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Does Lotrisone (clotrimazole and betamethasone) cause side effects?
Lotrisone (clotrimazole and betamethasone) is a cream or lotion that is a combination of an antifungal drug and a corticosteroid used to treat local fungal infections such as tinea pedis ("athlete's foot"), tinea cruris ("jock itch"), and tinea corporis (fungal infections elsewhere on the body). It also is used to treat allergic or inflammatory conditions.
Common side effects of Lotrisone include
- local redness,
- swelling/water retention (edema),
- tingling or prickling sensation,
- burning at the area of application,
- decreased pigmentation, and
- stretch marks.
Serious side effects of Lotrisone include
- growth retardation,
- intracranial hypertension,
- infection due to bacteria,
- Cushing's syndrome, and
- skin atrophy.
Drug interactions of Lotrisone include psoriasis treatment with anthralin, because long-term use or withdrawal of topical corticosteroids may aggravate psoriasis. Therefore, there should be an interval of at least 1 week between the discontinuance of topical steroids like betamethasone and the starting of anthralin.
Safety of using Lotrisone during pregnancy has not been evaluated.
What are the side effects of Lotrisone (clotrimazole and betamethasone)?
The most common side effects include:
- Local redness
- Swelling (edema)
- Tingling or prickling sensation
- Burning at the area of application
Other important side effects include:
- Water retention (edema)
- Decreased pigmentation
- Stretch marks
Possible serious side effects include:
- Growth retardation
- Intracranial hypertension
- Infection due to bacteria
- Cushing's syndrome
- Skin atrophy
Lotrisone (clotrimazole and betamethasone) side effects list for healthcare professionals
Clinical Trial Experience
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
In clinical trials common adverse reaction reported for Lotrisone cream was paresthesia in 1.9% of patients. Adverse reactions reported at a frequency < 1% included rash, edema, and secondary infection.
Because adverse reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
The following local adverse reactions have been reported with topical corticosteroids:
- acneiform eruptions,
- perioral dermatitis,
- allergic contact dermatitis,
- maceration of the skin,
- skin atrophy,
- capillary fragility (ecchymoses),
- telangiectasia, and
- sensitization (local reactions upon repeated application of product).
Ophthalmic adverse reactions of blurred vision, cataracts, glaucoma, increased intraocular pressure, and central serous chorioretinopathy have been reported with the use of topical corticosteroids, including topical betamethasone products.
Adverse reactions reported with the use of clotrimazole are:
- urticaria, and
- general irritation of the skin.
Lotrisone (clotrimazole and betamethasone) is a cream or lotion that is a combination of an antifungal drug and a corticosteroid used to treat local fungal infections such as tinea pedis ("athlete's foot"), tinea cruris ("jock itch"), and tinea corporis (fungal infections elsewhere on the body). It also is used to treat allergic or inflammatory conditions. Common side effects of Lotrisone include local redness, stinging, blistering, peeling, swelling/water retention (edema), itching, tingling or prickling sensation, hives, burning at the area of application, decreased pigmentation, and stretch marks. Safety of using Lotrisone during pregnancy has not been evaluated. It is unknown if clotrimazole or betamethasone is secreted in breast milk.
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Related Disease Conditions
Jock itch is an itchy red rash that appears in the groin area. The rash may be caused by a bacterial or fungal infection. People with diabetes and those who are obese are more susceptible to developing jock itch. Antifungal shampoos, creams, and pills may be needed to treat fungal jock itch. Bacterial jock itch may be treated with antibacterial soaps and topical and oral antibiotics.
Fungal nails (onychomycosis) may be caused by many species of fungi, but the most common is Trichophyton rubrum. Distal subungal onychomycosis starts as a discolored area at the nail's corner and slowly spread toward the cuticle. In proximal subungal onychomycosis, the infection starts at the cuticle and spreads toward the nail tip. Yeast onychomycosis is caused by Candida and may be the most common cause of fungal fingernail.
Athlete's foot (tinea pedis) is a skin infection caused by the ringworm fungus. Symptoms include itching, burning, cracking, peeling, and bleeding feet. Treatment involves keeping the feet dry and clean, wearing shoes that can breathe, and using medicated powders to keep your feet dry.
Is Jock Itch (Tinea Cruris) Contagious?
Jock itch is a fungal infection in the groin area that causes a raised, itchy, red rash. Jock itch can typically be treated with antifungal medications. People may need to seek medical care for jock itch if the groin area becomes swollen, tender, if red streaks appear, or if the lymph nodes become swollen.
Treatment & Diagnosis
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.