- Psoriasis Slideshow: Symptoms, Causes and Treatment
- Psoriasis Quiz: Test Your Medical IQ
- Moderate to Severe Forms of Psoriasis Slideshow
What is Tazorac (tazarotene)?
Tazorac (tazarotene) is retinoid used topically (on the skin) to treat acne and psoriasis. The exact mechanism of how Tazorac works is not known. Scientists believe that when Tazorac is applied to the skin, it affects the growth of skin cells and thereby reduces the formation of pimples and psoriasis plaques.
Tazorac may affect growth of skin cells by affecting the action of genes that control production of skin cells. It also reduces inflammation. Tazorac was withdrawn from the U.S. market in 2007, but is available on a very limited basis for restricted use. Women who would like to be considered for this medication should contact their doctor for an evaluation.
Common side effects of Tazorac include:
Serious side effects of Tazorac include:
- severe skin irritation (stinging, burning, itching) after applying the medicine,
- severe redness or discomfort,
- blistering or peeling skin, and
- warmth, swelling, oozing, or other signs of skin infection.
It may not be safe to breastfeed while using this Tazorac. Consult your doctor before breastfeeding.
What are the important side effects of Tazorac (tazarotene)?
Side effects of Tazarotene are:
- dry skin,
- stinging and burning,
- desquamation, and
- sun sensitivity.
Tazorac (tazarotene) side effects list for healthcare professionals
The following serious adverse reactions are discussed in more detail in other sections of the labeling:
Clinical Trials Experience
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.
A total of 439 subjects 14 to 87 years of age were treated with Tazorac Gel, 0.05% and 0.1% in two controlled clinical trials. The most frequent adverse events reported with Tazorac Gel, 0.05% and 0.1% occurring in 10 to 30% of subjects, in descending order, included:
Reactions occurring in 1 to 10% of subjects included:
Increases in “psoriasis worsening” and “sun-induced erythema” were noted in some subjects over the 4th to 12th months of treatment as compared to the first three months of a 1 year study. In general, the incidence of adverse events with Tazorac Gel 0.05% was 2 to 5% lower than that seen with Tazorac Gel 0.1%.
A total of 596 subjects 12 to 44 years of age were treated with Tazorac Gel, 0.05% and 0.1% in two controlled clinical trials. The most frequent adverse events reported during clinical trials with Tazorac Gel, 0.1% in the treatment of acne occurring in 10 to 30% of subjects, in descending order, included desquamation, burning/stinging, dry skin, erythema and pruritus. Reactions occurring in 1 to 10% of subjects included irritation, skin pain, fissuring, localized edema and skin discoloration.
Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. The following adverse reactions have been identified during postapproval use of tazarotene.
Skin and subcutaneous tissue disorders:
What drugs interact with Tazorac (tazarotene)?
No formal drug-drug interaction studies were conducted with Tazorac Gel.
In a trial of 27 healthy female subjects between the ages of 20-55 years receiving a combination oral contraceptive tablet containing 1 mg norethindrone and 35 mcg ethinyl estradiol, concomitant use of tazarotene administered as 1.1 mg orally (mean ± SD Cmax and AUC0-24 of tazarotenic acid were 28.9 ± 9.4 ng/mL and 120.6 ± 28.5 ng•hr/mL, respectively) did not affect the pharmacokinetics of norethindrone and ethinyl estradiol over a complete cycle.
The impact of tazarotene on the pharmacokinetics of progestin only oral contraceptives (i.e., minipills) has not been evaluated.
Tazorac (tazarotene) is retinoid used topically (on the skin) to treat acne and psoriasis. Common side effects of Tazorac include dry skin, redness, stinging and burning, irritation, itching, skin peeling, and sun sensitivity. Serious side effects of Tazorac include severe skin irritation (stinging, burning, itching) after applying the medicine, severe redness or discomfort, blistering or peeling skin, and warmth, swelling, oozing, or other signs of skin infection. Tazorac can cause birth defects. Pregnant women should not use Tazorac. Women of reproductive potential should use effective birth control to prevent pregnancy. It may not be safe to breastfeed while using this Tazorac. Consult your doctor before breastfeeding.
Multimedia: Slideshows, Images & Quizzes
Skin Quiz: Acne, Dry Skin, Dandruff & More
What's that all over you? Skin, of course! Test your knowledge of your most amazing organ with the Skin Quiz!
Acne (Pimples) Quiz: Test Your Medical IQ
Acne is the most common skin disorder in the world. If you suffer from acne, you are not alone and many treatment options are...
Psoriasis Quiz: Test Your Medical IQ
Take the mystery out of psoriasis. Take the Psoriasis Quiz and see what you know about the types, symptoms, treatments and more.
Picture of Psoriasis 1
A reddish, scaly rash often located over the surfaces of the elbows, knees, scalp, and around or in the ears, navel, genitals or...
Picture of Erythematous Deep Acne Scars
Acne scarring is a common sequel of severe inflammatory or cystic acne. It can present in a mild or cosmetically disfiguring...
Picture of Psoriasis 2
More than one-quarter of all individuals with psoriasis develop their disease during childhood or adolescence. See a picture of...
Picture of Psoriasis 3
This figure shows the erythema, scaling, and thickening of portions of the thumb and soles that are very common in both children...
Picture of Acne Vulgaris Nodulocystic
Inflammatory nodules, cysts, and pustules (left). See a picture of Acne Vulgaris Nodulocystic and learn more about the health...
Picture of Psoriasis Vulgaris Soles
Well-demarcated, erythematous plaques with thick, yellowish lamellar scale and desquamation on sites of pressure arising on the...
Picture of Psoriasis Vulgaris Palms
Silvery-white scaly plaque, sharply demarcated, of irregular configuration. See a picture of Psoriasis Vulgaris Palms and learn...
Picture of Guttate Psoriasis
Guttate psoriasis is a type of psoriasis that looks like small, salmon-pink drops on the skin. See a picture of Guttate Psoriasis...
Picture of Inverse Psoriasis
Inverse psoriasis consists of bright red, smooth (not scaly) patches found in the folds of the skin. See a picture of Inverse...
Picture of Pustular Psoriasis
Pustular psoriasis is an uncommon form of psoriasis. See a picture of Pustular Psoriasis and learn more about the health topic.
Picture of Erythrodermic Psoriasis
This is the least common type of psoriasis and can be quite serious. See a picture of Erythrodermic Psoriasis and learn more...
Picture of Psoriasis of the Scalp
The scalp may have fine, dry, scaly skin or have heavily crusted plaque areas. See a picture of Psoriasis of the Scalp and learn...
Picture of Cystic Acne
Cystic acne is a type of abscess that is formed when oil ducts become clogged and infected. See a picture of Cystic Acne and...
Picture of Psoriasis Vulgaris
Pinpoint pits and distal onycholysis (so-called "oil-spot" discoloration) are seen in the fingernails of a child with psoriasis....
Picture of Psoriasis Vulgaris Erythematous
Well-delineated erythematous plaque located on the elbow of a child with psoriasis.See a picture of Psoriasis Vulgaris...
Picture of Psoriasis Vulgaris Plaque
Well-delineated erythematous plaque with a silvery-white scale characteristic of psoriasis. See a picture of Psoriasis Vulgaris...
Picture of Acne
Exactly what causes acne? Acne develops when cells and natural oils begin to block up tiny hair follicles in the skin. See a...
Picture of Baby Acne
Pink pimples ("neonatal acne") are often caused by exposure in the womb to maternal hormones. See a picture of Baby Acne and...
Rosacea, Acne, Shingles: Common Adult Skin Diseases
Learn to spot and treat skin conditions commonly found in adults such as acne, eczema, shingles, psoriasis, rosacea, hives, cold...
Types of Psoriasis: Medical Pictures and Treatments
Learn about the common skin condition psoriasis. Explore about the different types of psoriasis such as vulgaris (plaque...
Skin Health: 15 Tips for Clear Skin
Acne, pimples, zits and blemishes often appear on the face, back, chest, neck, and shoulders where skin has the most amount of...
How to Get Rid of Acne: Skin Care Tips
Want to know how to get rid of blackheads? Discover tips on clogged pores, sunscreen SPF and how to remove makeup for different...
Acne: Causes, Solutions and Treatments for Adults
Adult acne causes include hormones, medications, makeup, and other things. Adult acne is treated with medications, products, face...
Acne Care Pictures: Skin Care Dos and Don'ts
Explore quick acne cover-ups, dos and don'ts. See solutions on how to best handle pesky pimples and remedies to avoid.
Psoriasis Types, Images, Treatments
What is psoriasis? Explore psoriasis treatment options such as topical ointments, phototherapy, natural remedies and more. Learn...
Acne 101: Types, Best Treatments, Medication, Cystic Acne
What is the best treatment for acne vulgaris? Can food choices influence acne? How can you get rid of blackheads? Learn why it's...
Psoriasis: Top 10 Causes, Triggers and Treatments
Psoriasis triggers a red, scaly rash of plaques on the skin typically affecting the elbows, knees, and scalp. Treatment involves...
Home Remedies for Psoriasis
Discover home remedies for psoriasis and help heal irritated skin.
Acne: Best and Worst Foods for Acne
Can what you eat cause a breakout -- or clear up your skin? Find out more about how some foods can affect your acne.
Related Disease Conditions
Acne is a localized skin inflammation as a result of overactivity of oil glands at the base of hair follicles. This inflammation, depending on its location, can take the form of a superficial pustule (contains pus), a pimple, a deeper cyst, congested pores, whiteheads, or blackheads. Treatments vary depending on the severity of the acne.
Psoriasis is a long-term skin condition that may cause large plaques of red, raised skin, flakes of dry skin, and skin scales. There are several types of psoriasis, including psoriasis vulgaris, guttate psoriasis, inverse psoriasis, and pustular psoriasis. Symptoms vary depending on the type of psoriasis the patient has. Treatment of psoriasis may include creams, lotions, oral medications, injections and infusions of biologics, and light therapy. There is no cure for psoriasis.
Scalp Psoriasis (Psoriasis of the Scalp)
Scalp psoriasis causes red, raised, scaly patches that may extend from the scalp to the forehead and the back of the neck and ears. Symptoms and signs include itching, hair loss, flaking, silvery scales, and red plaques. Treatment includes topical medicated shampoos, creams, gels, oils, ointments, and soaps, medications, and light therapy.
Is Psoriasis Contagious?
Psoriasis is an incurable skin disease that causes reddish patches of skin topped with a thick layer of dry silvery scales. Psoriasis cannot spread and is not contagious.
Cystic acne is distinguised by painful nodules on the chest, face, neck, and back. This form of acne is known to scar. Treatment may incorporate the use of hormonal therapies, oral antibiotics, and prescription medications.
Hidradenitis Suppurativa (Acne Inversa)
Hidradenitis suppurativa (HS or acne inversa) is a chronic skin condition that causes painful red abscesses in the groin and armpits that may drain foul-smelling pus. Treatment options include weight loss, smoking cessation, topical antibiotics, and avoidance of tight-fitting underwear. Finasteride and adalimumab may be helpful for those with resistant cases of HS.
What Is the Best Treatment for Psoriasis?
Psoriasis is an incurable chronic autoimmune disorder of the skin that causes patches of thick, flaky, scaly skin, mostly around the scalp, knees, and elbows, though any skin surface may be involved. Some people experience only small patches while others have red, inflamed skin and think scaly patches all over the body. The exact cause of psoriasis is not clear, but it isn’t contagious.
Treatment & Diagnosis
- Skin FAQs
- Acne FAQs
- Psoriasis FAQs
- Accutane (isotretinoin) for Acne linked to birth defects, depression and suicide
- Psoriasis, Lupus, Rheumatoid Arthritis Share One Gene
- Psoriasis Drugs Strike Immune Targets (Raptiva, Enbrel)
- Can Dermabrasion Cure Acne Scars?
- Is it Safe to Use Accutane for Acne?
- Can You Still Retain Symptoms Of PCOD (Acne, Obesity, Etc.) After Hysterectomy?
- How Do You Get Psoriasis?
- Can Psoriasis Be Caused by Allergy?
- Is It Eczema or Psoriasis?
- What Are the Triggers of Psoriasis?
- How to Get Rid of Acne
- Psoriasis PUVA Therapy Can Increase Melanoma Risk
Medications & Supplements
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.