- What is sofosbuvir, and how does it work?
- What brand names are available for sofosbuvir?
- Is it available as a generic drug?
- Do I need a prescription for it?
- What types of hepatitis C infections does it treat (uses)?
- Sofosbuvir side effects
- How do I use or take sofosbuvir (dosage)?
- Which drugs or supplements interact with sofosbuvir?
- Is it safe to take if I'm pregnant or breastfeeding?
- What else should I know about this drug?
What is sofosbuvir, and how does it work?
- Sofosbuvir is an oral, direct-acting antiviral agent used for treating infections with the hepatitis C virus (HCV).
- Other direct-acting hepatitis C treatments include:
- After administration sofosbuvir is first converted to an active form. The active form of sofosbuvir interferes with multiplication of the ribonucleic acid (RNA) of HCV leading to reduced numbers of hepatitis C virus in the body.
- Sofosbuvir is effective for treating infection with HCV genotype 1,2,3, or 4, and in clinical trials, 50% to 90% of individuals treated with the drug cleared the hepatitis C virus from their blood.
What types of hepatitis C infections does it treat (uses)?
Sofosbuvir side effects
The most common side effects reported by patients include:
Other side effects include:
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How do I use or take sofosbuvir (dosage)?
The recommended dose of sofosbuvir is one 400 mg tablet once daily with or without food for 12 to 24 weeks.
Which drugs or supplements interact with sofosbuvir?
Rifampin and St. John's wort may reduce blood levels of sofosbuvir by increasing its metabolism (break-down) in the intestine. Therefore, sofosbuvir should not be combined with rifampin or St. John's wort. Other drugs that also may reduce blood levels of sofosbuvir include:
- carbamazepine (Tegretol, Tegretol XR
- Equetro, Carbatrol)
- phenytoin (Dilantin, Dilantin-125)
- phenobarbital, oxcarbazepine (Tripetal)
- tipranavir (Aptivus)/ritonavir (Norvir)
Sofosbuvir and amiodarone should not be combined with another direct-acting antiviral agent because combining them may significantly reduce heart rate, especially in people who are taking beta-blockers or have underlying heart problems.
Is it safe to take if I'm pregnant or breastfeeding?
What else should I know about this drug?
- This drug is available in 400 mg tablets.
- Keep the tablets stored at room temperature below 30 C (86 F).
- The FDA approved Sovaldi in December 2013.
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Sofosbuvir, brand name Sovaldi, is an antiviral medication prescribed for the treatment of the hepatitis C virus (HCV) genotypes 1, 2, 3, and 4 infection. It is used in combination with ribavirin plus interferon or ribavirin (Rebetol, Copegus). Common side effects include:
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Reference: FDA Prescribing Information