Does Janumet (metformin and sitagliptin) cause side effects?
Insulin is a hormone produced by the pancreas. It limits blood glucose levels by reducing the amount of glucose released by the liver into the blood and by increasing the removal of glucose from blood by muscle and fat tissues.
Type 2 diabetes results when there is reduced sensitivity of muscle and fat to the effects of insulin. When the diabetes progresses, the pancreas produces less insulin. Both defects result in increased levels of glucose in the blood. Metformin is an oral medication that lowers blood glucose by increasing the sensitivity of liver, muscle, fat, and other tissues to the effects of insulin.
Increasing the sensitivity of tissues to insulin causes more glucose to be removed from blood and thereby reduces the level of glucose in the blood. In scientific studies, metformin reduced the complications of diabetes such as
Following a meal, incretin hormones such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are released from the intestine, and their levels increase in the blood. GLP-1 and GIP reduce blood glucose by increasing the production and release of insulin from the pancreas. GLP-1 also reduces blood glucose by reducing the secretion by the pancreas of glucagon, a hormone that increases the production of glucose by the liver and raises the level of glucose in the blood.
The net effect of increased release of GLP-1 and GIP is to reduce blood glucose levels. In addition, sitagliptin inhibits the enzyme, dipeptidyl peptidase-4 (DPP-4) that destroys GLP-1 and GIP and thereby increases the levels and activity of both hormones and thereby the release of insulin. As a result, blood glucose levels fall.
Common side effects of Janumet include
- stomach upset,
- back pain,
- joint or muscle pain,
- metallic taste in the mouth,
- vitamin B12 deficiency, and
- cold symptoms such as
Serious side effects of Janumet include
- lactic acidosis. Symptoms include
Drug interactions of Janumet include cimetidine, because it decreases the elimination of metformin from the body, which can increase the amount of metformin in the blood by 40%, which may increase the frequency of side effects from metformin.
It is unknown if sitagliptin is secreted in human breast milk. However, metformin is excreted into breast milk and can therefore be transferred to the nursing infant. Consult your doctor before breastfeeding.
What are the important side effects of Janumet (metformin and sitagliptin)?
Lactic acidosis is a serious side effect of metformin that occurs in one out of every 30,000 patients and is fatal in 50% of cases. The symptoms of lactic acidosis are
- trouble breathing,
- abnormal heartbeats,
- unusual muscle pain,
- stomach discomfort,
- light-headedness and
- feeling cold.
Patients at risk for lactic acidosis include those with
- reduced function of the kidneys or liver,
- congestive heart failure,
- severe acute illnesses, and
Janumet should be discontinued immediately if lactic acidosis is suspected.
Common Side Effects
- There have been postmarketing reports of acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis. If pancreatitis is suspected, promptly discontinue Janumet.
- Heart failure has been observed with two other members of the DPP-4 inhibitor class. Consider risks and benefits of Janumet in patients who have known risk factors for heart failure. Monitor patients for signs and symptoms.
- There have been postmarketing reports of acute renal failure,
- sometimes requiring dialysis. Before initiating Janumet and at
- least annually thereafter, assess renal function.
- Vitamin B12 deficiency: Metformin may lower Vitamin B12 levels. Measure hematologic parameters annually. When used with an insulin secretagogue (e.g., sulfonylurea) or with insulin, a lower dose of the insulin secretagogue or insulin may be required to reduce the risk of hypoglycemia.
- There have been postmarketing reports of serious allergic and hypersensitivity reactions in patients treated with sitagliptin (one of the components of Janumet), such as anaphylaxis, angioedema, and exfoliative skin conditions including Stevens-Johnson syndrome. In such cases, promptly stop Janumet, assess for other potential causes, institute appropriate monitoring and treatment, and initiate alternative treatment for diabetes.
- Severe and disabling arthralgia has been reported in patients taking DPP-4 inhibitors. Consider as a possible cause for severe joint pain and discontinue drug if appropriate.
- There have been postmarketing reports of bullous pemphigoid requiring hospitalization in patients taking DPP-4 inhibitors. Tell patients to report development of blisters or erosions. If bullous pemphigoid is suspected, discontinue Janumet.
Janumet (metformin and sitagliptin) side effects list for healthcare professionals
Clinical Trials Experience
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
Sitagliptin And Metformin Immediate-Release Coadministration In Patients With Type 2 Diabetes Inadequately Controlled On Diet and Exercise
Table 1 summarizes the most common (≥5% of patients) adverse reactions reported (regardless of investigator assessment of causality) in a 24-week placebo-controlled factorial study in which sitagliptin and metformin immediate-release were coadministered to patients with type 2 diabetes inadequately controlled on diet and exercise.
Table 1: Sitagliptin and Metformin Immediate-Release
Coadministered to Patients with Type 2 Diabetes Inadequately Controlled on Diet
and Exercise: Adverse Reactions Reported (Regardless of Investigator Assessment
of Causality) in ≥5% of Patients Receiving Combination Therapy
(and Greater than in Patients Receiving Placebo)*
|Number of Patients (%)|
N = 176
|Sitagliptin 100 mg once daily
N = 179
|Metformin Immediate-Release 500 mg or 1000 mg twice daily †
N = 364†
|Sitagliptin 50 mg twice daily + Metformin Immediate-Release 500 mg or 1000 mg twice daily †
N = 372†
|Diarrhea||7 (4.0)||5 (2.8)||28 (7.7)||28 (7.5)|
|Upper Respiratory Tract Infection||9 (5.1)||8 (4.5)||19 (5.2)||23 (6.2)|
|Headache||5 (2.8)||2 (1.1)||14 (3.8)||22 (5.9)|
† Data pooled for the patients given the lower and higher doses of metformin.
Sitagliptin Add-on Therapy In Patients With Type 2 Diabetes Inadequately Controlled On Metformin Immediate-Release Alone
In a 24-week placebo-controlled trial of sitagliptin 100 mg administered once daily added to a twice daily metformin immediate-release regimen, there were no adverse reactions reported regardless of investigator assessment of causality in ≥5% of patients and more commonly than in patients given placebo. Discontinuation of therapy due to clinical adverse reactions was similar to the placebo treatment group (sitagliptin and metformin immediate-release, 1.9%; placebo and metformin immediate-release, 2.5%).
Gastrointestinal Adverse Reactions
The incidences of pre-selected gastrointestinal adverse experiences in patients treated with sitagliptin and metformin immediate-release were similar to those reported for patients treated with metformin immediate-release alone. See Table 2.
Table 2: Pre-selected Gastrointestinal Adverse
Reactions (Regardless of Investigator Assessment of Causality) Reported in
Patients with Type 2 Diabetes Receiving Sitagliptin and Metformin
|Number of Patients (%)|
|Study of Sitagliptin and Metformin Immediate-Release in Patients Inadequately Controlled on Diet and Exercise||Study of Sitagliptin Add-on in Patients Inadequately Controlled on Metformin Immediate-Release Alone|
N = 176
|Sitagliptin 100 mg once daily
N = 179
|Metformin Immediate-Release 500 mg or 1000 mg twice daily *
N = 364
|Sitagliptin 50 mg bid + Metformin Immediate-Release 500 mg or 1000 mg twice daily *
N = 372
|Placebo and Metformin Immediate-Release ≥1500 mg daily
N = 237
|Sitagliptin 100 mg once daily and Metformin Immediate-Release ≥1500 mg daily
N = 464
|Diarrhea||7 (4.0)||5 (2.8)||28 (7.7)||28 (7.5)||6 (2.5)||11 (2.4)|
|Nausea||2 (1.1)||2 (1.1)||20 (5.5)||18 (4.8)||2 (0.8)||6 (1.3)|
|Vomiting||1 (0.6)||0 (0.0)||2 (0.5)||8 (2.2)||2 (0.8)||5 (1.1)|
|Abdominal Pain†||4 (2.3)||6 (3.4)||14 (3.8)||11 (3.0)||9 (3.8)||10 (2.2)|
|* Data pooled for the patients
given the lower and higher doses of metformin.
† Abdominal discomfort was included in the analysis of abdominal pain in the study of initial therapy.
Sitagliptin In Combination With Metformin Immediate-Release And Glimepiride
- In a 24-week placebo-controlled
study of sitagliptin 100 mg as add-on therapy in patients with type 2 diabetes
inadequately controlled on metformin immediate-release and glimepiride
(sitagliptin, N=116; placebo, N=113), the adverse reactions reported regardless
of investigator assessment of causality in ≥5% of patients treated with
sitagliptin and more commonly than in patients treated with placebo were:
- hypoglycemia (Table 3) and
- headache (6.9%, 2.7%).
Sitagliptin In Combination With Metformin Immediate-Release And Rosiglitazone
- In a placebo-controlled study
of sitagliptin 100 mg as add-on therapy in patients with type 2 diabetes
inadequately controlled on metformin immediate-release and rosiglitazone
(sitagliptin, N=181; placebo, N=97), the adverse reactions reported regardless
of investigator assessment of causality through Week 18 in ≥5% of patients
treated with sitagliptin and more commonly than in patients treated with
- upper respiratory tract infection (sitagliptin, 5.5%; placebo, 5.2%) and
- nasopharyngitis (6.1%, 4.1%).
- Through Week 54, the adverse reactions reported regardless of investigator assessment of causality in ≥5% of patients treated with sitagliptin and more commonly than in patients treated with placebo were:
Sitagliptin In Combination With Metformin Immediate-Release And Insulin
- In a 24-week placebo-controlled study of sitagliptin 100 mg as add-on therapy in patients with type 2 diabetes inadequately controlled on metformin immediate-release and insulin (sitagliptin, N=229; placebo, N=233), the only adverse reaction reported regardless of investigator assessment of causality in ≥5% of patients treated with sitagliptin and more commonly than in patients treated with placebo was hypoglycemia (Table 3).
- In all (N=5) studies, adverse reactions of hypoglycemia were based on all reports of symptomatic hypoglycemia; a concurrent glucose measurement was not required although most (77%) reports of hypoglycemia were accompanied by a blood glucose measurement ≤70 mg/dL.
- When the combination of sitagliptin and metformin immediate-release was coadministered with a sulfonylurea or with insulin, the percentage of patients reporting at least one adverse reaction of hypoglycemia was higher than that observed with placebo and metformin immediate-release coadministered with a sulfonylurea or with insulin (Table 3).
Table 3: Incidence and Rate of Hypoglycemia*
(Regardless of Investigator Assessment of Causality) in Placebo-Controlled
Clinical Studies of Sitagliptin in Combination with Metformin Immediate-Release
Coadministered with Glimepiride or Insulin
|Add-On to Glimepiride + Metformin Immediate-Release (24 weeks)||Sitagliptin 100 mg + Metformin Immediate-Release + Glimepiride||Placebo + Metformin Immediate-Release + Glimepiride|
|N = 116||N = 113|
|Overall (%)||19 (16.4)||1 (0.9)|
|Severe (%)‡||0 (0.0)||0 (0.0)|
|Add-On to Insulin + Metformin Immediate-Release (24 weeks)||Sitagliptin 100 mg + Metformin Immediate-Release + Insulin||Placebo + Metformin Immediate-Release + Insulin|
|N = 229||N = 233|
|Overall (%)||35 (15.3)||19 (8.2)|
|Severe (%)‡||1 (0.4)||1 (0.4)|
|* Adverse reactions of
hypoglycemia were based on all reports of symptomatic hypoglycemia; a
concurrent glucose measurement was not required: Intent-to-treat population.
† Based on total number of events (i.e., a single patient may have had multiple events).
‡ Severe events of hypoglycemia were defined as those events requiring medical assistance or exhibiting depressed level/loss of consciousness or seizure.
- The overall incidence of reported adverse reactions of hypoglycemia in patients with type 2 diabetes
inadequately controlled on diet and exercise was
- 0.6% in patients given placebo,
- 0.6% in patients given sitagliptin alone,
- 0.8% in patients given metformin immediate-release alone, and
- 1.6% in patients given sitagliptin in combination with metformin immediate-release.
- In patients with type 2 diabetes
inadequately controlled on metformin immediate-release alone, the overall
incidence of adverse reactions of hypoglycemia was
- 1.3% in patients given add-on sitagliptin and
- 2.1% in patients given add-on placebo.
- In the study of sitagliptin and
add-on combination therapy with metformin immediate-release and rosiglitazone,
the overall incidence of hypoglycemia was
- 2.2% in patients given add-on sitagliptin and
- 0.0% in patients given add-on placebo through Week 18.
Week 54, the overall incidence of hypoglycemia was
- 3.9% in patients given add-on sitagliptin and
- 1.0% in patients given add-on placebo.
Vital Signs And Electrocardiograms
- With the combination of sitagliptin and metformin immediate-release, no clinically meaningful changes in vital signs or in electrocardiogram parameters (including the QTc interval) were observed.
- In a pooled analysis of 19 double-blind clinical trials that included data from 10,246 patients randomized to receive sitagliptin 100 mg/day (N=5429) or corresponding (active or placebo) control (N=4817), the incidence of acute pancreatitis was 0.1 per 100 patient-years in each group (4 patients with an event in 4708 patient-years for sitagliptin and 4 patients with an event in 3942 patient-years for control).
- The most common adverse experience in sitagliptin monotherapy reported regardless of investigator assessment of causality in ≥5% of patients and more commonly than in patients given placebo was nasopharyngitis.
- In a 24-week clinical trial in which extended-release metformin or placebo was added to glyburide therapy, the most common (>5% and greater than placebo) adverse reactions in the combined treatment group were
- The incidence of laboratory adverse reactions was similar in patients treated with sitagliptin and metformin immediate-release (7.6%) compared to patients treated with placebo and metformin (8.7%).
- In most but not all studies, a small increase in white blood cell count (approximately 200 cells/microL difference in WBC vs. placebo; mean baseline WBC approximately 6600 cells/microL) was observed due to a small increase in neutrophils.
- This change in laboratory parameters is not considered to be clinically relevant.
- In controlled clinical trials of metformin of 29 weeks duration, a decrease to subnormal levels of previously normal serum Vitamin B12 levels, without clinical manifestations, was observed in approximately 7% of patients. Such decrease, possibly due to interference with B12 absorption from the B12-intrinsic factor complex, is, however, very rarely associated with anemia and appears to be rapidly reversible with discontinuation of metformin or Vitamin B12 supplementation.
Additional adverse reactions have been identified during postapproval use of sitagliptin with metformin, sitagliptin, or metformin. Because these reactions are reported voluntarily from a population of uncertain size, it is generally not possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
Hypersensitivity reactions including
- cutaneous vasculitis, and
- exfoliative skin conditions including Stevens-Johnson syndrome;
- upper respiratory tract infection;
- hepatic enzyme elevations;
- acute pancreatitis, including fatal and nonfatal hemorrhagic and necrotizing pancreatitis;
- worsening renal function, including acute renal failure (sometimes requiring dialysis);
- severe and disabling arthralgia;
- bullous pemphigoid;
- pain in extremity;
- back pain;
- cholestatic, hepatocellular, and mixed hepatocellular liver injury.
What drugs interact with Janumet (metformin and sitagliptin)?
Carbonic Anhydrase Inhibitors
- Topiramate or other carbonic anhydrase inhibitors (e.g., zonisamide, acetazolamide or dichlorphenamide) frequently cause a decrease in serum bicarbonate and induce non-anion gap, hyperchloremic metabolic acidosis.
- Concomitant use of these drugs with Janumet XR may increase the risk of lactic acidosis. Consider more frequent monitoring of these patients.
Drugs That Reduce Metformin Clearance
- Concomitant use of drugs that interfere with common renal tubular
transport systems involved in the renal elimination of metformin, including
organic cationic transporter-2 [OCT2] / multidrug and toxin extrusion [MATE]
inhibitors such as
- dolutegravir, and
- cimetidine) could increase systemic exposure to metformin and may increase the risk for lactic acidosis. Consider the benefits and risks of concomitant use.
- Alcohol is known to potentiate the effect of metformin on lactate metabolism.
- Warn patients against excessive alcohol intake while receiving Janumet XR.
Insulin Secretagogues Or Insulin
- Coadministration of Janumet XR with an insulin secretagogue (e.g., sulfonylurea) or insulin may require lower doses of the insulin secretagogue or insulin to reduce the risk of hypoglycemia.
- Use Of Metformin With Other Drugs
- Certain drugs tend to produce hyperglycemia and may lead to loss of glycemic control.
- These drugs include the thiazides and other
- When such drugs are administered to a patient receiving Janumet XR the patient should be closely observed to maintain adequate glycemic control.
Janumet (metformin and sitagliptin) is a combination of drugs used to reduce blood glucose (sugar) levels in individuals with type 2 diabetes. Common side effects of Janumet include stomach upset, nausea, vomiting, constipation, diarrhea, headache, weakness, back pain, joint or muscle pain, metallic taste in the mouth, vitamin B12 deficiency, and cold symptoms such as runny or stuffy nose, sneezing, and sore throat. There are no adequate studies of Janumet or the individual components in pregnant women. It is unknown if sitagliptin is secreted in human breast milk.
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People with diabetes can manage and prevent low or high blood sugar levels (hyperglycemia or hypoglycemia) by keeping a log of your blood sugar levels when you are eating and fasting and eat foods that are high in carbohydrates and sugar, for example, buttered potatoes, candy, sugary desserts, and fatty foods. Blood tests, for example, the hemoglobin A1c test (A1c test) and urinalysis can diagnose the type of diabetes the person has. Diabetes during pregnancy, called gestational diabetes, should be managed by you and your OB/GYN or another healthcare professional. Extremely high levels of blood glucose in the blood can be dangerous and life threatening if you have type 1, type 2, or gestational diabetes. If you or someone that you are with has extremely high blood glucose levels, call 911 or go to your nearest Urgent Care or Emergency Department immediately. To prevent and manage high blood glucose levels in people with diabetes keep a log of your blood sugar levels, eat foods that are high in carbohydrates sugar, for example, buttered potatoes, candy, sugary deserts, and fatty foods that you can share with your doctor and other healthcare professionals.
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Diabetes related foot problems can affect your health with two problems: diabetic neuropathy, where diabetes affects the nerves, and peripheral vascular disease, where diabetes affects the flow of blood. Common foot problems for people with diabetes include athlete's foot, fungal infection of nails, calluses, corns, blisters, bunions, dry skin, foot ulcers, hammertoes, ingrown toenails, and plantar warts.
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Diabetes and eye problems are generally caused by high blood sugar levels over an extended period of time. Types of eye problems in a person with diabetes include glaucoma, cataracts, and retinopathy. Examples of symptoms include blurred vision, headaches, eye aches, pain, halos around lights, loss of vision, watering eyes. Treatment for eye problems in people with diabetes depend on the type of eye problem. Prevention of eye problems include reducing blood pressure, cholesterol levels, quitting smoking, and maintaining proper blood glucose levels.
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Can Type 2 Diabetes be Cured?
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Tips for Managing Type 1 and 2 Diabetes at Home
Managing your diabetes is a full time commitment. The goal of diabetic therapy is to control blood glucose levels and prevent the complications of diabetes. Information about exercise, diet, and medication will help you manage your diabetes better. Blood glucose reagent strips, blood glucose meters, urine glucose tests, tests for urinary ketones, continuous glucose sensors, and Hemoglobin A1C testing information will enable you to mange your diabetes at home successfully.
What Are the Early Signs of Type 2 Diabetes?
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- Diabetes- Keeping Watch: Daily Diabetes Monitoring
- Diabetes: Maintaining Control
- Diabetes and Your Heart
- Diabetes and Diet: What Do I Eat?
- Diabetes: Maintaining Control with Nutrition
- Diabetes & Fitness: Get Moving!
- Diabetes Alert Day
- Diabetes: Scientific Research for Type I Diabetes
- Diabetes: Dealing with Your New Diagnosis
- Diabetes: Your Treatment Options
- Diabetes: Psychological Challenges
- Diabetes FAQs
- Type 2 Diabetes FAQs
- Type 1 Diabetes FAQs
- What if I get COVID-19 with Diabetes?
- Gee - Whats in a Name
- Diabetes - An Aspirin A Day
- Diabetes and Eye Disease...See No Evil
- Diabetes - David Meets Goliath
- Insulin...Getting Better All the Time
- Exercise Therapy in Type 2 Diabetes - Part 1
- Exercise Therapy in Diabetes - Part 2
- Insulin Resistance - Keypoints
- Diabetes Mellitus - The Work Pays Off
- Diabetes - Foot Care: A Walking Matter
- Ramipril, Heart Disease, Stroke & Diabetes
- Diabetes Type I...Insulin Therapy
- Heart Disease Stroke and Diabetes
- Hypoglycemia (Low Blood Sugar) Symptoms and Diabetes
- Rheumatoid Arthritis & Diabetes Gene (PTPN22)
- Diabetes Update - American Diabetes Association 2006
- What Foods to Eat to Reverse Diabetes
- How Bad Is Type 1 Diabetes?
- What Causes Type 1 Diabetes in Adults?
- Is Type 1 Diabetes Genetic?
- What Will Happen if Type 1 Diabetes Is Left Untreated?
- Can You Get Diabetes from Stress?
- How Do You Know if You Have Diabetes?
- Can oral diabetes medications cause impotence?
- Does Diabetes Cause Gum Disease?
- What Is the Treatment for Diabetes Eye Damage?
- Does Celiac Disease Cause Diabetes?
- Does Anti-Retroviral Therapy for HIV Cause Diabetes?
- Can You Have Type 1 Diabetes Without Symptoms?
- 6 Frequently Asked Diabetes Question
- What Kind of Candy Can You Eat With Diabetes?
- Is Weight Loss Caused by Diabetes Dangerous?
- Can Diabetes Cause Muscle Pain?
- 11 Diabetes Diet Tips for the Holidays
- Diabetes Diet
- Top 10 Questions to Ask Your Doctor About Diabetes
- Prediabetes Symptoms and Diagnosis
- Diabetes: Eating Well with Type 2 Diabetes
- Diabetes: What Can I Eat?
Medications & Supplements
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.