Medically Reviewed on 11/3/2022

Generic Name: spironolactone/hydrochlorothiazide

Brand and Other Names: Aldactazide

Drug Class: Thiazide Combos

What is spironolactone/hydrochlorothiazide, and what is it used for?

Spironolactone/hydrochlorothiazide is a combination medication used to treat high blood pressure (hypertension), heart failure, or extra fluid in the body (edema).

Spironolactone/hydrochlorothiazide is available under various brand names: Percodan, Endodan, Oxycodan


  • Somnolence and dizziness reported
  • Caution with hepatic impairment



  • May cause hypokalemia and hyponatremia; risk of hypokalemia may be increased in patients with cirrhosis, brisk diuresis, or if coadministered with other drugs that lower serum potassium
  • May cause hypomagnesemia, which can then result in hypokalemia which appears difficult to treat despite potassium repletion
  • May alter glucose tolerance and increase risk for hyperglycemia
  • May increase serum levels of calcium and uric acid by decreasing urinary excretion; may also increase cholesterol and triglycerides
  • Thiazides diuretics may add to or potentiate the action of other antihypertensive drugs
  • Sensitivity reactions to thiazides may occur in patients with or without a history of allergy or bronchial asthma
  • Sulfonamide derivatives, including thiazides, have been reported to exacerbate or activate systemic lupus erythematosus
  • Instruct patients to protect skin from sun and undergo regular skin cancer screening
  • Angle-closure glaucoma
    • Hydrochlorothiazide can cause acute angle-closure glaucoma and elevated intraocular pressure with or without noticeable acute myopic shift and/or choroidal effusions
    • May occur within hours of initiating therapy; discontinue therapy immediately in patients with acute decreases in visual acuity or ocular pain
    • Additional medical or surgical treatments may be needed if intraocular pressure remains uncontrolled
    • Untreated angle-closure glaucoma may result in permanent visual field loss
    • Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy

What are the side effects of spironolactone/hydrochlorothiazide?

Common side effects of spironolactone/hydrochlorothiazide include:

Serious side effects of spironolactone/hydrochlorothiazide include:

Rare side effects of spironolactone/hydrochlorothiazide include:

  • none

Seek medical care or call 911 at once if you have the following serious side effects:

  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug.

Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.


Salt and sodium are the same. See Answer

What is the dosage for spironolactone/hydrochlorothiazide?

Adult dosage


  • 25 mg/25 mg
  • 50 mg/50 mg

Edema, Ascites, Congestive Heart Failure

Adult dosage

  • 1-8 tablets/day orally (spironolactone 25 mg/hydrochlorothiazide 25 mg)
  • 1-4 tablets/day orally (spironolactone 50 mg/hydrochlorothiazide 50 mg)

Hypertension, Hypokalemia (Diuretic Induced)

Adult dosage

  • 2-4 tablets/day orally (spironolactone 25 mg/hydrochlorothiazide 25 mg)
  • 1-2 tablets/day orally (spironolactone 50 mg/hydrochlorothiazide 50 mg)

What drugs interact with spironolactone/hydrochlorothiazide?

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. 

Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your healthcare professional or doctor for additional medical advice, or if you have health questions or concerns.

Pregnancy and breastfeeding

Pregnancy & Lactation

  • Use with caution if benefits outweigh risks during pregnancy


  • Discontinue drug or do not nurse


Spironolactone/hydrochlorothiazide is a combination medication used to treat high blood pressure (hypertension), heart failure, or extra fluid in the body (edema). Common side effects of spironolactone/hydrochlorothiazide include drowsiness, dizziness, lack of energy, leg cramps, itching, and hair loss. Do not take if breastfeeding. Consult your doctor if pregnant. Somnolence and dizziness have been reported. Use with caution in people with hepatic impairment.

Treatment & Diagnosis

Medications & Supplements

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Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Medically Reviewed on 11/3/2022