- Does Tussionex (chlorpheniramine and hydrocodone) cause side effects?
- What are the important side effects of Tussionex (chlorpheniramine and hydrocodone)?
- Tussionex (chlorpheniramine and hydrocodone) side effects list for healthcare professionals
- What drugs interact with Tussionex (chlorpheniramine and hydrocodone)?
- Does Tussionex (chlorpheniramine and hydrocodone) cause addiction or withdrawal symptoms?
Does Tussionex (chlorpheniramine and hydrocodone) cause side effects?
Tussionex (chlorpheniramine and hydrocodone) is a combination of an antihistamine that blocks allergic reactions and reduces the production of mucus, and a narcotic that relieves pain and cough. Tussionex is a liquid that slowly releases the chlorpheniramine and hydrocodone after it is ingested.
Common side effects of Tussionex include
- disturbed coordination,
- drying and thickening of oral and other respiratory secretions,
- difficulty urinating,
- increased heart rate,
- blurred vision,
- double vision, and
Serious side effects of Tussionex include
- depressed breathing and impairment of thinking and the physical abilities required for driving or operating machinery.
Hydrocodone may be habit forming. Mental and physical dependence can occur but are unlikely when used for short-term relief of pain.
Drug interactions of Tussionex include alcohol and other drugs that can cause sedation such as benzodiazepines, narcotics, tricyclic antidepressants, antipsychotics, and certain antihypertensive medications (for example, clonidine, propranolol) because chlorpheniramine (although not generally sedating itself) and hydrocodone both add to the sedating effects of these drugs.
- Chlorpheniramine also can intensify the drying effects (due to decreased production of mucus) of other medications with anticholinergic properties.
Antihistamines are typically not recommended for use in pregnancy, especially during the third trimester, because of a risk of seizures in the fetus. The risk for depressed breathing in the newborn infant when the mother ingests hydrocodone is greatest in premature infants who are particularly sensitive to the effects of hydrocodone.
- Physicians may decide to prescribe Tussionex during pregnancy if the benefits to the mother are deemed to outweigh the risks to the fetus and newborn.
Chlorpheniramine and hydrocodone both are secreted in breast milk. Owing to the risk in infants of antihistamines causing hyperexcitability and even seizures, particularly in newborns and premature infants, Tussionex is not recommended for use in breastfeeding mothers.
What are the important side effects of Tussionex (chlorpheniramine and hydrocodone)?
The most frequent side effects of chlorpheniramine and hydrocodone include:
- disturbed coordination, and
- drying and thickening of oral and other respiratory secretions.
Other important side effects include:
- dyspepsia (indigestion),
- spasm of the ureter (which can lead to difficulty urinating),
- increased heart rate,
- blurred vision,
- double vision, and
Hydrocodone can depress breathing, and should be used with caution in elderly, debilitated patients, and in patients with serious lung disease. Hydrocodone can impair thinking and the physical abilities required for driving or operating machinery.
Hydrocodone may be habit forming. Mental and physical dependence can occur but are unlikely when used for short-term relief of pain.
Tussionex (chlorpheniramine and hydrocodone) side effects list for healthcare professionals
- Nausea and vomiting may occur; they are more frequent in ambulatory than in recumbent patients.
- Prolonged administration of Tussionex Pennkinetic Extended-Release Suspension may produce constipation.
General Disorders And Administration Site Conditions
Nervous System Disorders
- mental clouding,
- impairment of mental and physical performance,
- psychic dependence,
- mood changes.
Renal And Urinary Disorders
Respiratory, Thoracic And Mediastinal Disorders
- Dryness of the pharynx, occasional tightness of the chest, and respiratory depression.
- Tussionex Pennkinetic Extended-Release Suspension may produce dose-related respiratory depression by acting directly on brain stem respiratory centers.
- Use of Tussionex Pennkinetic Extended-Release Suspension in children less than 6 years of age has been associated with fatal respiratory depression.
- Overdose with Tussionex Pennkinetic Extended-Release Suspension in children 6 years of age and older, in adolescents, and in adults has been associated with fatal respiratory depression.
Skin And Subcutaneous Tissue Disorders
What drugs interact with Tussionex (chlorpheniramine and hydrocodone)?
- The use of benzodiazepines, opioids, antihistamines, antipsychotics, anti-anxiety agents, or other CNS depressants (including alcohol) concomitantly with Tussionex Pennkinetic Extended-Release Suspension may cause an additive CNS depressant effect, profound sedation, respiratory depression, coma, and death and should be avoided.
- The use of MAO inhibitors or tricyclic antidepressants with hydrocodone preparations may increase the effect of either the antidepressant or hydrocodone.
- The concurrent use of other anticholinergics with hydrocodone may produce paralytic ileus.
Does Tussionex (chlorpheniramine and hydrocodone) cause addiction or withdrawal symptoms?
Drug Abuse And Dependence
- Tussionex Pennkinetic Extended-Release Suspension is a Schedule II narcotic.
- Psychic dependence, physical dependence and tolerance may develop upon repeated administration of narcotics; therefore, Tussionex Pennkinetic Extended-Release Suspension should be prescribed and administered with caution.
- However, psychic dependence is unlikely to develop when Tussionex Pennkinetic Extended-Release Suspension is used for a short time for the treatment of cough.
- Physical dependence, the condition in which continued administration of the drug is required to prevent the appearance of a withdrawal syndrome, assumes clinically significant proportions only after several weeks of continued oral narcotic use, although some mild degree of physical dependence may develop after a few days of narcotic therapy.
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Related Disease Conditions
Cold Sores (Oral Herpes, Herpes Labialis)
Herpes simplex infections are common and when they appear around the mouth and lips, people often refer to them as "cold sores" and "fever blisters." Canker sores are different than cold sores. Air droplets can spread the virus, as can direct contact with the fluid from the blisters. Cold sore treatment include over-the-counter medication, as well as prescription medications.
How Do You Get Rid of a Cold Overnight?
Cold symptoms are part of your body’s healing processes. Most of the time, it does not require any help. However, you can get rid of a cold faster, even overnight, by resting, drinking hot fluids, blowing your nose, gargling with salt water, taking a hot shower, using a humidifier and taking OTC pain relievers and decongestants.
The common cold (viral upper respiratory tract infection) is a contagious illness that may be caused by various viruses. Symptoms include a stuffy nose, headache, cough, sore throat, and maybe a fever. Antibiotics have no effect upon the common cold, and there is no evidence that zinc and vitamin C are effective treatments.
Common Cold: Stages and Timeline of Symptom Progression
The common cold or viral rhinitis is an upper respiratory infection caused by several types of viruses. It is one of the most common infectious diseases affecting humans. A common cold may typically follow a certain pattern of progression that has four different stages.
Pimple vs. Cold Sore
Pimples are areas of skin inflammation with pus in the center. Cold sores are fluid-filled blisters. Pimples are caused by bacterial overgrowth and inflammation. Cold sores are caused by infection with herpes simplex viruses (HSV-1 and HSV-2). Benzoyl peroxide and sometimes antibiotics treat acne. Antiviral medications accelerate the healing process of oral herpes.
Do Cold Sores Mean You Have an STD?
Having a cold sore does not necessarily mean you have an STD. Most of the cold sores are caused by herpes simplex virus type 1 (HSV-1), which usually affects the lips and is not generally transmitted by sexual contact.
Cold and Cough Medicine for Infants and Children
The safety of giving infants and children over-the-counter (OTC) cold and cough medicine is important for caregivers to understand. While there is no "gold standard" recommendation for giving infants and children OTC cold and cough medicine for fever, aches, cough, and runny nose, a few standards have been recommended. The American Academy of Pediatrics recommends that OTC cold and cough medicine only be used in children age four years and older. The American College of Chest Physicians recommend that these medicines only be used in children age 15 years and older. The FDA recommends that OTC cold and cough medicine be used in children 2 years of age and older. However, there is agreement in regard to which OTC medications should not be used in children under the age of four (or the age of two, depending upon which guidelines are used), and they are 1) certain antihistamines like brompheniramine, chlorpheniramine maleate, and diphenhydramine (Benadryl); 2) cough expectorants (guaifenesin); 3) cough suppressants (dextromethorphan, DM); and 4) decongestants (pseudoephedrine and phenylephrine). Aspirin should never be given to infants, children, and adolescents due to the possibility of a rare, but often severe and even fatal illness called Reye's syndrome. REFERENCES:FDA. "Most Young Children with a Cough or Cold Don't Need Medicines." July 18, 2017. FDA. "Use Caution When Giving Cough and Cold Products to Kids." Updated: Nov 04, 2016.
How Long Is a Cold or Flu Contagious?
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How Do I Get Rid of a Cold Sore Overnight?
You cannot get rid of cold sores overnight. There is no cure for cold sores. However, to speed up the healing time of a cold sore, you can consult with your doctor and take prescription medications such as antiviral tablets and creams. A cold sore may go away without treatment within a week or two.
Adenovirus 14 (Killer Cold Virus)
Adenovirus infection, particularly Ad14, or the "killer cold virus" has been on the increase in the past two years. Symptoms range from those experienced with colds, sore throat, bronchitis, pneumonia, diarrhea, pinkeye, fever, bladder infection, and neurological conditions. Diagnosis and treatment options need to be discussed with your physician.
Cold, Flu, Allergy Treatments
Before treating a cold, the flu, or allergies with over-the-counter (OTC) medications, it's important to know what's causing the symptoms, which symptoms one wishes to relieve, and the active ingredients in the OTC product. Taking products that only contain the medications needed for relieving your symptoms prevents ingestion of unnecessary medications and reduces the chances of side effects.
Diabetes and Safe Medications for Colds and the Flu: OTC Medication Guide
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Is It a Cold or a Sinus Infection?
A sinus infection, also known as sinusitis or rhinosinusitis, is a condition in which the delicate membranes that line the sinuses may get swollen and become red. A cold or common cold is a viral infection. It affects the upper respiratory system, which includes the nose, mouth, throat, and lungs.
Killer Cold Virus (Adenovirus Infection, Ad14)
Second Source article from Government
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When you're feeling sick, it can be difficult to distinguish the symptoms of a COVID-19 infection from the symptoms of the common cold or the flu (influenza). While fever is common with the flu and COVID-19, sneezing is typically only associated with colds. Though sore throats are typical with colds, they are uncommon with COVID-19 infections and the flu.
How Do You Get Rid of a Cold in a Child Fast?
Most children suffer from at least six to eight cold episodes a year, and most recover spontaneously. There are over 200 cold viruses, but this condition is often caused by rhinoviruses. There is no vaccine against this, and antibiotics don’t work. Cold just have to run their course like most viral infections.
What Happens if a Pregnant Woman Gets a Cold?
Having an ordinary cold shouldn't be harmful to the baby or mother. Pregnant women are highly likely to pick up a cold at some time during pregnancy because it's normal to catch two or three colds a year. A healthy lifestyle is a must to keep the immune system strong and to prevent colds.
Do I Have a Cold Sore or Canker Sore?
Having a cold sore or canker sore is painful and differentiating them isn’t always easy. However, a cold sore isn’t the same as a canker sore. Cold sores are usually caused by the herpes virus and it is highly contagious. Canker sores are mouth ulcers that are not contagious.
Are Cold Sores (Fever Blisters) Contagious?
About 20% of cases of cold sores are caused by herpes simplex virus type 2 (HSV-2), and approximately 80% of cold sores are caused by herpes simplex virus type 1 (HSV-1). Cold sores are transmitted by sharing utensils and razors, kissing, and oral sex. There is no cure for cold sores.
What Can You Take for a Cold While Pregnant?
You may take over-the-counter (OTC) treatment after consulting with the physician because these are generally safe. OTC medications for colds and flus include acetaminophen, guaifenesin syrup and saline nasal drops or spray. You can also use natural remedies to treat a cold during pregnancy.
Genital Herpes and Cold Sores: 10 Myths and Facts
Genital herpes and cold sores (oral herpes) are the names given to two types of infection caused by the two types of herpes simplex virus (HSV): HSV-1 and HSV-2.
What to Do When a Cold Becomes Bronchitis?
Bronchitis or “chest cold” refers to the inflammation of the airways (bronchial tubes) in the lungs. Air passes through the lungs within a network of tubules called bronchial tubes. Bronchitis is often associated with persistent, nagging coughs with mucus.
Sinus Infection vs. Cold
Viruses cause the common cold and most sinus infections. Bacterial and fungal infections may also cause a sinus infection. Signs and symptoms of colds and sinus infections include nasal irritation or dryness, sore throat, stuffy nose, nasal discharge/congestion, sneezing, and cough. Additional symptoms of sinus infections include sinus pressure behind the cheeks or eyes, facial pain when pressure is applied, bad breath, and thick yellow or green mucus. Treatment focuses on symptom relief.
Cold vs. Flu
Though the common cold and flu share many signs and symptoms, they are caused by different viruses. Signs and symptoms include sneezing, sore throat, runny nose, fatigue, and cough. Treatment options for the cold and flu are similar and focus on reducing symptoms. Doctors may prescribe antivirals/neuraminidase inhibitors for the flu.
How Can Teens Cope With A Cold?
Usually, teens have a healthy immune system to cope with common cold. Getting plenty of rest and drinking lots of fluids can ease the symptoms.
Are Cold Sores and Canker Sores the Same Thing?
Although cold sores and canker sores have similarities, they are entirely different conditions. Canker sores are not contagious, but cold sores are. Canker sores show up inside the mouth, while cold sores are often seen on the lips.
What Can Trigger a Cold Sore?
After you get infected with HSV, it lies inactively in the nerve cells inside your skin and may appear as another cold sore at the same place as before.
Emphysema, Chronic Bronchitis, and Colds
If you have a COPD such as emphysema, avoiding chronic bronchitis and colds is important to avoid a more severe respiratory infection such as pneumonia. Avoiding cigarette smoking, practice good hygeine, stay away from crowds, and alerting your healthcare provider if you have a sinus infection or cold or cough that becomes worse. Treatment options depend upon the severity of the emphysema, bronchitis, or cold combination.
What Do You Give a Child With a Cold?
Unfortunately, there is no cure for the common cold. Antibiotics may be used to fight bacterial infections, but they have no effect on viruses.
What Is Good for a Child's Cold?
The common cold is one of the main reasons for missing schools in children and missing work in adults. Children are affected more commonly with cold than adults, who may have an average of two to three colds each year.
How Do You Treat a Cold Naturally?
Hundreds of viruses and bacteria can cause the common cold and flu. Most cases of cold and flu usually resolve in a week with simple home remedies and over the counter (OTC) medications. If there is no improvement in a few days, it is advised to consult a doctor.
Treatment & Diagnosis
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Medications & Supplements
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Professional side effects, drug interactions, and addiction sections courtesy of the U.S. Food and Drug Administration.