What is Terazol (terconazole)?
Terazol (terconazole) is an antifungal cream and suppository used to treat vaginal yeast infections (Candida). It prevents growth of yeast by preventing production of the membranes that surround the yeast cells.
Common side effects of Terazol include:
- irritation, and
- increased sensitivity and burning of the vulva or vagina.
Other side effects of Terazol include:
There are no known drug interactions with Terazol.
Tell your doctor if you are pregnant before using Terazol; it is unknown how it might affect a fetus. Pregnant women should use extra care when using the vaginal applicator. The Canadian manufacturer does not recommend using this product during the first 3 months of pregnancy.
Consult your doctor before breastfeeding.
What are the important side effects of Terazol (terconazole)?
The most common side effects associated with terconazole are:
- increased sensitivity and burning of the vulvae or vagina.
Other side effects include:
Terazol (terconazole) side effects list for healthcare professionals
Terazol 7 (terconazole) Vaginal Cream 0.4%
During controlled clinical studies conducted in the United States, 521 patients with vulvovaginal candidiasis were treated with terconazole 0.4% vaginal cream. Based on comparative analyses with placebo, the adverse experiences considered most likely related to terconazole 0.4% vaginal cream were:
Vulvovaginal burning (5.2%), itching (2.3%) or irritation (3.1%) occurred less frequently with terconazole 0.4% vaginal cream than with the vehicle placebo.
Fever (1.7% vs. 0.5% with placebo) and chills (0.4% vs. 0.0% with placebo) have also been reported.
The therapy-related dropout rate was 1.9%. The adverse drug experience on terconazole most frequently causing discontinuation was vulvovaginal itching (0.6%), which was lower than the incidence for placebo (0.9%).
Terazol 3 (terconazole) Vaginal Cream 0.8%
During controlled clinical studies conducted in the United States, patients with vulvovaginal candidiasis were treated with terconazole 0.8% vaginal cream for three days. Based on comparative analyses with placebo and a standard agent, the adverse experiences considered most likely related to terconazole 0.8% vaginal cream were headache (21% vs. 16% with placebo) and dysmenorrhea (6% vs. 2% with placebo).
Genital complaints in general, and burning and itching in particular, occurred less frequently in the terconazole 0.8% vaginal cream 3 day regimen (5% vs. 6%-9% with placebo). Other adverse experiences reported with terconazole 0.8% vaginal cream were abdominal pain (3.4% vs. 1% with placebo) and fever (1% vs. 0.3% with placebo).
The therapy-related dropout rate was 2.0% for the terconazole 0.8% vaginal cream. The adverse drug experience most frequently causing discontinuation of therapy was vulvovaginal itching, 0.7% with the terconazole 0.8% vaginal cream group and 0.3% with the placebo group.
Terazol 3 (terconazole) Vaginal Suppositories 80 mg
During controlled clinical studies conducted in the United States, 284 patients with vulvovaginal candidiasis were treated with terconazole 80 mg vaginal suppositories. Based on comparative analyses with placebo (295 patients), the adverse experiences considered adverse reactions most likely related to terconazole 80 mg vaginal suppositories were headache (30.3% vs. 20.7% with placebo) and pain of the female genitalia (4.2% vs. 0.7% with placebo).
Adverse reactions that were reported but were not statistically significantly different from placebo were burning (15.2% vs. 11.2% with placebo) and body pain (3.9% vs. 1.7% with placebo). Fever (2.8% vs. 1.4% with placebo) and chills (1.8% vs. 0.7% with placebo) have also been reported.
The therapy-related dropout rate was 3.5% and the placebo therapy-related dropout rate was 2.7%. The adverse drug experience on terconazole most frequently causing discontinuation was burning (2.5% vs. 1.4% with placebo) and pruritus (1.8% vs. 1.4% with placebo).
The following adverse drug reactions have been first identified during post-marketing experience with Terazol. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
What drugs interact with Terazol (terconazole)?
Terazol 7 (terconazole) Vaginal Cream 0.4% and Terazol® 3 (terconazole) Vaginal Suppositories 80 mg
The therapeutic effect of these products is not affected by oral contraceptive usage.
Terazol 3 (terconazole) Vaginal Cream 0.8%
The levels of estradiol (E2) and progesterone did not differ significantly when 0.8% terconazole vaginal cream was administered to healthy female volunteers established on a low dose oral contraceptive.
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Related Disease Conditions
Vaginal Yeast Infection in Women
Vaginal yeast infections in women are caused by an organism called Candida albicans. Symptoms of a vaginal yeast infection include vaginal pain with urination, vaginal discharge, odor, and itching. Treatment is generally OTC medications. A man can contract a yeast infection from his female sexual partner. Symptoms of a yeast infection in men include penile itching. Treatment is with oral or topical medication.
Yeast Infection vs. Diaper Rash in Infants, Toddlers, and Children
Diaper rash in infants, babies, toddlers, and children is caused by Candida, the most common type of fungus. Signs and symptoms of diaper rash is red, elevated skin that may be visible under and in the creases of the skin, groin, or anus. Yeast diaper rash is not painful. Treatments for diaper rash include antibiotic creams, lotions, natural home remedies, over-the-counter (OTC) medicine, and oral antibiotics. Yeast infections in infants, babies, toddlers, and children can cause diaper rash, thrush. Signs and symptoms of thrush include thick, white lacy patches on top of a red base can form on the tongue, palate, or elsewhere inside the palate. Treatment for yeast infections caused by Candida fungi are similar to the treatments for diaper rash. If Candida gets into the blood stream of an individual they may get sick with or without a fever. If the Candida infection spreads throughout the body up to 45% of people may die. Even with common mouth thrush can cause critical illness and may be more resistant to normal treatment.
Yeast infections vs. STDs in Men and Women
Oral Thrush in Children
Yeast infections are caused by an overgrowth of a type of fungus called Candida. Oral thrush is a yeast infection of the mouth and throat. Oral thrush and yeast infections are treated orally or topically with an antifungal antibiotic called nystatin.
Is a Yeast Infection Contagious?
Yeast are a fungi that has many types. A type of yeast that can cause infection in humans is called Candida. Candida can infect the mouth, vagina, penis, or other areas of the body. Symptoms of yeast infections depend on the area infected, however, may include itching, bumps on the skin, a reddish rash, or patches of skin that ooze a clear or yellow liquid. Most yeast infections are not contagious even though they are caused by a fungus.
Yeast Infection vs. Urinary Tract Infection (UTI)
Candida albicans typically causes vaginal yeast infections. Bacterial infections typically cause urinary tract infections (UTIs). Thick white cottage-cheese like vaginal discharge characterizes vaginal yeast infections. Painful, frequent urination characterize urinary tract infections. Antifungal medications treat yeast infections while prescription antibiotics treat UTIs.
Yeast Infection vs. Bacterial Vaginosis (BV)
Yeast infections and bacterial vaginosis (BV) both cause vaginal discharge. Yeast infection discharge is thick, white, and had a cottage cheese consistency. BV discharge is whitish-gray and is thinner. Vaginal odor, irritation, and pain may also be present. Treatment of yeast infections includes over-the-counter and prescription antifungals. BV treatment involves antibiotics.
Treatment & Diagnosis
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Medications & Supplements
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.