Does Pyridium (phenazopyridine) cause side effects?
Pyridium (phenazopyridine) is an oral urinary analgesic (pain relieving medication) used to relieve symptoms associated with lower urinary tract infections (UTIs) including urinary burning, pain, urgency, and frequency, and other symptoms.
Although the exact mechanism of action is unknown, Pyridium is thought to provide relief of symptoms of UTIs by acting as a local anesthetic on the lining of the urinary tract.
Pyridium is excreted in the urine and may cause urine to change to an orange or red color. Pyridium does not have any antibacterial action and should not be used to treat UTIs. It is only used to provide relief of symptoms associated with UTIs. Phenazopyridine is also available over-the-counter (OTC) in lower strengths.
Common side effects of Pyridium include
Serious side effects of Pyridium are rare and may include
- acute kidney failure,
- hemolytic anemia,
- hepatitis (liver injury), and
- methemoglobinemia.
No significant drug interactions have been reported with Pyridium use. There are no well-controlled studies of Pyridium in pregnant women. As with all drugs, Pyridium should be used in pregnancy only if clearly needed.
It is unknown if Pyridium is excreted in breast milk. Consult your doctor before breastfeeding.
What are the important side effects of Pyridium (phenazopyridine)?
Common side effects of phenazopyridine treatment affecting up to 10 percent of patients are:
Rare but serious side effects associated with phenazopyridine (occurring in <1%) include:
- acute kidney failure,
- hemolytic anemia,
- hepatitis (liver injury), and
- methemoglobinemia.
Pyridium (phenazopyridine) side effects list for healthcare professionals
Headache, rash, pruritus and occasional gastrointestinal disturbance. An anaphylactoid-like reaction has been described. Methemoglobinemia, hemolytic anemia, renal and hepatic toxicity have been reported, usually at overdosage levels.
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Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.
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