- Side Effects
- Drug Interactions
- Pregnancy & Breastfeeding
- What Else to Know
Generic Name: sodium citrate/dextrose/fructose
Brand Name: Nauzene
Drug Class: Antiemetic Agents
What is sodium citrate/dextrose/fructose, and what is it used for?
Sodium citrate/dextrose/fructose is a combination medication used for the temporary relief of nausea associated with an upset or sour stomach, including that due to overindulgence in food or drinks.
Sodium citrate is a sodium salt of citric acid, and dextrose and fructose are simple sugars found naturally in corn, honey, and fruits. Dextrose is similar to glucose, a form of sugar that can be directly used by the cells while fructose has to be metabolized by the liver first.
Sodium citrate is an alkalinizing agent that acts as an antacid and neutralizes the acid in the stomach. Dextrose and fructose are hyperosmolar carbohydrate solutions that have a direct effect on the gastrointestinal (GI) wall and reduce GI smooth muscle contraction. The combination drug reduces stomach acidity and also relieves nausea resulting from GI muscle contractions. Sodium citrate/dextrose/fructose is available over the counter (OTC).
- Do not use sodium citrate/dextrose/fructose if you have hereditary fructose intolerance.
- Exercise caution in case of diabetes. The sugars in the medication can increase blood glucose levels.
- Use with caution if you are on a sodium-restricted diet.
- Do not administer to a child without consulting with a physician.
- Sodium citrate reduces the acidity and pH level in the stomach which may interfere with the absorption of some drugs, if taken simultaneously.
- Sodium citrate/dextrose/fructose contains phenylalanine, an amino acid. Take with caution if you have phenylketonuria, an inherited disorder with inability to metabolize phenylalanine, which can cause its accumulation and result in brain damage.
What are the side effects of sodium citrate/dextrose/fructose?
Sodium citrate/dextrose/fructose has no listed side effects.
Call your doctor immediately if you experience any of the following symptoms or serious side effects while using this drug:
- Serious heart symptoms include fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness;
- Severe headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady;
- Severe nervous system reaction with very stiff muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, and feeling like you might pass out; or
- Serious eye symptoms include blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights.
This is not a complete list of all side effects or adverse reactions that may occur from the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may also report side effects or health problems to the FDA at 1-800-FDA-1088.
What are the dosages of sodium citrate/dextrose/fructose?
- 230 mg/968 mg/175 mg
- 0.921 g/4.35 g/4.17 g)15 mL
- Indicated for relief of nausea associated with an upset stomach, including that due to overindulgence in food and drink
- Chew 2-4 tablets completely; may repeat after 15 minutes if needed
- Not to exceed 6 doses/24 hours
- Safety and efficacy not established
- Sodium citrate/dextrose/fructose has no known side effect and there are no reports of overdose.
- Overdose is unlikely to cause serious adverse reactions. In case you experience any symptoms from overdose, report to the FDA.
What drugs interact with sodium citrate/dextrose/fructose?
Inform your doctor of all medications you are currently taking, who can advise you on any possible drug interactions. Never begin taking, suddenly discontinue, or change the dosage of any medication without your doctor’s recommendation.
- Sodium citrate/dextrose/fructose has no listed severe, serious, moderate, or mild interactions with other drugs.
The drug interactions listed above are not all of the possible interactions or adverse effects. For more information on drug interactions, visit the RxList Drug Interaction Checker.
It is important to always tell your doctor, pharmacist, or health care provider of all prescription and over-the-counter medications you use, as well as the dosage for each, and keep a list of the information. Check with your doctor or health care provider if you have any questions about the medication.
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Pregnancy and breastfeeding
- Use sodium citrate/dextrose/fructose during pregnancy only if it is clearly needed.
- It is not known if sodium citrate/dextrose/fructose is present in breast milk, use with caution in nursing mothers.
- If you are pregnant or breastfeeding, always check with your healthcare provider before taking any OTC drug, including sodium citrate/dextrose/fructose.
What else should I know about sodium citrate/dextrose/fructose?
- Take sodium citrate/dextrose/fructose exactly as per the label directions.
- Do not take more than 24 tablets in a 24-hour period.
- Sodium citrate/dextrose/fructose is meant only for a normally healthy person. Do not take without checking with your physician if you have any preexisting condition.
- Sodium citrate/dextrose/fructose is only for temporary relief of nausea from minor stomach upset. Stop use and seek medical help for diagnosis and appropriate treatment if nausea persists for longer than 2 weeks or recurs frequently.
- Store safely out of reach of children.
Sodium citrate/dextrose/fructose is a combination medication used for the temporary relief of nausea associated with an upset or sour stomach, including that due to overindulgence in food or drinks. Sodium citrate/dextrose/fructose has no listed side effects. Consult your doctor if pregnant or breastfeeding. Use with caution if you have diabetes or are on a sodium-restricted diet.
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