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Does Dobutamine cause side effects?
It is indicated when parenteral therapy is necessary for inotropic support in the short-term treatment of adults with cardiac decompensation due to depressed contractility resulting either from organic heart disease or from cardiac surgical procedures.
Common side effects of dobutamine include
- increased heart rate,
- increased blood pressure,
- irregular ventricular beats,
- chest pain,
- nausea, and
- shortness of breath.
Serious side effects of dobutamine include
Drug interactions of dobutamine include other agents that increase heart rate or blood pressure (sympathomimetics), such as
Use lower doses of dobutamine initially if the patient is also on linezolid as there is a risk of a significant increase in blood pressure. Calcium salts may decrease the effect of dobutamine, so monitor closely.
What are the important side effects of Dobutamine?
The most frequent adverse reactions include
- increased heart rate,
- increased blood pressure,
- irregular ventricular beats, and
- chest pain.
Other important side effects include
Serious side effects of dobutamine include
Dobutamine side effects list for healthcare professionals
Increased Heart Rate, Blood Pressure, And Ventricular Ectopic Activity
- A 10- to 20-mm increase in systolic blood pressure and an increase in heart rate of 5 to 15 beats/minute have been noted in most patients.
- Approximately 5% of patients have had increased premature ventricular beats during infusions. These effects are dose related.
- Precipitous decreases in blood pressure have occasionally been described in association with dobutamine therapy.
- Decreasing the dose or discontinuing the infusion typically results in rapid return of blood pressure to baseline values.
- In rare cases, however, intervention may be required and reversibility may not be immediate.
Reactions At Sites Of Intravenous Infusion
- Phlebitis has occasionally been reported. Local inflammatory changes have been described following inadvertent infiltration.
- Isolated cases of cutaneous necrosis (destruction of skin tissue) have been reported.
Miscellaneous Uncommon Effects
The following adverse effects have been reported in 1% to 3% of patients:
Isolated cases of thrombocytopenia have been reported.
Administration of dobutamine, like other catecholamines, can produce a mild reduction in serum potassium concentration, rarely to hypokalemic levels.
Infusions of up to 72 hours have revealed no adverse effects other than those seen with shorter infusions.
What drugs interact with Dobutamine?
Animal studies indicate that dobutamine may be ineffective if the patient has recently received a beta-blocking drug. In such a case, the peripheral vascular resistance may increase.
Preliminary studies indicate that the concomitant use of dobutamine and nitroprusside results in a higher cardiac output and, usually, a lower pulmonary wedge pressure than when either drug is used alone.
There was no evidence of drug interactions in clinical studies in which dobutamine was administered concurrently with other drugs, including
Dobutamine is a synthetic catecholamine used to help increase cardiac output in a failing heart due to heart disease or cardiac surgery. Common side effects of dobutamine include increased heart rate, increased blood pressure, irregular ventricular beats, chest pain, fever, headache, nausea, and shortness of breath. Available evidence suggests dobutamine may be safely used in pregnancy. Dobutamine should be used cautiously by breastfeeding mothers as it is unknown whether it is excreted in breast milk.
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Related Disease Conditions
Heart disease (coronary artery disease) occurs when plaque builds up in the coronary arteries, the vessels that supply blood to the heart. Heart disease can lead to heart attack. Risk factors for heart disease include: Smoking High blood pressure High cholesterol Diabetes Family history Obesity Angina, shortness of breath, and sweating are just a few symptoms that may indicate a heart attack. Treatment of heart disease involves control of heart disease risk factors through lifestyle changes, medications, and/or stenting or bypass surgery. Heart disease can be prevented by controlling heart disease risk factors.
Heart Disease: Sudden Cardiac Death
Second Source WebMD Medical Reference
Congenital Heart Defects
Congenital heart defects are heart problems that are present at birth. Genetics may play a role in some heart defects. Symptoms can range from nonexistent to severe and life-threatening. Fatigue, rapid breathing, and decreased blood circulation are a few possible symptoms of congenital heart defects. Many cases do not require any treatment. Procedures using catheters and surgery may be used to repair severe heart defects.
Stress and Heart Disease
The connection between stress and heart disease is not clear. Stress itself may be a risk factor, or high levels of stress may make risk factors for heart disease worse. The warning signs of stress can be physical, mental, emotional, or behavioral. Reducing stressors in an individuals life not only can lead to a more productive life, but may also decrease the risk for heart disease and causes of heart disease.
Heart Disease in Women
Heart disease in women has somewhat different symptoms, risk factors, and treatment compared to heart disease in men. Many women and health professionals are not aware of the risk factors for heart disease in women and may delay diagnosis and treatment. Lifestyle factors such as diet, exercise, tobacco use, overweight/obesity, stress, alcohol consumption, and depression influence heart disease risk in women. High blood pressure, high cholesterol, and diabetes also increase women's risk of heart disease. Electrocardiogram (EKG or ECG), stress-ECG, endothelial testing, ankle-brachial index (ABI), echocardiogram, nuclear imaging, electron beam CT, and lab tests to assess blood lipids and biomarkers of inflammation are used to diagnose heart disease. Early diagnosis and treatment of heart disease in women saves lives. Heart disease can be prevented and reversed with lifestyle changes.
Smoking and Heart Disease
Smoking increases the risk of heart disease in women and men. Nicotine in cigarettes decrease oxygen to the heart, increases blood pressure, blood clots, and damages coronary arteries. Learn how to quit smoking today, to prolong your life.
Heart Disease Treatment in Women
Heart disease treatment in women should take into account female-specific guidelines that were developed by the American Heart Association. Risk factors and symptoms of heart disease in women differ from those in men. Treatment may include lifestyle modification (diet, exercise, weight management, smoking cessation, stress reduction), medications, percutaneous intervention procedure (PCI), and coronary artery bypass grafting (CABG). Heart disease is reversible with treatment.
Treatment & Diagnosis
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Medications & Supplements
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.