Does Urocit-K (potassium citrate) cause side effects?
- renal tubular acidosis with calcium stones,
- hypocitraturic calcium oxalate nephrolithiasis (kidney stones), and
- uric acid lithiasis with or without calcium stones.
Urocit-K makes urine less acidic. Urocit-K works by crystallizing stone-forming salts such as
- calcium oxalate,
- calcium phosphate, and
- uric acid within the urinary bladder by increasing the urinary pH and urine citrate levels.
Common side effects of Urocit-K include
Serious side effects of Urocit-K include
- bleeding or perforation of the stomach or small intestine from ulcers,
- narrowing (stricture) of the small intestine from healed ulcers, and
- rarely, cardiac arrest.
Drug interactions of Urocit-K include potassium-sparring diuretics, which can increase potassium levels in body and potentially lead to cardiac arrest.
- Drugs that slow transit of food through the intestine such as atropine, loperamide, liraglutide, and similar drugs may delay passage of potassium tablets through the digestive system and result in increased irritation, ulceration or narrowing of the small intestine.
- Angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and certain diuretics increase potassium levels, causing high potassium levels in the blood when combined with potassium supplements.
- Salt substitutes (for example, Mrs. Dash) often contain potassium.
- Patients using salt substitutes while taking potassium supplements may develop high levels of potassium in the blood.
It is unknown if administering Urocit-K can further increase potassium levels. Urocit-K citrate should only be given if needed while breastfeeding.
What are the important side effects of Urocit-K (potassium citrate)?
Side effects of potassium citrate are:
- abdominal discomfort,
- increased potassium levels, and
- rarely cardiac arrest.
Potassium supplements can cause bleeding or perforation of the stomach or small intestine from ulcers, and narrowing (stricture) of the small intestine from healed ulcers.
Urocit-K (potassium citrate) side effects list for healthcare professionals
Some patients may develop minor gastrointestinal complaints during Urocit-K therapy, such as
- abdominal discomfort,
- loose bowel movements or
These symptoms are due to the irritation of the gastrointestinal tract, and may be alleviated by taking the dose with meals or snacks, or by reducing the dosage. Patients may find intact matrices in their feces.
What drugs interact with Urocit-K (potassium citrate)?
Potential Effects Of Potassium Citrate On Other Drugs
Concomitant administration of Urocit-K and a potassium-sparing diuretic (such as triamterene, spironolactone or amiloride) should be avoided since the simultaneous administration of these agents can produce severe hyperkalemia.
Potential Effects Of Other Drugs On Potassium Citrate
Drugs That Slow Gastrointestinal Transit Time
These agents (such as anticholinergics) can be expected to increase the gastrointestinal irritation produced by potassium salts.
Urocit-K (potassium citrate) is a urinary alkalinizing medication used to treat renal tubular acidosis with calcium stones, hypocitraturic calcium oxalate nephrolithiasis (kidney stones), and uric acid lithiasis with or without calcium stones. Common side effects of Urocit-K include abdominal discomfort, nausea, vomiting, diarrhea, and increased potassium levels. There are no adequate studies done on Urocit-K to determine safe and effective use in pregnant women. Urocit-K citrate should only be given if needed while breastfeeding.
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.