Peptic ulcer disease is characterized by sores, or ulcerations, in the lining tissues of the stomach or the duodenum, the first portion of the small intestine. Peptic ulcers can be caused by a number of conditions, including certain medications, excessive alcohol use, and other medical conditions. The primary symptom of peptic ulcer is upper abdominal pain. The pain can be sharp or dull and is often described as burning. Some affected people have indigestion that may quickly resolve after taking antacids or eating foods that neutralize stomach acids. Other people with peptic ulcers may not have symptoms at all or may have only very mild symptoms. The severity of the ulcers is not related to the severity of the symptoms they cause; mild ulcers may cause severe pain, while severe ulcers may only cause mild symptoms.
Loss of appetite and weight loss may occur in people with peptic ulcer disease. In certain cases, the ulcers may bleed into the gastrointestinal tract, resulting in dark (black or tarry) stool.
Other stomach ulcer (peptic ulcer) symptoms and signs
- Black Stools Due to Upper Gastrointestinal Bleeding
- Indigestion
- Loss of Appetite
- Mid to Upper Abdominal Pain
- Weight Loss
- Bloating or Gas
- Heartburn
- Nausea
- Vomiting
Main Article on Stomach Ulcer (Peptic Ulcer) Symptoms and Signs

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Examples of Medications for Stomach Ulcer (Peptic Ulcer) Symptoms and Signs
- aluminum hydroxide
- bismuth subsalicylate
- cimetidine, Tagamet HB
- cranberry
- esomeprazole (Nexium)
- famotidine (Pepcid AC)
- gotu kola
- Helidac (bismuth subsalicylate/metronidazole/tetracycline hydrochloride)
- lansoprazole (Heartburn Relief 24 Hour, Heartburn Treatment 24 Hour, Prevacid 24)
- licorice
- magaldrate
- misoprostol, Cytotec
- nizatidine (Axid, Axid AR)
- omeprazole
- pantoprazole
- Pylera (bismuth subcitrate potassium, metronidazole, and tetracycline hydrochloride)
- rabeprazole (Aciphex)
- ranitidine
- Side Effects of Prevacid (lansoprazole)
- Side Effects of Prilosec (omeprazole)
- slippery elm
- sucralfate
- Talicia (omeprazole magnesium, amoxicillin and rifabutin)
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