- What is St. John's wort (Hypericum perforatum)-oral, and how does it work (mechanism of action)?
- What brand names are available for St. John's wort (Hypericum perforatum)-oral?
- Is St. John's wort (Hypericum perforatum)-oral available as a generic drug?
- Do I need a prescription for St. John's wort (Hypericum perforatum)-oral?
- What are the side effects of St. John's wort (Hypericum perforatum)-oral?
- What is the dosage for St. John's wort (Hypericum perforatum)-oral?
- Which drugs or supplements interact with St. John's wort (Hypericum perforatum)-oral?
- Is St. John's wort (Hypericum perforatum)-oral safe to take if I'm pregnant or breastfeeding?
- What else should I know about St. John's wort (Hypericum perforatum)-oral?
What is St. John's wort (Hypericum perforatum)-oral, and how does it work (mechanism of action)?
St. John's wort is a commonly used over-the-counter (OTC) dietary supplement that is used to treat mild depression, anxiety, and sleep disorders. St. John's wort is a plant that has bright yellow flowers. A number of compounds that have pharmacological activity including naphthodianthrones (hypericin, pseudohypericin, protohypericin, and cyclopseudohypericin), flavonoids (quercetin, rutin, and luteolin), hyperforin, several amino acidsand tannins have been isolated from St. John's wort.
The exact mechanism of how St. John's wort works to alleviate symptoms of depression is not understood. Hyperforin and hypericin are thought to be the major active components. Studies suggest that hyperforin affect serotonin, norepinephrine, and dopamine which are chemicals that affect mood. Other studies show that hypericum has weak effects on catechol-O-methyl transferase, an enzyme that is responsible for the breakdown of chemicals in the brain including serotonin, norepinephrine, and dopamine. Read product labels and discuss dosing with your doctor before taking this dietary supplement.
What is the dosage for St. John's wort (Hypericum perforatum)-oral?
Dietary supplements such as St. John's wort are not regulated by the FDA, and are not subject to rigorous clinical studies that evaluate standardized drug dosages. Read product labels and discuss dosing with your doctor before taking this dietary supplement.
The most common dosage that has been used in the majority of studies is 0.3% hypericin or 5% hyperforin in a dosage of 300 to 400 mg three times daily.
Which drugs or supplements interact with St. John's wort (Hypericum perforatum)-oral?
: St. John's wort increases activity of several liver enzymes. Consequently, St. John's wort may decrease blood levels of drugs that are metabolized or broken-down by these enzymes. Examples of such drugs are warfarin (Coumadin), fluconazole (Diflucan), voriconazole (Vfend), itraconazole (Sporanox), fentanyl (Sublimaze), digoxin (Lanoxin), birth control pills and many other drugs.
St. John's wort should be avoided in patients taking prescription antidepressants due to the risk of serotonin syndrome. Symptoms of serotonin syndrome include agitation, hyperthermia (extreme body temperature), sweating, rapid heartbeat, and neuromuscular disturbances.
Additionally, St. John's wort may interact with other prescription medications. All patients should speak to their doctor or pharmacist before taking St. John's wort.
Is St. John's wort (Hypericum perforatum)-oral safe to take if I'm pregnant or breastfeeding?
What else should I know about St. John's wort (Hypericum perforatum)-oral?
How should I keep st. john's wort (Hypericum perforatum)-oral stored?
Capsules and caplets should be stored at room temperature between 15 C and 30 C (59 F and 86 F).
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St. John's Wort (Hypericum perforatum) is an herbal supplement used to treat anxiety and depression. Read product labels and discuss dosing with your doctor before taking this dietary supplement.
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Related Disease Conditions
Anxiety is a feeling of apprehension and fear characterized by symptoms such as trouble concentrating, headaches, sleep problems, and irritability. Anxiety disorders are serious medical illnesses that affect approximately 19 million American adults. Treatment for anxiety may incorporate medications and psychotherapy.
Depression is an illness that involves the body, mood, and thoughts and affects the way a person eats and sleeps, the way one feels about oneself, and the way one thinks about things. The principal types of depression are major depression, dysthymia, and bipolar disease (also called manic-depressive disease).
Sleep Disorders (How to Get a Good Night's Sleep)
A number of vital tasks carried out during sleep help maintain good health and enable people to function at their best. Sleep needs vary from individual to individual and change throughout your life. The National Institutes of Health recommend about 7-9 hours of sleep each night for older, school-aged children, teens, and most average adults; 10-12 for preschool-aged children; and 16-18 hours for newborns. There are two stages of sleep; 1) REM sleep (rapid-eye movement), and 2) NREM sleep (non-rapid-eye movement). The side effects of lack of sleep or insomnia include: Irritability Tiredness Feeling sleepy during the day Concentration or memory problems Lack of sleep and insomnia can be caused by medical conditions or diseases, medications, stress, or pain. The treatment for lack of sleep and insomnia depends upon the cause.
Depression in teenagers may be caused by many factors. Symptoms of teen depression include apathy, irresponsible behavior, sadness, sudden drop in grades, withdrawal from friends, and alcohol and drug use. Treatment of depression in adolescents may involve psychotherapy and medications.
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