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Does Cleocin (clindamycin) cause side effects?
Cleocin (clindamycin) is an oral antibiotic used to treat serious infections caused by susceptible bacteria. It is most often used to treat penicillin-allergic patients or in other situations where penicillin or other alternative antibiotics cannot be used.
Examples of infections that are treated with Cleocin include serious respiratory tract infections (for example, empyema, pneumonitis, and lung abscess), serious skin and soft tissue infections, and female pelvic and genital tract infections (for example, endometritis), and ovarian abscess.
It is effective against several types of bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, Staphylococcus epidermidis, and Propionibacterium acnes. It reduces growth of bacteria by interfering with their ability to make proteins.
Common side effects of Cleocin include
Serious side effects of Cleocin include
- Clostridium difficile associated diarrhea (CDAD) which causes
Drug interactions of Cleocin include neuromuscular blocking drugs (for example, pancuronium and vecuronium, which are used during surgery) because Cleocin may act as a neuromuscular blocker. This means it can increase the action of neuromuscular blocking drugs.
The frequency of congenital abnormalities was not increased when pregnant women used Cleocin during the second and third trimesters. Cleocin should not be used during the first trimester of pregnancy unless it is clearly needed because it has not been properly evaluated during the first trimester of pregnancy.
What are the important side effects of Cleocin (clindamycin)?
The most common side effects of clindamycin are
- stomach pain, and
Cleocin also frequently causes
Clindamycin causes Clostridium difficile associated diarrhea (CDAD) because it can alter the normal bacteria in the colon and encourage overgrowth Clostridium difficile, a bacteria which causes inflammation of the colon (pseudomembranous colitis).
Other serious side effects of clindamycin include:
- serious allergic reactions
- blood disorders
- Stevens-Johnson syndrome
- toxic epidermal necrolysis
Cleocin (clindamycin) side effects list for healthcare professionals
The following reactions have been reported with the use of clindamycin.
- Infections and Infestations: Clostridium difficile colitis
- Gastrointestinal: Abdominal pain, pseudomembranous colitis, esophagitis, nausea, vomiting, and diarrhea. The onset of pseudomembranous colitis symptoms may occur during or after antibacterial treatment. Esophageal ulcer has been reported. An unpleasant or metallic taste has been reported after oral administration.
- Hypersensitivity Reactions: Generalized mild to moderate morbilliform-like (maculopapular) skin rashes are the most frequently reported adverse reactions. Vesiculobullous rashes, as well as urticaria, have been observed during drug therapy. Severe skin reactions such as Toxic Epidermal Necrolysis, some with fatal outcome, have been reported. Cases of Acute Generalized Exanthematous Pustulosis (AGEP), erythema multiforme, some resembling Stevens-Johnson syndrome, anaphylactic shock, anaphylactic reaction and hypersensitivity have also been reported.
- Skin and Mucous Membranes: Pruritus, vaginitis, angioedema and rare instances of exfoliative dermatitis have been reported. (See Hypersensitivity Reactions.)
- Liver: Jaundice and abnormalities in liver function tests have been observed during clindamycin therapy.
- Renal: Although no direct relationship of clindamycin to renal damage has been established, renal dysfunction as evidenced by azotemia, oliguria, and/or proteinuria has been observed.
- Hematopoietic: Transient neutropenia (leukopenia) and eosinophilia have been reported. Reports of agranulocytosis and thrombocytopenia have been made. No direct etiologic relationship to concurrent clindamycin therapy could be made in any of the foregoing.
- Immune System: Drug reaction with eosinophilia and systemic symptoms (DRESS) cases have been reported.
- Musculoskeletal: Cases of polyarthritis have been reported.
What drugs interact with Cleocin (clindamycin)?
- Clindamycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Therefore, it should be used with caution in patients receiving such agents.
- Clindamycin is metabolized predominantly by CYP3A4, and to a lesser extent by CYP3A5, to the major metabolite clindamycin sulfoxide and minor metabolite N-desmethylclindamycin. Therefore inhibitors of CYP3A4 and CYP3A5 may increase plasma concentrations of clindamycin and inducers of these isoenzymes may reduce plasma concentrations of clindamycin.
- In the presence of strong CYP3A4 inhibitors, monitor for adverse reactions. In the presence of strong CYP3A4 inducers such as rifampicin, monitor for loss of effectiveness.
- In vitro studies indicate that clindamycin does not inhibit CYP1A2, CYP2C9, CYP2C19, CYP2E1 or CYP2D6 and only moderately inhibits CYP3A4.
- Antagonism has been demonstrated between clindamycin and erythromycin in vitro.
- Because of possible clinical significance, these two drugs should not be administered concurrently.
Cleocin (clindamycin) is an oral antibiotic used to treat serious infections caused by susceptible bacteria. It is most often used to treat penicillin-allergic patients or in other situations where penicillin or other alternative antibiotics cannot be used. Examples of infections that are treated with Cleocin include serious respiratory tract infections (for example, empyema, pneumonitis, and lung abscess), serious skin and soft tissue infections, and female pelvic and genital tract infections (for example, endometritis), and ovarian abscess. Common side effects of Cleocin include stomach pain, diarrhea, nausea, vomiting, metallic taste, low blood pressure, rash, and itching. Cleocin should not be used during the first trimester of pregnancy unless it is clearly needed because it has not been properly evaluated during the first trimester of pregnancy. Cleocin is excreted in breast milk and should not be used by nursing mothers or breastfeeding should be stopped.
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Related Disease Conditions
Staph Infection (Staphylococcus Aureus)
Staphylococcus or staph is a group of bacteria that can cause a multitude of diseases. Staph infections can cause illness directly by infection or indirectly by the toxins they produce. Symptoms and signs of a staph infection include redness, swelling, pain, and drainage of pus. Minor skin infections are treated with an antibiotic ointment, while more serious infections are treated with intravenous antibiotics.
Group B Strep
Group B strep are bacteria called Streptococcus agalactiae that may sometimes cause infections both in a pregnant woman and her baby. Symptoms include fever, seizures, heart rate abnormalities, breathing problems, and fussiness. Intravenous antibiotics are used to treat group B strep infections.
Upper Respiratory Tract Infection (URTI)
An upper respiratory infection is a contagious infection of the structures of the upper respiratory tract, which includes the sinuses, nasal passages, pharynx, and larynx. Common causes of an upper respiratory infection include bacteria and viruses such as rhinoviruses, group A streptococci, influenza, respiratory syncytial, whooping cough, diphtheria, and Epstein-Barr. Examples of symptoms of upper respiratory infection include sneezing, sore throat, cough, fever, and nasal congestion. Treatment of upper respiratory infections are based upon the cause. Generally, viral infections are treated symptomatically with over-the-counter (OTC) medication and home remedies.
Is a Staph Infection Contagious?
A staph infection is caused by the bacteria Staphylococcus aureus. Staph can cause boils, food poisoning, cellulitis, toxic shock syndrome, MRSA, and various other illnesses and infections. Most staph infections are transmitted from person to person.
Group A streptococcal infections are caused by group A streptococcus, a bacteria that causes a variety of health problems, including strep throat, impetigo, cellulitis, erysipelas, and scarlet fever. There are more than 10 million group A strep infections each year.
Is Strep Throat Contagious?
Strep throat is caused by group A streptococcus bacteria. Incubation period for strep throat is 1-5 days after exposure. If strep throat is treated with antibiotics, it is no longer contagious after 24 hours; if it is not treated with antibiotics, it is contagious for 2-3 weeks. Symptoms include fever, sore throat, tonsillitis, white spots or patches on the tonsils, and nausea and vomiting. Diagnosis of strep throat is performed through a rapid strep test.
Strep Throat (GAS): Treatment and Symptoms
Strep throat is a bacterial infection of the throat. Signs and symptoms of strep throat include headache, nausea, vomiting, sore throat, and fever. Strep throat symptoms in infants and children are different than in adults. Strep throat is contagious and is generally passed from person-to-person. Treatment for strep throat symptoms include home remedies and OTC medication; however, the only cure for strep throat are antibiotics.
Second Source article from Government
Group A Streptococcal Infections
Second Source article from Government
How Serious Is a Staph Infection?
A Staphylococcus or staph infection is caused by a germ that may be found in 30% of healthy people’s noses. Most of the time, these bacteria do not cause any health problems. However, in some people, it may cause skin and other organ infections. Most often, staph causes minor skin infections such as a boil. However, if it enters into your bloodstream and other organs, it may turn out to be deadly.
Hypersensitivity Pneumonitis is an inflammation of the lung caused by small airborne particles such as bacteria, mold, fungi, or inorganic matter. There are two types of hypersensitivity pneumonitis, acute and chronic. Symptoms include fever, chills, cough, shortness of breath, body aches. Examples of hypersensitivity pneumonitis include bagassosis, mushroom worker's disease, sauna taker's disease, pigeon breeder's disease, and farmer's lung disease. Most commonly, it results from exposure to pet birds.
Strep Throat: Should I Take Antibiotics?
Sore throats are usually caused by viruses (such as cold or flu) or from smoking. Very occasionally they can be caused by bacteria. Your doctor may advise and prescribe antibiotics for you when you have a bacterial infection or pus in your throat.
What Causes Strep Throat and How Long Does It Last?
Strep throat is a contagious infection that can be very uncomfortable. Learn the signs of strep throat, what causes strep throat, how doctors diagnose strep throat, and how doctors can treat strep throat.
Staph Infection Causes
Staph or Staphylococcus is a group of bacteria that is found over the skin of most individuals. Staph bacteria usually live inside the nose, but they do not cause an infection. Staph infections may turn deadly if the bacteria invade deeper into the body, entering the bloodstream, joints, bones, lungs, or heart.
How Can I Get Rid of Strep Throat Fast?
Most sore throats are caused by viruses, however, in some cases, the sore throat might be caused by bacteria called group A Streptococcus (group A strep). Learn what medical treatments can help ease your strep throat symptoms and speed up your recovery.
When Should You See a Doctor for Upper Respiratory Infection?
What is an upper respiratory infection? Learn the symptoms of an upper respiratory infection and what to do about it.
What Is the Difference Between Strep Throat and Sore Throat?
What Is The Difference Between Strep Throat and Sore Throat? Learn how to identify the symptoms and treat these throat conditions effectively.
Treatment & Diagnosis
- Strep Streptococcal Throat Infection FAQs
- Strep Throat Diagnosis & Treatment
- How Long Does It Take Strep to Go Away?
- Is It Easier to Get Staph Infection When You've Had it Before?
- How Do You Get Staph Infection?
- How to Get Rid of a Staph Infection
- What Are the Symptoms of Respiratory Distress?
- Strep Throat Complications
- Sore Throat: Is It Mono or Strep Throat?
- Superbug Staph (MRSA) Spread in Community
- Strep Throat Symptoms
- Sore Throat: Virus or Strep?
- Strep Throat Natural Home Remedies
Medications & Supplements
- clindamycin, oral (Cleocin)
- Metronidazole (Flagyl) vs. Clindamycin (Cleocin)
- clindamycin-oral solution, Cleocin Pediatric
- anistreplase-injection, Eminase
- topical clindamycin (Cleocin T, Clindagel)
- clindamycin vaginal suppository (Cleocin)
- streptokinase-injection, Kabikinase, Streptase
- clindamycin - injection, Cleocin
- clindamycin vaginal cream (Cleocin, Clindesse)
- Side Effects of topical Cleocin (clindamycin)
Prevention & Wellness
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.