- Osteoarthritis Overview Slideshow Pictures
- Osteoarthritis Quiz: Test Your Medical IQ
- Exercises for OA of the Knee Slideshow
Does Side Effects of Hyalgan (hyaluronic acid) cause side effects?
Hyalgan (hyaluronic acid) is a natural chemical found in almost all species of animals and in various parts of the human body that works as a biological lubricant, reducing friction between adjacent tissues.
It is present in high amounts in joints and synovial fluid (the fluid that fills the knee joint). Hyalgan is used to treat pain due to osteoarthritis of the knee in patients who do not get adequate relief from simple pain medicines or from exercise and physical therapy.
It is administered by injection directly into the knee joint (intra-articular injection). The exact mechanism by which Hyalgan works is not known. The synovial fluid in the knees helps lubricate and cushion our joints during movement. Sodium hyaluronate is the major component in the synovial fluid.
People with osteoarthritis do not have enough hyaluronic acid in their synovial fluid. It is thought that Hyalgan injection helps restore synovial fluid, thereby reducing some of the pain and discomfort associated with osteoarthritis.
Common side effects of Hyalgan include
- pain at the injection site,
- swelling of the knee,
- upset stomach, and
Other side effects of Hyalgan include
No clinically significant drug-drug interactions between Hyalgan injection and other medications have been reported.
Hyalgan (hyaluronic acid) side effects list for healthcare professionals
- Hyalgan was investigated in a pivotal clinical investigation conducted in the United States in which there were three arms (164 subjects treated with Hyalgan; 168 with placebo; and 163 with naproxen) (refer to Table 1).
- Common adverse events reported for the Hyalgan-treated subjects were
- Swelling and effusion, local skin reactions (ecchymosis and rash), and headache occurred at equal frequency in the Hyalgan- and placebo-treated groups. Hyalgan treated subjects had 48/164 (29%) incidents of gastrointestinal complaints that were not statistically different from the placebo-treated group.
- A statistically significant difference in the occurrence of pain at the injection site was noted in the Hyalgan-treated subjects: 38/164 (23%) in comparison to 22/168 (13%) in the placebo-treated subjects (p = 0.022).
- There were 6/164 (4%) premature discontinuations in Hyalgan-treated subjects due to injection site pain in comparison to 1/168 ( < 1%) in the placebo-treated subjects.
- These differences were not statistically significant. Two (2/164, 1.2%) Hyalgan-treated subjects and 3/168 (1.8%) placebo-treated subjects were reported to have positive bacterial cultures of effusion aspirated from the treated knee.
- The two Hyalgan-treated subjects and two of the placebo-treated subjects did not exhibit evidence of infection clinically or subsequently and were not treated with antibiotics. One of the placebo-treated subjects was hospitalized and received presumptive treatment for septic arthritis.
- Hyalgan has been
in clinical use in Europe since 1987. Analysis of the adverse events that have
been reported with the use of Hyalgan in
Europe reveals that most of the events are related to local symptoms such as
- swelling/effusion, and
- warmth or redness at the injection site.
- Usually such symptoms disappear within a few days by resting the affected joint and applying ice locally.
- Only sporadically have these events been more severe and longer lasting.
- Very rare cases of intra-articular infection have been reported.
- Strict aseptic technique must be followed in administering Hyalgan.
- Systemic allergic reactions rarely have been recorded.
- Isolated cases of an anaphylactic or anaphylactic-like reaction have been reported in post-marketing experience and they all resolved.
- Allergic-type signs and symptoms such as rash, pruritus, and urticaria also are very rare.
- A few cases of fever were reported. In some instances, they were associated with local reactions, in other cases, no association other than temporal was found with the use of the product.
- Adverse experience data from the literature contain no evidence of increased risk relating to retreatment with Hyalgan.
- The frequency and severity of adverse events occurring during repeat treatment cycles did not increase over that reported for a single treatment cycle.
Multimedia: Slideshows, Images & Quizzes
Osteoarthritis (OA): Treatment, Symptoms, Diagnosis
Osteoarthritis (OA) is a degenerative joint disease most often affecting major joints such as knees, hands, back, or hips....
Exercises for Knee Osteoarthritis and Joint Pain
Learn about osteoarthritis and exercises that relieve knee osteoarthritis pain, stiffness and strengthen the knee joint and...
Osteoarthritis Quiz: Test Your Medical IQ
How does osteoarthritis differ from other types of arthritis? Learn about osteoarthritis with this quiz.
Osteoarthritis: 15 Tips to Improve Daily Living With OA
Osteoarthritis joint pain can make it hard to carry out activities of daily living. Cartilage destruction can cause symptoms like...
Picture of Osteoarthritis
Osteoarthritis is a type of arthritis that is caused by the breakdown and eventual loss of the cartilage of one or more...
Tips for Healthy Joints: Exercise, Nutrition, & More in Pictures
Dealing with joint pain and arthritis? Learn why weight matters--and why NOT to stretch before exercise. See these solutions for...
Fun With Kids? Don't Let Arthritis Stop You
You can still have lots of fun with children despite arthritis. Our experts uncover ways to spend time with your kids or...
Exercises for Osteoarthritis -- Yoga, Swimming, & More
Check out this slideshow on Active Living From Day to Night with Osteoarthritis. Even with arthritis you can keep your active...
Related Disease Conditions
Osteoarthritis is a type of arthritis caused by inflammation, breakdown, and eventual loss of cartilage in the joints. Also known as degenerative arthritis, osteoarthritis can be caused by aging, heredity, and injury from trauma or disease.
Second Source article from Government
Osteoarthritis vs. Osteoporosis Differences and Similarities
Arthritis is defined as painful inflammation and joint stiffness. Osteoarthritis is a type of arthritis and the most common cause of chronic joint pain, affecting over 25 million Americans. Osteoarthritis is a type of arthritis that involves the entire joint. Osteoporosis is not a type of arthritis. It is a disease that mainly is caused by a loss of bone tissue that is not limited to the joint areas. It is possible for one person to have both osteoarthritis and osteoporosis. The differences in the signs and symptoms of osteoarthritis and osteoporosis include; pain, stiffness, and joint swelling, joint deformity, crackle sounds when the joint is moving, and walking with a limp. Osteoporosis is called the "silent disease" because it can progress for years without signs and symptoms before it is diagnosed, severe back pain, bone fractures, height loss, and difficulty or inability to walk. The differences in the causes of osteoarthritis and osteoporosis are that osteoarthritis usually is caused by wear and tear on the joints. Osteoporosis usually is caused by one or more underlying problems, for example, calcium and vitamin D deficiencies. Treatment for osteoarthritis and osteoporosis are not the same. There is no cure for osteoarthritis or osteoporosis.
Arthritis in Knee: 4 Stages of Osteoarthritis
Painful joint swelling is called arthritis. Osteoarthritis is due to wear and tear of the joints over many years. Arthritis maye develop in any joint, including the fingers, hips and knees. Usually, patients with arthritis feel pain in their joints even after moderate movements. There are four stages of osteoarthritis of the knee.
Osteoarthritis vs. Rheumatoid Arthritis
Osteoarthritis (OA) and rheumatoid arthritis (RA) are chronic joint disorders. RA is also an autoimmune disease. OA and RA symptoms and signs include joint pain, warmth, and tenderness. Over-the-counter pain relievers treat both diseases. There are several prescription medications that treat RA.
What Is the Main Cause of Osteoarthritis?
Osteoarthritis (OA) is a chronic degenerative disease of the joints affecting middle-aged and elderly people. It involves the breakdown of cartilage and associated inflammatory changes in the adjacent bone. It is a leading cause of chronic disability, affecting 30 million people in the United States alone.
Osteoarthritis and Treatment
Painful swelling of the joints due to wear and tear over many years is called osteoarthritis. Osteoarthritis may develop in any joint that includes the fingers, hips, and knees. There are many treatment options available to curb the complications of arthritis.
Treatment & Diagnosis
- Osteoarthritis FAQs
- Rheumatoid Arthritis vs. Osteoarthritis
- Osteoarthritis - Vitamin D May Prevent Progression
- Are Women More Susceptible to Osteoarthritis?
- Can You Get a Cartilage Transplant?
- What Is Cervical Osteoarthritis?
- What Is the Prognosis for Osteoarthritis?
- What Kind of Joint Injections Treat Osteoarthritis?
- What Are the Side Effects of Glucosamine?
- What Causes Arthritis and Baker's Cyst?
- Can You Be Too Young for a Knee Replacement?
- What Causes Early Onset of Hip Osteoarthritis?
- Osteoarthritis of the Hands
- Osteoarthritis vs. Carpal Tunnel: What's the Difference?
- Can You Prevent Osteoarthritis?
- Osteoarthritis Symptoms
- Osteoarthritis and Weight Loss Audio Podcast
Medications & Supplements
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.