Does Levaquin (levofloxacin) cause side effects?
Donnatal (belladonna/phenobarbital) is a combination of naturally occurring belladonna alkaloids and a barbiturate used to treat abdominal pain, bloating and cramps in patients with irritable bowel syndrome.
It is used occasionally as additional therapy in patients with duodenal ulcer. Belladonna alkaloids block the action of acetylcholine, a chemical that nerves to use to communicate with other nerves and muscles.
Acetylcholine stimulates the muscles of the intestines that propels digesting food through the intestine. It also affects the secretion of fluids by salivary glands and the stomach.
By blocking acetylcholine, belladonna alkaloids relax intestinal muscles, slow passage of digesting food through the intestines, and reduce gastric secretion. Phenobarbital produces sedation.
Common side effects of Donnatal include
- dry eyes,
- dry mouth,
- urinary hesitancy and retention (particularly in men),
- blurred vision,
- rapid heart rate,
- drowsiness, and
Serious side effects of Donnatal include
Patients with an unstable cardiac status, severe ulcerative colitis and acute intermittent porphyria should avoid Donnatal. Elderly patients may experience confusion, depression, and excitement even from small doses.
Drug interactions of Donnatal include voriconazole, bocepravir, ranolazine, and protease inhibitors, because phenobarbital reduces the blood levels of these drugs by increasing their breakdown in the body.
Donnatal should not be combined with potassium tablets because Donnatal slows the passage of potassium tablets through the gastrointestinal tract, leading to potassium-induced ulcers and high potassium levels in the blood.
What are the important side effects of Donnatal (belladonna/phenobarbital)?
Adverse reactions include:
- dry eyes;
- dry mouth;
- urinary hesitancy and retention (difficulty urinating, particularly in men);
- blurred vision;
- rapid heart rate;
- drowsiness; and
Patients with an unstable cardiac status, severe ulcerative colitis and acute intermittent porphyria should avoid belladonna/phenobarbital. Elderly patients may experience confusion, depression, and excitement even from small doses.
Donnatal (belladonna/phenobarbital) side effects list for healthcare professionals
Adverse reactions may include
- urinary hesitancy and retention;
- blurred vision;
- increased ocular tension;
- loss of taste sense;
- suppression of lactation;
- bloated feeling;
- musculoskeletal pain;
- severe allergic reaction or drug idiosyncrasies, including
- decreased sweating.
Elderly patients may react with symptoms of excitement, agitation, drowsiness, and other untoward manifestations to even small doses of the drug.
Donnatal (belladonna/phenobarbital) is a combination of naturally occurring belladonna alkaloids and a barbiturate used to treat abdominal pain, bloating and cramps in patients with irritable bowel syndrome. Common side effects of Donnatal include constipation, dry eyes, dry mouth, urinary hesitancy and retention (particularly in men), blurred vision, rapid heart rate, palpitations, headache, nervousness, drowsiness, and dizziness. Use of Donnatal during pregnancy has not been adequately evaluated. Donnatal is secreted in breast milk and may also reduce milk production.
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Medications & Supplements
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.