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Does Trental (pentoxifylline) cause side effects?
Common side effects of Trental include
Serious side effects of Trental include
- abnormal heart beats,
- elevation of liver function tests,
- yellowing skin and eyes (jaundice), and
Drug interactions of Trental include theophylline, because Trental reduces its breakdown in the liver, increasing blood levels and side effects of theophylline. Combining Trental with warfarin may increase the risk of bleeding.
What are the important side effects of Trental (pentoxifylline)?
Common adverse effects include:
- blurred vision,
- insomnia and
Other side effects include:
Trental (pentoxifylline) side effects list for healthcare professionals
Clinical Trial Adverse Drug Reactions
Because clinical trials are conducted under very specific conditions the adverse reaction rates observed in the clinical trials may not reflect the rates observed in practice and should not be compared to the rates in the clinical trials of another drug. Adverse drug reaction information from clinical trials is useful for identifying drug-related adverse events and for approximating rates.
The most frequent adverse event reported with Trental (pentoxifylline) is nausea (14%). Individual signs/symptoms listed in the table below occurred at an incidence between 1 and 3%, except when stated otherwise.
|Body as a whole||Malaise|
|Central nervous system||Dizziness/light-headedness (9.4%), headache (4.9 %)|
|Gastrointestinal system||Nausea (14%), vomiting (3.4%), abdominal discomfort, bloating, diarrhea, dyspepsia|
Less Common Clinical Trial Adverse Drug Reactions ( < 1%)
Organs of special sense: Blurred vision, scotoma, lacrimation, epistaxis.
Post-Market Adverse Drug Reactions
Hepatobiliary disorders: Intrahepatic cholestasis.
Immune system disorders: Severe anaphylactic/anaphylactoid reaction with, for example, angioneurotic edema, bronchospasms, sometimes shock.
Infections and infestations: Aseptic meningitis.
Investigations: Transaminase elevation.
Psychiatric: Sleep disturbances.
Skin and subcutaneous tissue disorders: Reddening of skin.
Vascular disorder: Haemorrhage
What drugs interact with Trental (pentoxifylline)?
Antacids: In patients with digestive side effects, antacids may be administered with Trental. In comparative bioavailability study, no interference with absorption of Trental by antacids was observed.
Antihypertensive agents: Trental (pentoxifylline) may potentiate the action of antihypertensive agents. Patients receiving these agents require blood pressure monitoring and possibly a dose reduction of the antihypertensive agents.
Anticoagulants: There have been reports of bleeding and/or prolonged prothrombin time in patients treated with Trental with and without anticoagulants, including vitamin K antagonists, or platelet aggregation inhibitors. Monitoring of anti-coagulant activity in these patients is recommended when pentoxifylline is introduced or the dose is changed.
Patients on warfarin should have more frequent monitoring of prothrombin time, while patients with other risk factors complicated by hemorrhage (e.g. recent surgery) should have periodic examinations for signs of bleeding, including hematocrit and haemoglobin.
Cimetidine: During concurrent use of cimetidine and pentoxifylline, cimetidine has been shown to significantly increase the steady-state plasma concentration of pentoxifylline, which may enhance the possibility of adverse effects.
Erythromycin: No data are available on the possible interaction of Trental and erythromycin. However concurrent administration of erythromycin and theomycin has resulted in significant elevation of serum theophylline levels with toxic reactions.
Hypoglycemic agents: The blood-sugar lowering effect of insulin or oral antidiabetic agents may be potentiated. In patients treated with hypoglycemic agents, a moderate adjustment in the dose of these agents may be required when Trental is prescribed. Therefore it is recommended that patients under medication for diabetes mellitus be carefully monitored
Sympathomimetics: Combined use with other xanthines or with sympathomimetics may cause excessive CNS stimulation.
Theophylline: Although causality has not been established, concurrent use of pentoxifylline with theophylline has resulted in elevated theophylline plasma levels, which may enhance the possibility of adverse effects.
Interactions with food have not been established.
Interactions with herbal product have not been established.
Interactions with laboratory tests have not been established.
Interactions with lifestyles have not been established.
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Related Disease Conditions
Heart disease (coronary artery disease) occurs when plaque builds up in the coronary arteries, the vessels that supply blood to the heart. Heart disease can lead to heart attack. Risk factors for heart disease include: Smoking High blood pressure High cholesterol Diabetes Family history Obesity Angina, shortness of breath, and sweating are just a few symptoms that may indicate a heart attack. Treatment of heart disease involves control of heart disease risk factors through lifestyle changes, medications, and/or stenting or bypass surgery. Heart disease can be prevented by controlling heart disease risk factors.
What Is the Difference Between Atherosclerosis and Arteriosclerosis?
Arteriosclerosis is a broader term for the condition in which the arteries narrow and harden, leading to poor circulation of blood throughout the body. Atherosclerosis is a specific kind of arteriosclerosis, but these terms are often used interchangeably. Both conditions lead to decreased blood flow to other parts of the body. Atherosclerosis is a progressive disease, which may either start in childhood or late adulthood.
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Stress and Heart Disease
The connection between stress and heart disease is not clear. Stress itself may be a risk factor, or high levels of stress may make risk factors for heart disease worse. The warning signs of stress can be physical, mental, emotional, or behavioral. Reducing stressors in an individuals life not only can lead to a more productive life, but may also decrease the risk for heart disease and causes of heart disease.
Heart Disease in Women
Heart disease in women has somewhat different symptoms, risk factors, and treatment compared to heart disease in men. Many women and health professionals are not aware of the risk factors for heart disease in women and may delay diagnosis and treatment. Lifestyle factors such as diet, exercise, tobacco use, overweight/obesity, stress, alcohol consumption, and depression influence heart disease risk in women. High blood pressure, high cholesterol, and diabetes also increase women's risk of heart disease. Electrocardiogram (EKG or ECG), stress-ECG, endothelial testing, ankle-brachial index (ABI), echocardiogram, nuclear imaging, electron beam CT, and lab tests to assess blood lipids and biomarkers of inflammation are used to diagnose heart disease. Early diagnosis and treatment of heart disease in women saves lives. Heart disease can be prevented and reversed with lifestyle changes.
Heart Disease Treatment in Women
Heart disease treatment in women should take into account female-specific guidelines that were developed by the American Heart Association. Risk factors and symptoms of heart disease in women differ from those in men. Treatment may include lifestyle modification (diet, exercise, weight management, smoking cessation, stress reduction), medications, percutaneous intervention procedure (PCI), and coronary artery bypass grafting (CABG). Heart disease is reversible with treatment.
Heart Attack Prevention
Heart disease and heart attacks can be prevented by leading a healthy lifestyle with diet, exercise, and stress management. Symptoms of heart attack in men and women include chest discomfort and pain in the shoulder, neck, jaw, stomach, or back.
Can Peripheral Artery Disease Affect the Heart?
Peripheral artery disease is a condition in which extremities (usually the legs) do not receive sufficient blood flow due to the narrowing of or blocks in arteries. Peripheral artery disease is also likely to be a sign of more widespread accumulation of fat deposits in the arteries (atherosclerosis or plaque).
Smoking and Heart Disease
Smoking increases the risk of heart disease in women and men. Nicotine in cigarettes decrease oxygen to the heart, increases blood pressure, blood clots, and damages coronary arteries. Learn how to quit smoking today, to prolong your life.
Treatment & Diagnosis
Medications & Supplements
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.