Sulforaphane

What other names is Sulforaphane known by?

Glucosinolate de Sulforaphane, SFN, Sulforafane, Sulforaphane Glucosinolate, Sulforofano, Sulphoraphane, 1-isothiocayanate-4-methyl-sulfonyl butane.

What is Sulforaphane?

Sulforaphane is a chemical found in certain kinds of vegetables such as broccoli, cabbage, and cauliflower.

Sulforaphane is used for the prevention of prostate cancer and other types of cancer.

Insufficient Evidence to Rate Effectiveness for...

  • Preventing cancer.
  • Other conditions.
More evidence is needed to rate the effectiveness of sulforaphane for these uses.

How does Sulforaphane work?

Sulforaphane may increase the death of cancer cells.

Are there safety concerns?

Sulforaphane is safe when used in the amounts found in foods. But there isn't enough information available to know if it is safe to take by mouth as a medicine.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Sulforaphane is safe in amounts found in food, but there's not enough information to know if it's safe in the larger amounts that are used as medicine.

QUESTION

Next to red peppers, you can get the most vitamin C from ________________. See Answer

Are there any interactions with medications?


Medications changed by the liver (Cytochrome P450 1A2 [CYP1A2] substrates)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Some medications are changed and broken down by the liver. Sulforaphane might decrease how quickly the liver breaks down some medications. Taking sulforaphane along with some medications that are changed by the liver might increase the effects and side effects of some medications. Before taking sulforaphane talk to your healthcare provider if you take any medications that are changed by the liver.

Some medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others.

Dosing considerations for Sulforaphane.

The appropriate dose of sulforaphane depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for sulforaphane. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

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Reviewed on 9/17/2019
References

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Zhang J, Svehlikova V, Bao Y, et al. Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation. Carcinogenesis 2003;24:497-503.. View abstract.

Zhang Y, Callaway EC. High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate. Biochem J 2002;364:301-7.. View abstract.