Does Mysoline (primidone) cause side effects?
Its exact mechanism of action is not known. Mysoline is converted into phenobarbital and phenylethylmalonamide (PEMA) in the body. Mysoline, phenobarbital, and PEMA all have anticonvulsant activity. In addition to its anticonvulsant activity, PEMA increases the anticonvulsant activity of phenobarbital.
Common side effects of Mysoline include
- difficulty speaking,
- burning or tingling from damaged nerves,
- difficulty moving,
- spinning sensation (vertigo),
- hyperactivity (children),
- depression, drowsiness, irritability, headache, restlessness, involuntary eye movements, and dizziness.
Serious side effects of Mysoline include
- acute psychosis,
- folate-deficiency anemia,
- liver toxicity,
- low blood calcium,
- weakening of bones,
- serious skin reactions (for example, Stevens-Johnson syndrome),
- increased risk of suicidal thoughts or behavior.
Suddenly stopping seizure medications may cause seizures.
- roflumilast, and
Mysoline has not been adequately evaluated in pregnant women. Some other seizure medications have been associated with birth defects. Mysoline is excreted in human milk and may cause adverse effects in the infant. Consult your doctor before breastfeeding.
What are the important side effects of Mysoline (primidone)?
Common side effects of primidone include:
- Difficulty speaking (dysarthria)
- Burning, tingling from damaged nerves (paresthesia)
- Difficulty moving (ataxia)
- Loss of balance (vertigo)
- Paradoxical excitement (children)
- Hyperactivity (children)
Possible serious side effects of primidone include:
- Acute psychosis
- Folate-deficiency anemia
- Liver toxicity
- Low blood calcium
- Weakening of bones
- Serious skin reactions (for example, Stevens-Johnson syndrome)
Seizure medications increase the risk of suicidal thoughts or behavior. Patients treated with seizure medications should be observed for the emergence or worsening of depression, suicidal thoughts or behavior, and unusual changes in mood or behavior.
Suddenly stopping medications for seizures may cause seizures.
Mysoline (primidone) side effects list for healthcare professionals
Occasionally, the following have been reported:
- emotional disturbances,
- sexual impotency,
- drowsiness, and
- morbilliform skin eruptions.
Other side effects have been reported rarely, such as
- agranulocytosis, and
- red-cell hypoplasia and aplasia.
These and, occasionally, other persistant or severe side effects may necessitate withdrawal of the drug. Megaloblastic anemia may occur as a rare idiosyncrasy to Mysoline and to other anticonvulsants. The anemia responds to folic acid without necessity of discontinuing medication.
Mysoline (primidone) is an anticonvulsant (anti-seizure) medication used alone or with other medications to treat grand mal, psychomotor, or focal epileptic seizures. It may be effective for grand mal seizures that are not responsive to other anticonvulsants. Common side effects of Mysoline include difficulty speaking, burning or tingling from damaged nerves, difficulty moving, spinning sensation (vertigo), hyperactivity (children), excitement, confusion, depression, drowsiness, irritability, headache, restlessness, involuntary eye movements, and dizziness. . Mysoline has not been adequately evaluated in pregnant women. Some other seizure medications have been associated with birth defects. Mysoline is excreted in human milk and may cause adverse effects in the infant.
Multimedia: Slideshows, Images & Quizzes
Epilepsy & Seizures Quiz: What Causes Seizures?
Do you know the difference between seizures and epilepsy? What are the types of seizures? Take the Epilepsy & Seizures Quiz to...
Epilepsy: Symptoms, Causes and Treatment
Learn about epilepsy stages, symptoms and treatment for this disorder of the brain's electrical system. Epileptic seizures cause...
Related Disease Conditions
Seizures Symptoms and Types
Seizures are divided into two categories: generalized and partial. Generalized seizures are produced by electrical impulses from throughout the brain, while partial seizures are produced by electrical impulses in a small part of the brain. Seizure symptoms include unconsciousness, convulsions, and muscle rigidity.
Epilepsy is a brain disorder in which the person has seizures. There are two kinds of seizures, focal and generalized. There are many causes of epilepsy. Treatment of epilepsy (seizures) depends upon the cause and type of seizures experienced.
Migraines and Seizures (Symptoms, Auras, Medication)
Migraines are a type of headache and seizures are the main symptom of epilepsy. Migraine headaches and seizures are two different neurological problems that have similar signs, symptoms, and auras, for example, sensitivity to light (photophobia) and sound, irritability, nausea, and vomiting. Symptoms unique to migraine and migraine auras are water retention, problems sleeping, appetite changes, and talkativeness. Symptoms unique to seizure and seizures auras are depression, a feeling of heaviness, a feeling that a seizure is approaching, and depression. Many of the symptoms of migraine and seizures are the same, however, seizures do not cause migraines; however, people who have seizures are twice as likely to have migraines and vice-versa. People who have migraines are twice as likely to have seizures, and people with seizures are twice as likely to have migraines; however, one condition does not cause the other.
Seizure vs. Seizure Disorders (Differences and Similarities)
The differences between a seizure, epilepsy, and seizure disorders are confusing to many people. What makes it more confusing, is that they are not the same thing. A seizure begins suddenly, and is a symptom of another disease. When a seizure occurs there is uncontrolled activity in the brain that usually only lasts for a short period. While a seizure disorder is a medical condition, in which the person has episodes of uncontrolled activity in the brain producing symptoms that include one or more seizures. Epilepsy is considered a seizure disorder.There are two types of major seizures, generalized and partial seizure type and the symptoms depend upon the part of the brain affected, and may include: Loss of consciousness Thought disturbances Convulsions Eye rolling Stiff limbs Twitching on only one side or a portion of the body like an arm or leg. Involuntary urination or bowel movement Repetitive shaking or jerking of the body Staring into space, sometimes with eye blinking No loss of consciousness, but the person becomes confused for a few minutes A third type of seizure is called unclassified seizure.Seizure disorders are classified under two types of major seizures (generalized and partial), and a third type called unclassified seizures. There are about 40 types of named seizure disorders. The symptoms and signs are different depending on the part of the brain affected by the seizure. Examples of seizure disorders are: Febrile seizures Benign Rolandic epilepsy Catamenial epilepsy Absence seizures Frontal lobe epilepsy Epilepsy Sometimes there is a known cause for a seizure like alcohol, cocaine or other illegal drug abuse, drug reactions, a severe chemical imbalance in the blood, or medical problems like low blood pressure. Treatment, management, and prevention of seizures include medication and avoiding any known causes or common triggers. REFERENCES: CDC. "Types of Seizures." Updated: Apr 10, 2017.Harvard Health Publications; Harvard Medical School. "Generalized Seizures (Grand Mal Seizures)."
Febrile seizures, or convulsions caused by fever, can be frightening in small children or infants. However, in general, febrile seizures are harmless. Febrile seizure is not epilepsy. It is estimated that one in every 25 children will have at least one febrile seizure. It is important to know what to do to help your child if he/she has a febrile seizure. Some of the features of a febrile seizure include: losing consciousness, shaking, moving limbs on both sides of the body, lasts 1-2 minutes. Less commonly, a febrile seizure may only affect one side of the body.
Treatment & Diagnosis
- Epilepsy and Seizures FAQs
- What Are the Different Types of Epilepsy?
- Why Remove Half A Brain?
- Seizure Symptoms: How to Assist the Victim
- Seizures: When the Computer Goes Haywire
- Senator Ted Kennedy: Seizure, Brain Cancer, and Death
- Brain Cancer Symptoms: Headaches and Seizures
- Does Lupus Cause Seizures?
- What Is a Jacksonian Seizure?
Medications & Supplements
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.