Does Lopid (gemfibrozil) cause side effects?
Because Lopid raises HDL and decreases triglycerides it is prescribed to prevent coronary heart disease in individuals without a history or symptoms of coronary heart disease who have low HDL, high LDL and high triglycerides. Lopid is prescribed after other therapies have failed, and it is not intended for treating patients who only have low HDL. Lopid is used together with diet and exercise.
Common side effects of Lopid include
Serious side effects of Lopid include
- muscle aches and pain,
- kidney damage,
- formation of gallstones and need for gallbladder surgery,
- abnormal blood liver tests,
- low red blood cells (anemia),
- low white blood cells (leukopenia), and
- low blood platelets (thrombocytopenia).
Drug interactions of Lopid include statins such as the following because these increase the risk of rhabdomyolysis (muscle injury) that when severe can lead to kidney damage and even death. Rhabdomyolysis may occur as early as three weeks or several months after starting combination therapy.
Lopid can increase the effect of the blood thinner, warfarin, and may lead to bleeding.
Colestipol and cholestyramine reduce the absorption of Lopid and reduce its effectiveness if taken at the same time. Lopid should be administered one hour before or 4-6 hours after administering colestipol or cholestyramine.
The effect of Lopid in pregnant women has not been well-studied. Lopid should be used during pregnancy only if the potential benefit justifies the unknown but potential risk to the fetus. It is unknown if Lopid is excreted in human milk. Consult your doctor before breastfeeding.
What are the important side effects of Lopid (gemfibrozil)?
Common side effects of gemfibrozil include:
Muscle aches and pain also occur. Rarely, these muscle-related symptoms are associated with damage to muscles that releases chemicals into the blood that that can damage the kidney. Muscle damage is of greatest concern when gemfibrozil is combined with statins.
The formation of gallstones and gallbladder surgery have been associated with the use of gemfibrozil. Pancreatitis, abnormal blood liver tests, as well as reduced red blood cells (anemia), white blood cells (leukopenia) and blood platelets (thrombocytopenia) also have been reported.
Lopid (gemfibrozil) side effects list for healthcare professionals
In the double-blind controlled phase of the primary prevention component of the Helsinki Heart Study, 2046 patients received Lopid for up to five years. In that study, the following adverse reactions were statistically more frequent in subjects in the Lopid group:
(N = 2046)
(N = 2035)
|Frequency in percent of subjects|
|Acute appendicitis (histologically confirmed in most cases where data were available)||1.2||0.6|
|Adverse events reported by more than 1% of subjects, but without a significant difference between groups:|
Gallbladder surgery was performed in 0.9% of Lopid and 0.5% of placebo subjects in the primary prevention component, a 64% excess, which is not statistically different from the excess of gallbladder surgery observed in the clofibrate group compared to the placebo group of the WHO study.
- Gallbladder surgery was also performed more frequently in the Lopid group compared to the placebo group (1.9% versus 0.3%, p=0.07) in the secondary prevention component.
- A statistically significant increase in appendectomy in the gemfibrozil group was seen also in the secondary prevention component (6 on gemfibrozil versus 0 on placebo, p=0.014).
- Nervous system and special senses adverse reactions were more common in the Lopid group.
- These included hypesthesia, paresthesias, and taste perversion.
- Other adverse reactions that were more common among Lopid treatment group subjects but where a causal relationship was not established include
From other studies it seems probable that Lopid is causally related to the occurrence of musculoskeletal symptoms, and to abnormal liver function tests and hematologic changes.
Reports of viral and bacterial infections (common cold, cough, urinary tract infections) were more common in gemfibrozil treated patients in other controlled clinical trials of 805 patients. Additional adverse reactions that have been reported for gemfibrozil are listed below by system. These are categorized according to whether a causal relationship to treatment with Lopid is probable or not established:
|CAUSAL RELATIONSHIP PROBABLE||CAUSAL RELATIONSHIP NOT ESTABLISHED|
|Gastrointestinal:||cholestatic jaundice||hepatoma colitis|
|System:||dizziness somnolence paresthesia peripheral neuritis decreased libido depression headache||confusion convulsions syncope|
|Eye:||blurred vision||retinal edema decreased male fertility|
|Musculoskeletal:||myopathy myasthenia myalgia painful extremities arthralgia s yno vitis rhabdomyolysis|
|Clinical||increased creatine phosphokinase increased bilirubin|
|Laboratory:||increased liver transaminases (AST, ALT) increased alkaline phosphatase anemia||positive antinuclear antibody|
|Hematopoietic:||leukopenia bone marrow hypoplasia eosinophilia angioedema||thrombocytopenia anaphylaxis|
|Immunologic:||laryngeal edema urticaria exfoliative dermatitis||Lupus-like syndrome vasculitis|
|Integumentary:||rash dermatitis pruritus||alopecia photosensitivity|
Lopid (gemfibrozil) is a blood lipid and cholesterol-altering medicine used to reduce elevated triglyceride levels that are high enough to cause pancreatitis. Common side effects of Lopid include upset stomach, stomach pain, diarrhea, headache, tiredness, nausea, and vomiting. Lopid should be used during pregnancy only if the potential benefit justifies the unknown but potential risk to the fetus. It is unknown if Lopid is excreted in human milk.
Multimedia: Slideshows, Images & Quizzes
Pancreatitis Quiz: Test Your Medical IQ
What does the pancreas do, and what happens in the body that causes pancreatitis? Test your medical IQ of pancreatitis with this...
High Cholesterol (Hyperlipidemia) Quiz: Test Your Medical IQ
High cholesterol can be a dangerous condition. Take the Cholesterol Quiz to understand what high cholesterol means in terms of...
Picture of Cholesterol
Cholesterol carried in particles of low density (LDL cholesterol) is referred to as the "bad" cholesterol because elevated levels...
How to Lower Your Cholesterol & Save Your Heart
Need to lower your cholesterol levels? Use these smart diet tips to quickly and easily lower your blood cholesterol levels....
Cholesterol Drugs: What to Expect With Heart Medication
When diet and exercise aren't enough, should you turn to drugs? Learn cholesterol basics, drug classes, and available drugs along...
Cholesterol Levels: What the Numbers Mean
Do you know the different cholesterol levels and what they mean? Learn the alphabet soup of cholesterol testing: LDL, HDL, good,...
Cholesterol: High Triglyceride Foods to Avoid
High triglycerides increase the risk of heart disease. Lower triglyceride levels and reduce cholesterol by eating foods that...
Related Disease Conditions
High Blood Cholesterol
Second Source article from Government
Cholesterol (Lowering Your Cholesterol)
High cholesterol and triglyceride levels increase the risk of cardiovascular disease. Getting your cholesterol and triglyceride levels in an optimal range will help protect your heart and blood vessels. Cholesterol management may include lifestyle interventions (diet and exercise) as well as medications to get your total cholesterol, LDL, HDL, and triglycerides in an optimal range.
Acute and Chronic Pancreatitis
Pancreatitis is a rare disease in which the pancreas becomes inflamed. There are two types of pancreatitis: acute and chronic. Symptoms of pancreatitis include abdominal pain, fever, nausea, vomiting, and a rapid pulse. Treatment of pancreatitis often requires hospitalization.
High Cholesterol: Frequently Asked Questions
Cholesterol occurs naturally in the body. High blood cholesterol levels increase a person's risk of developing heart disease, heart attacks, strokes, TIAs, and more. In addition to medication (fibrates, statins, bile acid sequestrants, and niacin), lifestyle changes can be made to lower blood cholesterol levels
Lower Cholesterol Levels with Diet and Medications
Cholesterol is naturally produced by the body, and is a building block for cell membranes and hormones. Low-density lipoprotein (LDL) cholesterol is the "bad" cholesterol, and high-density lipoprotein (HDL) cholesterol is the "good" cholesterol. High levels of LDL and low levels of HDL cholesterol put a person at risk for heart attack, stroke, transient ischemic attack (TIA or mini stroke), and peripheral artery disease. High cholesterol can be lowered by eating foods that lower cholesterol, for example, eat more high soluble fiber foods (oatmeal, oat bran, vegetables, and certain fruits), use olive oil, eat foods fortified with plant sterols and stanols, soy, nuts, and omega-3 fatty acids. Foods that raise LDL or bad cholesterol include foods high in saturated and trans fats, fatty meats, limit egg yolks, limit milk products, limit crackers, muffins, and snacks, and avoid unhealthy fast foods that are high in fat and sugar High cholesterol treatment includes lifestyle changes (diet and exercise), and medications such as statins, bile acid resins, and fibric acid derivatives.
HDL vs. LDL Cholesterol (Good and Bad)
HDL (high-density lipoprotein), or the "good" cholesterol, and LDL (low-density lipoprotein), or the "bad" cholesterol, are lipoproteins that carry cholesterol through the veins and arteries of the body. HDL and LDL combined, is your "total" blood cholesterol. The difference between the two are that high levels of the "good," or HDL cholesterol, may protect against narrowing of the blood vessels in the body, which protects you against heart attack, stroke, and other cardiovascular diseases. But high levels of LDL, or the "bad" cholesterol, may worsen the narrowing of the blood vessels in the body, which puts you at a greater risk of stroke, heart attack, and cardiovascular diseases, some of which are life threatening.Triglycerides are found in body fat and from the fats you eat.
Cholesterol Levels: What You Need to Know?
Managing your cholesterol levels can help to keep you healthy as you age.
What Are the Causes of High Cholesterol?
Your body naturally produces all the LDL (bad) cholesterol it needs. An unhealthy lifestyle – not enough exercise, too many unhealthy foods – makes your body produce more LDL cholesterol than it needs. This is the cause of high LDL cholesterol for most people.
Pancreatitis: Symptoms, Treatments, and Tests
Pancreatitis is a condition in which the pancreas develop swelling due to the destruction of the pancreatic tissue by its own enzymes. Digestive enzymes travel from the pancreas to the small intestine through the pancreatic duct.
Is Pancreatitis Life Threatening?
Yes, pancreatitis is a life threatening condition if left untreated. Severe recurrent pancreatitis may cause blood and fluid loss causing life threatening conditions such as multi organ failure. The range of disease is from self-limiting to fatal, with an incidence and mortality rate that increases with age.
What Are the Normal Cholesterol Levels According to Age?
Cholesterol is a waxy substance found in all the cells of the body. It is a type of fat that is produced by the liver. Cholesterol also comes from animal-derived foods, such as meat and dairy products.
What Are the Normal Cholesterol Levels By Age
Cholesterol is a waxy substance found in all the cells of the body. It is a type of fat that is produced by the liver. Cholesterol also comes from animal-derived foods, such as meat and dairy products. It is an essential substance needed by the body for various purposes. Too much cholesterol, however, harms the body and increases the risk of various medical conditions, such as high blood pressure and heart diseases.
Treatment & Diagnosis
- High Cholesterol (Hyperlipidemia) FAQs
- Pancreatitis FAQs
- Statins - - Doing More Than Lowering Your Cholesterol?
- Cholesterol: Questions To Ask Your Doctor
- Cholesterol: The Truth About Cholesterol
- Cholesterol: HDL cholesterol ratio
- Cholesterol - Mr. D.T.'s Story of Hope
- Cholesterol Guidelines for Adults (2001)
- Ashcroft Surgery for Gallstone Pancreatitis
- Cholesterol Guidelines
- Heart Attack Prevention From a Doctor's Perspective
- What Is an ERCP Procedure For Pancreatitis?
- How Serious Is Pancreatitis?
- What Should Cholesterol Levels Be After Heart Attack?
- Can MRI Find Pancreatic Duct Stones?
- Can Menopause Cause High Cholesterol?
- What are Cholesterol-Lowering Statins?
- Do Bile Acid Resins Lower Cholesterol?
- Can Fibrate Drugs Lower Cholesterol?
- How Do I Lower My Cholesterol (Triglycerides)
- Does Hypothyroidism Cause High Cholesterol?
- Does Exercise Lower Cholesterol?
- What Foods Lower Cholesterol?
- Does Stress Cause High Cholesterol?
- Cholesterol Treatment
- Cholesterol, The Basics Of Prevention
Medications & Supplements
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.