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Does Dexferrum (iron dextran) cause side effects?
Dexferrum (iron dextran) is an injectable form of iron used to treat iron-deficiency anemia, a condition in which the blood doesn't have enough healthy red blood cells because of a deficiency of available iron.
Dexferrum is only used to treat patients who cannot be adequately treated with oral iron supplements. Iron is an important mineral and is a necessary component of red blood cells and their ability to carry oxygen. Iron supplements replenish iron in the body and allow the transportation of oxygen.
Common side effects of Dexferrum include
- upset stomach,
- changes in taste, and
- pain and irritation or swelling where the injection was given.
Other side effects of Dexferrum include
- skin reactions,
- decreased white blood cell count,
- chest pain,
- high or low blood pressure,
- rapid or slow heartbeat,
- abnormal heart rhythms,
- joint pain,
- muscle pain,
- breathing problems, and
Serious side effects of Dexferrum include
- serious anaphylactic-type reactions, including death.
Large doses of Dexferrum may cause delayed reactions such as
- joint pain,
- moderate to high fever,
- feeling unwell (malaise),
- muscle pain,
- nausea, and
No clinically important drug-drug interactions between Dexferrum and other medications have been reported by the manufacturer.
What are the important side effects of Dexferrum (iron dextran)?
Common side effects include:
- Loose stools (diarrhea)
- Upset stomach
- Change in taste
- Pain and irritation or swelling where the injection was given
Other possible side effects include:
Dexferrum (iron dextran) side effects list for healthcare professionals
- Severe/Fatal: Anaphylactic reactions have been reported with the use of iron dextran injection; on occasions these reactions have been fatal. Such reactions, which occur most often within the first several minutes of administration, have been generally characterized by sudden onset of respiratory difficulty and/or cardiovascular collapse. Because fatal anaphylactic reactions have been reported after administration of iron dextran injection, the drug should be given only when resuscitation techniques and treatment of anaphylactic and anaphylactoid shock are readily available.
- Cardiovascular: Chest pain, chest tightness, shock, cardiac arrest, hypotension, hypertension, tachycardia, bradycardia, flushing, arrhythmias. (Flushing and hypotension may occur from too rapid injections by the intravenous route.)
- Dermatologic: Urticaria, pruritus, purpura, rash, cyanosis.
- Gastrointestinal: Abdominal pain, nausea, vomiting, diarrhea.
- Hematologic/lymphatic: Leucocytosis, lymphadenopathy.
- Musculoskeletal/soft tissue: Arthralgia, arthritis (may represent reactivation in patients with quiescent rheumatoid arthritis), myalgia; backache; sterile abscess; brown skin and/or underlying tissue discoloration (staining); cellulitis; swelling; inflammation; local phlebitis at or near intravenous injection site.
- Neurologic: Convulsions, seizures, syncope, headache, weakness, unresponsiveness, paresthesia, febrile episodes, chills, dizziness, disorientation, numbness, unconsciousness.
- Res piratory: Respiratory arrest, dyspnea, bronchospasm, wheezing.
- Urologic: Hematuria.
- Delayed reactions: Arthralgia, backache, chills, dizziness, fever, headache, malaise, myalgia, nausea, vomiting
- Miscellaneous: Febrile episodes, sweating, shivering, chills, malaise, altered taste.
What drugs interact with Dexferrum (iron dextran)?
Drug/Laboratory Test Interactions
- Large doses of iron dextran (5 mL or more) have been reported to give a brown color to serum from a blood sample drawn 4 hours after administration.
- The drug may cause falsely elevated values of serum bilirubin and falsely decreased values of serum calcium.
- Serum iron determinations (especially by colorimetric assays) may not be meaningful for 3 weeks following the administration of iron dextran.
- Serum ferritin peaks approximately 7 to 9 days after an intravenous dose of Dexferrum and slowly returns to baseline after about 3 weeks.
- Examination of the bone marrow for iron stores may not be meaningful for prolonged periods following iron dextran therapy because residual iron dextran may remain in the reticuloendothelial cells.
- Bone scans with 99m Tc-labeled bone seeking agents, in the presence of high serum ferritin levels or following iron dextran infusions, have been reported to show reduction of bony uptake, marked renal activity, and excessive blood pool and soft tissue accumulation.
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Dexferrum (iron dextran) is an injectable form of iron used to treat iron-deficiency anemia, a condition in which the blood doesn't have enough healthy red blood cells because of a deficiency of available iron. Common side effects of Dexferrum include diarrhea, headache, cramps, dizziness, upset stomach, changes in taste, and pain and irritation or swelling where the injection was given. There are no adequate and well-controlled studies of Dexferrum in pregnant women. Small amounts of Dexferrum are excreted into human milk.
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Related Disease Conditions
Anemia is the condition of having less than the normal number of red blood cells or less than the normal quantity of hemoglobin in the blood. The oxygen-carrying capacity of the blood is, therefore, decreased. There are several types of anemia such as iron deficiency anemia (the most common type), sickle cell anemia, vitamin B12 anemia, pernicious anemia, and aplastic anemia. Symptoms of anemia may include fatigue, malaise, hair loss, palpitations, menstruation, and medications. Treatment for anemia includes treating the underlying cause for the condition. Iron supplements, vitamin B12 injections, and certain medications may also be necessary.
Pernicious anemia is a blood disorder in which the body does not make enough red blood cells due to a lack of vitamin B12 in the blood. Pernicious anemia can develop from a lack of a protein that helps the body absorb vitamin B12, not getting enough B12 in the diet, and certain intestinal conditions that interfere with the absorption of vitamin B12 such as Crohn's disease, celiac sprue, or ulcerative colitis. There is no cure for pernicious anemia, thus treatment is life-long.
Sickle Cell Disease (Anemia)
Sickle cell anemia (sickle cell disease), a blood disease that shortens life expectancy, is caused by inherited abnormal hemoglobin. Symptoms of sickle cell anemia may include bacterial infections, painful swelling of the hands and feet, fever, leg ulcers, fatigue, anemia, eye damage, and lung and heart injury. Treatment for sickle cell anemia aims to manage and prevent the worst manifestations of the disease and focuses on therapies that block red blood cells from stacking together, which can lead to tissue and organ damage and pain.
How Do You Fix Anemia?
Anemia describes a condition in which you have a low red blood cell count and low hemoglobin levels. This is a serious condition as red blood cells and hemoglobin carry oxygen to all your cells, allowing them to burn energy. If you’re anemic, you’ll likely feel fatigued and short of breath, lacking physical stamina. You may have heart problems and appear pale. Anemia is often a symptom of some other disease or condition, so treatment varies widely depending on the root cause.
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Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.