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Suprax (cefixime) vs. ofloxacin: What's the difference?
- Suprax and ofloxacin are antibiotics used to treat bronchitis, pneumonia, urinary tract infections (UTIs), and gonorrhea.
- Suprax is also used to treat middle ear infections (otitis media), tonsillitis, throat infections (pharyngitis), laryngitis, and acute bacterial bronchitis in patients with chronic obstructive pulmonary disease (COPD).
- Ofloxacin is also used to treat staph infections and prostate infections caused by E. coli.
- Suprax is a brand name for cefixime.
- Brand names for ofloxacin include Ocuflox and Floxin.
- Suprax and ofloxacin are different types of antibiotics. Suprax is a cephalosporin antibiotic and ofloxacin is a fluoroquinolone antibiotic.
- Side effects of Suprax and ofloxacin that are similar include diarrhea, nausea, vomiting, vaginitis, itching, headaches, and dizziness.
- Side effects of Suprax that are different from ofloxacin include abdominal pain, skin rash, fever, joint pain, and abnormal liver tests.
- Side effects of ofloxacin that are different from Suprax include insomnia, allergic reactions (such as hives and anaphylaxis), skin sensitivity (photosensitivity), anxiety, euphoria, and hallucinations.
What are Suprax and ofloxacin?
Suprax is a cephalosporin antibiotic used to treat middle ear infections (otitis media), tonsillitis, throat infections (pharyngitis), pneumonia, bronchitis, laryngitis, urinary tract infections (UTIs), gonorrhea, and acute bacterial bronchitis in patients with chronic obstructive pulmonary disease (COPD). Other drugs in the cephalosporin class include cephalexin (Keflex), cefaclor (Ceclor), cefuroxime (Zinacef), cefpodoxime (Vantin), cefprozil (Cefzil), and injectable forms. Cephalosporins such as Suprax stop bacteria from multiplying by preventing bacteria from forming the walls that surround them and are necessary to protect bacteria from their environment and to keep the contents of the bacterial cell together. Most bacteria cannot survive without a cell wall. Suprax is active against a wide spectrum of bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes (the cause of strep throat), Hemophilus influenzae, Moraxella catarrhalis, E. coli, Klebsiella, Proteus mirabilis, Salmonella, Shigella, and Neisseria gonorrhoeae.
Ofloxacin is a fluoroquinolone antibiotic used to treat bacterial infections such as pneumonia, bronchitis, staph infections, STDs (gonorrhea, chlamydia), urinary tract infections, and prostate infections caused by E. coli. Other fluoroquinolones include levofloxacin (Levaquin), ciprofloxacin (Cipro), gatifloxacin (Tequin), norfloxacin (Noroxin), moxifloxacin (Avelox), and trovafloxacin (Trovan). Ofloxacin stops the multiplication of bacteria by inhibiting the reproduction and repair of their genetic material (DNA).
What are the side effects of Suprax and ofloxacin?
Common side effects of Suprax include:
Other side effects include:
The most common side effects of ofloxacin include:
Allergic reactions have been described, such as hives and anaphylaxis (shock).
Other important side effects include symptoms of nervous system stimulation, such as:
Patients taking ofloxacin can develop skin sensitivity (photsensitivity) to direct sunlight and should avoid exposure to sunlight or use sun protection and sunscreens.
Ofloxacin as well as other antibiotics in the fluoroquinolone class of antibiotics have been associated with tendinitis and even rupture of tendons, particularly the Achilles tendon. Some physicians recommend that patients discontinue vigorous exercise while they are taking fluoroquinolone antibiotics.
Children and adolescents under 18 years of age should avoid using ofloxacin, as safe use in these patients has not been established.
Many antibiotics, including ofloxacin, can alter the normal bacteria in the colon and encourage overgrowth of a bacterium (Clostridium difficile) responsible for the development of inflammation of the colon (pseudomembranous colitis). Pseudomembranous colitis can cause fever, abdominal pain, diarrhea, and sometimes even shock.
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What is the dosage of Suprax vs. ofloxacin?
The recommended adult dose for otitis media, tonsillitis, pharyngitis, and urinary tract infections is 400 mg once daily or divided and given as 200 mg every 12 hours.
Pediatric patients (6 months and older) have a recommended dose of 8 mg/kg/day once daily or in two doses of 4/mg/kg every 12 hours.
The usual dose for patients with normal renal function is 200 to 400 mg every 12 hours. Dosages require adjustment in patients with severely abnormal liver or kidney function.
What drugs interact with Suprax and ofloxacin?
Probenecid (Benemid) may increase the blood concentration of Suprax by decreasing the kidney's ability to remove Suprax. This interaction sometimes is used to enhance the effect of cephalosporins.
Combining Suprax with aminoglycosides -- for example, tobramycin (Tobradex) -- produces additive bacterial killing effects but also may increase the risk of harmful effects to the kidney.
Suprax may cause a false positive urine ketone test.
Ofloxacin reduces the elimination of theophylline, elevating blood levels of theophylline. (Theophylline is used to open airways in the treatment of asthma.) If concurrent use of ofloxacin and theophylline cannot be avoided, frequent blood tests to monitor theophylline blood levels should be performed.
Both high and low blood sugar levels have been reported, especially in patients with diabetes who were also receiving insulin or other medications used to lower blood sugar. Careful monitoring of blood sugar levels is recommended.
Sucralfate (Carafate), iron, multivitamins containing zinc, didanosine (Videx), as well as antacids containing calcium, magnesium, or aluminum should not be taken within two hours before or after taking ofloxacin.
Are Suprax and ofloxacin safe to use while pregnant or breastfeeding?
Avoid ofloxacin during pregnancy, because it is secreted in breast milk and can cause adverse events in the infant.
Nursing mothers should avoid ofloxacin, as safe use has not been established.
Suprax (cefixime) and ofloxacin are antibiotics used to treat bronchitis, pneumonia, urinary tract infections (UTIs), and gonorrhea. Suprax is also used to treat middle ear infections (otitis media), tonsillitis, throat infections (pharyngitis), laryngitis, and acute bacterial bronchitis in patients with chronic obstructive pulmonary disease (COPD). Ofloxacin is also used to treat staph infections and prostate infections caused by E. coli.
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Laryngitis is an inflammation of the voice box (vocal cords). The most common cause of acute laryngitis is an infection, which inflames the vocal cords. Symptoms may vary from the degree of laryngitis and age of the person (laryngitis in infants and children is more commonly caused by croup).
Urinary Tract Infection (UTI)
A urinary tract infection (UTI) is an infection of the bladder, kidneys, ureters, or urethra. E. coli, a type of bacteria that lives in the bowel and near the anus, causes most UTIs. UTI symptoms include pain, abdominal pain, mild fever, urinary urgency, and frequency. Treatment involves a course of antibiotics.
Tonsillitis is a contagious infection with symptoms of bad breath, snoring, congestion, headache, hoarseness, laryngitis, and coughing up blood. Tonsillitis can be caused by acute infection of the tonsils, and several types of bacteria or viruses (for example, strep throat or mononucleosis). There are two types of tonsillitis, acute and chronic. Acute tonsillitis lasts from 1-2 weeks while chronic tonsillitis can last from months to years. Treatment of tonsillitis and adenoids include antibiotics, over-the-counter medications, and home remedies to relieve pain and inflammation, for example, saltwater gargle, slippery elm throat lozenges, sipping warm beverages and eating frozen foods (ice cream, popsicles), serrapeptase, papain, and andrographism Some people with chronic tonsillitis may need surgery (tonsillectomy or adenoidectomy).
Staph (Staphylococcus) Infection
Staphylococcus or staph is a group of bacteria that can cause a multitude of diseases. Staph infections can cause illness directly by infection or indirectly by the toxins they produce. Symptoms and signs of a staph infection include redness, swelling, pain, and drainage of pus. Minor skin infections are treated with an antibiotic ointment, while more serious infections are treated with intravenous antibiotics.
Middle Ear Infection (Otitis Media)
A middle ear infection (otitis media) can cause earache, temporary hearing loss, and pus drainage from the ear. It is most common in babies, toddlers, and young children. Learn about causes and treatment.
Sore throat (throat pain) usually is described as pain or discomfort in the throat area. A sore throat may be caused by bacterial infections, viral infections, toxins, irritants, trauma, or injury to the throat area. Common symptoms of a sore throat include a fever, cough, runny nose, hoarseness, earaches, sneezing, and body aches. Home remedies for a sore throat include warm soothing liquids and throat lozenges. OTC remedies for a sore throat include OTC pain relievers such as ibuprofen or acetaminophen. Antibiotics may be necessary for some cases of sore throat.
Pneumonia is inflammation of the lungs caused by fungi, bacteria, or viruses. Symptoms and signs include cough, fever, shortness of breath, and chills. Antibiotics treat pneumonia, and the choice of the antibiotic depends upon the cause of the infection.
Bronchitis is inflammation of the airways in the lung. Acute bronchitis is short in duration (10-20 days) in comparison with chronic bronchitis, which lasts for months to years. Causes of acute bronchitis include viruses and bacteria, which means it can be contagious. Acute bronchitis caused by environmental factors such as pollution or cigarette smoke is not contagious. Common symptoms for acute bronchitis include nasal congestion, cough, headache, sore throat, muscle aches, and fatigue. Acute bronchitis in children also my include runny nose, fever, and chest pain. Treatment for acute bronchitis are OTC pain relievers, cough suppressants (although not recommended in children), and rest. Infrequently antibiotics may be prescribed to treat acute bronchitis.
E. coli (0157:H7) Infection
There are many types of E. coli (Escherichia coli). E. coli can cause urinary tract and bladder infections, or lead to sepsis. E coli O157:H7 (EHEC) causes bloody diarrhea and colitis. Complications of E. coli infection include hemorrhagic diarrhea, hemolytic-uremic syndrome, and thrombotic thrombocytopenic purpura. Symptoms include severe abdominal pain and bloody diarrhea. E coli O157:H7 commonly is due to eating raw or undercooked hamburger or raw milk or dairy products.
Chronic bronchitis is a cough that occurs daily with production of sputum that lasts for at least 3 months, 2 years in a row. Causes of chronic bronchitis include cigarette smoking, inhaled irritants, and underlying disease processes (such as asthma, or congestive heart failure). Symptoms include cough, shortness of breath, and wheezing. Treatments include bronchodilators and steroids. Complications of chronic bronchitis include COPD and emphysema.
Group A streptococcal infections are caused by group A Streptococcus, a bacteria that causes a variety of health problems, including strep throat, impetigo, cellulitis, erysipelas, and scarlet fever. There are more than 10 million group A strep infections each year.
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