GENERIC NAME: STREPTOKINASE - INJECTION (strep-toe-KYE-naze)
BRAND NAME(S): Kabikinase, Streptase
USES: This medication is an enzyme which works to break up and dissolve blood clots which can block arteries. It is used in the treatment of heart attack or lung blood clots (pulmonary embolism) as well as leg blood clots (deep venous thrombosis-DVT).
HOW TO USE: This medication is given by injection by a health care professional. It is important this medication be used as prescribed. It is most effective when administered as soon as possible (within 6 hours after symptoms (e.g., chest pain) appear.
SIDE EFFECTS: Nausea, dizziness, low blood pressure or mild fever may occur. It can also cause nerve damage. If any of these effects persist or worsen, notify your doctor promptly. Notify your doctor promptly if you develop: easy bruising, headache, flushing, rapid or abnormal heartbeat, chest pain. A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching, swelling, severe dizziness, trouble breathing. Immediately report any signs of bleeding to your doctor. If you notice other effects not listed above, contact your doctor or pharmacist.
PRECAUTIONS: Tell your doctor if you have: bleeding disorders, high blood pressure, endocarditis, recent biopsy or surgery, recent injury, any allergies. Use extra caution to avoid injury and trauma (e.g., carefully brush teeth) while using this medication due to the increased risk of bleeding. This medication should be used only if clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known if this medication appears in breast milk. Consult your doctor before breast-feeding.
DRUG INTERACTIONS: Tell your doctor of any over-the-counter or prescription medication you may take, including: blood thinners (e.g., warfarin), NSAID (e.g., ibuprofen, naproxen), aspirin. Drugs that can reverse effects of streptokinase include: aminocaproic acid, aprotinin, tranexamic acid. Do not start or stop any medicine without doctor or pharmacist approval.
OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.
NOTES: Laboratory tests will be done frequently while using this medication to monitor its effects and to prevent side effects.
MISSED DOSE: Continued or repeated doses are usually not necessary for this medication.
STORAGE: Store in a cool area as directed. Discard any unused medication after the expiration date on the label. Reconstituted solution may be refrigerated between 36 to 46 degrees F (2 to 8 degrees C) if used within 8 hours. Discard unused portion.
Related Disease Conditions
Heart Attack (Myocardial Infarction)
A heart attack occurs when a blood clot completely obstructs a coronary artery supplying blood to the heart muscle. Learn about warning signs, causes, complications, risk factors, and treatment.
Deep Vein Thrombosis (DVT, Blood Clot in the Legs)
Deep vein thrombosis (DVT) is a blood clot in the deep veins, and can be caused by broken bones, trauma to a limb, immobility, medications, smoking, cancer, genetic predisposition, and cancer. Symptoms and signs of a deep vein thrombosis in a leg are swelling, tenderness, redness, warmth, and pain. Treatments for DVT include medications and surgery.
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.