simeprevir, Olysio

  • Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

blood test hepatitis C std lab

What is simeprevir, and how does it work (mechanism of action)?

Simeprevir is an oral, direct-acting an-tiviral agent used for treating infections with the hepatitis C virus (HCV). Boceprevir (Victrelis), telaprevir (Incivek), and sofosbuvir (Sovaldi) are other direct-acting drugs for treating HCV. Simeprevir blocks the effect of pro-teases which are enzymes that HCV needs for making new viruses, leading to reduced numbers of HCV in the body. Simeprevir is effective for treating people infected with HCV genotype 1, including those with liver disease. The FDA approved simeprevir in November 2013.

What brand names are available for simeprevir?

Olysio

Is simeprevir available as a generic drug?

GENERIC AVAILABLE: No

Do I need a prescription for simeprevir?

Yes

What are the side effects of simeprevir?

The most common side effects associated with simeprevir treatment are:

Quick GuideHepatitis C (Hep C) Symptoms and Treatment

Hepatitis C (Hep C) Symptoms and Treatment

What is the dosage for simeprevir?

The recommended dose of simeprevir is one 150 mg capsule once daily with food for 12 weeks in combination with peginter-feron and ribavarin. It should be followed by 12 or 36 additional weeks of peginterferon and ribavirin depending on prior response. It can also be combined with sofosbuvir (Sovaldi) for 12 weeks.

Is simeprevir safe to take if I'm pregnant or breastfeeding?

It is not known if simeprevir is secreted into breast milk.

What else should I know about simeprevir?

What preparations of simeprevir are available?

Capsules: 150 mg

How should I keep simeprevir stored?

Capsules should be stored at room temperature below 30 C (86 F).

Medically reviewed by John Cunha, DO

REFERENCE: FDA.gov prescribing information. simeprevir.

Quick GuideHepatitis C (Hep C) Symptoms and Treatment

Hepatitis C (Hep C) Symptoms and Treatment

Summary

Simeprevir (Olysio) is an oral, direct-acting antiviral agent prescribed for treating infections with HCV (hepatitis C virus). Simeprevir is used in combination with ribavirin (Rebetol, Copegus) and peginterferon to treat hepatitis C infections. Drug interactions, warnings and precautions, side effects, and dosage information should be reviewed prior to taking this medication.

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See more info: simeprevir on RxList
Reviewed on 8/8/2017
References
Medically reviewed by John Cunha, DO

REFERENCE: FDA.gov prescribing information. simeprevir.

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