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Does Xylocaine (lidocaine) cause side effects?
Xylocaine is used on the skin to stop itching and pain from certain skin conditions (e.g., scrapes, minor burns, eczema, insect bites) and to treat minor discomfort and itching caused by hemorrhoids and certain other problems of the genital/anal area (e.g., anal fissures, itching around the vagina/rectum).
Common side effects of Xylocaine include
- temporary redness,
- stinging, and
- swelling at the application site.
Serious but rare side effects of Xylocaine include
- other local anesthetics,
- antineoplastic agents,
- quinine, and
During pregnancy, Xylocaine should be used only when clearly needed. Discuss the risks and benefits with your doctor.
What are the important side effects of Xylocaine (lidocaine)?
Common side effects of lidocaine are:
- injection site pain,
- feeling lightheaded,
- low blood pressure,
- blurry or double vision, and
Other important side effects which may be serious include:
- abnormal heart beats,
- slow heart beat,
- heart block,
- severe allergic reactions,
- respiratory arrest, and
People allergic to anesthetics similar to lidocaine should not use lidocaine.
Xylocaine (lidocaine) side effects list for healthcare professionals
Adverse experiences following the administration of lidocaine are similar in nature to those observed with other amide local anesthetic agents. These adverse experiences are, in general, dose-related and may result from high plasma levels caused by excessive dosage or rapid absorption, or may result from a hypersensitivity, idiosyncrasy, or diminished tolerance on the part of the patient. Serious adverse experiences are generally systemic in nature. The following types are those most commonly reported:
There have been rare reports of endotracheal tube occlusion associated with the presence of dried jelly residue in the inner lumen of the tube.
Central Nervous System
CNS manifestations are excitatory and/or depressant and may be characterized by
- blurred or double vision,
- sensations of heat,
- cold or numbness,
- respiratory depression, and
The excitatory manifestations may be very brief or may not occur at all, in which case the first manifestation of toxicity may be drowsiness merging into unconsciousness and respiratory arrest.
Drowsiness following the administration of lidocaine is usually an early sign of a high blood level of the drug and may occur as a consequence of rapid absorption.
Allergic reactions are characterized by cutaneous lesions, urticaria, edema, or anaphylactoid reactions. Allergic reactions may occur as a result of sensitivity either to the local anesthetic agent or to other components in the formulation. Allergic reactions as a result of sensitivity to lidocaine are extremely rare and, if they occur, should be managed by conventional means. The detection of sensitivity by skin testing is of doubtful value.
What drugs interact with Xylocaine (lidocaine)?
Examples of Drugs Associated with Methemoglobinemia
|Nitrates/Nitrites||nitric oxide, nitroglycerin, nitroprusside, nitrous oxide|
|Local anesthetics||articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine, tetracaine|
|Antineoplastic Agents||cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase|
|Antibiotics||dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides|
|Anticonvulsants||Phenobarbital, phenytoin, sodium valproate,|
|Other drugs||acetaminophen, metoclopramide, quinine, sulfasalazine|
Xylocaine (lidocaine topical) is a local anesthetic that works by causing temporary numbness/loss of feeling in the skin and mucous membranes. Common side effects of Xylocaine include temporary redness, stinging, and swelling at the application site. During pregnancy, Xylocaine should be used only when clearly needed. It is unknown if Xylocaine passes into breast milk.
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Related Disease Conditions
Hemorrhoids (Internal and External)
Hemorrhoids (piles) are swollen veins in the rectum and anus. Causes include pregnancy, obesity, diarrhea, low-fiber diet, and prolonged sitting on the toilet. Treatment varies depending upon the severity of the hemorrhoids. Some treatment options include over-the-counter creams and suppositories, stool softeners, warm sitz baths, and hemorrhoidectomies.
Natural Home Remedies for Sunburn
There are many natural and home remedies that are thought to relieve the symptoms and signs of a sunburn. Check out our top 30 tips to cool that sunburn, for example, drink lots of water, juice, or sports drinks; apply a cool compress containing Burow's solution; coconut oil can be used as a moisturizer after sunburn pain has stopped; apply topical over-the-counter (OTC) 1% hydrocortisone cream; and take OTC pain relievers like NSAIDs (nonsteroidal anti-inflammatory drugs) such as ibuprofen (Advil, Motrin) or naproxen (Aleve).
Eczema refers to skin inflammation. There are many different types of eczema that produce symptoms and signs that range from oozing blisters to crusty plaques of skin. Treatment varies depending upon the type of eczema the person has.
Burns (First Aid)
Burn types are based on their severity: first-degree burns, second-degree burns, and third-degree burns. First-degree burns are similar to a painful sunburn. The damage is more severe with second-degree burns, leading to blistering and more intense pain. The skin turns white and loses sensation with third-degree burns. Burn treatment depends upon the burn location, total burn area, and intensity of the burn.
Recovery From Hemorrhoid Banding
Hemorrhoids and band will dry up and fall off within one to two weeks after the procedure. However, some bleeding will be seen with the stool passage for a few days.
Sunburn (Sun Poisoning)
Sunburn is caused by overexposure to UV radiation from the sun. UV rays can also damage the eyes. Repeated overexposure to UV rays also increases the risk for scarring, freckles, wrinkles, and dry skin. Symptoms of sunburn include painful, red, tender, and hot skin.The skin may blister, swell, and peel. Sun poisoning (severe sunburn) include nausea, fever, chills, rapid pulse, dizziness and more. Home remedies can help relieve sunburn pain, blisters, and peeling. Severe sunburns may need medical treatment. Sun protection and sunscreen for an person's skin type is recommended to decrease the chance of a severe sunburn and sun poisoning.
Is Eczema Contagious?
Eczema is a skin condition characterized by inflamed, rough skin patches that occasionally produce fluid-filled bumps that may ooze. There is no cure for eczema, though eczema may be treated with moisturization, eczema cream, and topical steroids.
Can You Pop a Hemorrhoid?
Hemorrhoids or piles are swollen, inflamed veins around the anus or lower part of the rectum (the terminal part of the large bowel). They often get better on their own within a few days, but some may need medications and even surgery to go away. You must not pop a hemorrhoid because doing so can lead to painful and serious complications. You must always consult your doctor for a definitive diagnosis and treatment.
What Is the Main Cause of Eczema?
The exact cause of eczema is unknown. It is caused due to an overactive immune system that responds aggressively when exposed to triggers.
Ringworm vs. Eczema
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How Bad Are Second-Degree Burns
Second-degree burns are a type of burns that are severe than the first-degree burns (minor burns that affect the superficial layer of the skin) but milder than the third-degree burns (that cause major loss of the skin). They affect the epidermis as well as the layer (dermis) that is deeper to the epidermis.
How Do Hemorrhoids Go Away?
Hemorrhoid symptoms may go away with diet and lifestyle modifications. You must, however, seek immediate medical care if your symptoms do not go away in a week or you experience symptoms.
Atopic Dermatitis vs. Eczema
Atopic dermatitis and eczema both refer to skin conditions. Atopic dermatitis is a cause of eczema, which refers to skin conditions that cause inflammation and irritation. The terms are sometimes used interchangeably. Eczema is not a condition in itself, but a description for a group of skin diseases that cause skin inflammation and irritation.
Can You Get Rid Of Eczema?
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Burn: First-Degree Burn
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Treatment & Diagnosis
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Medications & Supplements
- lidocaine viscous
- lidocaine injection (Xylocaine)
- lidocaine patch (Lidoderm)
- lidocaine spray - mucous membrane, Xylocaine
- lidocaine jelly - mucous membrane, Xylocaine
- lidocaine injection (Xylocaine)
- What Is Used as Topical Anesthetic?
- lidocaine solution - mucous membrane
- lidocaine and prilocaine (EMLA)
- lidocaine/prilocaine disc - topical, Emla
- lidocaine - topical, Lidamantle, Xylocaine
- lidocaine topical
- lidocaine transdermal
- Side Effects of EMLA (lidocaine and prilocaine)
- hydrocortisone/lidocaine - topical, Lida Mantle HC
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.