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Does Pitocin (oxytocin) cause side effects?
Pitocin (oxytocin) is a protein produced by the pituitary gland of mammals including man. Pitocin is a man-made version of oxytocin used to stimulate contraction of the uterus. Pitocin works by increasing the concentration of calcium inside muscle cells that control contraction of the uterus. Increased calcium increases contraction of the uterus.
Common side effects of Pitocin include
Serious side effects of Pitocin include
- severe allergic reactions,
- bleeding after childbirth,
- abnormal heartbeats,
- high blood pressure (hypertension), and
- rupture of the uterus.
Pitocin may be secreted in breast milk. Mothers should not breastfeed for at least one day after stopping Pitocin.
Pitocin (oxytocin) side effects list for healthcare professionals
The following adverse reactions have been reported in the mother:
- Anaphylactic reaction
- Premature ventricular contractions
- Postpartum hemorrhage
- Pelvic hematoma
- Cardiac arrhythmia
- Subarachnoid hemorrhage
- Fatal afibrinogenemia
- Hypertensive episodes
- Rupture of the uterus
Excessive dosage or hypersensitivity to the drug may result in
- uterine hypertonicity,
- tetanic contraction, or
- rupture of the uterus.
The possibility of increased blood loss and afibrinogenemia should be kept in mind when administering the drug.
Severe water intoxication with convulsions and coma has occurred, associated with a slow oxytocin infusion over a 24-hour period. Maternal death due to oxytocin-induced water intoxication has been reported.
The following adverse reactions have been reported in the fetus or neonate:
|Due to induced uterine motility:||Due to use of oxytocin in the mother:|
|Bradycardia||Low Apgar scores at five minutes|
|Premature ventricular contractions and other arrhythmias||Neonatal jaundice|
|Permanent CNS or brain damage||Neonatal retinal hemorrhage|
|Neonatal seizures have been reported with the use of Pitocin.|
For medical advice about adverse reactions contact your medical professional. To report suspected adverse reactions, contact JHP at 1-866-923-2547 or MEDWATCH at 1-800-FDA-1088 (1- 800-332-1088) or http://www.fda.gov/medwatch/.
What drugs interact with Pitocin (oxytocin)?
Severe hypertension has been reported when oxytocin was given three to four hours following prophylactic administration of a vasoconstrictor in conjunction with caudal block anesthesia.
Cyclopropane anesthesia may modify oxytocin's cardiovascular effects, so as to produce unexpected results such as hypotension. Maternal sinus bradycardia with abnormal atrioventricular rhythms has also been noted when oxytocin was used concomitantly with cyclopropane anesthesia.
Pitocin (oxytocin) is a protein produced by the pituitary gland of mammals including man. Pitocin is a man-made version of oxytocin used to stimulate contraction of the uterus. Common side effects of Pitocin include nausea and vomiting. Pitocin should not be used during pregnancy unless for inducing labor or abortion. Pitocin may be secreted in breast milk. Mothers should not breastfeed for at least one day after stopping Pitocin.
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.