Brand Name: Sivextro
Generic Name: tedizolid phosphate
Drug Class: Oxazolidinones
What is Sivextro, and how does it work?
Sivextro is a tablet for people 12 years of age and older who have a skin infection or an infection in the tissue below the skin. Sivextro is an antibiotic that works by stopping the growth of certain bacteria.
Sivextro should not be used for people under 12 years old. It is not known if Sivextro works or is safe for people under age 12.
What are the side effects of Sivextro?
Sivextro may cause serious side effects, including diarrhea from C-diff (Clostridioides difficile) infection. Call your healthcare provider right away if you get stomach cramps, fever, watery diarrhea, diarrhea that does not go away, or bloody stools. C-diff infection can happen 2 or more months after you have finished your antibacterial medicine.
Common side effects of Sivextro include:
Some less common side effects are:
Problems with your skin
- itching, red or itchy rash, hives, acne
- hot flushes or feeling like you are blushing or your face, neck or chest is red
- not able to feel something as well
- a tingling or prickling sensation
Problems with your sleep
- hard time sleeping
Problems with your body
Problems with infections
- vagina that is infected, inflamed or itchy
- fungal infections of skin, mouth
Problems with your eyes
- eye strain
- blurred or impaired vision
- seeing dots or spots in your eyes
Problems with your heart
- Your heartbeat does not feel normal. It could feel like your heart is beating too fast or pumping harder than usual.
Problems with your vascular system
Problems with your blood work
Your doctor may tell you that you have the following while taking Sivextro:
If you have any side effect that bothers you or does not go away, tell your doctor.
These are not all the possible side effects of Sivextro. For information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is the dosage for Sivextro?
The recommended dosage of Sivextro is 200 mg administered once daily for six (6) days either orally (with or without food) or as an intravenous (IV) infusion in patients 12 years of age or older.
The recommended dosage and administration of Sivextro are described in Table 1.
Table 1: Dosage of Sivextro
|Infection||Route||Dosage||Frequency||Infusion Time||Duration of Treatment|
|Acute Bacterial Skin and Skin Structure Infections (ABSSSI)||Intravenous||200 mg||Once daily||1 hour||6 days|
|Oral||200 mg||Once daily||Not Applicable|
No dose adjustment is necessary when changing from intravenous to oral Sivextro.
If patients miss a dose, they should take it as soon as possible anytime up to 8 hours prior to their next scheduled dose. If less than 8 hours remain before the next dose, wait until their next scheduled dose.
What drugs interact with Sivextro?
- Orally administered Sivextro inhibits Breast Cancer Resistance Protein (BCRP) in the intestine, which can increase the plasma concentrations of orally administered BCRP substrates, and the potential for adverse reactions.
- If possible, an interruption in the treatment of the co-administered BCRP substrate medicinal product should be considered during treatment with Sivextro, especially for BCRP substrates with a narrow therapeutic index (e.g., methotrexate or topotecan).
- If coadministration cannot be avoided, monitor for adverse reactions related to the concomitantly administered BCRP substrates, including rosuvastatin.
IMAGESBrowse our medical image collection of allergic skin disorders such as psoriasis and dermatitis and more caused by allergies See Images
Is Sivextro safe to use while pregnant or breastfeeding?
- Based on animal reproduction studies, Sivextro may cause fetal harm when administered to pregnant women.
- The available data on the use of Sivextro in pregnant women are insufficient to evaluate for a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes.
- Advise pregnant women of the potential risks to a fetus.
- There is no information on the presence of tedizolid in human milk. Tedizolid is present in rat milk. When a drug is present in animal milk, it is likely that the drug will be present in human milk.
- There are no data on the effects of Sivextro on the breastfed child or on milk production.
Sivextro is a tablet for people 12 years of age and older who have a skin infection or an infection in the tissue below the skin. Sivextro is an antibiotic that works by stopping the growth of certain bacteria. Serious side effects of Sivextro include diarrhea from C-diff (Clostridioides difficile) infection.
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Related Disease Conditions
Is MRSA Contagious?
MRSA stands for methicillin-resistant Staphylococcus aureus. MRSA typically spreads through person-to-person contact, but it can also spread via aerosolized droplets. An MRSA skin infection will rapidly become painful, swollen, drain pus, and be warm to the touch.
Staph (Staphylococcus) Infection
Staphylococcus or staph is a group of bacteria that can cause a multitude of diseases. Staph infections can cause illness directly by infection or indirectly by the toxins they produce. Symptoms and signs of a staph infection include redness, swelling, pain, and drainage of pus. Minor skin infections are treated with an antibiotic ointment, while more serious infections are treated with intravenous antibiotics.
Is a Staph Infection Contagious?
A staph infection is caused by the bacteria Staphylococcus aureus. Staph can cause boils, food poisoning, cellulitis, toxic shock syndrome, MRSA, and various other illnesses and infections. Most staph infections are transmitted from person to person.
MRSA (methicillin-resistant Staphylococcus aureus) bacteria causes skin infections with the following signs and symptoms: cellulitis, abscesses, carbuncles, impetigo, styes, and boils. Normal skin tissue doesn't usually allow MRSA infection to develop. Individuals with depressed immune systems and people with cuts, abrasions, or chronic skin disease are more susceptible to MRSA infection.
Are Skin Rashes Contagious?
Direct and indirect contact can spread some types of rashes from person to person. Rash treatment depends upon a rash's underlying cause. A rash that sheds large amounts of skin warrants urgent medical attention. Rashes can be either contagious or noncontagious. Noncontagious rashes include seborrheic dermatitis, atopic dermatitis, contact dermatitis, stasis dermatitis, psoriasis, nummular eczema, drug eruptions, hives, heat rash (miliaria), and diaper rash. Rashes usually considered contagious include molluscum contagiosum (viral), impetigo (bacterial), herpes (herpes simplex, types 1 and 2 viruses), rash caused by Neisseria meningitides (N. meningitides) (bacterial), rash and blisters that accompany shingles (herpes zoster virus), ringworm (fungal) infections (tinea), scabies (itch mite), chickenpox (viral), measles and rubella (viral), erythema infectiosum (viral), pityriasis rosea (viral), cellulitis and erysipelas (bacterial), lymphangitis (bacterial, and folliculitis (bacterial).
Can you get rid of MRSA completely?
Yes, an individual may get rid of MRSA completely by following the prescription given by doctors strictly. MRSA can be treated with powerful antibiotics, nose ointments, and other therapies.
How Serious Is a Staph Infection?
A Staphylococcus or staph infection is caused by a germ that may be found in 30% of healthy people’s noses. Most of the time, these bacteria do not cause any health problems. However, in some people, it may cause skin and other organ infections. Most often, staph causes minor skin infections such as a boil. However, if it enters into your bloodstream and other organs, it may turn out to be deadly.
Staph Infection Causes
Staph or Staphylococcus is a group of bacteria that is found over the skin of most individuals. Staph bacteria usually live inside the nose, but they do not cause an infection. Staph infections may turn deadly if the bacteria invade deeper into the body, entering the bloodstream, joints, bones, lungs, or heart.
Treatment & Diagnosis
Medications & Supplements
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.