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Does Cleocin Vaginal Ovules (clindamycin) cause side effects?
Cleocin Vaginal Ovules (clindamycin) is an antibiotic used to treat bacterial vaginosis (formerly referred to as Haemophilus vaginitis, Gardnerella vaginitis, nonspecific vaginitis, Corynebacterium vaginitis, or anaerobic vaginosis) in non-pregnant women.
Clindamycin in general is an antibiotic used for treating several other infections as well. It is effective against several types of bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, and Staphylococcus epidermidis, and Propionibacterium acnes. It reduces growth of bacteria by interfering with their ability to make proteins.
Common side effects of Cleocin Vaginal Ovules include
- vaginal yeast infection,
- inflammation of the vulva and vagina,
- vulvovaginal disorder,
- trichomonal vaginitis,
- abdominal pain,
- diarrhea, and
Serious side effects of Cleocin Vaginal Ovules include
- severe colitis (inflammation of the colon) with diarrhea or bloody diarrhea (including C. difficile colitis).
Very little clindamycin is absorbed into the bloodstream when given vaginally so the likelihood of drug interactions is low.
The frequency of congenital abnormalities was not increased when pregnant women used oral clindamycin during the second and third trimesters. Pregnant women who used clindamycin vaginal cream during the second trimester reported abnormal labor more frequently than those who received placebo.
Oral clindamycin is excreted in breast milk and should not be used by nursing mothers or nursing should be stopped. It is unknown if Cleocin Vaginal Ovules are excreted in breast milk. Consult your doctor before breastfeeding.
What are the important side effects of Cleocin Vaginal Ovules (clindamycin)?
The most common side effects of clindamycin vaginal suppositories are:
- vaginal moniliasis, a fungal infection
- vulvovaginal disorder
- trichomonal vaginitis
Other side effects that may occur include:
Possible serious side effects of clindamycin include:
- Orally administered and injected clindamycin may cause severe colitis (inflammation of the colon).
- Vaginal formulations of clindamycin may be absorbed into the blood stream, and colitis with diarrhea or bloody diarrhea (including C.difficile colitis) have been reported with the use of clindamycin vaginal suppositories.
Cleocin Vaginal Ovules (clindamycin) side effects list for healthcare professionals
In clinical trials, 3 (0.5%) of 589 nonpregnant women who received treatment with Cleocin Vaginal Ovules discontinued therapy due to drug-related adverse events. Adverse events judged to have a reasonable possibility of having been caused by clindamycin phosphate vaginal suppositories were reported for 10.5% of patients. Events reported by 1% or more of patients receiving Cleocin Vaginal Ovules were as follows:
- Urogenital system: Vulvovaginal disorder (3.4%), vaginal pain (1.9%), and vaginal moniliasis (1.5%).
- Body as a whole: Fungal infection (1.0%).
- Other events reported by < 1% of patients included:
- Urogenital system: Menstrual disorder, dysuria, pyelonephritis, vaginal discharge, and vaginitis/vaginal infection.
- Body as a whole: Abdominal cramps, localized abdominal pain, fever, flank pain, generalized pain, headache, localized edema, and moniliasis.
- Digestive system: Diarrhea, nausea, and vomiting.
- Skin: Nonapplication-site pruritis, rash, application-site pain, and application-site pruritis.
Other clindamycin formulations
The overall systemic exposure to clindamycin from Cleocin Vaginal Ovules is substantially lower than the systemic exposure from therapeutic doses of oral clindamycin hydrochloride (two-fold to 20-fold lower) or parenteral clindamycin phosphate (40-fold to 50-fold lower).
Although these lower levels of exposure are less likely to produce the common reactions seen with oral or parenteral clindamycin, the possibility of these and other reactions cannot be excluded.
The following adverse reactions and altered laboratory tests have been reported with the oral or parenteral use of clindamycin and may also occur following administration of Cleocin Vaginal Ovules:
- Gastrointestinal: Abdominal pain, esophagitis, nausea, vomiting, and diarrhea.
- Hematopoietic: Transient neutropenia (leukopenia), eosinophilia, agranulocytosis, and thrombocytopenia have been reported. No direct etiologic relationship to concurrent clindamycin therapy could be made in any of these reports.
- Hypersensitivity Reactions: Maculopapular rash and urticaria have been observed during drug therapy. Generalized mild to moderate morbilliform-like skin rashes are the most frequently reported of all adverse reactions. Rare instances of erythema multiforme, some resembling Stevens-Johnson syndrome, have been associated with clindamycin. A few cases of anaphylactoid reactions have been reported. If a hypersensitivity reaction occurs, the drug should be discontinued.
- Liver: Jaundice and abnormalities in liver function tests have been observed during clindamycin therapy.
- Musculoskeletal: Rare instances of polyarthritis have been reported.
- Renal: Although no direct relationship of clindamycin to renal damage has been established, renal dysfunction as evidenced by azotemia, oliguria, and/or proteinuria has been observed in rare instances.
What drugs interact with Cleocin Vaginal Ovules (clindamycin)?
- Clindamycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents.
- Therefore, it should be used with caution in patients receiving such agents.
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Bacterial Vaginosis (BV)
Bacterial vaginosis is an abnormal vaginal condition with signs and symptoms of vaginal discharge, vaginal odor, and vaginal pain. Bacterial vaginosis results from an overgrowth of normal bacteria in the vagina. Although it may cause some disturbing symptoms (discharge and odor), it is not dangerous and cannot be passed by sex. Diagnosis becomes important to exclude serious infections like gonorrhea and Chlamydia. Many treatment options are available such as oral antibiotics and vaginal gels.
Vaginitis (Inflammation of the Vagina)
Vaginitis refers to inflammation of the vagina. Vaginitis can be caused by infections, menopause, or poor hygiene. Symptoms of vaginitis include vaginal itching, discharge, odor, pain, or discomfort. Treatment for vaginitis depends on the cause. Antibiotics may be necessary for some forms of vaginitis.
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Yeast Infection vs. Diaper Rash in Infants, Toddlers, and Children
Diaper rash in infants, babies, toddlers, and children is caused by Candida, the most common type of fungus. Signs and symptoms of diaper rash is red, elevated skin that may be visible under and in the creases of the skin, groin, or anus. Yeast diaper rash is not painful. Treatments for diaper rash include antibiotic creams, lotions, natural home remedies, over-the-counter (OTC) medicine, and oral antibiotics. Yeast infections in infants, babies, toddlers, and children can cause diaper rash, thrush. Signs and symptoms of thrush include thick, white lacy patches on top of a red base can form on the tongue, palate, or elsewhere inside the palate. Treatment for yeast infections caused by Candida fungi are similar to the treatments for diaper rash. If Candida gets into the blood stream of an individual they may get sick with or without a fever. If the Candida infection spreads throughout the body up to 45% of people may die. Even with common mouth thrush can cause critical illness and may be more resistant to normal treatment.
Vaginal Yeast Infection in Women
Vaginal yeast infections in women are caused by an organism called Candida albicans. Symptoms of a vaginal yeast infection include vaginal pain with urination, vaginal discharge, odor, and itching. Treatment is generally OTC medications. A man can contract a yeast infection from his female sexual partner. Symptoms of a yeast infection in men include penile itching. Treatment is with oral or topical medication.
Oral Thrush in Children
Yeast infections are caused by an overgrowth of a type of fungus called Candida. Oral thrush is a yeast infection of the mouth and throat. Oral thrush and yeast infections are treated orally or topically with an antifungal antibiotic called nystatin.
Is a Yeast Infection Contagious?
Yeast are a fungi that has many types. A type of yeast that can cause infection in humans is called Candida. Candida can infect the mouth, vagina, penis, or other areas of the body. Symptoms of yeast infections depend on the area infected, however, may include itching, bumps on the skin, a reddish rash, or patches of skin that ooze a clear or yellow liquid. Most yeast infections are not contagious even though they are caused by a fungus.
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What Happens if You Don't Treat a Yeast Infection?
Yeast infections are contagious. They can be transmitted through sexual contact. Those with weak immunity have a high risk of the infection. Yeast infections can be vaginal (candidiasis), oral (thrush) or penile. Untreated yeast infections may spread to other areas, cause symptoms or pass to others.
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Vaginal yeast infection is also called vaginal candidiasis. It is caused when there is an overgrowth of a germ called Candida albicans that is a normal resident of the vagina.
What Is the Main Cause of a Yeast Infection?
Yeast infections are mainly caused by yeast-like fungus named Candida or Monilia. Yeast infections may affect the skin, mouth or vagina. Your doctor will use different methods of testing yeast infections depending on the area of your infection or symptoms.
Home Remedies for Yeast Infections
Yeast infection is caused when there is an overgrowth of a fungus called Candida albicans, which naturally lives in the oral cavity, vagina, and skin. It causes conditions like oral candidiasis or vaginal candidiasis. It is characterized by irritation, inflammation, itching, and painful discharge.
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Yeast Infection vs. Urinary Tract Infection (UTI)
Candida albicans typically causes vaginal yeast infections. Bacterial infections typically cause urinary tract infections (UTIs). Thick white cottage-cheese like vaginal discharge characterizes vaginal yeast infections. Painful, frequent urination characterize urinary tract infections. Antifungal medications treat yeast infections while prescription antibiotics treat UTIs.
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Yeast Infection vs. Bacterial Vaginosis (BV)
Yeast infections and bacterial vaginosis (BV) both cause vaginal discharge. Yeast infection discharge is thick, white, and had a cottage cheese consistency. BV discharge is whitish-gray and is thinner. Vaginal odor, irritation, and pain may also be present. Treatment of yeast infections includes over-the-counter and prescription antifungals. BV treatment involves antibiotics.
How Do You Get Bacterial Vaginosis?
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Medications & Supplements
- Doxycycline vs. clindamycin
- clindamycin/benzoyl peroxide - topical, Benzaclin, Duac
- clindamycin, oral (Cleocin)
- Metronidazole (Flagyl) vs. Clindamycin (Cleocin)
- clindamycin vaginal suppository (Cleocin)
- clindamycin and benzoyl peroxide combination pack-topical, Z-Clinz
- topical clindamycin (Cleocin T, Clindagel)
- clindamycin and benzoyl peroxide gel (Benzaclin, Acanya, Duac, Onexton)
- clindamycin-oral solution, Cleocin Pediatric
- clindamycin - injection, Cleocin
- clindamycin vaginal cream (Cleocin, Clindesse)
- Side Effects of topical Cleocin (clindamycin)
- Side Effects of Cleocin (oral clindamycin)
- Side Effects of BenzaClin (clindamycin/benzoyl peroxide)
- Veltin (clindamycin phosphate and tretinoin) Gel
Prevention & Wellness
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.