- What other names is Stinging Nettle known by?
- What is Stinging Nettle?
- How does Stinging Nettle work?
- Are there safety concerns?
- Are there any interactions with medications?
- Dosing considerations for Stinging Nettle.
Bichu, Common Nettle, Feuille d'Ortie, Graine d'Ortie, Grande Ortie, Great Stinging Nettle, Nettle, Nettle Leaf, Nettle Seed, Nettle Worth, Nettles, Ortie, Ortie Brûlante, Ortie des Jardins, Ortie Dioïque, Ortie Méchante, Ortiga, Small Nettle, Stinging Nettles, Urtica, Urtica dioica, Urtica urens, Urticae Herba et Folium, Urticae Radix.
Stinging nettle is a plant. The root and above ground parts are used as medicine.
Stinging nettle root is taken by mouth for urination problems related to an enlarged prostate (benign prostatic hyperplasia [BPH]). These problems include nighttime urination, urination that is too frequent, painful urination, inability to urinate, and irritable bladder.
Stinging nettle root is also used for elevated blood glucose, joint ailments, as a "water pill" (diuretic), and as an astringent. It is also used in women who have high levels of male sex hormones. This condition is called hyperandrogenism.
Stinging nettle above ground parts are used along with large amounts of fluids in so-called "irrigation therapy" for urinary tract infections (UTI), urinary tract inflammation, and kidney stones (nephrolithiasis). The above-ground parts are also used for seasonal allergies (hay fever) and osteoarthritis.
The above ground parts of stinging nettle are also taken by mouth for internal bleeding, including uterine bleeding, nosebleeds, and bowel bleeding. The above ground parts are also used for anemia, poor circulation, an enlarged spleen, diabetes and other hormone disorders, too much acid in the stomach, diarrhea, asthma, lung congestion, heart failure, rash, eczema, cancer, preventing the signs of aging, "blood purification," wound healing, and as a general tonic.
In foods, young stinging nettle leaves are eaten as a cooked vegetable.
In manufacturing, stinging nettle extract is used as an ingredient in hair and skin products.
Stinging nettle leaf has a long history of use. It was used primarily as a diuretic and laxative in ancient Greek times.
Don't confuse stinging nettle (Urtica dioica) with white dead nettle (Lamium album).
Possibly Effective for...
- Osteoarthritis. Taking stinging nettle leaf preparations by mouth or applying it to the skin might reduce pain in people with osteoarthritis. Taking stinging nettle leaf preparations by mouth might also reduce the need for pain medications.
Insufficient Evidence to Rate Effectiveness for...
- Hay fever. Early research suggests that using stinging nettle above ground parts at the first signs of hay fever symptoms may help provide relief.
- Benign prostatic hyperplasia (BPH). There is contradictory evidence about the effectiveness of stinging nettle, taken alone or together with other ingredients, for improving symptoms of BPH. Early research suggests that taking stinging nettle root preparations for up to 24 months improves urinary tract symptoms in people with BPH. However, stinging nettle root preparations may not improve the flow and force of urine. Many studies have evaluated a particular combination product that contains stinging nettle and saw palmetto (PRO 160/120 by Willmar Schwabe GmbH, Germany). Some research suggests that taking this product by mouth can improve urinary tract symptoms in men with BPH. This combination seems to be comparable to the prescription medication finasteride for relieving symptoms of BPH, and it may be better tolerated. But it's not known if this benefit is due to stinging nettle, saw palmetto, or both ingredients. Another product containing a combination of stinging nettle root, saw palmetto lipoidal extract, pumpkin seed oil, lemon bioflavonoid, and beta-carotene does not improve symptoms of BPH.
- Bleeding. Some early research suggests that applying a specific product (Ankaferd blood stopper) containing alpinia, licorice, thyme, stinging nettle, and common grape vine to the skin reduces bleeding during surgery. However, it does not seem to reduce the duration of surgery.
- Diabetes. Some early research suggests that taking a stinging nettle leaf preparation daily for 8 weeks does not help control of blood sugar levels in people with uncontrolled, advanced diabetes. However, other early research shows that taking a stinging nettle leaf preparation for 3 months decreases blood sugar and A1c levels in people with diabetes who are taking antidiabetes medications.
- Inflammation of the gums (gingivitis). Early research suggests that using a mouthwash containing stinging nettle, juniper, and yarrow twice daily for 3 months does not reduce plaque or bleeding in people with gingivitis.
- Excess male hormone levels in women (hyperandrogenism). Early research suggests that taking a stinging nettle root preparation for about 4 months is not more effective than standard therapy for improving menstrual cycle conditions, oily skin, or acne in women with excess male hormone levels.
- Poor circulation.
- Water retention.
- Wound healing.
- Other conditions.
Stinging nettle contains ingredients that might decrease inflammation and increase urine output.
Stinging nettle is POSSIBLY SAFE when taken by mouth for up to 2 years or when applied to the skin appropriately. However, it might cause stomach complaints and sweating. Touching the stinging nettle plant can cause skin irritation.
Special Precautions & Warnings:Pregnancy and breast-feeding: Stinging nettle is LIKELY UNSAFE to take during pregnancy. It might stimulate uterine contractions and cause a miscarriage. It's also best to avoid stinging nettle if you are breast-feeding.
Diabetes: There is some evidence that stinging nettle above ground parts can decrease blood sugar levels. This might increase the chance of blood sugar levels becoming too low in people being treated for diabetes. Monitor your blood sugar carefully.
Low blood pressure: Stinging nettle above ground parts might lower blood pressure. In theory, stinging nettle might increase the risk of blood pressure dropping too low in people prone to low blood pressure. If you have low blood pressure, discuss stinging nettle with your healthcare provider before starting it.
Kidney problems: The above ground parts of stinging nettle seem to increase urine flow. If you have kidney problems, discuss stinging nettle with your healthcare provider before starting it.
LithiumInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Stinging nettle might have an effect like a water pill or "diuretic." Taking stinging nettle might decrease how well the body gets rid of lithium. This could increase how much lithium is in the body and result in serious side effects. Talk with your healthcare provider before using this product if you are taking lithium. Your lithium dose might need to be changed.
Medications for diabetes (Antidiabetes drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Stinging nettle above ground parts might decrease blood sugar. Diabetes medications are also used to lower blood sugar. Taking stinging nettle along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.
Some medications used for diabetes include glimepiride (Amaryl), glyburide (Diabeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
Medications for high blood pressure (Antihypertensive drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Stinging nettle above ground parts might to decrease blood pressure. Taking stinging nettle along with medications for high blood pressure might cause your blood pressure to go too low.
Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), and many others.
Sedative medications (CNS depressants)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Large amounts of stinging nettle above ground parts might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. Taking stinging nettle along with sedative medications might cause too much sleepiness.
Warfarin (Coumadin)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Stinging nettle above ground parts contain large amounts of vitamin K. Vitamin K is used by the body to help blood clot. Warfarin (Coumadin) is used to slow blood clotting. By helping the blood clot, stinging nettle might decrease the effectiveness of warfarin (Coumadin). Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.
The following doses have been studied in scientific research:
- For osteoarthritis: 9 grams of crude stinging nettle leaf has been used daily. Also, an infusion containing 50 mg of stinging nettle leaf has been taken along with 50 mg of diclofenac daily for 14 days.
- For osteoarthritis: Fresh stinging nettle leaf has been applied to painful joints for 30 seconds once per day for one week. Also a specific cream containing stinging nettle leaf extract (Liquid Phyto-Caps Nettle Leaf by Gaia Herbs) has been applied twice daily for 2 weeks.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).
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Balzarini, J., Neyts, J., Schols, D., Hosoya, M., Van Damme, E., Peumans, W., and De Clercq, E. The mannose-specific plant lectins from Cymbidium hybrid and Epipactis helleborine and the (N-acetylglucosamine)n-specific plant lectin from Urtica dioica are potent and selective inhibitors of human immunodeficiency virus and cytomegalovirus replication in vitro. Antiviral Res 1992;18(2):191-207. View abstract.
Bercovich, E. and Saccomanni, M. Analysis of the results obtained with a new phytotherapeutic association for LUTS versus control. [corrected]. Urologia. 2010;77(3):180-186. View abstract.
Beyazit, Y., Kurt, M., Kekilli, M., Goker, H., and Haznedaroglu, I. C. Evaluation of hemostatic effects of Ankaferd as an alternative medicine. Altern.Med.Rev. 2010;15(4):329-336. View abstract.
Bombardelli E and Morazzoni P. Urtica dioica L. Fitoterapia 1997;68(5):387-402.
Cai, T., Mazzoli, S., Bechi, A., Addonisio, P., Mondaini, N., Pagliai, R. C., and Bartoletti, R. Serenoa repens associated with Urtica dioica (ProstaMEV) and curcumin and quercitin (FlogMEV) extracts are able to improve the efficacy of prulifloxacin in bacterial prostatitis patients: results from a prospective randomised study. Int.J Antimicrob.Agents 2009;33(6):549-553. View abstract.
Christensen, R. and Bliddal, H. Is Phytalgic(R) a goldmine for osteoarthritis patients or is there something fishy about this nutraceutical? A summary of findings and risk-of-bias assessment. Arthritis Res.Ther. 2010;12(1):105. View abstract.
Chrubasik S, Enderlein W, Bauer R, and Grabner W. Evidence for antirheumatic effectiveness of Herba Urticae dioicae in acute arthritis: A pilot study. Phytomedicine 1997;4(2):105-108.
Chrubasik, J. E., Roufogalis, B. D., Wagner, H., and Chrubasik, S. A comprehensive review on the stinging nettle effect and efficacy profiles. Part II: urticae radix. Phytomedicine. 2007;14(7-8):568-579. View abstract.
Chrubasik, J. E., Roufogalis, B. D., Wagner, H., and Chrubasik, S. A. A comprehensive review on nettle effect and efficacy profiles, Part I: herba urticae. Phytomedicine. 2007;14(6):423-435. View abstract.
Czarnetzki, B. M., Thiele, T., and Rosenbach, T. Immunoreactive leukotrienes in nettle plants (Urtica urens). Int Arch Allergy Appl.Immunol. 1990;91(1):43-46. View abstract.
Dathe G and Schmid H. [Phytotherapy of the benign prostatic hyperplasia (BPH). Double-blind study with an extract of Radicus Urticae (ERU)]. Urologe B 1987;27:223-226.
Edgcumbe, D. P. and McAuley, D. Hypoglycaemia related to ingestion of a herbal remedy. Eur.J.Emerg.Med. 2008;15(4):236-237. View abstract.
Engelmann U, Boos G, and Kres H. [Therapy of benign prostatic hyperplasia with Bazoton liquidum]. Urologe B 1996;36:287-291.
Fischer M and Wilbert D. [Efficacy testing of a phytopharmacon in the treatment of benign prostate hyperplasia (BPH)]. In: Rutishauser G. Benigne Prostatahyperplasie. Munchen: Zuckerscherdt;1992.
Francois, K. O., Auwerx, J., Schols, D., and Balzarini, J. Simian immunodeficiency virus is susceptible to inhibition by carbohydrate-binding agents in a manner similar to that of HIV: implications for further preclinical drug development. Mol.Pharmacol. 2008;74(2):330-337. View abstract.
Gansser D and Spiteller G. Aromatase inhibitors from Urtica dioica roots. Planta Medica 1995;61:138-140.
Goetz P. [Treatment of benign prostate hyperplasia with nettle roots]. Zeitschrift für Phytotherapie 1989;10:175-178.
Hallwachs, O. [Urination disorders caused by prostatic hyperplasia. Effect of Bazoton, Harzol and Prosta-capsules]. MMW.Munch.Med Wochenschr. 10-30-1981;123(44):1675-1676. View abstract.
Hill, N., Stam, C., and van Haselen, R. A. The efficacy of Prrrikweg gel in the treatment of insect bites: a double-blind, placebo-controlled clinical trial. Pharm World Sci 1996;18(1):35-41. View abstract.
Hirano, T., Homma, M., and Oka, K. Effects of stinging nettle root extracts and their steroidal components on the Na+,K(+)-ATPase of the benign prostatic hyperplasia. Planta Med 1994;60(1):30-33. View abstract.
Hryb, D. J., Khan, M. S., Romas, N. A., and Rosner, W. The effect of extracts of the roots of the stinging nettle (Urtica dioica) on the interaction of SHBG with its receptor on human prostatic membranes. Planta Med 1995;61(1):31-32. View abstract.
Huber, R., Bross, F., Schempp, C., and Grundemann, C. Arnica and stinging nettle for treating burns - a self-experiment. Complement Ther.Med. 2011;19(5):276-280. View abstract.
Jacquet, A., Girodet, P. O., Pariente, A., Forest, K., Mallet, L., and Moore, N. Phytalgic, a food supplement, vs placebo in patients with osteoarthritis of the knee or hip: a randomised double-blind placebo-controlled clinical trial. Arthritis Res.Ther. 2009;11(6):R192. View abstract.
Klingelhoefer, S., Obertreis, B., Quast, S., and Behnke, B. Antirheumatic effect of IDS 23, a stinging nettle leaf extract, on in vitro expression of T helper cytokines. J Rheumatol. 1999;26(12):2517-2522. View abstract.
Koch, E. Extracts from Fruits of Saw Palmetto (Sabal serrulata) and Roots of Stinging Nettle (Urtica dioica): Viable Alternatives in the Medical Treatment of Benign Prostatic Hyperplasia and Associated Lower Urinary Tracts Symptoms. Planta Med 2001;67(6):489-500. View abstract.
Konieczynski, P. and Wesolowski, M. Water-extractable magnesium, manganese and copper in leaves and herbs of medicinal plants. Acta Pol.Pharm. 2012;69(1):33-39. View abstract.
Kraus R, Spiteller G, and Bartsch W. [(10E,12Z)-9-Hydroxy-10,12-octadecadienoic acid, an aromatase inhibitor from roots of Urtica dioica]. Liebigs Ann Chem 1991;335-339.
Krzeski, T., Kazon, M., Borkowski, A., Witeska, A., and Kuczera, J. Combined extracts of Urtica dioica and Pygeum africanum in the treatment of benign prostatic hyperplasia: double-blind comparison of two doses. Clin Ther 1993;15(6):1011-1020. View abstract.
Kulze, A. and Greaves, M. Contact urticaria caused by stinging nettles. Br.J Dermatol. 1988;119(2):269-270. View abstract.
Lichius, J. J., Lenz, C., Lindemann, P., Muller, H. H., Aumuller, G., and Konrad, L. Antiproliferative effect of a polysaccharide fraction of a 20% methanolic extract of stinging nettle roots upon epithelial cells of the human prostate (LNCaP). Pharmazie 1999;54(10):768-771. View abstract.
Lopatkin, N. A., Sivkov, A. V., Medvedev, A. A., Walter, K., Schlefke, S., Avdeichuk, IuI, Golubev, G. V., Mel'nik, K. P., Elenberger, N. A., and Engelman, U. [Combined extract of Sabal palm and nettle in the treatment of patients with lower urinary tract symptoms in double blind, placebo-controlled trial]. Urologiia. 2006;(2):12, 14-12, 19. View abstract.
Lopatkin, N., Sivkov, A., Schlafke, S., Funk, P., Medvedev, A., and Engelmann, U. Efficacy and safety of a combination of Sabal and Urtica extract in lower urinary tract symptoms--long-term follow-up of a placebo-controlled, double-blind, multicenter trial. Int.Urol.Nephrol. 2007;39(4):1137-1146. View abstract.
Luczaj, L. and Szymanski, W. M. Wild vascular plants gathered for consumption in the Polish countryside: a review. J.Ethnobiol.Ethnomed. 2007;3:17. View abstract.
Namazi, N., Esfanjani, A. T., Heshmati, J., and Bahrami, A. The effect of hydro alcoholic Nettle (Urtica dioica) extracts on insulin sensitivity and some inflammatory indicators in patients with type 2 diabetes: a randomized double-blind control trial. Pak.J.Biol.Sci. 8-1-2011;14(15):775-779. View abstract.
Obertreis, B., Ruttkowski, T., Teucher, T., Behnke, B., and Schmitz, H. Ex-vivo in-vitro inhibition of lipopolysaccharide stimulated tumor necrosis factor-alpha and interleukin-1 beta secretion in human whole blood by extractum urticae dioicae foliorum. Arzneimittelforschung 1996;46(4):389-394. View abstract.
Oliver, F., Amon, E. U., Breathnach, A., Francis, D. M., Sarathchandra, P., Black, A. K., and Greaves, M. W. Contact urticaria due to the common stinging nettle (Urtica dioica)-- histological, ultrastructural and pharmacological studies. Clin Exp Dermatol. 1991;16(1):1-7. View abstract.
Patten G. Medicinal plant review: Urtica. Aust J Med Herbalism 1993;5(1):5-13.
Pavone, C., Abbadessa, D., Tarantino, M. L., Oxenius, I., Lagana, A., Lupo, A., and Rinella, M. [Associating Serenoa repens, Urtica dioica and Pinus pinaster. Safety and efficacy in the treatment of lower urinary tract symptoms. Prospective study on 320 patients]. Urologia. 2010;77(1):43-51. View abstract.
Purnak, T., Ozaslan, E., Beyazit, Y., and Haznedaroglu, I. C. Upper gastrointestinal bleeding in a patient with defective hemostasis successfully treated with ankaferd blood stopper. Phytother.Res. 2011;25(2):312-313. View abstract.
Ramos RR, Alarcon-Aguilar F, Lara-Lemus A, and et al. Hypoglycemic effect of plants used in Mexico as antidiabetics. Archives of Medical Research 1992;23(1):59-64.
Randall, C. F. Stinging nettles for osteoarthritis pain of the hip. Br.J Gen.Pract. 1994;44(388):533-534. View abstract.
Randall, C., Dickens, A., White, A., Sanders, H., Fox, M., and Campbell, J. Nettle sting for chronic knee pain: a randomised controlled pilot study. Complement Ther.Med. 2008;16(2):66-72. View abstract.
Randall, C., Meethan, K., Randall, H., and Dobbs, F. Nettle sting of Urtica dioica for joint pain--an exploratory study of this complementary therapy. Complement Ther Med 1999;7(3):126-131. View abstract.
Rayburn, K., Fleischbein, E., Song, J., Allen, B., Kundert, M., Leiter, C., and Bush, T. Stinging nettle cream for osteoarthritis. Altern.Ther.Health Med. 2009;15(4):60-61. View abstract.
Rhodes, L., Primka, R. L., Berman, C., Vergult, G., Gabriel, M., Pierre-Malice, M., and Gibelin, B. Comparison of finasteride (Proscar), a 5 alpha reductase inhibitor, and various commercial plant extracts in in vitro and in vivo 5 alpha reductase inhibition. Prostate 1993;22(1):43-51. View abstract.
Riehemann, K., Behnke, B., and Schulze-Osthoff, K. Plant extracts from stinging nettle (Urtica dioica), an antirheumatic remedy, inhibit the proinflammatory transcription factor NF-kB. FEBS Lett 1-8-1999;442(1):89-94. View abstract.
Safarinejad, M. R. Urtica dioica for treatment of benign prostatic hyperplasia: a prospective, randomized, double-blind, placebo-controlled, crossover study. J.Herb.Pharmacother. 2005;5(4):1-11. View abstract.
Sahin, M., Yilmaz, H., Gursoy, A., Demirel, A. N., Tutuncu, N. B., and Guvener, N. D. Gynaecomastia in a man and hyperoestrogenism in a woman due to ingestion of nettle (Urtica dioica). N.Z.Med.J. 2007;120(1265):U2803. View abstract.
Schneider H, Honold E, and Masuhr T. Treatment of benign prostatic hyperplasia with a combination plant preparation. Results of an observational study of sabal extract WS 1473 and Urtica extract WS 1031 in the offices of urologists. Fortschr Med 1995;113(3):37-40.
Schneider, T. and Rubben, H. [Stinging nettle root extract (Bazoton-uno) in long term treatment of benign prostatic syndrome (BPS). Results of a randomized, double-blind, placebo controlled multicenter study after 12 months]. Urologe A 2004;43(3):302-306. View abstract.
Swanston-Flatt, S. K., Day, C., Flatt, P. R., Gould, B. J., and Bailey, C. J. Glycaemic effects of traditional European plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. Diabetes Res 1989;10(2):69-73. View abstract.
Tahri, A., Yamani, S., Legssyer, A., Aziz, M., Mekhfi, H., Bnouham, M., and Ziyyat, A. Acute diuretic, natriuretic and hypotensive effects of a continuous perfusion of aqueous extract of Urtica dioica in the rat. J Ethnopharmacol 2000;73(1-2):95-100. View abstract.
Van der Weijden, G. A., Timmer, C. J., Timmerman, M. F., Reijerse, E., Mantel, M. S., and van, der, V. The effect of herbal extracts in an experimental mouthrinse on established plaque and gingivitis. J Clin Periodontol. 1998;25(5):399-403. View abstract.
Van Parijs J, Broekaert WF, and Peumans WJ. Urtica dioica agglutinin: a plant lectin with antifungal properties. Archives Internationales de Physiologie et de Biochimie 1988;96(1):31.
Wagner H, Geiger WN, Boos G, and et al. Studies on the binding of Urtica dioica agglutinin (UDA) and other lectins in an in vitro epidermal growth factor receptor test. Phytomedicine 1995;4:287-290.
Wagner H, Willer F, Samtleben R, and et al. Search for the antiprostatic principle of stinging nettle (Urtica dioica) roots. Phytomedicine 1994;1:213-224.
Anon. Quercetin. Alt Med Rev 1998;3:140-3.
Baykul, T., Alanoglu, E. G., and Kocer, G. Use of Ankaferd Blood Stopper as a hemostatic agent: a clinical experience. J Contemp Dent Pract 2010;11(1):E088-E094. View abstract.
Cabeza M, Bratoeff E, Heuze I, et al. Effect of beta-sitosterol as inhibitor of 5 alpha-reductase in hamster prostate. Proc West Pharmacol Soc 2003;46:153-5.
Caliskaner Z, Karaayvaz M, Ozturk S. Misuse of a herb: stinging nettle (Urtica urens) induced severe tongue oedema. Complement Ther Med 2004;12:57-8. View abstract.
Dar SA, Ganai FA, Yousuf AR, et al. Pharmacological and toxicological evaluation of Urtica dioica. Pharm Biol 2013;51:170-80. View abstract.
Durak I, Biri H, Devrim E, et al. Aqueous extract of Urtica dioica makes significant inhibition on adenosine deaminase activity in prostate tissue from patients with prostate cancer. Cancer Biol Ther 2004;3:855-7. View abstract.
Eyi, E. G., Engin-Ustun, Y., Kaba, M., and Mollamahmutoglu, L. Ankaferd blood stopper in episiotomy repair. Clin Exp Obstet Gynecol 2013;40(1):141-143. View abstract.
Farzami B, Ahmadvand D, Vardasbi S, Majin FJ, Khaghani Sh. Induction of insulin secretion by a component of Urtica dioica leave extract in perifused Islets of Langerhans and its in vivo effects in normal and streptozotocin diabetic rats. J Ethnopharmacol. 2003;89(1):47-53. View abstract.
Hartmann RW, Mark M, and Soldati F. Inhibition of a 5 a-reductase and aromatase by PHL-00801 (Prostatonin®), a combination of PY102 (Pygeum africanum) and UR 102 (Urtica dioica) extracts. Phytomedicine 1996;3(2):121-128.
Kassen A, Berges R, Senge T, et al. Effect of beta-sitosterol on transforming growth factor-beta-1 expression and translocation protein kinase C alpha in human prostate stromal cells in vitro. Eur Urol 2000;37:735-41. . View abstract.
Kianbakht S, Khalighi-Sigaroodi F, Dabaghian FH. Improved glycemic control in patients with advanced type 2 diabetes mellitus taking Urtica dioica leaf extract: a randomized double-blind placebo-controlled clinical trial. Clin. Lab. 2013;59:1071-1076.
Konrad L, Muller HH, Lenz C, et al. Antiproliferative effect on human prostate cancer cells by a stinging nettle root (Urtica dioica) extract. Planta Med 2000;66:44-7. View abstract.
Lichius JJ, Muth C. The inhibiting effects of Urtica dioica root extracts on experimentally induced prostatic hyperplasia in the mouse. Planta Med 1997;63:307-10. . View abstract.
Lopatkin N, Sivkov A, Walther C, et al. Long-term efficacy and safety of a combination of sabal and urtica extract for lower urinary tract symptoms--a placebo-controlled, double-blind, multicenter trial. World J Urol 2005;23:139-46. View abstract.
Lopatkin N, Sivkov A, Walther C, et al. Long-term efficacy and safety of a combination of sabal and urtica extract for lower urinary tract symptoms--a placebo-controlled, double-blind, multicenter trial. World J Urol 2005;23:139-46. View abstract.
Marks L, Partin AW, Epstein JI, et al. Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia. J Urol 2000;163:1451-6. View abstract.
Mills S, Bone K. Principles and Practice of Phytotherapy. London: Churchill Livingstone, 2000.
Mittman P. Randomized, double-blind study of freeze-dried Urtica dioica in the treatment of allergic rhinitis. Planta Med 1990;56:44-7. View abstract.
Najafipour F, Rahimi AO, Mobaseri M, Agamohamadzadeh N, Nikoo A, Aliasgharzadeh A. Therapeutic effects of stinging nettle (Urtica dioica) in women with hyperandrogenism. Int J Curr Res Aca Rev. 2014;2(7):153-160.
Oelke, M, Berges R, Schläfke S, Burkart M. Fixed-dose combination PRO 160/120 of sabal and urtica extracts improved nocturia in men with LUTS suggestive of BPH: re-evaluation of four controlled clinical studies. World J Urol. 2014;32:1149-1154.
Onal S, Timur S, Okutucu B, Zihnioglu F. Inhibition of alpha-glucosidase by aqueous extracts of some potent antidiabetic medicinal herbs. Prep Biochem Biotechnol. 2005;35(1):29-36. View abstract.
Randall C, Randall H, Dobbs F, et al. Randomized controlled trial of nettle sting for treatment of base-of-thumb pain. J R Soc Med 2000;93:305-9. View abstract.
Rau O, Wurglics M, Dingermann T, Abdel-Tawab M, Schubert-Zsilavecz M. Screening of herbal extracts for activation of the human peroxisome proliferator-activated receptor. Pharmazie. 2006;61(11):952-6. View abstract.
Schottner M, Gansser D, Spiteller G, et al. Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG). Planta Med 1997;63:529-32. View abstract.
Schöttner M, Spiteller G, Gansser D. Lignans Interfering with 5alpha-dihydrotestosterone binding to human sex hormone-binding globulin. J Nat Prod. 1998;61(1):119-21. View abstract.
Simões-Pires CA, Hmicha B, Marston A, Hostettmann K. A TLC bioautographic method for the detection of alpha- and beta-glucosidase inhibitors in plant extracts. Phytochem Anal. 2009;20(6):511-5. View abstract.
Sokeland J, Albrecht J. [Combination of Sabal and Urtica extract vs. finasteride in benign prostatic hyperplasia (Aiken stages I to II). Comparison of therapeutic effectiveness in a one year double-blind study]. Urologe A 1997;36:327-33. View abstract.
Sokeland J. Combined sabal and urtica extract compared with finasteride in men with benign prostatic hyperplasia: analysis of prostate volume and therapeutic outcome. BJU Int 2000;86:439-42. View abstract.
Vontobel HP, Herzog R, Rutishauser G, Kres H. [Results of a double-blind study on the effectiveness of ERU (extractum radicis Urticae) capsules in conservative treatment of benign prostatic hyperplasia]. (Abstract). Urologe A 1985;24:49-51. View abstract.