Does Skelaxin (metaxalone) cause side effects?

Skelaxin (metaxalone) is a skeletal muscle relaxer used as an adjunct to physical therapy to treat short-term painful muscle and skeletal conditions.

Skelaxin does not act directly on skeletal muscle, and the exact mechanism of action of Skelaxin is unknown. Skelaxin relaxes muscles possibly by affecting the central nervous system (brain and spinal cord) and by causing sedation.

Common side effects of Skelaxin include

Serious side effects of Skelaxin include

No important drug interactions have been described with Skelaxin. Skelaxin may increase the sedative effects of alcohol and drugs that cause sedation, for example, benzodiazepines, antidepressants, and opioids.

Skelaxin has not been adequately studied in pregnant women.

It is unknown if Skelaxin is excreted in breast milk. Safety for use in nursing mothers has not been established. Consult your doctor before breastfeeding.

What are the important side effects of Skelaxin (metaxalone)?

The most common side effects with metaxalone are:

Other important, but less common, side effects include:

GENERIC AVAILABLE: Yes

Skelaxin (metaxalone) side effects list for healthcare professionals

The most frequent reactions to metaxalone include:

CNS: drowsiness, dizziness, headache, and nervousness or “irritability”;

Digestive: nausea, vomiting, gastrointestinal upset.

Other adverse reactions are:

Immune System: hypersensitivity reaction, rash with or without pruritus;

Hematologic: leukopenia; hemolytic anemia;

Hepatobiliary: jaundice.

Though rare, anaphylactoid reactions have been reported with metaxalone.

What drugs interact with Skelaxin (metaxalone)?

No information provided.

Summary

Skelaxin (metaxalone) is a skeletal muscle relaxer used as an adjunct to physical therapy to treat short-term painful muscle and skeletal conditions. Common side effects of Skelaxin include drowsiness, dizziness, headache, nervousness, irritability, nausea, vomiting, and upset stomach. Skelaxin has not been adequately studied in pregnant women. It is unknown if Skelaxin is excreted in breast milk.

Treatment & Diagnosis

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Medically Reviewed on 9/14/2020
References
FDA Prescribing Information

Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.