- Rheumatoid Arthritis Slideshow Pictures
- Joint-Friendly Exercises to Reduce RA Pain Slideshow
- Take the RA Quiz
- Does Trilisate (choline magnesium salicylate or trisalicylate) cause side effects?
- What are the important side effects of Trilisate (choline magnesium salicylate or trisalicylate)?
- Trilisate (choline magnesium salicylate or trisalicylate) side effects list for healthcare professionals
- Does Trilisate (choline magnesium salicylate or trisalicylate) cause addiction or withdrawal symptoms?
- What drugs interact with Trilisate (choline magnesium salicylate or trisalicylate)?
Does Trilisate (choline magnesium salicylate or trisalicylate) cause side effects?
Trilisate (choline magnesium salicylate or trisalicylate) is a nonsteroidal anti-inflammatory drug (NSAID), referred to as a salicylate, effective in treating fever, pain, and inflammation in the body caused by soft tissue injuries, tendinitis, bursitis, and arthritic conditions.
It works by reducing the levels of prostaglandins, chemicals that are responsible for pain, fever, and inflammation. The salicylates block the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower concentrations of prostaglandins. As a consequence, inflammation, pain and fever are reduced. The brand name Trilisate is no longer available in the U.S.
Common side effects of Trilisate include
Serious side effects of Trilisate include
- severe abdominal pain,
- easy bruising or bleeding,
- fast heartbeat,
- persistent nausea or vomiting,
- unusual tiredness,
- change in the amount or color of urine,
- yellowing of the eyes or skin (jaundice),
- unusual bleeding, and
- hearing loss.
Drug interactions of Trilisate include methotrexate because the blood levels of methotrexate may increase, presumably because the elimination of methotrexate from the body is reduced. This may lead to more methotrexate-related side effects.
- Concurrent use of Trilisate and warfarin may cause excessive bleeding as Trilisate enhances the effect of warfarin. It is therefore important to reduce the dosage of warfarin. NSAIDs may reduce the blood pressure-lowering effects of drugs that are given to reduce blood pressure. This may occur because prostaglandins play a role in the regulation of blood pressure.
- Persons who have more than three alcoholic beverages per day may be at increased risk of developing stomach ulcers when taking Trilisate or other NSAIDs.
- Trilisate, as other salicylates, should not be given within six weeks of influenza virus vaccine as this can increase risk of Reye's syndrome (a serious, often fatal disease that causes numerous detrimental effects to many organs, especially the brain and liver) due to unknown mechanisms.
It is also unknown if Trilisate can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Trilisate should be given to a pregnant woman only if clearly needed. Because of the known effects of other salicylate drug products on the fetal cardiovascular system (closure of ductus arteriosus), use during late pregnancy should be avoided.
What are the important side effects of Trilisate (choline magnesium salicylate or trisalicylate)?
Common side effects of choline magnesium salicylate are
- stomach ulcers,
- nausea, or
Patients should tell their doctor immediately if any of these unusual but potentially serious side effects occur:
Trilisate (choline magnesium salicylate or trisalicylate) side effects list for healthcare professionals
The most frequent adverse reactions observed with Trilisate (choline magnesium trisalicylate) preparations in clinical trials (7- 12) are
- tinnitus and
- gastrointestinal complaints including
These occur in less than twenty percent (20%) of patients. Should tinnitus develop, reduction of daily dosage is recommended until the tinnitus is resolved. Less frequent adverse reactions, occurring in less than two percent (2%) of patients, are:
Adverse reactions occurring in less than one percent (1%) of patients are:
- gastric ulceration,
- positive fecal occult blood,
- elevation in serum BUN and creatinine,
- weight gain,
- epistaxis and
Spontaneous reporting has yielded isolated or rare reports of the following adverse experiences:
Does Trilisate (choline magnesium salicylate or trisalicylate) cause addiction or withdrawal symptoms?
Drug abuse and dependence have not been reported with Trilisate (choline magnesium trisalicylate) preparations.
What drugs interact with Trilisate (choline magnesium salicylate or trisalicylate)?
- Foods and drugs that alter urine pH may affect renal clearance of salicylate and plasma salicylate concentrations. Raising urine pH, as with chronic antacid use, can enhance renal salicylate clearance and diminish plasma salicylate concentration; urine acidification can decrease urinary salicylate excretion and increase plasma levels.
- When salicylate drug products are concurrently dosed with other plasma protein bound drug products, adverse effects may result.
- Although Trilisate (choline magnesium trisalicylate) preparations are a rational choice for anti- inflammatory and analgesic therapy in patients on oral anticoagulants due to their demonstrated lack of effect in vivo and in vitro on platelet aggregation, bleeding time, platelet count, prothrombin time, and serum thromboxane B2 generation (7), the potential exists for increased levels of unbound warfarin with their concurrent use.
- Prothrombin time should be closely monitored and warfarin dose appropriately adjusted when therapy with Trilisate (choline magnesium trisalicylate) preparations is initiated.
- The effect of Trilisate (choline magnesium trisalicylate) on blood prothrombin levels has not been established. Salicylates may increase the therapeutic as well as toxic effects of methotrexate, particularly when administered in chemotherapeutic doses, by inhibition of renal methotrexate excretion and by displacement of plasma protein bound methotrexate.
- Caution should be exercised in administering Trilisate (choline magnesium trisalicylate) to rheumatoid arthritis patients on methotrexate.
- When sulfonylurea oral hypoglycemic agents are co- administered with salicylates, the hypoglycemic effect may be enhanced via increased insulin secretion or by displacement of sulfonylurea agents from binding sites.
- Insulin- treated diabetics on high doses of salicylates should also be closely monitored for a similar hypoglycemic response.
- Other drugs with which salicylate competes for protein binding sites, and whose plasma concentration or free fraction may be altered by concurrent salicylate administration, include the following: phenytoin, valproic acid, and carbonic anhydrase inhibitors.
- The efficacy of uricosuric agents may be decreased when administered with salicylate products.
- Although low doses of salicylate (1 to 2 grams per day) have been reported to decrease urate excretion and elevate plasma urate concentrations, intermediate doses (2 to 3 grams per day) usually do not alter urate excretion.
- Larger salicylate doses (over 5 grams per day) can induce uricosuria and lower plasma urate levels.
- Corticosteroids can reduce plasma salicylate levels by increasing renal elimination and perhaps by also stimulating hepatic metabolism of salicylates.
- By monitoring plasma salicylate levels, salicylate dosage may be titrated to accommodate changes in corticosteroid dose or to avoid salicylate toxicity during corticosteroid taper.
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Related Disease Conditions
Buildup of uric acid crystals in a joint causes gouty arthritis. Symptoms and signs include joint pain, swelling, heat, and redness, typically of a single joint. Gout may be treated with diet and lifestyle changes, as well as medication.
Which Foods Make Arthritis Worse?
Certain foods can contribute to arthritis joint inflammation, like processed foods high in salt, alcohol, red meat and others. Foods that are good for the joints are beans, greens and other whole foods that have high fiber and nutrient content and low calories; these foods promote weight loss, which improves arthritis symptoms, and some may lower inflammation, generally.
Rheumatoid Arthritis (RA)
Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints, the tissue around the joints, as well as other organs in the body. Because it can affect multiple other organs of the body, rheumatoid arthritis is referred to as a systemic illness and is sometimes called rheumatoid disease. The 16 characteristic early RA signs and symptoms include the following. Anemia Both sides of the body affected (symmetric) Depression Fatigue Fever Joint deformity Joint pain Joint redness Joint stiffness Joint swelling Joint tenderness Joint warmth Limping Loss of joint function Loss of joint range of motion Many joints affected (polyarthritis)
16 Early Rheumatoid Arthritis (RA) Symptoms and Signs
Early RA symptoms and signs vary differently from person to person. The most common body parts that are initially affected by RA include the small joints of the hands, wrists, and feet, and the knees and hip joints. Joint inflammation causes stiffness. Warmth, redness, and pain may vary in degree.
Arthritis (Joint Inflammation)
Arthritis is inflammation of one or more joints. When joints are inflamed they can develop stiffness, warmth, swelling, redness and pain. There are over 100 types of arthritis, including osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, lupus, gout, and pseudogout.
Osteoarthritis is a type of arthritis caused by inflammation, breakdown, and eventual loss of cartilage in the joints. Also known as degenerative arthritis, osteoarthritis can be caused by aging, heredity, and injury from trauma or disease.
Septic arthritis, or infectious arthritis, is infection of one or more joints by bacteria, viruses, or fungi. Symptoms and signs of septic arthritis include fever, joint pain, chills, swelling, redness, warmth, and stiffness. Treatment involves antibiotics and the drainage of the infected joint.
Psoriatic arthritis is a disease that causes skin and joint inflammation. Symptoms and signs include painful, stiff, and swollen joints, tendinitis, and organ inflammation. Treatment involves anti-inflammatory medications and exercise.
14 Early Signs of Arthritis in the Legs
Leg arthritis affects the joints of the hips, knees, ankles or feet. The early signs and symptoms of arthritis in the legs include pain, swelling, stiffness, decreased range of motion, trouble walking, fever, bump-like swelling and other symptoms.
12 Early Signs of Arthritis in Hands
Hand arthritis occurs when there is inflammation in one or more joints of the hand and wrist. A few of the common types of arthritis that affect the hands are osteoarthritis, rheumatoid arthritis, post-traumatic arthritis (arthritis as a result of an injury), psoriatic arthritis and gout.
Second Source article from Government
Reactive arthritis is a chronic, systemic rheumatic disease characterized by three conditions, including conjunctivitis, joint inflammation, and genital, urinary, or gastrointestinal system inflammation. Inflammation leads to pain, swelling, warmth, redness, and stiffness of the affected joints. Non-joint areas may experience irritation and pain. Treatment for reactive arthritis depends on which area of the body is affected. Joint inflammation is treated with anti-inflammatory medications.
Rheumatoid Arthritis vs. Fibromyalgia
Though rheumatoid arthritis (RA) and fibromyalgia have similar symptoms, RA is an autoimmune disease and fibromyalgia is a chronic pain syndrome. RA symptoms include joint redness, swelling, and pain that lasts more than six weeks. Fibromyalgia symptoms include widespread pain, tingling feet or hands, depression, and bowel irritability. Home remedies for both include stress reduction, exercise, and getting enough sleep.
Pain Management and Rheumatoid Arthritis
Second Source article from WebMD
Second Source article from Government
Fungal arthritis is inflammation of a joint by a fungus that has invaded the body and is growing in the normally sterile joint. Fungal arthritis symptoms and signs include pain, redness, loss of range of motion, and swelling. Fungal arthritis treatment includes antibiotics, adequate drainage of the joint, and sometimes surgery.
Osteoarthritis vs. Osteoporosis Differences and Similarities
Arthritis is defined as painful inflammation and joint stiffness. Osteoarthritis is a type of arthritis and the most common cause of chronic joint pain, affecting over 25 million Americans. Osteoarthritis is a type of arthritis that involves the entire joint. Osteoporosis is not a type of arthritis. It is a disease that mainly is caused by a loss of bone tissue that is not limited to the joint areas. It is possible for one person to have both osteoarthritis and osteoporosis. The differences in the signs and symptoms of osteoarthritis and osteoporosis include; pain, stiffness, and joint swelling, joint deformity, crackle sounds when the joint is moving, and walking with a limp. Osteoporosis is called the "silent disease" because it can progress for years without signs and symptoms before it is diagnosed, severe back pain, bone fractures, height loss, and difficulty or inability to walk. The differences in the causes of osteoarthritis and osteoporosis are that osteoarthritis usually is caused by wear and tear on the joints. Osteoporosis usually is caused by one or more underlying problems, for example, calcium and vitamin D deficiencies. Treatment for osteoarthritis and osteoporosis are not the same. There is no cure for osteoarthritis or osteoporosis.
11 Home Remedies for Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a long-term disorder that progressively affects many parts of the body. Home remedies, diet, and lifestyle changes can help reduce pain and discomfort associated with RA alongside medical treatment. Home remedies alone cannot effectively treat RA or prevent the progression of the disease.
17 Early Signs of Arthritis in the Back
Arthritis in the back arises due to the inflammation of facet joints in the spine or sacroiliac joints between the spine and the pelvis. Some of the early signs of arthritis in the back include back pain, stiffness, swelling, bone grinding, loss of flexibility, fatigue, muscle spasms and other symptoms.
Arthritis in Knee: 4 Stages of Osteoarthritis
Painful joint swelling is called arthritis. Osteoarthritis is due to wear and tear of the joints over many years. Arthritis maye develop in any joint, including the fingers, hips and knees. Usually, patients with arthritis feel pain in their joints even after moderate movements. There are four stages of osteoarthritis of the knee.
Early Signs of Arthritis in the Knee
Arthritis refers to the redness and swelling of the joints. It usually develops slowly over 10 to 15 years, interfering with daily life activities. Knowing the early signs of arthritis can help you take appropriate treatment and incorporate modifications in your diet and lifestyle.
Can Rheumatoid Arthritis Be Caused by Stress?
Rheumatoid arthritis is a chronic inflammatory joint condition and an autoimmune disease. At times, treatment can make rheumatoid arthritis symptoms (pain and swelling) disappear for a while. This symptom-free period is referred to as “remission.” A remission is followed by the reappearance of symptoms and this period is known as a flare-up. Research says that rheumatoid arthritis can be caused by stress.
Rheumatoid Arthritis vs. Arthritis
Arthritis is a general term used to describe joint disease. Rheumatoid arthritis (RA) is a type of arthritis in which the body’s immune system mistakenly attacks the joints, causing chronic inflammation.
Early Signs and Symptoms of Arthritis in Knuckles
Pain, swelling, and tenderness are usually considered as early signs and symptoms of knuckle arthritis. Tiny bumps pop out on the top knuckles of some of the fingers, and fingers become stiff.
How Serious Is Rheumatoid Arthritis?
Rheumatoid arthritis (RA) is a chronic inflammatory disorder that typically affects the joints and other body parts, such as the skin, eyes, lungs, heart and blood vessels. RA is an autoimmune disorder, a condition where the body’s immune system attacks its own tissues. If not diagnosed early and appropriately treated, RA can lead to permanent deformities, disabilities and serious systemic complications.
Early Signs of Arthritis in the Feet
There are more than 30 joints in the ankle and feet. Arthritis can affect one or multiple joints in the feet. Excess weight, hereditary tendencies, old injuries, and poor footwear are a few predisposing factors of arthritis.
Juvenile Rheumatoid Arthritis (JRA)
Juvenile rheumatoid arthritis (JRA) annually affects one child in every thousand. There are six types of JRA. Treatment of juvenile arthritis depends upon the type the child has and should focus on treating the symptoms that manifest.
What Are the Four Stages of Rheumatoid Arthritis?
Rheumatoid arthritis is a chronic inflammatory disease characterized by pain and inflammation in joints, typically of the hands and feet. It is an autoimmune disease in which the immune system of the body attacks its own healthy cells, resulting in inflammation of the membrane lining the joints and damage to joint tissue.
Early Signs of Arthritis in the Fingers
The earliest signs of arthritis are pain, swelling and stiffness. If these symptoms are experienced in the fingers, it is likely because of rheumatoid arthritis. The signs and symptoms of arthritis in the fingers include popping sounds, joint deformity, warmth, mucus cysts and bone spurs.
Non-Radiographic Axial Spondyloarthritis (nr-axSpA)
Non-radiographic spondyloarthritis (nr-axSpA) is an inflammatory arthritis that mainly affects the joints of the spine. Morning stiffness and back pain are the usual symptoms of nr-axSpA. Nonsteroidal anti-inflammatory drugs, exercise, and biologics are treatments for nr-axSpA.
What Is the Most Common Cause of Septic Arthritis in Kids?
Septic arthritis can be caused by bacterial, fungal or viral infections. Staphylococcus aureus, a type of bacteria, is the most common cause of septic arthritis in infants. Septic arthritis is a general term for any joint pain caused by infection of the joint.
Breastfeeding With Rheumatoid Arthritis
You can breastfeed your baby even if you have rheumatoid arthritis (RA). However, you must always consult your doctor before you start the process.
Safest Rheumatoid Arthritis Drugs During Pregnancy
None of the drugs used in the treatment of rheumatoid arthritis (RA) is completely safe during pregnancy. You must discuss with your physician regarding the decision to use, modify, or stop any medications.
Early Signs of Arthritis in Shoulder
Early signs and symptoms of arthritis in the shoulder include pain in the shoulder joint that's worse when lifting heavy objects, pain that radiates down the arm and shoulder joint sounds like grinding, clicking, and crackling.
Osteoarthritis vs. Rheumatoid Arthritis
Osteoarthritis (OA) and rheumatoid arthritis (RA) are chronic joint disorders. RA is also an autoimmune disease. OA and RA symptoms and signs include joint pain, warmth, and tenderness. Over-the-counter pain relievers treat both diseases. There are several prescription medications that treat RA.
Can Rheumatoid Arthritis Affect Pregnancy?
Yes, rheumatoid arthritis (RA) affects pregnancy. RA can lead to complications like preterm birth, raised blood pressure (preeclampsia), and low birth weight babies.
Early Signs of Arthritis in the Wrist
Wrist arthritis is inflammation (swelling) of one or more joints of the wrist. Wrist arthritis is long-lasting or permanent and eventually causes severe joint damage. The early signs of arthritis in the wrist include morning stiffness, redness, tenderness, pain, swelling, weakness, warmth and other symptoms.
Do Steroids Help With Arthritis?
Arthritis is the inflammation of one or more joints in the body. The disease is one of the most common chronic health conditions in the United States. Steroids are a class of drugs that reduce inflammation and have a suppressing effect on the immune system.
What Is the Main Cause of Osteoarthritis?
Osteoarthritis (OA) is a chronic degenerative disease of the joints affecting middle-aged and elderly people. It involves the breakdown of cartilage and associated inflammatory changes in the adjacent bone. It is a leading cause of chronic disability, affecting 30 million people in the United States alone.
Causes of Rheumatoid Arthritis
Rheumatoid arthritis (RA) is an autoimmune disorder (the body’s immune system mistakenly attacks its own cells). Certain factors increase the risk of RA.
Early Signs and Symptoms of Arthritis in Thumb
The earliest sign and symptom of thumb arthritis is pain, swelling, and tenderness with activities that involve pinching action. The pain may be dull, achy, or sharp at the base of the thumb. The pain can occur when we grip, grasp, or pinch an object or use the thumb to apply force.
Quackery of Arthritis
Arthritis patients are sometimes vulnerable to quackery (the business of promoting unproven remedies). These "quick fix" treatments are promoted as cure-alls, but they really have no right to such claims. Consumers should be wary of products that have marketing claims like "will cure," "ancient remedy," "has no side effects," and "revolutionary new scientific breakthrough." Read about arthritis remedies and tests that have no scientific proof of benefits.
Osteoarthritis and Treatment
Painful swelling of the joints due to wear and tear over many years is called osteoarthritis. Osteoarthritis may develop in any joint that includes the fingers, hips, and knees. There are many treatment options available to curb the complications of arthritis.
Treatment & Diagnosis
- Steroids: for the Treatment of Arthritis
- What Are the Four Stages of Osteoarthritis?
- Rheumatoid Arthritis vs. Lupus: Differences and Similarities
- What Is the Best Treatment for Osteoarthritis?
- What Is the Best Treatment for Arthritis?
- What Is the Treatment for Septic Arthritis?
- Physical and Occupational Therapy for Arthritis
- Rheumatoid Arthritis (RA)
- Psoriatic Arthritis
- Septic Arthritis
- Reactive Arthritis
- Juvenile Idiopathic Arthritis
- Non-Radiographic Axial Spondyloarthritis (nr-axSpA)
- Arthritis Treatment Update
- Arthritis Pain Relief Update
- Arthritis and Active Sports
- Psoriatic Arthritis: Diagnosis and Treatment
- Osteoarthritis Specific References
- Rheumatoid Arthritis FAQs
- Psoriatic Arthritis FAQs
- Osteoarthritis FAQs
- Why Does Pregnancy Affect the Course of Rheumatoid Arthritis (RA)?
- Are Corticosteroids Safe for Pregnant and Nursing Women with Rheumatoid Arthritis?
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- What Kind of Doctor Treats Ankylosing Spodylitis & Reactive Arthritis?
- What Is Meant by Seronegative Arthritis?
- What Is the Prognosis for Osteoarthritis?
- What Are the Side Effects of Remicade for Rheumatoid Arthritis?
- What Kind of Joint Injections Treat Osteoarthritis?
- What Are the Side Effects of Glucosamine?
- What Is Cervical Osteoarthritis?
- Are Women More Susceptible to Osteoarthritis?
- Are Hidradenitis and Rheumatoid Arthritis Related?
- What Are the Different Types of Psoriatic Arthritis?
- What Is Sero Negative Arthritis?
- Will Rheumatoid Arthritis Nodules Go Away?
- What's the Rheumatoid Arthritis Prognosis?
- What Are Home Remedies for Rheumatoid Arthritis?
Medications & Supplements
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.