Spleen Extract

Last Editorial Review: 6/11/2021
Other Name(s):

Bovine Spleen, Concentré de Rate, Extracto de Bazo, Extrait de Rate, Extrait de Rate Hydrolysé, Extrait Splénique, Extrait Splénique Prédigéré, Facteurs Spléniques, Hydrolyzed Spleen Extract, Predigested Spleen Extract, Rate Bovine, Rate Crue, Raw Spleen, Spleen, Spleen Concentrate, Spleen Factors, Spleen Peptides, Spleen Polypeptides, Splenopentin, Tuftsin.


The spleen is an organ in people and animals that has three major jobs. First, it breaks down and removes old and damaged red blood cells. It also holds a reserve of blood that can be released into the circulatory system to meet a sudden demand, such as bleeding (hemorrhage). It also provides some white cells to fight infection. Spleen extract is produced from animal spleens and is used as medicine.

Spleen extract is given “as replacement therapy” in cases where the spleen has been surgically removed and or isn't working properly.

People with low white blood cell counts, cancer, infections, or HIV-related infections take spleen extract to boost the immune system.

Spleen extract is also used for treating “autoimmune” diseases such as celiac disease, systemic lupus erythematosus (SLE), dermatitis herpetiformis, and rheumatoid arthritis.

Some people use spleen extract for a kidney disorder called glomerulonephritis, a blood disorder called thrombocytopenia, an intestinal disease called ulcerative colitis, and a blood vessel condition called vasculitis.

How does it work?

Spleen extract contains ingredients that are thought to stimulate the immune system.


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Uses & Effectiveness

Insufficient Evidence to Rate Effectiveness for...

More evidence is needed to rate the effectiveness of spleen extract for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

Side Effects

It is not known if spleen extract is safe. There is some concern about contamination from sick or diseased animals. Until more is known, don't use products containing spleen extract.


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Special Precautions & Warnings

Pregnancy and breast-feeding: Not enough is known about the use of spleen extract during pregnancy and breast-feeding. Stay on the safe side and avoid use.


The appropriate dose of spleen extract depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for spleen extract. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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