Does Cortenema (hydrocortisone enema) cause side effects?

Cortenema (hydrocortisone enema) is a corticosteroid used rectally for the treatment of ulcerative proctitis, inflamed hemorrhoids, and anal itching, burning, and inflammation caused by several conditions that affect the anal area.

Common side effects of Cortenema include

Serious side effects of Cortenema include

The risk of drug interactions from Cortenema is low because it is administered rectally. 

Cortenema has not been adequately evaluated during pregnancy

Hydrocortisone taken orally can appear in breast milk, and can have adverse effects on the baby. It is unknown if Cortenema administered rectally is absorbed in sufficient amounts to appear in breast milk. Consult your doctor before breastfeeding.

What are the important side effects of Cortenema (hydrocortisone enema)?

Side effects of hydrocortisone enema include:

Other side effects include:

Possible serious side effects include:

Cortenema (hydrocortisone enema) side effects list for healthcare professionals

Local pain or burning, and rectal bleeding attributed to Cortenema have been reported rarely. Apparent exacerbations or sensitivity reactions also occur rarely. The following adverse reactions should be kept in mind whenever corticosteroids are given by rectal administration.

Fluid and Electrolyte Disturbances




  • Impaired wound healing;
  • thin fragile skin;
  • petechiae and ecchymoses;
  • facial erythema;
  • increased sweating;
  • may suppress reactions to skin tests.





What drugs interact with Cortenema (hydrocortisone enema)?

No information provided.

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Medically Reviewed on 12/31/2020
FDA Prescribing Information

Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.