What is Diabinese (chlorpropamide)?
The primary difference between the first and second-generation sulfonylureas is in the way they are eliminated from the body. Second-generation sulfonylureas usually are taken less frequently each day than first-generation sulfonylureas and generally are preferred when there is poor function of the kidneys.
Approximately 90% of patients with diabetes have type II diabetes, formerly called non-insulin-dependent diabetes mellitus. Type II diabetes usually occurs in adults and is associated with obesity and a strong family history of diabetes.
The inability to control blood glucose in type II diabetes is caused by reduced insulin release by the pancreas as well as decreased removal of glucose from the blood by the body's cells.
Drug interactions of Diabinese include blood thinners, chloramphenicol, clofibrate, alcohol, monoamine oxidase inhibitors (MAOIs), nonsteroidal anti-inflammatory drugs (NSAIDs), sulfonamides, and drugs that make urine more acidic including ammonium chloride because they can increase the risk of hypoglycemia.
- Diuretics including hydrochlorothiazide and furosemide may increase blood glucose, reducing the effect of Diabinese.
- Alcohol may interact with Diabinese, to cause moderate to severe facial flushing and an increase in facial temperature.
- Beta-blockers may lower or increase glucose levels when used alone.
- When used with sulfonylureas, beta-blocking drugs may interfere with glucose-lowering by the sulfonylureas.
- In addition, beta-blockers can blunt some of the body's protective responses to hypoglycemia, for example, increased heart rate, thus making it difficult for patients to recognize hypoglycemia. This notwithstanding, beta-blockers have been used successfully in diabetic patients and have been associated with improved survival in diabetics with high blood pressure.
No adequate safety and efficacy studies of Diabinese, have been conducted in humans. Sulfonylureas generally are not a good choice for pregnant women.
Diabinese is excreted in breast milk. Because hypoglycemia may occur in the infant who breastfeeds from a mother taking Diabinese, either formula feedings or discontinuation of Diabinese, is strongly recommended in females who are breastfeeding.
What are the side effects of Diabinese?
What are the common side effects of Diabinese?
Common side effects of Diabinese include
- hypoglycemia (symptoms include hunger, nausea, tiredness, sweating, headache, heart palpitations, numbness around the mouth, tingling of the fingers, tremors, muscle weakness, blurred vision, cold sensation, excessive yawning, irritability, confusion, or loss of consciousness),
- weight gain,
- sun sensitivity (skin rash), and
- allergic-type skin-reactions such as itching and hives.
What are the serious side effects of Diabinese?
Serious side effects of Diabinese rarely include
What drugs interact with Diabinese?
The following products can lead to hypoglycemia:
- The hypoglycemic action of sulfonylurea may be potentiated by certain drugs including nonsteroidal anti-inflammatory agents and other drugs that are
- When such drugs are administered to a patient receiving Diabinese (chlorpropamide) , the patient should be observed closely for hypoglycemia. When such drugs are withdrawn from a patient receiving Diabinese (chlorpropamide) , the patient should be observed closely for loss of control.
- Miconazole: A potential interaction between oral miconazole and oral hypoglycemic agents leading to severe hypoglycemia has been reported. Whether this interaction also occurs with intravenous, topical, or vaginal preparations of miconazole is not known.
- Alcohol: In some patients, a disulfiram-like reaction may be produced by the ingestion of alcohol. Moderate to large amounts of alcohol may increase the risk of hypoglycemia (ref.l), (ref. 2).
The following products can lead to hyperglycemia:
- Certain drugs tend to produce hyperglycemia and may lead to loss of control. These drugs include
- When such drugs are administered to a patient receiving Diabinese (chlorpropamide), the patient should be closely observed for loss of control. When such drugs are withdrawn from a patient receiving Diabinese (chlorpropamide) , the patient should be observed closely for hypoglycemia.
- Since animal studies suggest that the action of barbiturates may be prolonged by therapy with chlorpropamide, barbiturates should be employed with caution.
Diabinese side effects list for healthcare professionals
- Body as a Whole: Disulfiram-like reactions have rarely been reported with Diabinese (chlorpropamide).
- Central and Peripheral Nervous System: Dizziness and headache.
- Hypoglycemia: See prescribing information.
- Gastrointestinal: Gastrointestinal disturbances are the most common reactions; nausea has been reported in less than 5% of patients, and diarrhea, vomiting, anorexia, and hunger in less than 2%. Other gastrointestinal disturbances have occurred in less than 1% of patients including proctocolitis. They tend to be dose-related and may disappear when dosage is reduced.
- Liver/Biliary: Cholestatic jaundice and hepatitis may occur rarely, which may progress to liver failure; Diabinese (chlorpropamide) should be discontinued if this occurs. Hepatic porphyria and disulfiram-like reactions have been reported with Diabinese (chlorpropamide) .
- Skin/Appendages: Pruritus has been reported in less than 3% of patients. Other allergic skin reactions, e.g., urticaria and maculopapular eruptions have been reported in approximately 1% or less of patients. These may be transient and may disappear despite continued use of Diabinese (chlorpropamide) ; if skin reactions persist the drug should be discontinued.
- As with other sulfonylureas, porphyria cutanea tarda and photosensitivity reactions have been reported.
- Skin eruptions rarely progressing to erythema multiforme and exfoliative dermatitis have also been reported.
- Hematologic Reactions: Leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia, aplastic anemia, pancytopenia, and eosinophilia have been reported with sulfonylureas.
- Metabolic/Nutritional Reactions: Hypoglycemia. Hepatic porphyria and disulfiram-like reactions have been reported with Diabinese (chlorpropamide) . See Drug Interactions section below.
- Endocrine Reactions: On rare occasions, chlorpropamide has caused a reaction identical to the syndrome of inappropriate antidiuretic hormone (ADH) secretion. The features of this syndrome result from excessive water retention and include hyponatremia, low serum osmolality, and high urine osmolality. This reaction has also been reported for other sulfonylureas.
Diabinese (chlorpropamide) is an oral blood sugar-lowering drug in the sulfonylurea class used to manage type II diabetes. Common side effects of Diabinese include nausea, vomiting, heartburn, diarrhea, headache, hypoglycemia, weight gain, sun sensitivity (skin rash), and allergic-type skin-reactions such as itching and hives. Sulfonylureas generally are not a good choice for pregnant women. Because hypoglycemia may occur in the infant who breastfeeds from a mother taking Diabinese, either formula feedings or discontinuation of Diabinese, is strongly recommended in females who are breastfeeding.
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Related Disease Conditions
Normal Blood Sugar Levels In Adults with Diabetes
People with diabetes can manage and prevent low or high blood sugar levels (hyperglycemia or hypoglycemia) by keeping a log of your blood sugar levels when you are eating and fasting and eat foods that are high in carbohydrates and sugar, for example, buttered potatoes, candy, sugary desserts, and fatty foods. Blood tests, for example, the hemoglobin A1c test (A1c test) and urinalysis can diagnose the type of diabetes the person has. Diabetes during pregnancy, called gestational diabetes, should be managed by you and your OB/GYN or another healthcare professional. Extremely high levels of blood glucose in the blood can be dangerous and life threatening if you have type 1, type 2, or gestational diabetes. If you or someone that you are with has extremely high blood glucose levels, call 911 or go to your nearest Urgent Care or Emergency Department immediately. To prevent and manage high blood glucose levels in people with diabetes keep a log of your blood sugar levels, eat foods that are high in carbohydrates sugar, for example, buttered potatoes, candy, sugary deserts, and fatty foods that you can share with your doctor and other healthcare professionals.
Diabetes Symptoms in Women
Diabetes symptoms in women include vaginal itching, pain, or discharge, loss of interest or pain after having sex, polycystic ovarian syndrome (POS), and urinary tract infections or UTIs (which are more common in women. Symptoms of diabetes that are the same in women and men are excessive thirst and hunger, bad breath, and skin infections, darkening of skin in areas of body creases (acanthosis nigricans), breath odor that is fruity, sweet, or acetone, and tingling or numbness in the hands or feet, blurred vision, fatigue, tingling or numbness in the hands or feet, wounds that heal slowly, irritability, and weight loss or gain. Complications of type 1 and type 2 diabetes are the same, for example, skin, eye, and circulation problems, low blood sugar (hypoglycemia), high blood sugar (hyperglycemia), ketoacidosis, and amputation. If diabetes is not managed a person may not survive.
Diabetes Symptoms in Men
Early symptoms of diabetes are different in men, such as low testosterone. In many cases, prediabetes that will progress to type 2 diabetes if it is not treated early.
Diabetes (Type 1 and Type 2)
Diabetes is a chronic condition characterized by high levels of sugar (glucose) in the blood. The two types of diabetes are referred to as type 1 (insulin dependent) and type 2 (non-insulin dependent). Symptoms of diabetes include increased urine output, thirst, hunger, and fatigue. Treatment of diabetes depends on the type.
Type 2 Diabetes Diet Plan
A type 2 diabetes diet or a type 2 diabetic diet is important for blood sugar (glucose) control in people with diabetes to prevent complications of diabetes. There are a variety of type 2 diabetes diet eating plans such as the Mediterranean diet, Paleo diet, ADA Diabetes Diet, and vegetarian diets.Learn about low and high glycemic index foods, what foods to eat, and what foods to avoid if you have type 2 diabetes.
Type 1 vs. Type 2 Diabetes: Differences
Diabetes mellitus is a metabolic condition in which a person's blood sugar (glucose) levels are too high. Over 29.1 million children and adults in the US have diabetes. Of that, 8.1 million people have diabetes and don't even know it. Type 1 diabetes (insulin-dependent, juvenile) is caused by a problem with insulin production by the pancreas. Type 2 diabetes (non-insulin dependent) is caused by: Eating a lot of foods and drinking beverages with simple carbohydrates (pizza, white breads, pastas, cereals, pastries, etc.) and simple sugars (donuts, candy, etc.) Consuming too many products with artificial sweeteners (We found out that they are bad for us!) Lack of activity Exercise Stress Genetics While the signs and symptoms of both types of diabetes are the same, which include: Increased urination Increased hunger Increased thirst Unexplained weight loss. However, the treatments are different. Type 1 diabetes is insulin dependent, which means a person with this type of diabetes requires treatment with insulin. People with type 2 diabetes require medication, lifestyle changes like eating a healthy diet, and getting regular exercise.
Which is Worse - Type 1 or Type 2 Diabetes?
Learn about the similarities and differences between Type 1 and Type 2 Diabetes.
Pregnancy and Gestational Diabetes
Gestational diabetes is a form of diabetes that can occur during pregnancy. Pregnant women with gestational diabetes have not had the condition prior to becoming pregnant. Usually, gestational diabetes has no symptoms or signs and of gestational diabetes. Gestational diabetes can cause insulin resistance, hypoglycemia, hypoglycemia, and diabetic ketoacidosis. Treatment of gestational diabetes is managing the condition by checking your blood sugar as recommended, diet changes, getting enough exercise, and monitoring your baby's growth.
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Prediabetes is a situation where a person's blood sugar levels are higher than they should be, but aren't high enough to be diagnosed with type 2 diabetes. There are no signs or symptoms of prediabetes. Some of the risk factors for prediabetes are high blood pressure, high cholesterol, heart disease, smoking, family history, poor diet, and lack of activity. Diet changes along with other healthy lifestyle changes are important in treating prediabetes.
Type 2 Diabetes
Type 2 diabetes is a chronic condition that may be reversible with diet and lifestyle changes. Symptoms include excessive thirst, frequent urination, weight loss, fatigue, and an unusual odor to your urine. Most people don't know they have type 2 diabetes until they have a routine blood test. Treatment options include medications, a type 2 diabetes diet, and other lifestyle changes.
Diabetes and Safe Medications for Colds and the Flu: OTC Medication Guide
If you have diabetes and catch a cold or the flu, can be more difficult to recover from infections and their complications, for example, pneumonia. Home remedies and over-the-counter (OTC) drugs used for the treatment of the signs and symptoms of colds and the flu may affect blood sugar levels in people with diabetes.Some medications are OK to take if you have diabetes get a cold or the flu include nonsteroidal anti-inflammatory drugs or NSAIDs, like acetaminophen (Tylenol) and ibuprofen (Motrin) to control symptoms of fever and pain. Most cough syrups are safe to take; however, check with your pediatrician to see what medications are safe to give your child if he or she has type 1 or 2 diabetes. If you have diabetes and are sick with a cold or flu, you need to check your blood sugar levels more frequently. Continue taking your regular medications. Eat a diabetic low-glycemic index diet rich in antioxidants. To prevent colds and the flu drink at least eight 8 ounce glasses of water a day. To replenish fluids, drink sports drinks like Gatorade and Pedialyte to replenish electrolytes. Avoid people who are sick, sneezing, coughing, or have other symptoms of a cold or flu.
Are Bananas Good for Diabetes?
Bananas are a type of fruit that is rich in fiber, carbohydrates, vitamin B6, phytonutrients, antioxidants and potassium. People who have diabetes can consume bananas in moderation, preferably if they are small, unripe and eaten along with protein and healthy fats.
Diabetes Treatment: Medication, Diet, and Insulin
The major goal in treating diabetes is controlling elevated blood sugar without causing abnormally low levels of blood sugar. Type 1 diabetes is treated with: insulin, exercise, and a diabetic diet. Type 2 diabetes is first treated with: weight reduction, a diabetic diet, and exercise. When these measures fail to control the elevated blood sugar, oral medications are used. If oral medications are still insufficient, insulin medications are considered.
Gestational Diabetes (Diabetes during Pregnancy))
Learning how to avoid gestational diabetes is possible and maintaining a healthy weight and diet before and during pregnancy can help. Discover risk factors, tests and treatments for, and signs and symptoms of gestational diabetes.
Type 1 Diabetes (Symptoms, Causes, Diet, Treatment, Life Expectancy)
Type 1 diabetes mellitus (juvenile) is an auto-immune disease with no known cause at this time, although there are a few risk factors. Symptoms of type 1 diabetes include frequent urination, unintentional weight loss, dry and itchy skin, vision problems, wounds that heal slowly, and excessive thirst. Type 1 diabetes is diagnosed with blood tests. A healthy lifestyle and controlling blood glucose levels can improve life expectancy.
Types of Diabetes Type 2 Medications
Type 2 diabetes oral medications are prescribed to treat type 2 diabetes in conjuction with lifestyle changes like diet and exercise. There are nine classes of drugs approved for the treatment of type 2 diabetes. Examples of type 2 oral diabetes medications include acarbose (Precose), chlorpropamide (Diabinese), glipizide (Glucotrol, Glucotrol XL), and metformin (Glucophage). Side effects, drug interactions, warnings and precautions, dosage, and breastfeeding and pregnancy safety information should be reviewed prior to taking any medication.
Can Diabetes Make My Legs Hurt?
Yes, diabetes, particularly a poorly controlled diabetes where the blood sugars are high, is a major cause of pain and uncomfortable sensations in the leg. Diabetic leg pain may present as a dull ache in the soles, calves, and thighs or present with pins and needles like sensation in the lower limb.
Is Diabetes Inherited From Mother or Father?
Diabetes is a hereditary disease, which means that the child is at high risk of developing diabetes compared to the general population at the given age. Diabetes can be inherited from either mother or father.
Diabetes Foot Problems
Diabetes related foot problems can affect your health with two problems: diabetic neuropathy, where diabetes affects the nerves, and peripheral vascular disease, where diabetes affects the flow of blood. Common foot problems for people with diabetes include athlete's foot, fungal infection of nails, calluses, corns, blisters, bunions, dry skin, foot ulcers, hammertoes, ingrown toenails, and plantar warts.
Diabetes insipidus is a condition in which the patient has frequent urination. Symptoms of diabetes insipidus include irritable, listless, fever, vomiting, or diarrhea due to the loss of large volumes of urine. There are three types of diabetes insipidus, central, nephrogenic, dipsogenic, and gestational. Treatment depends upon the type of diabetes insipidus.
How to Prevent Diabetes Naturally
Prediabetes is a condition in which a person has early symptoms of diabetes, but has not yet fully developed the condition. If prediabetes is not treated with lifestyle changes, the person could develop type 2 diabetes. Type 2 diabetes and prediabetes can be prevented with lifestyle changes, for example, eating a healthy diet, getting more exercise, reducing stress, quitting smoking, reducing or managing blood pressure and cholesterol, and managing any other health conditions or risk factors that you may have for developing type 2 diabetes.
Eye Problems and Diabetes
Diabetes and eye problems are generally caused by high blood sugar levels over an extended period of time. Types of eye problems in a person with diabetes include glaucoma, cataracts, and retinopathy. Examples of symptoms include blurred vision, headaches, eye aches, pain, halos around lights, loss of vision, watering eyes. Treatment for eye problems in people with diabetes depend on the type of eye problem. Prevention of eye problems include reducing blood pressure, cholesterol levels, quitting smoking, and maintaining proper blood glucose levels.
What Are the Early Signs of Diabetes?
The early signs of diabetes depend on if one has type 1 or type 2 diabetes. Type 1 diabetes usually occurs in children, whereas type 2 diabetes is prevalent in adults.
Can Type 1 Diabetes be Cured?
Type 1 diabetes is a disorder of the pancreas. The organ doesn't make enough insulin. Learn what medical treatments can help ease your type 1 diabetes symptoms and speed up your recovery.
Why Is Diabetes Increasing in the United States
As per the National Diabetes Statistics Report (2020), around 34.2 million people in the United States have diabetes.
Diabetes and Kidney Disease
In the United States diabetes is the most common cause of kidney failure. High blood pressure and high levels of blood glucose increase the risk that a person with diabetes will eventually progress to kidney failure. Kidney disease in people with diabetes develops over the course of many years. albumin and eGFR are two key markers for kidney disease in people with diabetes. Controlling high blood pressure, blood pressure medications, a moderate protein diet, and compliant management of blood glucose can slow the progression of kidney disease. For those patients who's kidneys eventually fail, dialysis or kidney transplantation is the only option.
Which Country Has the Highest Diabetes Rate?
Diabetes mellitus (DM), or simply referred to as diabetes, is a condition that impairs the body's ability to use blood glucose, known as blood sugar, and other nutrients including fats and proteins. Insulin, a hormone produced by the pancreas, helps glucose from the food get into the cells to be used for the production of energy.
Hypoglycemia Without Diabetes: Causes and Diet
Hypoglycemia (low blood sugar level) is a condition most seen in patients with diabetes, who are on insulin or medications. Hypoglycemia is uncommon to happen in people without diabetes.
Sex, Urinary, and Bladder Problems of Diabetes
Having diabetes can mean early onset and increased severity of bladder symptoms (urinary incontinence and urinary tract infections) and changes in sexual function. Men may have erectile dysfunction; and women may have problems with sexual response and vaginal lubrication. Keep your diabetes under control, and you can lower your risk of sexual and urologic problems.
What Population Is Most Affected by Diabetes?
Diabetes can affect anyone, but certain ethnic groups are more affected by it than others.
Is Diabetes A Lifestyle Choice
Diabetes mellitus or diabetes is a metabolic disease that is characterized by high levels of blood sugar (glucose).
What Percentage of Japanese Have Diabetes?
The prevalence of diabetes has been on the rise in Japan in recent years. The increase can be ascribed to a sedentary lifestyle and increased fat consumption.
Can Type 2 Diabetes be Cured?
Type 2 diabetes is a long-term medical condition in which the body is not able to regulate blood sugar (glucose) level because of the inability of the body to properly use insulin. An individual can get type 2 diabetes because of a number of factors that reduce insulin action or quantity in the body. The goals of diabetes management are to eliminate symptoms and prevent the development of complications. Many drugs, both oral and injectable, are available for diabetes management.
Is Diabetes Insipidus Life-Threatening?
Diabetes insipidus (DI) is an uncommon disease that manifests as a frequent urge for urination and extreme thirst. It has nothing to do with blood sugar levels. Although in both diabetes mellitus and insipidus, patients experience a large volume of urine production, the cause is completely different.
How and Why Does Ethnicity Affect Diabetes?
Diabetes is a condition that causes elevated blood sugar levels. Acquired risk factors are associated with diabetes although ethnicity plays a role in increasing the incidence of the condition.
What Are the 3 Most Common Symptoms of Undiagnosed Diabetes?
Diabetes mellitus has become a worldwide epidemic, thanks to changing lifestyles and increasing obesity. Type 2 diabetes affects approximately 13% of the population of the United States. Worldwide prevalence of diabetes is estimated to be around 463 million people. Type 2 diabetes accounts for over 90% of patients with diabetes.
Tips for Managing Type 1 and 2 Diabetes at Home
Managing your diabetes is a full time commitment. The goal of diabetic therapy is to control blood glucose levels and prevent the complications of diabetes. Information about exercise, diet, and medication will help you manage your diabetes better. Blood glucose reagent strips, blood glucose meters, urine glucose tests, tests for urinary ketones, continuous glucose sensors, and Hemoglobin A1C testing information will enable you to mange your diabetes at home successfully.
Is Quinoa Good for Diabetes?
Quinoa (pronounced as keen-wah) or Chenopodium quinoa is an annual herb of the goosefoot family. The herb is known for its edible starchy seeds. It is native to the Andean highlands and is popular over the world for its health benefits. Quinoa seeds may be used as cooked grains or grounded into flour.
Diabetes: Caring for Your Diabetes at Special Times
Taking care of a disease such as diabetes is a life-long process. Learn how to care for yourself or loved one with diabetes in situations such as illness, work, school, travel, or a natural disaster.
Do Certain Ethnic Groups Have a Higher Risk of Diabetes?
One out of every 10 people in the United States has diabetes. Pacific Islanders, Alaskan natives and American Indians have the highest prevalence rates of diabetes among groups studied in the United States Census.
What Is Type 1 Diabetes and How Do You Get It?
What is type 1 diabetes? Learn the differences between type 1 and type 2 diabetes, as well as the symptoms and treatments for type 1 diabetes.
What Are the Early Signs of Type 2 Diabetes?
Type 2 Diabetes is a chronic disease characterized by increased blood sugar (glucose) level. Type 2 Diabetes is caused by either insufficient insulin secretion or resistance to that hormone’s action. Insulin is produced by the pancreas and helps process the glucose in the blood. Thus, with inadequate insulin, the bodies can’t burn all the blood sugar for energy in an efficient way. This means the glucose level in the blood rises, causing a variety of symptoms and when severe may even lead to death.
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Medications & Supplements
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.