medications, and surgery. The life expectancy of a person with COPD depends on the stage of the disease.
Group A streptococcal infections are caused by group A Streptococcus, a bacteria that causes a variety of health problems, including strep throat, impetigo, cellulitis, erysipelas, and scarlet fever. There are more than 10 million group A strep infections each year.
Shigellosis is a disease caused by the Shigella bacteria. Bloody diarrhea, stomach cramps, and fever are common symptoms. Mild infections usually resolve on their own. Antibiotics are used to treat more severe cases.
Treatment & Diagnosis
- Urinary Tract Infection FAQs
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- Strep Streptococcal Throat Infection FAQs
- Ear Infection FAQs
- COPD (Chronic Obstructive Pulmonary Disease) FAQs
- Bronchitis FAQs
- How Do You Get Staph Infection?
- What Causes an Ear Infection?
- How Do You Get an Ear Infection?
- How to Get Rid of a Staph Infection
- Urinary Tract Infection (UTI) Symptoms
- E. coli Infection Facts
- Urinary Tract Infection (UTI) Treatment
Medications & Supplements
- Penicillin (Antibiotics)
- Augmentin (amoxicillin/clavulanic acid, Augmentin XR, Augmentin ES-600, Amoclan)
- Amoxicillin vs. Augmentin (Comparison of Side Effects and Antibiotic Uses)
- cefixime (Suprax)
- Suprax (cefixime) vs. cefuroxime
- Suprax (cefixime) vs. Keflex (cephalexin)
- Suprax (cefixime) vs. azithromycin
- Cefdinir vs. cefixime (Suprax) 3rd Generation Antibiotics
- Suprax (cefixime) vs. ofloxacin
- Suprax (cefixime) vs. cefpodoxime
- Suprax (cefixime) vs. Rocephin (ceftriaxone)
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