Does Auvi-Q (epinephrine) cause side effects?
Auvi-Q is an auto-injector that talks the user step by step through the injection process. Epinephrine, the medicine contained in Auvi-Q, is an excitatory chemical naturally made by our bodies. Epinephrine stimulates alpha- and beta-adrenergic receptors found throughout the body.
When injected during an allergic reaction, epinephrine works in multiple ways to treat the many signs of anaphylaxis. It causes blood vessels to constrict or tighten which helps to increase blood pressure and decrease swelling.
Epinephrine also stimulates the heart muscle, causing the heart to beat faster and pump more blood to the vital organs. Epinephrine helps patients breathe better by relaxing the muscles in the lungs and allowing the airways to open up. Additionally, it also helps to prevent further release of inflammatory chemicals that were triggered by the initial allergic reaction.
Common side effects of Auvi-Q include
- fast/irregular/pounding heartbeat,
- vomiting, and
- breathing problems.
Serious side effects of Auvi-Q include
- arrhythmias, including fatal ventricular fibrillation.
Drug interactions of Auvi-Q include cardiac glycosides, diuretics (water pills), or drugs for treating irregular heartbeats (antiarrhythmics), because coadministration can cause the development of irregular heartbeats.
- The effects of Auvi-Q may be enhanced by medicines such as tricyclic antidepressants, monoamine oxidase inhibitors, levothyroxine, and certain antihistamines.
- The treatment benefits of Auvi-Q can be reduced by beta-adrenergic blocking medicines such as propranolol and alpha-adrenergic blocking medicines such as phentolamine. Some anti-migraine medications may also interfere with the benefits of Auvi-Q treatment.
It is unknown if Auvi-Q is excreted in breast milk. Since many drugs are excreted in breast milk and have the potential of causing harm to the nursing infant, caution should be used when Auvi-Q is administered to a breastfeeding mother.
What are the important side effects of Auvi-Q (epinephrine)?
The most common side effects of Auvi-Q include:
- fast, irregular, or pounding heartbeat;
- vomiting; and
- breathing problems.
Auvi-Q is intended for administration in the muscle or fat tissues in the outer thigh only. Injecting Auvi-Q in other areas of the body including the buttocks, hands, or feet may not provide effective treatment of anaphylaxis and may even cause side effects.
Auvi-Q (epinephrine) side effects list for healthcare professionals
Due to lack of randomized, controlled clinical trials of epinephrine for the treatment of anaphylaxis, the true incidence of adverse reactions associated with the systemic use of epinephrine is difficult to determine. Adverse reactions reported in observational trials, case reports, and studies are listed below.
Common adverse reactions to systemically administered epinephrine include
- nausea and vomiting;
- headache; and/or
- respiratory difficulties.
- Arrhythmias, including fatal ventricular fibrillation, have been reported, particularly in patients with underlying cardiac disease or those receiving certain drugs.
- Rapid rises in blood pressure have produced cerebral hemorrhage, particularly in elderly patients with cardiovascular disease.
- Angina may occur in patients with coronary artery disease.
- Rare cases of stress cardiomyopathy have been reported in patients treated with epinephrine.
- Accidental injection into the digits, hands or feet may result in loss of blood flow to the affected area.
- Adverse events experienced as a result of accidental injections may include increased heart rate, local reactions including injection site pallor, coldness and hypoesthesia or injury at the injection site resulting in bruising, bleeding, discoloration, erythema or skeletal injury.
- Injection of epinephrine into the buttock has resulted in cases of gas gangrene.
- Rare cases of serious skin and soft tissue infections, including necrotizing fasciitis and myonecrosis caused by Clostridia (gas gangrene), have been reported at the injection site following epinephrine injection in the thigh.
What drugs interact with Auvi-Q (epinephrine)?
- Patients who receive epinephrine while concomitantly taking cardiac glycosides, diuretics, or anti-arrhythmics should be observed carefully for the development of cardiac arrhythmias.
- The effects of epinephrine may be potentiated by tricyclic antidepressants, monoamine oxidase inhibitors, levothyroxine sodium, and certain antihistamines, notably chlorpheniramine, tripelennamine, and diphenhydramine.
- The cardiostimulating and bronchodilating effects of epinephrine are antagonized by beta-adrenergic blocking drugs, such as propranolol.
- The vasoconstricting and hypertensive effects of epinephrine are antagonized by alpha-adrenergic blocking drugs, such as phentolamine.
- Ergot alkaloids may also reverse the pressor effects of epinephrine.
Auvi-Q (auto-injectable epinephrine) is a sympathomimetic catecholamine used for self-administration during life-threatening allergic reactions, including anaphylaxis. Common side effects of Auvi-Q include fast/irregular/pounding heartbeat, sweating, shakiness, headache, paleness, overexcitement, nervousness, anxiety, weakness, dizziness, nausea, vomiting, and breathing problems. Use of Auvi-Q has not been adequately evaluated in pregnant women. It is unknown if Auvi-Q is excreted in breast milk.
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.