- Osteoarthritis Overview Slideshow Pictures
- Osteoarthritis Quiz: Test Your Medical IQ
- Exercises for OA of the Knee Slideshow
Does Daypro (oxaprozin) cause side effects?
NSAIDs work by reducing the levels of prostaglandins, chemicals that are responsible for pain, fever, and inflammation. Daypro blocks the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower concentrations of prostaglandins. As a consequence, inflammation, pain and fever are reduced.
Common side effects of Daypro include
- ringing in the ears,
- abdominal pain,
- fluid retention, and
- shortness of breath.
Serious side effects of include
- increased bleeding after an injury,
- bleeding in the stomach and intestine,
- ulcers (signs include black tarry stools, weakness, and dizziness upon standing may be the only signs of the bleeding),
- impaired kidney function,
- blood clots,
- heart attacks,
- high blood pressure (hypertension), and
- heart failure.
Daypro may reduce the blood pressure lowering effects of blood pressure medications.
- When Daypro is used in combination with methotrexate or aminoglycoside antibiotics the blood levels of those drugs may increase, presumably because their elimination is reduced. This may lead to more side effects from methotrexate or aminoglycoside.
- Individuals taking oral blood thinners or anticoagulants should avoid Daypro because Daypro also thins the blood, and excessive blood thinning may lead to bleeding. Daypro increases the negative effect of cyclosporine on kidney function.
- If aspirin is taken with Daypro there may be an increased risk for developing an ulcer.
- Persons who have more than 3 alcoholic beverages per day may be at increased risk of developing stomach ulcers when taking Daypro or other NSAIDs.
What are the important side effects of Daypro (oxaprozin)?
The most common side effects from oxaprozin are
- ringing in the ears,
- abdominal pain,
- fluid retention, and
- shortness of breath.
NSAIDs reduce the ability of blood to clot and therefore increase bleeding after an injury. Oxaprozin also may cause bleeding in the stomach and intestine as well as ulcers.
People who are allergic to other NSAIDs should not use oxaprozin. NSAIDs reduce the flow of blood to the kidneys and impair function of the kidneys. The impairment is most likely to occur in patients with preexisting impairment of kidney function or congestive heart failure, and use of NSAIDs in these patients should be done cautiously.
Individuals with asthma are more likely to experience allergic reactions to oxaprozin and other NSAIDs. Fluid retention, blood clots, heart attacks, hypertension, and heart failure also have been associated with the use of NSAIDs.
Daypro (oxaprozin) side effects list for healthcare professionals
The following adverse reactions are discussed in greater detail in other sections of the labeling:
- Cardiovascular Thrombotic Events
- GI Bleeding, Ulceration and Perforation
- Heart Failure and Edema
- Renal Toxicity and Hyperkalemia
- Anaphylactic Reactions
- Serious Skin Reactions
- Hematologic Toxicity
Clinical Trials Experience
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
- Adverse reaction data were derived from patients who received Daypro in multidose, controlled, and open-label clinical trials.
- Rates for events from clinical trial experience are based on 2253 patients who took 1200 mg to 1800 mg Daypro per day in clinical trials.
- Of these, 1721 patients were treated for at least 1 month, 971 patients for at least 3 months, and 366 patients for more than 1 year.
Incidence Greater Than 1%
In clinical trials of Daypro or in patients taking other NSAIDs, the following adverse reactions occurred at an incidence greater than 1%.
Cardiovascular system: edema.
Digestive system: abdominal pain/distress, anorexia, constipation, diarrhea, dyspepsia, flatulence, gastrointestinal ulcers (gastric/duodenal), gross bleeding/perforation, heartburn, liver enzyme elevations, nausea, vomiting.
Hematologic system: anemia, increased bleeding time.
Skin and appendages: pruritus, rash.
Special senses: tinnitus.
Urogenital system: abnormal renal function, dysuria or frequency.
Incidence Greater Than 1%
The following adverse reactions were reported in clinical trials or in patients taking other NSAIDs.
Digestive system: alteration in taste, dry mouth, eructation, esophagitis, gastritis, glossitis, hematemesis, jaundice, liver function abnormalities including liver failure, stomatitis, hemorrhoidal or rectal bleeding.
The following adverse reactions have been identified during post approval use of Daypro. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
Body as a whole: serum sickness.
Hematologic system: agranulocytosis, pancytopenia.
Urogenital: acute interstitial nephritis, nephrotic syndrome, acute renal failure.
What drugs interact with Daypro (oxaprozin)?
See Table 2 for clinically significant drug interactions with oxaprozin.
Table 2: Clinically Significant Drug Interactions with Oxaprozin
|Drugs That Interfere with Hemostasis|
|Intervention:||Monitor patients with concomitant use of Daypro with anticoagulants (e.g., warfarin), antiplatelet drugs (e.g., aspirin), SSRIs, and SNRIs for signs of bleeding.|
|Clinical Impact:||Controlled clinical studies showed that the concomitant use of NSAIDs and analgesic doses of aspirin does not produce any greater therapeutic effect than the use of NSAIDs alone. In a clinical study, the concomitant use of an NSAID and aspirin was associated with a significantly increased incidence of GI adverse reactions as compared to use of the NSAID alone.|
|Intervention:||Concomitant use of Daypro and analgesic doses of aspirin is not generally recommended because of the increased risk of bleeding.|
Daypro is not a substitute for low dose aspirin for cardiovascular protection.
|ACE Inhibitors, Angiotensin Receptor Blockers, and Beta-Blockers|
|Clinical Impact:||Clinical studies, as well as post-marketing observations, showed that NSAIDs reduced the natriuretic effect of loop diuretics (e.g., furosemide) and thiazide diuretics in some patients. This effect has been attributed to the NSAID inhibition of renal prostaglandin synthesis.|
|Intervention:||During concomitant use of Daypro with diuretics, observe patients for signs of worsening renal function, in addition to assuring diuretic efficacy including antihypertensive effects.|
|Clinical Impact:||The concomitant use of oxaprozin with digoxin has been reported to increase the serum concentration and prolong the half-life of digoxin.|
|Intervention:||During concomitant use of Daypro and digoxin, monitor serum digoxin levels.|
|Clinical Impact:||NSAIDs have produced elevations in plasma lithium levels and reductions in renal lithium clearance. The mean minimum lithium concentration increased 15%, and the renal clearance decreased by approximately 20%. This effect has been attributed to NSAID inhibition of renal prostaglandin synthesis.|
|Intervention:||During concomitant use of Daypro and lithium, monitor patients for signs of lithium toxicity.|
|Clinical Impact:||Concomitant use of NSAIDs and methotrexate may increase the risk for methotrexate toxicity (e.g., neutropenia, thrombocytopenia, renal dysfunction) because NSAID administration may result in increased plasma levels of methotrexate, especially in patients receiving high doses of methotrexate.|
|Intervention:||During concomitant use of Daypro and methotrexate, monitor patients for methotrexate toxicity.|
|Clinical Impact:||Concomitant use of Daypro and cyclosporine may increase cyclosporine’s nephrotoxicity.|
|Intervention:||During concomitant use of Daypro and cyclosporine, monitor patients for signs of worsening renal function.|
|NSAIDs and Salicylates|
|Clinical Impact:||Concomitant use of oxaprozin with other NSAIDs or salicylates (e.g., diflunisal, salsalate) increases the risk of GI toxicity, with little or no increase in efficacy.|
|Intervention:||The concomitant use of oxaprozin with other NSAIDs or salicylates is not recommended.|
|Clinical Impact:||Concomitant use of Daypro and pemetrexed may increase the risk of pemetrexed-associated myelosuppression, renal, and GI toxicity (see the pemetrexed prescribing information).|
|Intervention:||During concomitant use of Daypro and pemetrexed, in patients with renal impairment whose creatinine clearance ranges from 45 to 79 mL/min, monitor for myelosuppression, renal and GI toxicity.|
NSAIDs with short elimination half-lives (e.g., diclofenac, indomethacin) should be avoided for a period of two days before, the day of, and two days following administration of pemetrexed.In the absence of data regarding potential interaction between pemetrexed and NSAIDs with longer half-lives (e.g., meloxicam, nabumetone), patients taking these NSAIDs should interrupt dosing for at least five days before, the day of, and two days following pemetrexed administration.
|Clinical Impact:||Concomitant use of corticosteroids with Daypro may increase the risk of GI ulceration or bleeding.|
|Intervention:||Monitor patients with concomitant use of Daypro with corticosteroids for signs of bleeding.|
|Clinical Impact:||While oxaprozin does alter the pharmacokinetics of glyburide, coadministration of oxaprozin to type II non-insulin dependent diabetic patients did not affect the area under the glucose concentration curve nor the magnitude or duration of control.|
|Intervention:||During concomitant use of Daypro and glyburide, monitor patient’s blood glucose in the beginning phase of cotherapy.|
Laboratory Test Interactions
False-positive urine immunoassay screening tests for benzodiazepines have been reported in patients taking Daypro. This is due to lack of specificity of the screening tests.
False-positive test results may be expected for several days following discontinuation of Daypro therapy. Confirmatory tests, such as gas chromatography/mass spectrometry, will distinguish Daypro from benzodiazepines.
Multimedia: Slideshows, Images & Quizzes
Osteoarthritis (OA): Treatment, Symptoms, Diagnosis
Osteoarthritis (OA) is a degenerative joint disease most often affecting major joints such as knees, hands, back, or hips....
Exercises for Knee Osteoarthritis and Joint Pain
Learn about osteoarthritis and exercises that relieve knee osteoarthritis pain, stiffness and strengthen the knee joint and...
Osteoarthritis Quiz: Test Your Medical IQ
How does osteoarthritis differ from other types of arthritis? Learn about osteoarthritis with this quiz.
Osteoarthritis: 15 Tips to Improve Daily Living With OA
Osteoarthritis joint pain can make it hard to carry out activities of daily living. Cartilage destruction can cause symptoms like...
Picture of Osteoarthritis
Osteoarthritis is a type of arthritis that is caused by the breakdown and eventual loss of the cartilage of one or more...
Tips for Healthy Joints: Exercise, Nutrition, & More in Pictures
Dealing with joint pain and arthritis? Learn why weight matters--and why NOT to stretch before exercise. See these solutions for...
Fun With Kids? Don't Let Arthritis Stop You
You can still have lots of fun with children despite arthritis. Our experts uncover ways to spend time with your kids or...
Exercises for Osteoarthritis -- Yoga, Swimming, & More
Check out this slideshow on Active Living From Day to Night with Osteoarthritis. Even with arthritis you can keep your active...
Related Disease Conditions
Osteoarthritis is a type of arthritis caused by inflammation, breakdown, and eventual loss of cartilage in the joints. Also known as degenerative arthritis, osteoarthritis can be caused by aging, heredity, and injury from trauma or disease.
Second Source article from Government
Osteoarthritis vs. Osteoporosis Differences and Similarities
Arthritis is defined as painful inflammation and joint stiffness. Osteoarthritis is a type of arthritis and the most common cause of chronic joint pain, affecting over 25 million Americans. Osteoarthritis is a type of arthritis that involves the entire joint. Osteoporosis is not a type of arthritis. It is a disease that mainly is caused by a loss of bone tissue that is not limited to the joint areas. It is possible for one person to have both osteoarthritis and osteoporosis. The differences in the signs and symptoms of osteoarthritis and osteoporosis include; pain, stiffness, and joint swelling, joint deformity, crackle sounds when the joint is moving, and walking with a limp. Osteoporosis is called the "silent disease" because it can progress for years without signs and symptoms before it is diagnosed, severe back pain, bone fractures, height loss, and difficulty or inability to walk. The differences in the causes of osteoarthritis and osteoporosis are that osteoarthritis usually is caused by wear and tear on the joints. Osteoporosis usually is caused by one or more underlying problems, for example, calcium and vitamin D deficiencies. Treatment for osteoarthritis and osteoporosis are not the same. There is no cure for osteoarthritis or osteoporosis.
Osteoarthritis vs. Rheumatoid Arthritis
Osteoarthritis (OA) and rheumatoid arthritis (RA) are chronic joint disorders. RA is also an autoimmune disease. OA and RA symptoms and signs include joint pain, warmth, and tenderness. Over-the-counter pain relievers treat both diseases. There are several prescription medications that treat RA.
What Is the Main Cause of Osteoarthritis?
Osteoarthritis (OA) is a chronic degenerative disease of the joints affecting middle-aged and elderly people. It involves the breakdown of cartilage and associated inflammatory changes in the adjacent bone. It is a leading cause of chronic disability, affecting 30 million people in the United States alone.
Treatment & Diagnosis
- Osteoarthritis FAQs
- Rheumatoid Arthritis vs. Osteoarthritis
- Osteoarthritis: 2004 Perspectives
- Osteoarthritis - Vitamin D May Prevent Progression
- Are Women More Susceptible to Osteoarthritis?
- Can You Get a Cartilage Transplant?
- What Is Cervical Osteoarthritis?
- What Is the Prognosis for Osteoarthritis?
- What Kind of Joint Injections Treat Osteoarthritis?
- What Are the Side Effects of Glucosamine?
- What Causes Arthritis and Baker's Cyst?
- Can You Be Too Young for a Knee Replacement?
- What Causes Early Onset of Hip Osteoarthritis?
- Osteoarthritis of the Hands
- Osteoarthritis vs. Carpal Tunnel: What's the Difference?
- Can You Prevent Osteoarthritis?
- Osteoarthritis Symptoms
- Osteoarthritis and Weight Loss Audio Podcast
Medications & Supplements
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.