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Does Thalitone (chlorthalidone) cause side effects?
Thalitone (chlorthalidone) is a thiazide diuretic used in the treatment of high blood pressure, congestive heart failure, and edema (fluid retention). The brand name Thalitone is discontinued in the U.S.
Common side effects of Thalitone include
Serious side effects of Thalitone include
- low blood levels of potassium, sodium, and magnesium due to increased excretion via urine;
- high blood calcium levels, especially in persons who are taking calcium supplements;
- increased levels of uric acid in the blood (but gout rarely occurs), and
- high blood sugars in patients with diabetes.
Drug interactions of Thalitone include loop diuretics such as furosemide, bumetanide, and torsemide, because Thalitone can lower blood potassium and magnesium levels because both potassium and magnesium are lost in the urine.
- Low potassium and magnesium levels can lead to abnormal heart rhythms, especially in patients taking digoxin. Thalitone reduces the kidney's ability to eliminate lithium in the urine. As a result, patients taking Thalitone at the same time as drugs containing lithium may develop high levels of lithium and lithium toxicity.
- Nonsteroidal anti-inflammatory drugs (NSAIDs) can reduce the effectiveness of Thalitone though the reason for this is not clear.
- Blood sugar levels can be elevated by thiazide diuretics. Patients with diabetes may need to adjust the doses of medications they are taking for treating diabetes.
What are the important side effects of Thalitone (chlorthalidone)?
Chlorthalidone generally is well tolerated.
Side effects include:
More serious side effects include:
- Low blood levels of potassium, sodium, and magnesium due to increased excretion via urine.
- High blood calcium levels also can occur, especially in persons who are taking calcium supplements.
- Thiazide diuretics such as chlorthalidone increase the levels of uric acid in the blood, but gout (which is caused by high levels of uric acid) rarely occurs.
- Chlorthalidone can cause high blood sugars in patients with diabetes.
Thalitone (chlorthalidone) side effects list for healthcare professionals
The following adverse reactions have been observed, but there is not enough systematic collection of data to support an estimate of their frequency.
- Gastrointestinal System Reactions: anorexia, gastric irritation, nausea, vomiting, cramping, diarrhea, constipation, jaundice (intrahepatic cholestatic jaundice), pancreatitis.
- Central Nervous System Reactions: dizziness, vertigo, paresthesias, headache, xanthopsia.
- Hematologic Reactions: leukopenia,agranulocytosis,thrombocytopenia, aplastic anemia.
- Dermatologic-Hypersensitivity Reactions: purpura, photosensitivity, rash, urticaria, necrotizing angiitis (vasculitis) (cutaneous vasculitis), Lyell's syndrome (toxic epidermal necrolysis).
- Cardiovascular Reaction: Orthostatic hypotension may occur and may be aggravated by alcohol,barbiturates or narcotics.
- Other Adverse Reactions: hyperglycemia, glycosuria, hyperuricemia, muscle spasm,weakness,restlessness,impotence.
Whenever adverse reactions are moderate or severe, chlorthalidone dosage should be reduced or therapy withdrawn.
What drugs interact with Thalitone (chlorthalidone)?
- Chlorthalidone may add to or potentiate the action of other antihypertensive drugs.
- Insulin requirements in diabetic patients may be increased, decreased or unchanged. Higher dosage of oral hypoglycemic agents may be required.
- Chlorthalidone and related drugs may increase the responsiveness to tubocurarine.
- Chlorthalidone and related drugs may decrease arterial responsiveness to norepinephrine. This diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use.
- Lithium renal clearance is reduced by chlorthalidone,increasing the risk of lithium toxicity.
Drug/Laboratory Test Interactions
Thalitone (chlorthalidone) is a thiazide diuretic used in the treatment of high blood pressure, congestive heart failure, and edema (fluid retention). Common side effects of Thalitone include dizziness, lightheadedness, headache, fatigue, nausea, vomiting, abdominal pain, and constipation. Thiazide diuretics including Thalitone cross the placenta and can cause jaundice in the fetus or newborn. Thalitone should not be used during pregnancy unless absolutely necessary. Large doses of thiazide diuretics may suppress milk production, but the American Academy of Pediatrics considers thiazides to be compatible with breastfeeding.
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Related Disease Conditions
High Blood Pressure (Hypertension)
High blood pressure (hypertension) is a disease in which pressure within the arteries of the body is elevated. About 75 million people in the US have hypertension (1 in 3 adults), and only half of them are able to manage it. Many people do not know that they have high blood pressure because it often has no has no warning signs or symptoms. Systolic and diastolic are the two readings in which blood pressure is measured. The American College of Cardiology released new guidelines for high blood pressure in 2017. The guidelines now state that blood normal blood pressure is 120/80 mmHg. If either one of those numbers is higher, you have high blood pressure. The American Academy of Cardiology defines high blood pressure slightly differently. The AAC considers 130/80 mm Hg. or greater (either number) stage 1 hypertension. Stage 2 hypertension is considered 140/90 mm Hg. or greater. If you have high blood pressure you are at risk of developing life threatening diseases like stroke and heart attack.REFERENCE: CDC. High Blood Pressure. Updated: Nov 13, 2017.
Congestive Heart Failure (CHF)
Congestive heart failure (CHF) refers to a condition in which the heart loses the ability to function properly. Heart disease, high blood pressure, diabetes, myocarditis, and cardiomyopathies are just a few potential causes of congestive heart failure. Signs and symptoms of congestive heart failure may include fatigue, breathlessness, palpitations, angina, and edema. Physical examination, patient history, blood tests, and imaging tests are used to diagnose congestive heart failure. Treatment of heart failure consists of lifestyle modification and taking medications to decrease fluid in the body and ease the strain on the heart. The prognosis of a patient with congestive heart failure depends on the stage of the heart failure and the overall condition of the individual.
Hypertension-Related Kidney Disease
Second Source WebMD Medical Reference
What Are the 4 Stages of Congestive Heart Failure?
The New York Heart Association developed the four stages of congestive heart failure depending on the functional capabilities of the heart which includes Class I, Class II, Class III, and Class IV.
High Blood Pressure Treatment (Natural Home Remedies, Diet, Medications)
High blood pressure (hypertension) means high pressure (tension) in the arteries. Treatment for high blood pressure include lifestyle modifications (alcohol, smoking, coffee, salt, diet, exercise), drugs and medications such as ACE inhibitors, angiotensin receptor blockers, beta blockers, diuretics, calcium channel blockers (CCBs), alpha blockers, clonidine, minoxidil, and Exforge.
Portal hypertension is most commonly caused by cirrhosis, a disease that results from scarring of the liver. Other causes of portal hypertension include blood clots in the portal vein, blockages of the veins that carry the blood from the liver to the heart, and a parasitic infection called schistosomiasis. Symptoms of portal hypertension include varices (enlarged veins), vomiting blood, blood in the stool, black and tarry stool, ascites (abnormal fluid collection within the peritoneum, the sac that contains the intestines within the abdominal cavity), confusion and lethargy, splenomegaly or enlargement of the spleen, and decreased white blood cell counts.
What Causes Congestive Heart Failure?
Congestive heart failure is a chronic disease that progresses with time if left untreated. Heart failure can occur due to diseases of the heart, the blood vessels supplying oxygen and nutrients to the heart, or sometimes from factors outside the heart (extracardiac causes). With proper management, people who have congestive heart failure can lead nearly normal lives, depending on the severity of the condition.
Pulmonary hypertension is elevated pressure in the pulmonary arteries that carry blood from the lungs to the heart. The most common symptoms are fatigue and difficulty breathing. If the condition goes undiagnosed, more severe symptoms may occur. As pulmonary hypertension worsens, some people with the condition have difficulty performing any activities that require physical exertion. While there is no cure for pulmonary hypertension, it can be managed and treated with medications and supplemental oxygen to increase blood oxygen levels.
Hypertensive Kidney Disease
High blood pressure can damage the kidneys and is one of the leading causes of kidney failure (end-stage renal kidney disease). Kidney damage, like hypertension, can be unnoticeable and detected only through medical tests. If you have kidney disease, you should control your blood pressure. Other treatment options include prescription medications.
Pseudotumor Cerebri (Idiopathic Intracranial Hypertension)
Pseudotumor Cerebri (intracranial hypertension) is a condition where there is an increase in pressure of fluid surrounding the brain and spinal cord (cerebrospinal fluid or CSF) mimicing a brain tumor. The cause is unknown. The most common symptom is headache but also include eye-pain, vision loss and double vision. Pseudotumor cerebri is diagnosed with MRI or CAT scans and treated by discontinuing offending medications (if applicable), weight loss and diuretic medications. The condition can also be helped by repeated drainage of spinal fluid using the lumbar puncture.
Can High Blood Pressure Hurt My Eyes?
Unfortunately, yes. Suffering from untreated or poorly controlled high blood pressure for a long time can be detrimental to your eyes. Several eye diseases are directly or indirectly caused by high blood pressure (hypertension).
Preeclampsia (Pregnancy Induced Hypertension)
Preeclampsia is related to increased blood pressure and protein in the mother's urine. Preeclampsia typically begins after the 20th week of pregnancy. When preeclampsia causes seizures, it is termed "eclampsia" and is the second leading cause of maternal death of in the US. Preeclampsia is the leading cause of fetal complications. Risk factors for preeclampsia include high blood pressure, obesity, multiple births, and women with preexisting medical conditions such as diabetes, kidney disease, rheumatoid arthritis, lupus, or scleroderma. Pregnancy planning and lifestyle changes may reduce the risk of preeclampsia during pregnancy.
Hypertension-Induced Chronic Kidney Disease
Hypertension-induced chronic kidney disease (CKD) is a long-standing kidney condition that develops over time due to persistent or uncontrolled high blood pressure (hypertension).
High Blood Pressure Symptoms
Most people with high blood pressure have no signs or symptoms, even if blood pressure readings reach dangerously high levels. In some patients, symptoms may include fatigue, headaches, dizziness, confusion, sweating, chest pain and vision problems.
What Is High Blood Pressure (Hypertension)?
High blood pressure or hypertension is when the blood pressure readings consistently range from 140 or higher for systolic or 90 or higher for diastolic. Blood pressure readings above 180/120 mmHg are dangerously high and require immediate medical attention.
How Does High Blood Pressure Affect Pregnancy?
High blood pressure during pregnancy can cause serious complications. Learn more about the signs of and risks associated with the condition.
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.