Does Sudafed (pseudoephedrine) cause side effects?

Sudafed (pseudoephedrine) is a decongestant used to reduce nasal congestion caused by allergies or the common cold. Sudafed causes blood vessels in the nasal passages to shrink (vasoconstrict).

Vasoconstriction reduces nasal congestion by preventing fluid from draining from blood vessels into nasal passages. Sudafed also directly stimulates beta-adrenergic receptors and causes relaxation of bronchioles, as well as increased heart rate and contractility. Sudafed is available over-the-counter (OTC) and as a generic. 

Common side effects of Sudafed include

Serious side effects of Sudafed include

Drug interactions of Sudafed include monoamine oxidase inhibitors (MAOIs) because such combinations may cause an acute hypertensive episode.

Use of Sudafed by pregnant women has not been adequately evaluated. Sudafed is secreted in breast milk. However, it is considered safe to use while breastfeeding.

What are the important side effects of Sudafed (pseudoephedrine)?

Common side effects of pseudoephedrine include:

Pseudoephedrine should not be used by people with severe hypertension or coronary artery disease.

It should be used with caution in people with

Sudafed (pseudoephedrine) side effects list for healthcare professionals

Common side effects of Sudafed include

What drugs interact with Sudafed (pseudoephedrine)?

Sudafed drug interactions include

Summary

Sudafed (pseudoephedrine) is a decongestant used to reduce nasal congestion caused by allergies or the common cold. Common side effects of Sudafed include tremor, restlessness, insomnia, nausea, vomiting, and nervousness. Serious side effects of Sudafed include high blood pressure (hypertension), heart attack, abnormal heartbeats, and ischemic colitis. Use of Sudafed by pregnant women has not been adequately evaluated. Sudafed is secreted in breast milk. However, it is considered safe to use while breastfeeding.

Treatment & Diagnosis

Medications & Supplements

FDA Logo

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Medically Reviewed on 6/29/2020
References
FDA Prescribing Information

Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.
CONTINUE SCROLLING FOR RELATED SLIDESHOW