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- What is sulfamethoxazole and trimethoprim, and how does it work (mechanism of action)?
- What brand names are available for sulfamethoxazole and trimethoprim?
- Is sulfamethoxazole and trimethoprim available as a generic drug?
- Do I need a prescription for sulfamethoxazole and trimethoprim?
- What are the uses for sulfamethoxazole and trimethoprim?
- What are the side effects of sulfamethoxazole and trimethoprim?
- What is the dosage for sulfamethoxazole and trimethoprim?
- Which drugs or supplements interact with sulfamethoxazole and trimethoprim?
- Is sulfamethoxazole and trimethoprim safe to take if I'm pregnant or breastfeeding?
- What else should I know about sulfamethoxazole and trimethoprim?
What is sulfamethoxazole and trimethoprim, and how does it work (mechanism of action)?
Bactrim is a combination of two synthetic (man-made) antibiotics, sulfamethoxazole and trimethoprim. Both drugs reduce the ability of some bacteria to utilize folic acid for growing. Sulfamethoxazole is an anti-bacterial sulfonamide, a "sulfa" drug. It disrupts the production of dihydrofolic acid while trimethoprim disrupts the production of tetrahydrofolic acid. Dihydrofolic acid and tetrahydrofolic acid are forms of folic acid that bacteria and human cells use for producing proteins. Trimethoprim inhibits production of tetrahydrofolic acid by inhibiting the enzyme responsible for making tetrahydrofolic acid from dihydrofolic acid. By combining both drugs, two important steps required in the production of bacterial proteins are interrupted, and the combination is more effective than either drug alone. Bactrim was approved by the FDA in 1973.
What brand names are available for sulfamethoxazole and trimethoprim?
Bactrim, Bactrim DS, Sulfatrim Pediatric
What are the uses for sulfamethoxazole and trimethoprim?
Sulfamethoxazole/trimethoprim is used for treating infections due to susceptible bacteria. Examples include urinary tract infections, flares of chromic bronchitis due to bacteria, middle ear infections, for prevention of infections due to pneumococcus in organ transplant recipients, for the treatment or prevention of Pneumocystis carinii pneumonia, chancroid, and prevention of toxoplasma encephalitis in patients with AIDS.
What are the side effects of sulfamethoxazole and trimethoprim?
Common side effects of sulfamethoxazole/trimethoprim are:
Other side effects include:
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What is the dosage for sulfamethoxazole and trimethoprim?
The recommended adult dose for urinary tract infections is one double strength tablet (Bactrim DS, Septra DS) or two single strength tablets every 12 hours for 10 to 14 days.
Flares of chronic bronchitis are treated with a similar regimen for 14 days.
Sulfamethoxazole/trimethoprim should be taken with 6 to 8 ounces of liquid to prevent crystals from forming in the urine. Persons with advanced kidney disease may require lower doses.
Which drugs or supplements interact with sulfamethoxazole and trimethoprim?
Sulfamethoxazole/trimethoprim can enhance the blood-thinning effects of warfarin (Coumadin), possibly leading to bleeding. Sulfonamides such as sulfamethoxazole can increase the metabolism (break-down and elimination) of cyclosporine (causing loss of effectiveness of cyclosporine), and can add to the kidney damage caused by cyclosporine.
Blood levels of phenytoin (Dilantin) may be increased by treatment with sulfamethoxazole/trimethoprim. This may lead to side effects associated with phenytoin (Dilantin, Dilantin-125) such as dizziness, and reduced attention.
Sulfamethoxazole/trimethoprim also may increase blood levels of digoxin (Lanoxin) and possibly lead to serious toxic effects. Anemia, due to a reduction in folic acid, can occur in persons receiving sulfamethoxazole/trimethoprim in combination with:
- valproic acid (Depakote, Depakote ER, Depakene, Depacon, Stavzor),
- methotrexate (Rheumatrex, Trexall),
- triamterene, or
Increased blood levels of potassium may occur when sulfamethoxazole/trimethoprim is combined with ACE inhibitors.
Is sulfamethoxazole and trimethoprim safe to take if I'm pregnant or breastfeeding?
Use of sulfonamides may cause bilirubin to be displaced from proteins in the infant's blood. Displacement of bilirubin can lead to jaundice and a dangerous condition called kernicterus in the infant. For this reason, sulfamethoxazole/trimethoprim should not be used near term (late in pregnancy) among women.
Sulfamethoxazole/trimethoprim should not be used by nursing mothers because sulfamethoxazole is excreted in milk and can cause kernicterus.
What else should I know about sulfamethoxazole and trimethoprim?
What preparations of sulfamethoxazole and trimethoprim are available?
Tablets: 160 mg trimethoprim and 800 mg sulfamethoxazole (Bactrim DS, Septra DS); 80 mg trimethoprim and 400 mg sulfamethoxazole (Bactrim; Septra).
How should I keep sulfamethoxazole and trimethoprim stored?
The tablets should be kept at room temperature, 15 C -30 C (59 F - 86 F).
Sulfamethoxazole and trimethoprim; cotrimoxazole (Bactrim, Bactrim DS, Septra, Septra DS) is a drug prescribed for urinary tract infections (UTIs), middle ear infections, respiratory infections, pneumonia, chancroid, for the prevention of infections of transplant recipients, and prevention of toxoplasma encephalitis in patients with AIDS. Side effects, dosage, drug interactions, pregnancy and breastfeeding safety information is also provided in the information.
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Treatment & Diagnosis
- Urine Odor
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- Leg Sores
- Urinary Urgency
- Kidney Infection (Pyelonephritis)
- Groin Pain
- Bladder Infection
- Urinary Tract Infection (UTI)
- MRSA Infection
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Middle ear infection or inflammation (otitis media) is inflammation of the middle ear. There are two forms of this type of ear infection, acute and chronic. Acute otitis media is generally short in duration, and chronic otitis media generally lasts several weeks. Seventy-five percent of children in the U.S. suffer from otitis media at some point.
Signs and symptoms in babies, toddlers, and children may:
- Be irritable and pull and tug at their ears
- Be fussy
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- Have a fever
- A buildup of pus in the ear
- Have signs and symptoms of an upper respiratory infection
Treatment depends upon the type (chronic or acute).
ImpetigoImpetigo is a contagious skin infection caused by staph and strep bacteria. There are two types of impetigo: nonbullous and bullous. Symptoms of nonbullous impetigo include small blisters on the nose, face, arms, or legs and possibly swollen glands. Bullous impetigo signs include blisters in various areas, particularly in the buttocks area. Treatment involves:
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- removing the crusts of popped blisters, and
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Take the MRSA Quiz!It's the MRSA Quiz! For the carriers among us, you'd be surprised that the infectious superbug is lurking on this body part! Take the quiz and learn how to keep this Staph infection at bay.
Prostatitis (Inflammation of the Prostate Gland)Prostatitis is an inflammation of the prostate gland. Signs and symptoms of prostatitis include painful or difficulty urinating, fever, chills, body aches, blood in the urine, pain in the rectum, groin, abdomen, or low back, and painful ejaculation or sexual dysfunction. Causes of prostatitis include STDs, bacteria from urinary tract infections, or e. Coli. Treatment for prostatitis depends on if it is a bacterial infection or chronic inflammation of the prostate gland.
Small Intestinal Bacterial Overgrowth (SIBO)
Small intestinal bacterial overgrowth (SIBO) refers to a condition in which abnormally large numbers of bacteria (at least 100,000 bacteria per ml of fluid) are present in the small intestine, but they are more like the bacteria that are found in the colon. There are many conditions associated with SIBO, including:
- Crohn's disease
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It has been theorized that SIBO may be responsible for the symptoms of at least some patients with irritable bowel syndrome.
Symptoms of SIBO include:
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Typhoid FeverTyphoid fever is an illness caused by the Salmonella typhi bacteria. The illness is contracted by ingesting the bacteria in contaminated water or food. Symptoms include headaches, fever, diarrhea, lethargy, aches and pains, and poor appetite. Treatment focuses on killing the Salmonella bacteria with antibiotics.
Urinary Tract InfectionA urinary tract infection (UTI) is an infection of the bladder, kidneys, ureters, or urethra. E. coli, a type of bacteria that lives in the bowel and near the anus, causes most UTIs. UTI symptoms include pain, abdominal pain, mild fever, urinary urgency and frequency. Treatment involves a course of antibiotics.
Wegener's GranulomatosisGranulomatosis with Polyangiitis (GPA or Wegener's granulomatosis) is a condition that usually affects young or middle-aged adults, is an inflammation of the arteries supplying blood to the sinuses, lungs, and kidneys. Symptoms of granulomatosis with polyangiitis include:
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