- Rheumatoid Arthritis Slideshow Pictures
- Take the RA Quiz
- Joint-Friendly Exercises to Reduce RA Pain Slideshow
Does Ansaid (flurbiprofen) cause side effects?
Ansaid (flurbiprofen) is a nonsteroidal anti-inflammatory drug (NSAID) effective in treating fever, and inflammation and pain caused by rheumatoid arthritis or osteoarthritis, as well as soft tissue injuries, such as tendinitis and bursitis.
As a group, NSAIDs are non-narcotic relievers of mild to moderate pain of many causes, including injury, menstrual cramps, arthritis, and other musculoskeletal conditions. They work by reducing the levels of prostaglandins, chemicals that are responsible for pain, fever, and inflammation.
Ansaid blocks the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower concentrations of prostaglandins. As a consequence, inflammation, pain and fever are reduced. The brand name Ansaid has been discontinued; generic versions are available.
Common side effects of Ansaid include
- stomach ulcerations,
- abdominal burning,
- water retention,
- sensitivity to sunlight,
- nausea, and
Serious side effects of Ansaid include
- serious gastrointestinal bleeding,
- liver toxicity,
- ringing in the ears,
- rare but severe allergic reactions,
- aggravation of peptic ulcer disease or poor kidney function,
- heart attack,
- accumulation of fluid,
- worsening heart failure, and
- causing or worsening high blood pressure (hypertension) and kidney failure.
- Patients taking lithium can develop toxic blood levels of lithium because Ansaid may inhibit the elimination of lithium from the body by the kidney.
- Side effects from methotrexate and cyclosporine also may be increased by Ansaid.
- Ansaid may reduce the effectiveness of medications that are used to treat high blood pressure because it causes or worsens high blood pressure.
- NSAIDs may diminish the blood pressure-lowering effects of angiotensin converting enzyme (ACE) inhibitors.
- Combining NSAIDs with angiotensin receptor blockers (for example, valsartan, losartan, irbesartan) or angiotensin converting enzyme inhibitors (for example, enalapril, captopril) in patients who are elderly, volume-depleted (including those on diuretic therapy), or with poor kidney function may result in reduced kidney function, including kidney failure.
- Persons who have more than three alcoholic beverages per day are at increased risk of developing stomach ulcers when taking Ansaid or other NSAIDs.
What are the important side effects of Ansaid (flurbiprofen)?
Most patients benefit from flurbiprofen and other NSAIDs with few side effects. However, serious side effects can occur, and generally tend to be dose related. Therefore, it is often desirable to use the lowest effective dose to minimize side effects. The most common side effects of flurbiprofen involve the gastrointestinal system. These are:
- Abdominal burning
- Water retention
- Sensitivity to sunlight
- Serious gastrointestinal bleeding
- Liver toxicity
Other important side effects include:
Flurbiprofen should be avoided by patients with a history of asthma attacks, hives, or other allergic reactions to aspirin or other NSAIDs. Rare but severe allergic reactions have been reported in such individuals.
It also should be avoided by patients with peptic ulcer disease or poor kidney function, since this medication can aggravate both conditions.
Ansaid (flurbiprofen) side effects list for healthcare professionals
TABLE 2: Reported adverse events in patients receiving ANSAID (flurbiprofen)
or other nonsteroidal anti-inflammatory drugs
|Reported in patients treated with ANSAID||Reported in patients treated with other products but not ANSAID|
|Incidence of 1% or greater †||Incidence < 1% - Causal Relationship Probable ‡||Incidence < 1% - Causal Relationship Unknown ‡|
|BODY AS A WHOLE
| < 1%:
|CARDIOVASCULAR SYSTEM||congestive heart failure
| < 1%:
elevated liver enzymes
jaundice (cholestatic and
inflammation with loss of
blood and protein
| > 1%:
|HEMIC AND LYMPHATIC SYSTEM||aplastic anemia
decrease in hemoglobin
iron deficiency anemia
|lymphadenopathy|| > 1%:
increased bleeding time
|METABOLIC AND NUTRITIONAL SYSTEM
body weight changes
|hyperuricemia||hyperkalemia|| < 1%:
nervousness and other manifestations of entral nervous system (CNS) stimulation (eg, anxiety, insomnia, increased reflexes, tremor)
symptoms associated with CNS inhibition (eg, amnesia, asthenia, depression,
| < 1%:
| < 1%:
|SKIN AND APPENDAGES
| < 1%:
changes in vision
|changes in taste
transient hearing loss
| > 1%:
signs and symptoms
suggesting urinary tract infection
vaginal and uterine
| > 1%:
abnormal renal function
|† from clinical trials
‡ from clinical trials, post-marketing surveillance, or literature
What drugs interact with Ansaid (flurbiprofen)?
- Reports suggest that nonsteroidal anti-inflammatory drugs may diminish the antihypertensive effect of ACE-inhibitors.
- This interaction should be given consideration in patients taking nonsteroidal antiinflammatory drugs concomitantly with ACE-inhibitors.
- The effects of warfarin and NSAIDs on GI bleeding are synergistic, such that users of both drugs together have a risk of serious GI bleeding higher than users of either drug alone.
- The physician should be cautious when administering ANSAID (flurbiprofen) to patients taking warfarin or other anticoagulants.
- Concurrent administration of aspirin lowers serum flurbiprofen concentrations.
- The clinical significance of this interaction is not known; however, as with other NSAIDs, concomitant administration of flurbiprofen and aspirin is not generally recommended because of the potential for increased adverse effects.
Beta-adrenergic blocking agents
- Flurbiprofen attenuated the hypotensive effect of propranolol but not atenolol.
- The mechanism underlying this interference is unknown.
- Patients taking both flurbiprofen and a beta-blocker should be monitored to ensure that a satisfactory hypotensive effect is achieved.
- Clinical studies, as well as post marketing observations, have shown that ANSAID (flurbiprofen) can reduce the natriuretic effect of furosemide and thiazides in some patients.
- This response has been attributed to inhibition of renal prostaglandin synthesis.
- During concomitant therapy with NSAIDs, the patient should be observed closely for signs of renal failure, as well as diuretic efficacy.
- NSAIDs have produced an elevation of plasma lithium levels and a reduction in renal lithium clearance.
- The mean minimum lithium concentration increased 15% and the renal clearance was decreased by approximately 20%.
- These effects have been attributed to inhibition of renal prostaglandin synthesis by the nonsteroidal anti-inflammatory drug.
- Thus, when nonsteroidal anti-inflammatory drugs and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity.
- Nonsteroidal anti-inflammatory drugs have been reported to competitively inhibit methotrexate accumulation in rabbit kidney slices.
- This may indicate that they could enhance the toxicity of methotrexate.
- Caution should be used when nonsteroidal anti-inflammatory drugs are administered concomitantly with methotrexate.
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Related Disease Conditions
Buildup of uric acid crystals in a joint causes gouty arthritis. Symptoms and signs include joint pain, swelling, heat, and redness, typically of a single joint. Gout may be treated with diet and lifestyle changes, as well as medication.
Which Foods Make Arthritis Worse?
Certain foods can contribute to arthritis joint inflammation, like processed foods high in salt, alcohol, red meat and others. Foods that are good for the joints are beans, greens and other whole foods that have high fiber and nutrient content and low calories; these foods promote weight loss, which improves arthritis symptoms, and some may lower inflammation, generally.
Rheumatoid Arthritis (RA)
Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints, the tissue around the joints, as well as other organs in the body. Because it can affect multiple other organs of the body, rheumatoid arthritis is referred to as a systemic illness and is sometimes called rheumatoid disease. The 16 characteristic early RA signs and symptoms include the following. Anemia Both sides of the body affected (symmetric) Depression Fatigue Fever Joint deformity Joint pain Joint redness Joint stiffness Joint swelling Joint tenderness Joint warmth Limping Loss of joint function Loss of joint range of motion Many joints affected (polyarthritis)
16 Early Rheumatoid Arthritis (RA) Symptoms and Signs
Early RA symptoms and signs vary differently from person to person. The most common body parts that are initially affected by RA include the small joints of the hands, wrists, and feet, and the knees and hip joints. Joint inflammation causes stiffness. Warmth, redness, and pain may vary in degree.
Arthritis (Joint Inflammation)
Arthritis is inflammation of one or more joints. When joints are inflamed they can develop stiffness, warmth, swelling, redness and pain. There are over 100 types of arthritis, including osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, lupus, gout, and pseudogout.
Osteoarthritis is a type of arthritis caused by inflammation, breakdown, and eventual loss of cartilage in the joints. Also known as degenerative arthritis, osteoarthritis can be caused by aging, heredity, and injury from trauma or disease.
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Arthritis in Knee: 4 Stages of Osteoarthritis
Painful joint swelling is called arthritis. Osteoarthritis is due to wear and tear of the joints over many years. Arthritis maye develop in any joint, including the fingers, hips and knees. Usually, patients with arthritis feel pain in their joints even after moderate movements. There are four stages of osteoarthritis of the knee.
Can Rheumatoid Arthritis Be Caused by Stress?
Rheumatoid arthritis is a chronic inflammatory joint condition and an autoimmune disease. At times, treatment can make rheumatoid arthritis symptoms (pain and swelling) disappear for a while. This symptom-free period is referred to as “remission.” A remission is followed by the reappearance of symptoms and this period is known as a flare-up. Research says that rheumatoid arthritis can be caused by stress.
Rheumatoid Arthritis vs. Arthritis
Arthritis is a general term used to describe joint disease. Rheumatoid arthritis (RA) is a type of arthritis in which the body’s immune system mistakenly attacks the joints, causing chronic inflammation.
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Juvenile Rheumatoid Arthritis (JRA)
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What Are the Four Stages of Rheumatoid Arthritis?
Rheumatoid arthritis is a chronic inflammatory disease characterized by pain and inflammation in joints, typically of the hands and feet. It is an autoimmune disease in which the immune system of the body attacks its own healthy cells, resulting in inflammation of the membrane lining the joints and damage to joint tissue.
Non-Radiographic Axial Spondyloarthritis (nr-axSpA)
Non-radiographic spondyloarthritis (nr-axSpA) is an inflammatory arthritis that mainly affects the joints of the spine. Morning stiffness and back pain are the usual symptoms of nr-axSpA. Nonsteroidal anti-inflammatory drugs, exercise, and biologics are treatments for nr-axSpA.
Breastfeeding With Rheumatoid Arthritis
You can breastfeed your baby even if you have rheumatoid arthritis (RA). However, you must always consult your doctor before you start the process.
Safest Rheumatoid Arthritis Drugs During Pregnancy
None of the drugs used in the treatment of rheumatoid arthritis (RA) is completely safe during pregnancy. You must discuss with your physician regarding the decision to use, modify, or stop any medications.
Osteoarthritis vs. Rheumatoid Arthritis
Osteoarthritis (OA) and rheumatoid arthritis (RA) are chronic joint disorders. RA is also an autoimmune disease. OA and RA symptoms and signs include joint pain, warmth, and tenderness. Over-the-counter pain relievers treat both diseases. There are several prescription medications that treat RA.
Can Rheumatoid Arthritis Affect Pregnancy?
Yes, rheumatoid arthritis (RA) affects pregnancy. RA can lead to complications like preterm birth, raised blood pressure (preeclampsia), and low birth weight babies.
Do Steroids Help With Arthritis?
Arthritis is the inflammation of one or more joints in the body. The disease is one of the most common chronic health conditions in the United States. Steroids are a class of drugs that reduce inflammation and have a suppressing effect on the immune system.
What Is the Main Cause of Osteoarthritis?
Osteoarthritis (OA) is a chronic degenerative disease of the joints affecting middle-aged and elderly people. It involves the breakdown of cartilage and associated inflammatory changes in the adjacent bone. It is a leading cause of chronic disability, affecting 30 million people in the United States alone.
Causes of Rheumatoid Arthritis
Rheumatoid arthritis (RA) is an autoimmune disorder (the body’s immune system mistakenly attacks its own cells). Certain factors increase the risk of RA.
Osteoarthritis and Treatment
Painful swelling of the joints due to wear and tear over many years is called osteoarthritis. Osteoarthritis may develop in any joint that includes the fingers, hips, and knees. There are many treatment options available to curb the complications of arthritis.
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Medications & Supplements
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.