Does Mysoline (primidone) cause side effects?
Its exact mechanism of action is not known. Mysoline is converted into phenobarbital and phenylethylmalonamide (PEMA) in the body. Mysoline, phenobarbital, and PEMA all have anticonvulsant activity. In addition to its anticonvulsant activity, PEMA increases the anticonvulsant activity of phenobarbital.
Common side effects of Mysoline include
- difficulty speaking,
- burning or tingling from damaged nerves,
- difficulty moving,
- spinning sensation (vertigo),
- hyperactivity (children),
- depression, drowsiness, irritability, headache, restlessness, involuntary eye movements, and dizziness.
Serious side effects of Mysoline include
- acute psychosis,
- folate-deficiency anemia,
- liver toxicity,
- low blood calcium,
- weakening of bones,
- serious skin reactions (for example, Stevens-Johnson syndrome),
- increased risk of suicidal thoughts or behavior.
Suddenly stopping seizure medications may cause seizures.
- roflumilast, and
Mysoline has not been adequately evaluated in pregnant women. Some other seizure medications have been associated with birth defects. Mysoline is excreted in human milk and may cause adverse effects in the infant. Consult your doctor before breastfeeding.
What are the important side effects of Mysoline (primidone)?
Common side effects of primidone include:
- Difficulty speaking (dysarthria)
- Burning, tingling from damaged nerves (paresthesia)
- Difficulty moving (ataxia)
- Loss of balance (vertigo)
- Paradoxical excitement (children)
- Hyperactivity (children)
Possible serious side effects of primidone include:
- Acute psychosis
- Folate-deficiency anemia
- Liver toxicity
- Low blood calcium
- Weakening of bones
- Serious skin reactions (for example, Stevens-Johnson syndrome)
Seizure medications increase the risk of suicidal thoughts or behavior. Patients treated with seizure medications should be observed for the emergence or worsening of depression, suicidal thoughts or behavior, and unusual changes in mood or behavior.
Suddenly stopping medications for seizures may cause seizures.
Mysoline (primidone) side effects list for healthcare professionals
Occasionally, the following have been reported:
- emotional disturbances,
- sexual impotency,
- drowsiness, and
- morbilliform skin eruptions.
Other side effects have been reported rarely, such as
- agranulocytosis, and
- red-cell hypoplasia and aplasia.
These and, occasionally, other persistant or severe side effects may necessitate withdrawal of the drug. Megaloblastic anemia may occur as a rare idiosyncrasy to Mysoline and to other anticonvulsants. The anemia responds to folic acid without necessity of discontinuing medication.
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Migraines and Seizures (Symptoms, Auras, Medication)
Migraines are a type of headache and seizures are the main symptom of epilepsy. Migraine headaches and seizures are two different neurological problems that have similar signs, symptoms, and auras, for example, sensitivity to light (photophobia) and sound, irritability, nausea, and vomiting. Symptoms unique to migraine and migraine auras are water retention, problems sleeping, appetite changes, and talkativeness. Symptoms unique to seizure and seizures auras are depression, a feeling of heaviness, a feeling that a seizure is approaching, and depression. Many of the symptoms of migraine and seizures are the same, however, seizures do not cause migraines; however, people who have seizures are twice as likely to have migraines and vice-versa. People who have migraines are twice as likely to have seizures, and people with seizures are twice as likely to have migraines; however, one condition does not cause the other.
Seizures Symptoms and Types
Seizures are divided into two categories: generalized and partial. Generalized seizures are produced by electrical impulses from throughout the brain, while partial seizures are produced by electrical impulses in a small part of the brain. Seizure symptoms include unconsciousness, convulsions, and muscle rigidity.
Epilepsy is a brain disorder in which the person has seizures. There are two kinds of seizures, focal and generalized. There are many causes of epilepsy. Treatment of epilepsy (seizures) depends upon the cause and type of seizures experienced.
Seizure vs. Seizure Disorders: What's the Difference?
Seizures and seizure disorders are not the same medical problems. A seizure happens when the electrical activity in the brain is uncontrolled. There are about 40 different types of seizure disorders, in which epilepsy is one. Symptoms depend on the type of disorder, but can include loss of consciousness, uncontrolled twitching or shaking of one side, or the entire body.
Febrile seizures, or convulsions caused by fever, can be frightening in small children or infants. However, in general, febrile seizures are harmless. Febrile seizure is not epilepsy. It is estimated that one in every 25 children will have at least one febrile seizure. It is important to know what to do to help your child if he/she has a febrile seizure. Some of the features of a febrile seizure include losing consciousness, shaking, moving limbs on both sides of the body, and lasts 1-2 minutes. Less commonly, a febrile seizure may only affect one side of the body.
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Medications & Supplements
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.