- What is sofosbuvir, and how does it work?
- What brand names are available for sofosbuvir?
- Is it available as a generic drug?
- Do I need a prescription for it?
- What types of hepatitis C infections does it treat (uses)?
- Sofosbuvir side effects
- How do I use or take sofosbuvir (dosage)?
- Which drugs or supplements interact with sofosbuvir?
- Is it safe to take if I'm pregnant or breastfeeding?
- What else should I know about this drug?
What is sofosbuvir, and how does it work?
- Sofosbuvir is an oral, direct-acting antiviral agent used for treating infections with the hepatitis C virus (HCV).
- Other direct-acting hepatitis C treatments include:
- After administration sofosbuvir is first converted to an active form. The active form of sofosbuvir interferes with multiplication of the ribonucleic acid (RNA) of HCV leading to reduced numbers of hepatitis C virus in the body.
- Sofosbuvir is effective for treating infection with HCV genotype 1,2,3, or 4, and in clinical trials, 50% to 90% of individuals treated with the drug cleared the hepatitis C virus from their blood.
Do I need a prescription for it?
Yes, you need a prescription from your doctor or health care professional for this drug.
What types of hepatitis C infections does it treat (uses)?
Sofosbuvir side effects
The most common side effects reported by patients include:
Other side effects include:
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How do I use or take sofosbuvir (dosage)?
The recommended dose of sofosbuvir is one 400 mg tablet once daily with or without food for 12 to 24 weeks.
Which drugs or supplements interact with sofosbuvir?
Rifampin and St. John's wort may reduce blood levels of sofosbuvir by increasing its metabolism (break-down) in the intestine. Therefore, sofosbuvir should not be combined with rifampin or St. John's wort. Other drugs that also may reduce blood levels of sofosbuvir include:
- carbamazepine (Tegretol, Tegretol XR
- Equetro, Carbatrol)
- phenytoin (Dilantin, Dilantin-125)
- phenobarbital, oxcarbazepine (Tripetal)
- tipranavir (Aptivus)/ritonavir (Norvir)
Sofosbuvir and amiodarone should not be combined with another direct-acting antiviral agent because combining them may significantly reduce heart rate, especially in people who are taking beta-blockers or have underlying heart problems.
Is it safe to take if I'm pregnant or breastfeeding?
What else should I know about this drug?
- This drug is available in 400 mg tablets.
- Keep the tablets stored at room temperature below 30 C (86 F).
- The FDA approved Sovaldi in December 2013.
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Sofosbuvir, brand name Sovaldi, is an antiviral medication prescribed for the treatment of the hepatitis C virus (HCV) genotypes 1, 2, 3, and 4 infection. It is used in combination with ribavirin plus interferon or ribavirin (Rebetol, Copegus). Common side effects include:
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Liver (Anatomy and Function)
The liver is the largest gland and organ in the body. There are a variety of liver diseases caused by liver inflammation, scarring of the liver, infection of the liver, gallstones, cancer, toxins, genetic diseases, and blood flow problems. Symptoms of liver disease generally do not occur until the liver disease is advanced. Some symptoms of liver disease include jaundice, nausea and vomiting, easy bruising, bleeding excessively, fatigue, weakness, weight loss, shortness of breath, leg swelling, impotence, and confusion. Treatment of diseases of the liver depends on the cause.
Hepatitis (Viral Hepatitis A, B, C, D, E, G)
Hepatitis is most often viral, due to infection with one of the hepatitis viruses (A, B, C, D, E, F (not confirmed), and G) or another virus (such as those that cause infectious mononucleosis, cytomegalovirus disease). The main nonviral causes of hepatitis are alcohol and drugs. Many patients infected with hepatitis A, B, and C have few or no symptoms of illness. For those who do develop symptoms of viral hepatitis, the most common are flu-like symptoms including: loss of appetite, nausea, vomiting, fever, weakness, tiredness, and aching in the abdomen. Treatment of viral hepatitis is dependent on the type of hepatitis.
Hepatitis C (HCV, Hep C)
Hepatitis C is an inflammation of the liver due to the hepatitis C virus (HCV), which is usually spread by blood transfusion, hemodialysis, and needle sticks, especially with intravenous drug abuse. Symptoms of chronic hepatitis include fatigue, fever, muscle aches, loss of appetite, and fever. Chronic hepatitis C may be cured in most individuals with drugs that target specific genomes of hepatitis C.
Is Hepatitis Contagious?
Hepatitis means "inflammation of the liver," and there are several different types of such as A, B, C, D, and E. Some types of hepatitis are contagious and some types are not. Hepatitis symptoms vary upon the type of disease; however, the following symptoms may develop in someone with hepatitis: fatigue, nausea and vomiting, abdominal pain and discomfort, jaundice (yellowing of the skin and whites of the eyes), and loss of appetite. Treatment for hepatitis depends upon the cause. Some types of hepatitis have a vaccine to prevent spread of disease such as hepatitis A and B.
Is Hepatitis C Contagious?
Hepatitis C or hep C causes acute and chronic liver disease. Hep C is a form of liver disease with symptoms like fatigue, jaundice, nausea and vomiting, anorexia, and abdominal discomfort. Hepatitis C is a contagious viral infection caused by people sharing drug needles, surgical instruments that have not been properly sanitized, and organ transplantation.
Hepatitis C Cure (Symptoms, Transmission, Treatments, and Cost)
Hepatitis is inflammation of the liver. There are a variety of toxins, diseases, illicit drugs, medications, bacterial and viral infections, and heavy alcohol use can case inflammation of the liver. Hepatitis C viral infection (HCV) is one type of hepatitis. According to the CDC, in 2014 there were an estimated 30,500 cases of acute hepatitis C infections in the US. An estimated 2.7-3.9 million people in the US have chronic hepatitis C. The virus is spread from person-to-person via blood-to-blood contact. Symptoms of HCV infection include joint pain, jaundice, dark urine, nausea, fatigue, fever, loss of appetites, clay colored stool. Hepatitis C can be cured with medications in most people. There is no vaccine against the hepatitis C virus.
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Reference: FDA Prescribing Information