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- What is sulfamethoxazole, and how does it work (mechanism of action)?
- Is sulfamethoxazole available as a generic drug?
- Do I need a prescription for sulfamethoxazole?
- What are the side effects of sulfamethoxazole?
- What is the dosage for sulfamethoxazole?
- Which drugs or supplements interact with sulfamethoxazole?
- Is sulfamethoxazole safe to take if I'm pregnant or breastfeeding?
- What else should I know about sulfamethoxazole?
What is sulfamethoxazole, and how does it work (mechanism of action)?
Sulfamethoxazole is an anti- bacterial sulfonamide. It prevents the formation of dihydrofolic acid, a compound that bacteria must be able to make in order to survive. Although it was once a very useful antibiotic, it is almost obsolete as a single agent today due to the development of bacterial resistance to its effects. Sulfamethoxazole is now used primarily in combination with trimethoprim, a combination product known as Bactrim or Septra. Sulfamethoxazole was approved by the FDA in 1961. According to the FDA database, all brand and generic formulations of sulfamethoxazole have been discontinued.
What are the side effects of sulfamethoxazole?
: Common side effects of sulfamethoxazole are:
Sulfamethoxazole should be stopped at the first appearance of a skin rash since the rash may become severe. Serious rashes include Stevens-Johnson syndrome (aching joints and muscles; redness, blistering, and peeling of the skin); toxic epidermal necrolysis (difficulty in swallowing; peeling, redness, loosening, and blistering of the skin). Sulfamethoxazole therapy also can cause extensive sunburn, following exposure to sunlight. Patients receiving sulfamethoxazole should avoid excessive exposure to sunlight and should wear sunscreen.
Other important rare side effects include:
Sulfamethoxazole may form crystals in the urine which may damage the kidney and cause bleeding into the urine. It is important to drink additional liquids during sulfonamide therapy to prevent these side effects.
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What is the dosage for sulfamethoxazole?
Sulfamethoxazole usually is taken two or three times daily, with or without meals. It should be taken with 6 to 8 ounces of liquid to prevent crystals from forming in the urine. Persons with advanced kidney diseases may require lower doses.
Which drugs or supplements interact with sulfamethoxazole?
Sulfamethoxazole can enhance the blood-thinning effects of warfarin (Coumadin), possibly leading to bleeding. Sulfonamides such as sulfamethoxazole can increase the metabolism (break-down and elimination) of cyclosporine (causing loss of effectiveness of cyclosporine), and can add to the kidney damage caused by cyclosporine. All sulfonamides can crystallize in urine when the urine is acidic. Since methenamine (Hiprex, Urex, Mandelamine) causes an acidic urine, it should not be used with sulfonamides.
Is sulfamethoxazole safe to take if I'm pregnant or breastfeeding?
The effects of the sulfonamide class of antibiotics on the fetus have not been adequately studied. Therefore, physicians may use them if the benefits are deemed to outweigh potential risks. On the other hand, use of sulfonamides near term (that is, near the ninth month of pregnancy) may cause bilirubin to be displaced from proteins in the infant's blood. Displacement of bilirubin can lead to a dangerous condition called kernicterus in which the bilirubin damages the brain. For this reason, sulfonamides should not be used near term birth.
What else should I know about sulfamethoxazole?
What preparations of sulfamethoxazole are available?
Tablets: 500 mg and 1 gm.
How should I keep sulfamethoxazole stored?
The tablets should be kept at room temperature, 15 C - 30 C (59 F - 86 F).
Reference: FDA Prescribing Information
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Sulfamethoxazole (Gantanol, Gantanol DS) is an antibiotic prescribed for the treatment of malaria, pinkeye due to chlamydia, toxoplasmosis, and urinary tract infections. According to the FDA database, all brand and generic formulations of sulfamethoxazole have been discontinued. Side effects, drug interactions, warnings and precautions, and patient safety information should be reviewed prior to taking any medication.
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STDs in Men Overview
Sexually transmitted diseases (STDs) are infections transmitted during sexual contact. They may be caused by viruses, bacteria, or parasites. STDs in men cause no symptoms or symptoms like
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Some STDs in men are treatable while others are not. STDs are diagnosed with tests that identify proteins or genetic material of the organisms causing the infection. The prognosis of an STD depends on whether the infection is treatable or not. Use of latex condoms can help reduce the risk of contracting an STD but it does not eliminate the risk entirely.
sulfonamides-oralSulfonamides are a class of drugs from a sulfur-containing chemical (sulfanilamide). Examples of sulfonamides include sulfamethoxazole/trimethoprim (Bactrim, Bactrim DS, Co-trimoxazole, Septra, Septra DS, Cotrim, SMZ-TMP, SMZ-TMP DS, Sulfatrim); sulfasalazine (Azulfidine, Sulfazine); and sulfisoxazole (Truxazole, Gantrisin). Some of these drugs are available only in generic forms. Side effects of sulfonamides may include dizziness, lethargy, diarrhea, nausea, vomiting, headache, serious skin rashes and anorexia. Sulfonamides are not recommended for women who are pregnant or breastfeeding. Side effects and drug interactions should be reviewed prior to taking this medication.
ToxoplasmosisToxoplasmosis (toxo) is a parasitic infection that causes flulike symptoms, swollen lymph nodes, and muscle aches and pains that may last from a few days to several weeks. Toxoplasmosis can be contracted by touching the hands to the mouth after gardening, cleaning a cat's litter box, or anything that came into contact with cat feces. Toxoplasmosis can also be contracted by eating raw or partly cooked meat, especially pork or lamb, or touching the hands to the mouth after contact with raw or undercooked meat.
Urinary Tract InfectionA urinary tract infection (UTI) is an infection of the bladder, kidneys, ureters, or urethra. E. coli, a type of bacteria that lives in the bowel and near the anus, causes most UTIs. UTI symptoms include pain, abdominal pain, mild fever, urinary urgency and frequency. Treatment involves a course of antibiotics.