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"These findings will help better characterize high-risk versions of obstructive sleep apnea," said co-author Ali Azarbarzin, director of the Sleep Apnea Health Outcomes Research Group at Brigham and Women's Hospital and Harvard Medical School in Boston. "We think that including a higher-risk version of obstructive sleep apnea in a randomized clinical trial would hopefully show that treating sleep apnea could help prevent future cardiovascular outcomes."
For the study, his team collected data on more than 4,500 middle-aged and older adults who were part of two research studies — one of fractures in men and the other, a multi-ethnic study of atherosclerosis (hardening of the arteries) that included both men and women.
Airway obstruction accounted for 38% of the risk seen in the first study and 12% in the other. Similar findings for premature death were also seen.
"That's something that makes this metric specific to sleep apnea," said lead author Dr. Gonzalo Labarca, an instructor in medicine at Brigham and Women's Hospital and Harvard Medical School. "The connections are less explained by obesity or another factor."
Marishka Brown, director of the National Center for Sleep Disorders Research, said understanding these mechanisms could change the way that sleep apnea clinical trials are designed and what is measured in clinical practice.
The findings were published July 26 in the American Journal of Respiratory and Critical Care Medicine.
SOURCE: U.S. National Heart, Lung, and Blood Institute, news release, July 26, 2023
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