Does Trusopt (dorzolamide) cause side effects?

Trusopt (dorzolamide) ophthalmic solution (a liquid that is placed in the eyes) is a carbonic anhydrase inhibitor used to treat glaucoma

Many parts of the body, including the eye, contain the enzyme carbonic anhydrase. Carbonic anhydrase controls secretion of fluid within the eye and thereby determines the pressure within the eye (intraocular pressure); the greater the amount of fluid that is secreted, the higher the pressure. 

Patients with glaucoma have increased intraocular pressure. Trusopt blocks carbonic anhydrase thereby decreasing secretion of fluid and intraocular pressure. This reduces the risk of nerve damage and loss of vision that is caused by increased intraocular pressure in patients with glaucoma. 

Common side effects of Trusopt include

  • eye irritation,
  • eye burning,
  • eye stinging,
  • eye discomfort,
  • bitter taste, and
  • allergic eye reaction or eye inflammation (superficial punctate keratitis).

Serious side effects of Trusopt include

Drug interactions of Trusopt include oral carbonic anhydrase inhibitors, because the combination may lead to increased adverse effects. When used with other eye drops for reducing intraocular pressure, administration of both drugs should be separated by at least 10 minutes. 

There are no adequate and well-controlled studies of Trusopt in pregnant women. Trusopt should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. 

It is unknown if Trusopt is excreted into breast milk. Consult your doctor before breastfeeding.

What are the important side effects of Trusopt (dorzolamide)?

The most common side effects of dorzolamide include:

  • irritation,
  • eye burning,
  • eye stinging,
  • discomfort of the eye.

These effects generally are temporary and occur immediately after administration. Approximately 1 in 4 patients complain of a bitter taste, and 1 in 10 patients experience an allergic eye reaction or eye inflammation (superficial punctate keratitis).

Other important, but less common side effects include:

  • blurred vision,
  • excessive tearing,
  • dry eyes, and
  • increased sensitivity to light.

Bacterial infections of the eye have been reported and may be due to accidental contamination of the containers with bacteria during handling. Dorzolamide is a sulfonamide and can be absorbed into the body.

Individuals who are allergic to sulfonamides may react to dorzolamide. Therefore, dorzolamide should not be administered to patients with allergies to sulfonamides, and it can cause some of the side effects of sulfonamides. Severe skin reactions also have been reported.

Trusopt (dorzolamide) side effects list for healthcare professionals

Clinical Studies Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

Controlled clinical trials

The most frequent adverse reactions associated with Trusopt were

  • ocular burning,
  • stinging, or
  • discomfort immediately following ocular administration (approximately one-third of patients).

Approximately one-quarter of patients noted a bitter taste following administration. Superficial punctate keratitis occurred in 10 to 15% of patients and signs and symptoms of ocular allergic reaction in approximately 10%.

Reactions occurring in approximately 1 to 5% of patients were

Other ocular reactions and systemic reactions were reported infrequently, including

In a 3-month, double-masked, active-treatment-controlled, multicenter study in pediatric patients, the adverse reactions profile of Trusopt was comparable to that seen in adult patients.

Post-Marketing Experience

The following adverse reactions have been identified during post-approval use of Trusopt. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Signs and symptoms of systemic allergic reactions including

What drugs interact with Trusopt (dorzolamide)?

Oral Carbonic Anhydrase Inhibitors

  • There is a potential for an additive effect on the known systemic effects of carbonic anhydrase inhibition in patients receiving an oral carbonic anhydrase inhibitor and Trusopt.
  • The concomitant administration of Trusopt and oral carbonic anhydrase inhibitors is not recommended.

High-Dose Salicylate

  • Therapy Although acid-base and electrolyte disturbances were not reported in the clinical trials with dorzolamide hydrochloride ophthalmic solution, these disturbances have been reported with oral carbonic anhydrase inhibitors and have, in some instances, resulted in drug interactions (e.g., toxicity associated with high-dose salicylate therapy).
  • Therefore, the potential for such drug interactions should be considered in patients receiving Trusopt.

Treatment & Diagnosis

Medications & Supplements

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Medically Reviewed on 12/7/2020
References
FDA Prescribing Information

Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.