- Bacterial Infections 101 Pictures Slideshow
- Take the Tummy Trouble Quiz
- Hepatitis C Slideshow Pictures
Does Principen (ampicillin) cause side effects?
- middle ear,
- stomach and intestines,
- bladder, and
- kidney caused by susceptible bacteria.
It also is used for treating
Because of the increased use of antibiotics, many bacterial strains have become resistant to penicillins; bacteria causing serious infections should be tested for resistance against penicillins and other antibiotics.
Common side effects of Principen include:
- loss of appetite,
- abdominal pain,
- confusion and
Serious side effects of Principen include:
- rare allergic reactions [seizures, severe allergic reactions (anaphylaxis)],
- low platelet or red blood cell count, and
- pseudomembranous colitis (symptoms include diarrhea, fever, abdominal pain, and possibly shock).
Principen is considered safe during pregnancy. If Principen is used during pregnancy, the potential benefit of ampicillin for the mother should be weighed against the potential risk of side effects in the infant.
What are the important side effects of Principen (ampicillin)?
Common side effects of ampicillin include:
- loss of appetite,
- abdominal pain,
- confusion and
Patients with a history of allergic reactions to other penicillins should not receive ampicillin.
Persons who are allergic to the cephalosporin class of antibiotics, which are related to the penicillins may or may not be allergic to penicillins [for example, cefaclor (Ceclor), cephalexin (Keflex), and cefprozil (Cefzil)].
Serious but rare reactions include seizures, severe allergic reactions (anaphylaxis), and low platelet or red blood cell count.
Ampicillin can alter the normal bacteria in the colon and encourage overgrowth of some bacteria such as Clostridium difficile which causes inflammation of the colon (pseudomembranous colitis).
Principen (ampicillin) side effects list for healthcare professionals
As with other penicillins, it may be expected that untoward reactions will be essentially limited to sensitivity phenomena. They are more likely to occur in individuals who have previously demonstrated hypersensitivity to penicillin and in those with a history of allergy, asthma, hay fever, or urticaria.
The following adverse reactions have been reported as associated with the use of ampicillin:
Gastrointestinal: glositis, stamatitis, nausea, vomiting, enterocolitis, pseudomembranous colitis, and diarrhea. These reactions are usually associated with oral dosage forms of the drugs.
Hypersensitivity Reactions: An erythematous, mildly pruritic, maculopapular skin rash has been reported fairly frequently. The rash, which usually does not develop within the first week of therapy, may cover the entire body including the soles, palms, and oral mucosa. The eruption usually disappears in three to seven days.
Other hypersensitivity reactions that have been reported are:
Anaphylaxis is the most serious reaction experienced and has usually been associated with the parenteral dosage form of the drug
Note: Urticaria, other skin rashes, and serum sickness-like reactions may be controlled by antihistamines, and if necessary, systemic corticosteroids. Whenever such reactions occur, ampicillin should be discontinued unless, in the opinion of the physician, the condition being treated is life-threatening, and amenable only to ampicillin therapy. Serious anaphylactoid reactions require emergency measures.
Liver: Moderate elevation in serum glutamic oxalaacetic transaminase (SGOT) has been noted, but the significance of this finding is unknown.
Hemic and Lymphatic Systems: Anemia, thrombocytopenia, thrombocytopenic purpura, eosinophilia, leukapenia, and agranulacytosis have been reported during therapy with penicillins. These reactions are usually reversible on discontinuation of therapy and are believed to be hypersensitivity phenomena.
Other: Other adverse reactions that have been reported with the use at ampicillin are laryngeal stride and high fever. An occasional patient may complain of sore mouth or tongue as with any oral penicillin preparation.
What drugs interact with Principen (ampicillin)?
When administered concurrently, the following drugs may interact with ampicillin.
Allopurinol: Increased possibility of skin rash, particularly in hyperuricemic patients may occur.
Bacteriostatic Antibiotics: Chloramphenicol, erythromycins, sulfonamides, or tetracyclines may interfere with the bactericidal effect of penicillins. This has been demonstrated in view, however, the clinical significance of this interaction is not well documented.
Oral Contraceptives: May be less effective and increased breakthrough bleeding may occur.
Probenecid: May decrease renal tubular secretion of ampicillin resulting in increased blood levels and/or ampicillin toxicity.
Drug/Laboratory Test Interaction
After treatment with ampicillin, a false-positive reaction for glucose in the urine may occur with copper sulfate tests (Benedict's solution, Fehling's solution, or Clinitest tablets) but not with enzyme based tests such as Clinistix and Glucose Enzymatic Test Strip USP.
Principen (ampicillin) is a penicillin antibiotic used to treat infections of the middle ear, sinuses, stomach and intestines, bladder, and kidney caused by susceptible bacteria. It also is used for treating uncomplicated gonorrhea, meningitis, endocarditis and other serious infections. Common side effects of Principen include nausea, vomiting, loss of appetite, diarrhea, abdominal pain, rash, itching, headache, confusion and dizziness. Principen is considered safe during pregnancy. If Principen is used during pregnancy, the potential benefit of ampicillin for the mother should be weighed against the potential risk of side effects in the infant. Principen is excreted in breast milk and may cause diarrhea or allergic responses in nursing infants.
Multimedia: Slideshows, Images & Quizzes
Meningitis Quiz: Test Your Infectious Disease IQ
What is meningitis and what causes it? Take our Meningitis Quiz to learn the causes, symptoms, treatments, and complications of...
Ear Infection Quiz: Test Your Medical IQ
Is it possible to prevent ear infections? Take the Ear Infection (Otitis Media) Quiz to learn the risks, causes, symptoms and...
Picture of The Clap (Gonorrhea)
A sexually transmitted infection (STI) caused by the bacterium Neisseria gonorrhoea. See a picture of The Clap (Gonorrhea) and...
Ear Infection Symptoms, Causes, and Treatment
Learn about the causes and symptoms of ear infections and how they are diagnosed and treated. Read about treatments such as ear...
Bladder Infections: UTI Causes, Symptoms, Treatments
Urinary tract infections (UTI), including bladder infections, affect women and men, causing UTI symptoms like kidney infection....
Ear Infections: All About Ear Conditions
What's that? I can't hear you. Maybe it's tinnitus, or impacted ear wax, or cauliflower ear (yup, that's a thing). Find out what...
Related Disease Conditions
Kidney Infection in Adults
Second Source article from Government
Endocarditis, a serious infection of one of the four heart valves is caused by growth of bacteria on one of the heart valves; leading to an infected massed called a "vegetation." The infection can be caused by having bacteria in the bloodstream after dental work, colonoscopy, or other similar procedures. Endocarditis symptoms include: fever, fatigue, weakness, chills, aching muscles and joints, night sweats, edema in the legs, feet, or abdomen, malaise, shortness of breath and small skin lesions. Treatment for endocarditis is generally aggressive antibiotic treatment.
Middle Ear Infection (Otitis Media)
Middle ear infection (otitis media) is inflammation of the middle ear. There are two forms of this type of ear infection, acute and chronic. Acute otitis media is generally short in duration, and chronic otitis media generally lasts several weeks. Babies, toddlers, and children with a middle ear infection may be irritable, pull and tug at their ears, and experience numerous other symptoms and signs. Treatment depends upon the type of ear infection.
Gonorrhea In Women
Gonorrhea is a bacterial infection transmitted during sexual contact. In women, symptoms include a yellow vaginal discharge, burning or frequent urination, and redness, swelling, burning and itching of the vaginal area. Gonorrhea can be treated with injectable (penicillin) or oral medications.
Kidney Infection (Pyelonephritis)
Kidney infection (pyelonephritis) usually is caused by E. coli and other bacteria that have spread from the bladder from a UTI (urinary tract infection), poor hygiene, sexual intercourse, pregnancy, catheter, cystoscope exam, surgery, kidney stones, or prostate enlargement. Symptoms of kidney infection include back pain, frequent urination, pain during urination, fever, and or pus or blood in the urine. Kidney infection can be cured with antibiotic treatment. Cranberry juice may prevent UTIs, but that hasn’t been proven in all research studies.
Bladder Infection (Cystitis)
Bladder infection is an infection of the bladder, usually caused by bacteria or, rarely, by Candida. Certain people, including females, the elderly, men with enlarged prostates, and those with chronic medical conditions are at increased risk for bladder infection. Bladder infections are treated with antibiotics, but cranberry products and adequate hydration may help prevent bladder infections.
Is Meningitis Contagious?
Meningitis, inflammation of the meninges, symptoms and signs include neck stiffness, headache, and fever. There are five types of meningitis: viral, bacterial, fungal, parasitic, and noninfectious.
Inner Ear Infection (Labyrinthitis)
Labyrinthitis is inflammation of the labyrinth (the part of the ear responsible for balance and hearing). Doctors do not know the exact cause of labyrinthitis; however, they often are associated viral infections of the inner ear. Symptoms of labyrinthitis are ear pain or earache, ear discharge, problems with balance and walking, ringing in the ears, dizziness, nausea, vomiting, and vertigo. Viral infections associated with labyrinthitis are contagious. Home remedies may help labyrinthitis symptoms and signs. Over-the-counter (OTC) and prescription medication may treat inner ear infections, labyrinthitis symptoms like vertigo and nausea, and help ear pain.
Ear Infection Home Treatment
Infections of the outer, middle, and inner ear usually are caused by viruses. Most outer (swimmer's ear) and middle ear (otitis media) infections can be treated at home with remedies like warm compresses for ear pain relief, tea tree, ginger, or garlic oil drops. Symptoms of an outer ear (swimmer's ear) and middle ear infection include mild to severe ear pain, pus draining from the ear, swelling and redness in the ear, and hearing problems. Middle and inner ear infections may cause fever, and balance problems. Inner ear infections also may cause nausea, vomiting, vertigo, ringing in the ear, and labyrinthitis (inflammation of the inner ear). Most outer and middle ear infections do not need antibiotics. Inner ear infections should be treated by a doctor specializing in ear and hearing problems.
Inner Ear Infection (Symptoms, Signs, Treatments, Home Remedies)
An inner ear infection or otitis interna is caused by viruses or bacteria and can occur in both adults and children. An inner ear infection can cause symptoms and signs, for example, a severe ear, dizziness, vertigo, nausea and vomiting, and vertigo. An inner ear infection also may cause inflammation of the inner ear or labyrinthitis. Inner ear infections are not contagious; however, the bacteria and viruses that cause the infection can be transmitted to other people. Good hygiene practices will help decrease the chances of the infection spreading to others. Inner ear infection symptoms and signs like ear pain and nausea may be relieved with home remedies or over the counter (OTC) medication. Some inner ear infections will need to be treated and cured with antibiotics or prescription pain or antinausea medication.
Meningitis is inflammation of the membranes that cover the spinal cord and brain. Symptoms include fever, headache, and a stiff neck. Treatment of meningitis depends upon the cause of the infection and may include antibiotics or antiviral medications.
Treatment & Diagnosis
- Ear Infection FAQs
- Meningitis FAQs
- Gonorrhea Treatment Recommendations Update
- Kidney Infections During Pregnancy
- What Is the Difference Between a Bladder Infection vs. UTI?
- What Causes an Ear Infection?
- How Do You Get an Ear Infection?
- Is there Over-the-Counter Ear Infection Medicine?
- Oral Gonorrhea Symptoms
- Fungal Meningitis and Steroid Injections: a Health-Care Disease
Medications & Supplements
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.