- What is sodium iodide I 131, and how does it work (mechanism of action)?
- What are the uses for sodium iodide I 131?
- What are the side effects of sodium iodide I 131?
- What is the dosage for sodium iodide I 131?
- Which drugs or supplements interact with sodium iodide I 131?
- Is sodium iodide I 131 safe to take if I'm pregnant or breastfeeding?
- What else should I know about sodium iodide I 131?
What is sodium iodide I 131, and how does it work (mechanism of action)?
Sodium iodide I 131 is an oral medication used to treat hyperthyroidism (overactive thyroid gland) and some cases of thyroid cancer. It falls under the category of an anti-thyroid drug but differs from the other anti-thyroid drugs, propylthiouracil (PTU) and methimazole (Tapazole), because it is radioactive. Sodium iodide I 131 is taken by mouth, readily absorbed into the body and is trapped within the thyroid gland. The trapped sodium iodide I 131 irradiates the thyroid gland thereby damaging it. As a result, the activity of the thyroid gland (that is, the production and release of thyroid hormone) is reduced. Excess sodium iodide I 131 is eliminated from the body in the urine by the kidneys. The sodium iodide retained in the body loses most of its radioactivity over several weeks. The half-life of the radioactivity is eight days. The FDA approved sodium iodide I 131 in August 1971.
What brand names are available for sodium iodide I 131?
Sodium Iodide I 131 Therapeutic, Hicon
Is sodium iodide I 131 available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for sodium iodide I 131?
What are the side effects of sodium iodide I 131?
The side effects commonly seen with sodium iodide I 131 treatment are mild with the smaller doses given for hyperthyroidism but may be more severe with the larger doses given for thyroid cancer. Sodium iodide I 131 may cause suppression of the bone marrow, resulting in anemia, and reductions in white blood cells and platelets. It also may cause acute leukemia.
Other important side effects that can occur with large doses include symptoms of:
Thyroid crisis (due to the release of large amounts of thyroid hormone), severe inflammation of the salivary glands, and chromosomal abnormalities may occur. On day three after treatment, a constellation of signs and symptoms may occur including:
Finally, temporary hair thinning may occur two to three months after treatment.
What is the dosage for sodium iodide I 131?
The usual sodium iodide I 131 dose ranges from 4-10 mCi to treat hyperthyroidism. Doses to treat thyroid cancer are individualized and are usually 10-27 times greater than for hyperthyroidism.
Which drugs or supplements interact with sodium iodide I 131?
Non-radioactive iodine, thyroid hormone, propylthiouracil (PTU) or methimazole (Tapazole, Northyx) may all interfere with the trapping of sodium iodide I 131 by the thyroid gland. Thyroid hormone, drugs that contain iodine (for example, amiodarone [Coradone]), and iodine containing contrast agents all interfere with the action of sodium iodide I 131.
Is sodium iodide I 131 safe to take if I'm pregnant or breastfeeding?
Sodium iodide I 131 has been shown to cause harm to a developing fetus. Use in pregnant women should be avoided.
What else should I know about sodium iodide I 131?
What preparations of sodium iodide I 131 are available?
Capsules; with radioactivity of 0.75 to 100 mCi per capsule. (A millicurie is a unit for measuring activity). Sodium iodide I 131also is available as a liquid in vials containing 5 to 150 mCi/vial.
How should I keep sodium iodide I 131 stored?
Sodium iodide I 131 should be store at room temperature, 20-25 C (68-77 C). Sodium iodide I 131 is ordered for individual patients in a hospital setting. It arrives at room temperature in a lead container to minimize radiation exposure to hospital personnel. Special handling is required.
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Sodium iodide I 131 (Iodotope, Sodium Iodide I 131 Therapeutic) is a medication prescribed for the treatment of hyperthyroidism, and in some cases of thyroid cancer. Review side effects, dosage, drug interactions, and patient safety information prior to taking this medication.
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Hyperthyroidism is an excess of thyroid hormone due to an overactive thyroid gland. Symptoms can include increased heart rate, weight loss, heart palpitations, frequent bowel movements, depression, fatigue, fine or brittle hair, sleep problems, thinning skin, and irregular vaginal bleeding. Graves' disease is the most common cause of hyperthyroidism. Many other health problems or taking excess thyroid hormone medication can cause an overactive thyroid gland. Treatment for the condition is with medication, radioactive iodine, thyroid surgery (rarely), or reducing the dose of thyroid hormone. No diet has been shown to treat hyperthyroidism or its symptoms and signs.
There are several types of thyroid disorders including hypothyroidism, hyperthyroidism, goiters, thyroid nodules, and thyroid cancer. Symptoms vary by condition. Diagnosis is made with blood tests, scans, ultrasound, or biopsy. Treatments depend on the disorder and can include medication or surgery.
There are four major types of thyroid cancer: papillary, follicular, medullary, and anaplastic thyroid cancer. Tumors on the thyroid are referred to as thyroid nodules. Symptoms of thyroid cancer include swollen lymph nodes, pain in the throat, difficulty swallowing, hoarseness, and a lump near the Adam's apple. Treatment usually involves chemotherapy, surgery, radioactive iodine, hormone treatment or external radiation and depends upon the type of thyroid cancer, the patient's age, the tumor size, and whether the cancer has metastasized.
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