- Side Effects
- Drug Interactions
- Pregnancy & Breastfeeding
Brand and Other Names: Aldactazide
Drug Class: Thiazide Combos
What is spironolactone/hydrochlorothiazide, and what is it used for?
Spironolactone/hydrochlorothiazide is available under various brand names: Percodan, Endodan, Oxycodan
- Somnolence and dizziness reported
- Caution with hepatic impairment
- May cause hyperkalemia; risk may be increased in patients with renal insufficiency, diabetes mellitus, or if coadministered with other drugs/diet that raise serum potassium levels
- Gynecomastia reported
- May cause hypokalemia and hyponatremia; risk of hypokalemia may be increased in patients with cirrhosis, brisk diuresis, or if coadministered with other drugs that lower serum potassium
- May cause hypomagnesemia, which can then result in hypokalemia which appears difficult to treat despite potassium repletion
- May alter glucose tolerance and increase risk for hyperglycemia
- May increase serum levels of calcium and uric acid by decreasing urinary excretion; may also increase cholesterol and triglycerides
- Thiazides diuretics may add to or potentiate the action of other antihypertensive drugs
- Sensitivity reactions to thiazides may occur in patients with or without a history of allergy or bronchial asthma
- Sulfonamide derivatives, including thiazides, have been reported to exacerbate or activate systemic lupus erythematosus
- Instruct patients to protect skin from sun and undergo regular skin cancer screening
- Angle-closure glaucoma
- Hydrochlorothiazide can cause acute angle-closure glaucoma and elevated intraocular pressure with or without noticeable acute myopic shift and/or choroidal effusions
- May occur within hours of initiating therapy; discontinue therapy immediately in patients with acute decreases in visual acuity or ocular pain
- Additional medical or surgical treatments may be needed if intraocular pressure remains uncontrolled
- Untreated angle-closure glaucoma may result in permanent visual field loss
- Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy
What are the side effects of spironolactone/hydrochlorothiazide?
Common side effects of spironolactone/hydrochlorothiazide include:
Serious side effects of spironolactone/hydrochlorothiazide include:
- difficulty breathing,
- swelling of the face, lips, tongue, or throat,
- sore throat,
- burning in the eyes,
- skin pain,
- red or purple skin rash that spreads and causes blistering and peeling,
- skin rash,
- swollen glands,
- flu-like symptoms,
- muscle aches,
- severe weakness,
- unusual bruising,
- yellowing of the skin or eyes (jaundice),
- sudden weakness,
- ill feeling,
- sore throat,
- mouth sores,
- easy bruising,
- unusual bleeding,
- purple or red pinpoint spots under the skin,
- eye pain,
- vision problems,
- breast swelling and tenderness,
- slow heart rate,
- weak pulse,
- muscle weakness,
- tingly feeling,
- uneven heart rate,
- extreme thirst,
- increased urination,
- leg discomfort,
- muscle weakness,
- limp feeling,
- slurred speech,
- severe weakness,
- loss of coordination, and
- feeling unsteady
Rare side effects of spironolactone/hydrochlorothiazide include:
Seek medical care or call 911 at once if you have the following serious side effects:
- Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
- Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
- Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out.
This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug.
Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.
What is the dosage for spironolactone/hydrochlorothiazide?
- 25 mg/25 mg
- 50 mg/50 mg
- 1-8 tablets/day orally (spironolactone 25 mg/hydrochlorothiazide 25 mg)
- 1-4 tablets/day orally (spironolactone 50 mg/hydrochlorothiazide 50 mg)
Hypertension, Hypokalemia (Diuretic Induced)
- 2-4 tablets/day orally (spironolactone 25 mg/hydrochlorothiazide 25 mg)
- 1-2 tablets/day orally (spironolactone 50 mg/hydrochlorothiazide 50 mg)
What drugs interact with spironolactone/hydrochlorothiazide?
If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first
- Spironolactone/hydrochlorothiazide has severe interactions with no other drugs.
- Spironolactone/hydrochlorothiazide has serious interactions with the following drugs:
- aminolevulinic acid oral
- aminolevulinic acid topical
- methyl aminolevulinate
- potassium acid phosphate
- potassium chloride
- potassium citrate
- potassium phosphates, IV
- tretinoin topical
- Spironolactone/hydrochlorothiazide has moderate interactions with at least 208 other drugs.
- Spironolactone/hydrochlorothiazide has minor interactions with at least 162 other drugs.
This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products.
Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your healthcare professional or doctor for additional medical advice, or if you have health questions or concerns.
Pregnancy and breastfeeding
Pregnancy & Lactation
- Use with caution if benefits outweigh risks during pregnancy
- Discontinue drug or do not nurse
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Spironolactone/hydrochlorothiazide is a combination medication used to treat high blood pressure (hypertension), heart failure, or extra fluid in the body (edema). Common side effects of spironolactone/hydrochlorothiazide include drowsiness, dizziness, lack of energy, leg cramps, itching, and hair loss. Do not take if breastfeeding. Consult your doctor if pregnant. Somnolence and dizziness have been reported. Use with caution in people with hepatic impairment.
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Related Disease Conditions
Blood Pressure Readings: Ranges, Normal, High, Low
Blood pressure is the force applied by the blood over the inner walls of the arteries. Although the average blood pressure for a person remains constant, it shows minor fluctuations throughout the day—declining while relaxing and momentarily increasing while being excited or under stress. An increase in resting blood pressure can scar, stiffen, or harden the arteries.
Why Is My Bottom Blood Pressure Number High?
Isolated diastolic hypertension (IDH) occurs when your systolic blood pressure is normal, and only your diastolic blood pressure is high (over 80 mm Hg). Causes of high diastolic blood pressure include a high-sodium diet, obesity, lack of physical activity, excessive alcohol consumption, stress and anxiety.
How Can I Lower My Blood Pressure in Minutes?
Learn how to lower your high blood pressure quickly and how to better manage this condition.
High Blood Pressure (Hypertension)
High blood pressure (hypertension) is a disease in which pressure within the arteries of the body is elevated. About 75 million people in the US have hypertension (1 in 3 adults), and only half of them are able to manage it. Many people do not know that they have high blood pressure because it often has no has no warning signs or symptoms. Systolic and diastolic are the two readings in which blood pressure is measured. The American College of Cardiology released new guidelines for high blood pressure in 2017. The guidelines now state that blood normal blood pressure is 120/80 mmHg. If either one of those numbers is higher, you have high blood pressure. The American Academy of Cardiology defines high blood pressure slightly differently. The AAC considers 130/80 mm Hg. or greater (either number) stage 1 hypertension. Stage 2 hypertension is considered 140/90 mm Hg. or greater. If you have high blood pressure you are at risk of developing life threatening diseases like stroke and heart attack.REFERENCE: CDC. High Blood Pressure. Updated: Nov 13, 2017.
How to Lower My Blood Pressure Immediately
If you face any complications of high blood pressure such as a stroke or heart attack, contact your physician without any delay. Do not attempt home remedies in such grave situations. If you have high blood pressure, without any complications, the first thing to do is to calm down and lie flat.
What Is Normal Blood Pressure and Pulse by Age?
The American Heart Association outlines that a normal blood pressure reading of 120/80 mm Hg for adults. Here is a chart that breaks down the ideal blood pressure range by age.
What Is Considered Stroke-Level High Blood Pressure?
Blood pressure readings above 180/120 mmHg are considered stroke-level, dangerously high, and require immediate medical attention.
What Does it Mean When the Bottom Number of Your Blood Pressure is Over 100?
Diastolic blood pressure (DBP) is the pressure exerted on the walls of the arteries when the heart muscle relaxes between beats. When the bottom number of blood pressure (diastole) is over 100 mmHg, it may be called diastolic hypertension (DHT). Diastolic blood pressure means the blood pressure reading during the phase when your heart relaxes (diastole). Force of the blood against the walls of the arteries (the blood vessels carrying blood from the heart to other sites) in the body is called blood pressure. The heart pumps the blood into the arteries as it contracts (systole).
How Do You Check Your Blood Pressure With Fingers?
Most doctors recommend the use of a blood pressure machine to check blood pressure. An individual may check heart rate with their fingers, but not blood pressure.
What Is Normal Blood Pressure for a 60-Year-Old?
According to current guidelines from the American Heart Association, normal blood pressure for adults under the age of 65 is any blood pressure below 120/80 mmHg.
Is 120 Over 60 a Good Blood Pressure Reading?
If your systolic blood pressure is normal (between 100-120), and your diastolic blood pressure is lower (60 or below), you are considered to have low blood pressure, or isolated diastolic hypotension. Low diastolic blood pressure should be monitored closely.
Is 150 Over 90 a Good Blood Pressure?
Blood pressure of 150/90 mmHg comes under the category of stage I hypertension and means that you have high blood pressure.
What Is the Blood Pressure of a Very Fit Person?
Studies show that a very fit person who exercises regularly will have a lower resting blood pressure (usually below 120/80 mm Hg) than someone who leads a sedentary lifestyle.
How Can I Bring My Blood Pressure Down Immediately?
High blood pressure is diagnosed when the force of your blood pressing against the artery wall is too high for an extended period of time. Bring your blood pressure down immediately by taking a hot shower or bath and practicing deep breathing and relaxation techniques.
How Is Diastolic Hypertension Treated?
Diastolic hypertension, where only your diastolic blood pressure is elevated, may be treated with lifestyle changes such as weight loss, reducing your sodium intake or alcohol consumption, and quitting smoking. Medications may be prescribed in more severe cases.
Which Is More Important: Systolic or Diastolic Blood Pressure?
Systolic blood pressure is often given more attention as a risk factor for heart disease. However, both systolic and diastolic blood pressure are equally important in monitoring the health of your heart.
When is the Best Time to Measure Your Blood Pressure?
Hypertension, also known as high blood pressure, requires regular blood pressure checks. Measure your blood pressure at least twice a day at the same time every day.
Can Blood Pressure Spike For No Reason?
It is normal for your blood pressure to rise and fall throughout the day. Your blood pressure can fluctuate at any time due to various reasons.
Which ACE Inhibitor Is the Best for Hypertension?
The best ACE inhibitors for hypertension include Trandolapril, Enalapril, and Ramipril.
Can You Take Turmeric if You Take Blood Pressure Medicine?
Turmeric is one of the most used spices in Asian cuisine. This yellow spice has been hailed for its healing properties for centuries. A turmeric latte is touted for its myriad health benefits. Turmeric contains several anti-inflammatory compounds collectively called curcuminoids.
Is A Manual Blood Pressure More Accurate?
Manual blood pressure gives accurate results when used correctly by a trained person. However, manual blood pressure measurement is not the recommended type of blood pressure monitoring for home use because it requires some training.
What Time of Day Is Blood Pressure Highest?
Your blood pressure follows a pattern, rising a while before you wake up. It is the highest at midday and tends to drop in the evening or late afternoon.
Things to Know About High Blood Pressure Treatment
High blood pressure (hypertension) means high pressure (tension) in the arteries. Treatment for high blood pressure include lifestyle modifications (alcohol, smoking, coffee, salt, diet, exercise), drugs and medications such as ACE inhibitors, angiotensin receptor blockers, beta blockers, diuretics, calcium channel blockers (CCBs), alpha blockers, clonidine, minoxidil, and Exforge.
Can You Take Turmeric with Blood Pressure Medication?
Turmeric may not react well with some medications, including blood pressure medication.
Can Drinking Water Lower Your Blood Pressure?
Keeping well hydrated by drinking six to eight glasses of water daily (even more if working in hot and humid conditions) is beneficial for the blood pressure. High blood pressure (BP) or hypertension is a condition caused by the persistent high pressure of blood against the walls of arteries. It is also called systolic pressure (constantly greater than 139 mmHg) or diastolic pressure (constantly more than 89 mmHg).
Why is My Blood Pressure Suddenly High and Low?
Blood pressure can be defined as the force your blood creates when it's flowing through your arteries. Blood pressure may be high or low due to medication side effects, certain medical conditions, or unknown reasons.
How Do I Know If I Have High or Low Blood Pressure Numbers?
High or low blood pressure can lead to serious health conditions. Learn more about what you should do if your pressure is outside the ideal range.
What Foods Can I Eat to Lower My Blood Pressure Immediately?
What is high blood pressure and how can you lower it? Learn the best foods to help lower your blood pressure immediately.
Is It Okay to Take Blood Pressure Multiple Times?
International hypertension societies recommend taking multiple blood pressure measurements over several days.
What Blood Pressure Is Considered Life-Threatening?
Blood pressure that is 180/120 mm Hg or higher is considered dangerous and can lead to serious life-threatening complications. Check out the center below for more medical references on blood pressure, including multimedia (slideshows, images, and quizzes), related disease conditions, treatment and diagnosis, medications, and prevention or wellness.
Is Turmeric OK to Take With High Blood Pressure?
Turmeric is an ancient remedy, a perennial plant in the ginger family. Turmeric may help lower blood pressure, but talk to your doctor if you take medication to make sure it doesn't interact with it.
When Is Blood Pressure Lowest and Highest During the Day?
Your blood pressure fluctuates throughout the day. Check your blood pressure twice a day at around the same time every day.
Which Blood Pressure Number Is the Most Important?
The blood that flows through the arteries (blood vessels carrying blood from the heart to other parts of the body) exerts pressure against the arterial walls. The number above (120) is called the systolic blood pressure and the number below (80) is called the diastolic blood pressure. Though both readings are important, many doctors believe that systolic blood pressure is a better predictor of complications of hypertension, such as heart disease or stroke.
Can High Blood Pressure (HBP) Cause Blood in Urine?
Blood in your urine is also known as hematuria. Very rarely, it is caused by high blood pressure (HBP) — also known as hypertension.
What Are the Best Fruits for Lowering Blood Pressure?
The best fruits for lowering blood pressure include citrus fruits, berries, bananas, pomegranates, prunes, and melons.
What Are the 4 Stages of Hypertension?
Learn the four stages of hypertension, which include normal, elevated blood pressure, stage I hypertension, and stage II hypertension.
18 Ways to Lower Blood Pressure Without Medication
Lifestyle changes and home remedies are effective in controlling high blood pressure (hypertension). Check out the center below for more medical references on hypertension, including multimedia (slideshows, images, and quizzes), related disease conditions, treatment and diagnosis, medications, and prevention or wellness.
What Are the Top Drinks to Lower Blood Pressure?
The top drinks for lowering blood pressure include beverages that are rich in nutrients and low in sodium and fats. Learn the 10 best blood-pressure-lowering drinks here.
Why Does Alcohol Cause Hypertension?
Alcoholic beverages are regular drinks in most parts of the world. No one knows how alcohol causes hypertension, but it may be due to the effects of alcohol endothelium, nervous system, cortisol levels or other body systems.
What Can I Eat To Lower My Blood Pressure Immediately?
Learn what you can eat to lower your blood pressure to a more healthy level and help you manage hypertension.
What Is Normal Blood Pressure by Age?
What is normal blood pressure? Learn about normal blood pressure by age and the risk factors of hypertension.
What Will Happen if Your Blood Pressure is Too High?
High blood pressure, also known as hypertension, can have negative consequences on your health. Learn what happens if your blood pressure is too high, the causes of high blood pressure, and what you can do to treat it.
What Are the Signs Your Blood Pressure Is Too High?
What is high blood pressure, and how do you lower it? Learn the signs of high blood pressure and what to do if your blood pressure numbers go above a healthy range.
Can I Check My Blood Pressure With My Phone?
The force of the blood against the walls of the blood vessels carrying blood from the heart to other sites in the body (the arteries) is called blood pressure. The heart pumps blood into the arteries as it contracts (systole).
How Often Should Blood Pressure be Checked?
People older than 40 years should check their blood pressure once a year, while those between 18 and 40 years old should check it every three to five years.
What Are Abnormal Blood Pressure Number Ranges?
Abnormal blood pressure, especially high blood pressure, is a common issue with no initial symptoms. Learn how to keep your blood pressure in the normal range.
Can High Blood Pressure Hurt My Eyes?
Unfortunately, yes. Suffering from untreated or poorly controlled high blood pressure for a long time can be detrimental to your eyes. Several eye diseases are directly or indirectly caused by high blood pressure (hypertension).
What Are the New Blood Pressure Guidelines for Seniors?
Hypertension or high blood pressure (high BP) is a medical condition where the pressure in the blood vessels is persistently elevated. The heart pumps blood into the arteries, which circulate blood to all parts of the body. In cases of high blood pressure, the heart has to work harder to push the blood column ahead.
How Can I Lower My Blood Pressure in 30 Seconds?
Blood pressure refers to the tension — or pressure — your blood places on the walls of your arteries as it passes through your body. Lower your BP in 30 seconds by practicing deep breathing, taking a warm shower, and meditating or reading.
What Is High Blood Pressure (Hypertension)?
High blood pressure or hypertension is when the blood pressure readings consistently range from 140 or higher for systolic or 90 or higher for diastolic. Blood pressure readings above 180/120 mmHg are dangerously high and require immediate medical attention.
What Is “Normal” Blood Pressure?
Normal blood pressure is when the pressure is less than or upto 120/80 mmHg. The value 120 denotes the systolic pressure, and the value 80 denotes the diastolic pressure.
What Is the Drug of Choice for Hypertension?
Angiotensin-converting enzyme (ACE) inhibitors are the drug of choice for hypertension. Learn about other high blood pressure medications.
What Is the Proper Way to Take Your Blood Pressure?
Nowadays, you can easily measure your blood pressure at home using an automated blood pressure machine or sphygmomanometer. Here’s how to do it step-by-step to make sure you’re doing it the right way.
What Causes High Blood Pressure in Children?
Research states that kidney disease is the main cause of high blood pressure in children; however, here are the other potential causes of hypertension in kids.
How Does High Blood Pressure Affect Pregnancy?
High blood pressure during pregnancy can cause serious complications. Learn more about the signs of and risks associated with the condition.
Is Pseudotumor Cerebri the Same as Intracranial Hypertension?
Pseudotumor cerebri (PTC) is also called idiopathic intracranial hypertension (IIH). The condition causes symptoms similar to a brain tumor.
What Can You Do For Treatment if Your Blood Pressure Is Too Low?
Learn what medical treatments can help with your low blood pressure and speed up your recovery.
What BP Is Hypertension?
Hypertension occurs when blood pressure readings are 130/80 mmHg or higher. Learn about blood pressure levels, as well as symptoms, risk factors, and treatment options for high blood pressure. Check out the center below for more medical references on hypertension, including multimedia (slideshows, images, and quizzes), related diseases, treatment, diagnosis, medications, and prevention or wellness.
What Is a Normal Blood Pressure Check?
A normal blood pressure check should be below 120/80 mmHg in adults (18 years and older).
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