What is Topicort (desoximetasone)?

Topicort (desoximetasone) is a corticosteroid used on the skin (topically) to treat adults with moderate to severe plaque psoriasis. Topicort is also used to treat other skin conditions responsive to corticosteroids

The naturally occurring corticosteroid is cortisol or hydrocortisone produced by the adrenal gland. Corticosteroids have potent anti-inflammatory actions and also suppress the immune response.

Common side effects of Topicort include:

  • application site burning,
  • itching,
  • irritation, and
  • dryness.

Other side effects of Topicort include: 

Serious side effects of Topicort include:

  • softening and breakdown of skin,
  • secondary infection, and
  • skin atrophy. 

Prolonged use (greater than two weeks) of high doses of Topicort can depress the ability of the body's adrenal glands to produce corticosteroids. Abruptly stopping Topicort in these individuals can cause symptoms of corticosteroid insufficiency, along with nausea, vomiting, and shock.

Topicort has no listed drug interactions. Tell your doctor all medications and supplements you use. 

Topicort has not been adequately evaluated in pregnant women. Pregnant patients should not use corticosteroids extensively, in large amounts, or for prolonged periods of time. 

It is unknown if Topicort is secreted in breast milk. Consult your doctor before breastfeeding.

What are the important side effects of Topicort (desoximetasone)?

Common side effects of Topicort include:

Other side effects include:

Other less common side effects include:

Possible serious side effects include:

  • Maceration of the skin
  • Secondary infection
  • Skin atrophy

Prolonged use (greater than two weeks) of high doses of Topicort can depress the ability of the body's adrenal glands to produce corticosteroids. Abruptly stopping Topicort in these individuals can cause symptoms of corticosteroid insufficiency, along with:

Topicort (desoximetasone) side effects list for healthcare professionals

The following local adverse reactions are reported infrequently with topical corticosteroids, but may occur more frequently with the use of occlusive dressings. These reactions are listed in an approximate decreasing order of occurrence:

  • burning,
  • itching,
  • irritation,
  • dryness,
  • folliculitis,
  • hypertrichosis,
  • acneiform eruptions,
  • hypopigmentation,
  • perioral dermatitis,
  • allergic contact dermatitis,
  • maceration of the skin,
  • secondary infection,
  • skin atrophy,
  • striae, and
  • miliaria.

In controlled clinical studies the incidence of adverse reactions was low (0.2%) for Topicort (desoximetasone) Ointment USP, 0.05% and included mild burning sensation at the site of application.

What drugs interact with Topicort (desoximetasone)?

No information provided.

Summary

Topicort (desoximetasone) is a corticosteroid used on the skin (topically) to treat adults with moderate to severe plaque psoriasis. Topicort is also used to treat other skin conditions responsive to corticosteroids. Common side effects of Topicort include application site burning, itching, irritation, and dryness. Other side effects of Topicort include folliculitis, rash around the mouth, allergic contact dermatitis, abnormal hair growth, acne, loss of skin pigmentation (hypopigmentation), stretch marks, and “sweat rash.” Topicort has not been adequately evaluated in pregnant women. It is unknown if Topicort is secreted in breast milk.

Treatment & Diagnosis

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Medically Reviewed on 5/13/2020
References
FDA Prescribing Information

Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.
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