What is Skyrizi (risankizumab-rzaa) and how is it used?

Skyrizi is a prescription medicine used to treat adults with moderate to severe plaque psoriasis who may benefit from taking injections or pills (systemic therapy) or treatment using ultraviolet or UV light (phototherapy).

What are the most important side effects and other facts about Skyrizi (risankizumab-rzaa)?

Skyrizi may cause serious side effects, including:

  • Infections. Skyrizi may lower the ability of your immune system to fight infections and may increase your risk of infections. Your healthcare provider should check you for infections and tuberculosis (TB) before starting treatment with Skyrizi and may treat you for TB before you begin treatment with Skyrizi if you have a history of TB or have active TB. Your healthcare provider should watch you closely for signs and symptoms of TB during and after treatment with Skyrizi.

Tell your healthcare provider right away if you have an infection or have symptoms of an infection, including:

Other side effects of Skyrizi (risankizumab-rzaa)

Skyrizi may cause serious side effects. 

The most common side effects of Skyrizi include:

These are not all of the possible side effects of Skyrizi. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the dosage for Skyrizi (risankizumab-rzaa)?

  • Use Skyrizi exactly as your healthcare provider tells you to use it.
  • If you miss your Skyrizi dose, inject a dose as soon as you remember. Then, take your next dose at your regular scheduled time. Call your healthcare provider if you are not sure what to do.
  • If you inject more Skyrizi than prescribed, call your healthcare provider right away.

Skyrizi (risankizumab-rzaa) contraindications, pregnancy safety and drug interactions

It is not known if Skyrizi is safe and effective in children under 18 years of age.

Before using Skyrizi, tell your healthcare provider about all of your medical conditions, including if you:

  • have an infection that does not go away or that keeps coming back.
  • have TB or have been in close contact with someone with TB.
  • have recently received or are scheduled to receive an immunization (vaccine). You should avoid receiving live vaccines during treatment with Skyrizi.
  • are pregnant or plan to become pregnant. It is not known if Skyrizi can harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if Skyrizi passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-thecounter medicines, vitamins, and herbal supplements.

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Summary

Skyrizi (risankizumab-rzaa) is a prescription injection psoriasis medication used to treat adults with psoriasis who may benefit from taking injections or pills (systemic therapy) or treatment using ultraviolet or UV light (phototherapy). Serious Skyrizi side effects include lowering the ability of your immune system to fight infections and possibly increasing your risk of infections. The most common side effects of Skyrizi include upper respiratory infections, feeling, tired, fungal skin infection, injection site reactions, and headache. It is not known if Skyrizi is safe and effective in children under 18 years of age.

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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Medically Reviewed on 4/20/2020
References
Article courtesy of the U.S. Food and Drug Administration
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