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Does Librax cause side effects?
Librax (chlordiazepoxide hydrochloride and clidinium bromide) is a combination of an anti-anxiety medication and antispasmodic used as therapy for peptic ulcer disease and irritable bowel syndrome (IBS). It also may be useful in management of acute gastroenteritis (stomach flu). It also blocks the acid secretion of the gastrointestinal tract and inhibits the action of nerves that are very active in certain diseases.
Common side effects of Librax include
- constipation, and dry mouth,
- urinary hesitancy or retention (particularly in the elderly), and
- reduced mental alertness.
Serious side effects of Librax include skin eruptions and liver abnormalities.
Librax should not be used in people with glaucoma or urinary retention (difficulty urinating) due to benign prostatic hypertrophy (BPH) because clidinium blocks the action of choline, increasing intraocular pressure and causing difficulty urinating.
Librax is not recommended for use in pregnant women because it increases the risk of congenital malformations during the first trimester. The medications in Librax may pass into breast milk. Consult your doctor before breastfeeding.
What are the important side effects of Librax?
- Adverse reactions may include drowsiness, dizziness, and confusion. Nausea, constipation, and dry mouth may occur.
- Urinary hesitancy or retention are seen, particularly in the elderly.
- Skin eruptions and liver abnormalities are less common.
- Avoid driving or operating machinery while taking chlordiazepoxide hydrochloride/clidinium bromide because it reduces mental alertness.
Librax side effects list for healthcare professionals
No side effects or manifestations not seen with either compound alone have been reported with the administration of Librax. However, since Librax contains chlordiazepoxide hydrochloride and clidinium bromide, the possibility of untoward effects which may be seen with either of these two compounds cannot be excluded.
When chlordiazepoxide hydrochloride has been used alone the necessity of discontinuing therapy because of undesirable effects has been rare. Drowsiness, ataxia and confusion have been reported in some patients - particularly the elderly and debilitated. While these effects can be avoided in almost all instances by proper dosage adjustment, they have occasionally been observed at the lower dosage ranges. In a few instances syncope has been reported.
Other adverse reactions reported during therapy with chlordiazepoxide hydrochloride include
- isolated instances of skin eruptions,
- minor menstrual irregularities,
- nausea and constipation,
- extrapyramidal symptoms, as well as
- increased and decreased libido.
Such side effects have been infrequent and are generally controlled with reduction of dosage. Changes in EEG patterns (low-voltage fast activity) have been observed in patients during and after chlordiazepoxide hydrochloride treatment.
Blood dyscrasias, including agranulocytosis, jaundice and hepatic dysfunction have occasionally been reported during therapy with chlordiazepoxide hydrochloride. When chlordiazepoxide hydrochloride treatment is protracted, periodic blood counts and liver function tests are advisable.
Adverse effects reported with use of Librax are those typical of anticholinergic agents, i.e., dryness of the mouth, blurring of vision, urinary hesitancy and constipation. Constipation has occurred most often when Librax therapy has been combined with other spasmolytic agents and/or a low residue diet.
To report suspected adverse reactions, contact Valeant Pharmaceuticals North America LLC at 1-800-321-4576 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Does Librax cause addiction or withdrawal symptoms?
Drug Abuse And Dependence
- Withdrawal symptoms, similar in character to those noted with barbiturates and alcohol (convulsions, tremor, abdominal and muscle cramps, vomiting and sweating), have occurred following abrupt discontinuance of chlordiazepoxide.
- The more severe withdrawal symptoms have usually been limited to those patients who had received excessive doses over an extended period of time.
- Generally milder withdrawal symptoms (e.g., dysphoria and insomnia) have been reported following abrupt discontinuance of benzodiazepines taken continuously at therapeutic levels for several months.
- Consequently, after extended therapy, abrupt discontinuation should generally be avoided and a gradual dosage tapering schedule followed.
- Addiction-prone individuals (such as drug addicts or alcoholics) should be under careful surveillance when receiving chlordiazepoxide or other psychotropic agents because of the predisposition of such patients to habituation and dependence.
What drugs interact with Librax?
- The concomitant use of benzodiazepines and opioids increases the risk of respiratory depression because of actions at different receptor sites in the CNS that control respiration.
- Benzodiazepines interact at GABAA sites and opioids interact primarily at mu receptors.
- When benzodiazepines and opioids are combined, the potential for benzodiazepines to significantly worsen opioid-related respiratory depression exists.
- Limit dosage and duration of concomitant use of benzodiazepines and opioids, and follow patients closely for respiratory depression and sedation.
Librax (chlordiazepoxide hydrochloride and clidinium bromide) is a combination of an anti-anxiety medication and antispasmodic used as therapy for peptic ulcer disease and irritable bowel syndrome (IBS). It also may be useful in management of acute gastroenteritis (stomach flu). Common side effects of Librax include drowsiness, dizziness, confusion, nausea, constipation, and dry mouth, urinary hesitancy or retention (particularly in the elderly), and reduced mental alertness. Librax is not recommended for use in pregnant women because it increases the risk of congenital malformations during the first trimester. The medications in Librax may pass into breast milk.
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Related Disease Conditions
Stomach Flu (Gastroenteritis)
Stomach flu (gastroenteritis) is a term referred used to describe a variety of gastrointestinal problems. The most common signs and symptoms of gastroenteritis are nausea, vomiting, diarrhea, and abdominal pain. The most common cause of gastroenteritis in the United States is Norovirus. Other causes of gastroenteritis include Rotavirus, Astrovirus, Adenovirus, and Sapovirus. There are bacterial causes of gastroenteritis such as Salmonella, Shigella, Campylobacter Aeromonas, E. coli, Clostridium, Vibrio, Campylobacter, and Yersinia spp. Parasites that cause gastroenteritis include Giardia, Cryptosporidium, Cyclospora, and Entamoeba. Treatment for gastroenteritis is generally home remedies such as keeping hydrated to prevent dehydration. At times, hospitalization may be necessary if dehydration occurs.
Peptic Ulcer (Stomach Ulcer)
Peptic or stomach ulcers are ulcers in the lining of the stomach, duodenum, or esophagus. Learn about symptoms, causes, diet, and treatment.
Is the Stomach Flu Contagious?
The stomach flu or gastroenteritis is caused by bacteria, viruses, and parasites. Symptoms include vomiting, diarrhea, nausea, and abdominal pain. Learn about how it is spread and how you can prevent infection.
Second Source article from Government
Stomach Flu vs. Food Poisoning
The stomach flu (viral gastroenteritis) and food poisoning are not the same infections. However, they do have a few similar symptoms, for example: Nausea Vomiting Diarrhea Fever Abdominal (stomach) pain and cramping. Symptoms and signs of food poisoning show up earlier (2 hours up to a couple of days) in comparison to the stomach flu in which symptoms may take 4 hours up to 48 hours (2 days) before symptoms begin. Medical treatment for the stomach flu and food poisoning generally is not necessary. A bland diet, drinking plenty of fluids, and rest may be the only treatment necessary.
How Do You Know if You Have the Stomach Flu?
What is stomach flu and how do you know when you have it? Learn what causes stomach flu and how it is treated.
IBS vs. IBD: Differences and Similarities
IBS (irritable bowel syndrome) and IBD (inflammatory bowel disease) are both problems with the digestive tract (gastrointestinal or GI tract), but they are not the same disease. IBS is a functional disorder (a problem with the way the GI tract functions), and IBD is a disease that causes chronic prolonged inflammation of the GI tract, that can lead to ulcers and other problems that may require surgery. The most common forms of IBD are Crohn's disease and ulcerative colitis, or UC. Researchers do not know the exact cause of either disease, but they believe that IBS may be caused and triggered by a variety of factors (foods, stress, and the nervous system of the GI tract), while IBD may be genetic or due a problem with the immune system.Common symptoms of both diseases are an urgent need to have a bowel movement, diarrhea, nausea, vomiting, and abdominal pain and cramping. There are differences between the signs and symptoms of irritable bowel syndrome and inflammatory bowel disease, for example, symptoms unique to IBD are: Fever Joint pain or soreness Skin changes Rectal bleeding Anemia Eye redness or pain Unintentional weight loss Feeling tired Symptoms unique to irritable bowel syndrome include: Sexual problems Fibromyalgia Abdominal bloating Whitish mucous in the stool Changes in bowel movements and in the way stools look An urgent need to urinate Urinating frequently Treatment for IBS is with diet recommendations from a doctor or nutritionist, medication, and lifestyle changes like stress management and avoiding foods that trigger the condition. Treatments for IBD depend upon the type of disease, its symptoms, and health of the patient. Surgery may be necessary for some individuals.REFERENCES: Brown, AC, et al. "Existing Dietary Guidelines for Crohn's Disease and Ulcerative Colitis." Medscape. Lehrer, J. "Irritable Bowel Syndrome." Medscape. Updated: Apr 04, 2017. Rowe, W. "Inflammatory Bowel Disease." Medscape. Updated: Jun 17, 2016. Romanowski, A, MS, RD. "Matching the Right Diet to the Right Patient." Medscape. Jan 27, 2017.
IBS Triggers (Prevention)
Irritable bowel syndrome (IBS) is a functional disease that can affect the quality of those who suffer from this condition. People with IBS can make lifestyle changes that may modify or control the number and severity of episodes. Certain foods, medications, and hormone levels may trigger IBS episodes, for example fatty foods, dairy products, eating foods in large quantities, foods that contain high levels of sorbitol, foods that produce intestinal gas (broccoli, onions, cabbage, and beans), chocolate, caffeine, physiological stress, some antibiotics, some antidepressants, medicine with sorbitol, and menstrual pain. Exercise, diet, and other lifestyle changes can decrease IBS flares, and prevent the number and severity of IBS episodes of diarrhea and constipation.
How Long Does the Stomach Flu Last?
Stomach flu or viral gastroenteritis is an infection caused by a virus that infects your stomach. Although the term has flu in it, it is not a true flu. Symptoms that include vomiting and diarrhea, fever and stomach pain can last for one to three days depending on the cause. Diarrhea may persist longer, for up to 10 days, after the disappearance of other symptoms.
How Can I Treat IBS Naturally?
Irritable bowel syndrome or IBS refers to a medical condition that affects the bowel. IBS is associated with a group of symptoms that include repeated episodes of pain or cramps in the abdomen, bloating, and changes in bowel movements, which may be diarrhea, constipation, or both. Read about 6 lifestyle changes.
Symptoms Of An IBS Attack- What To Know
IBS or irritable bowel syndrome is a medical condition affecting the large bowel. It is a type of functional bowel or gastrointestinal (GI) disorders. This means that although it causes disturbing symptoms, it does not cause any structural damage to the bowel.
Peptic Ulcer Disease
Peptic ulcers are sores that develop on the inner lining of your stomach and the upper portion of your small bowel (duodenum). Peptic ulcers cause symptoms like heartburn, nausea, vomiting, weight loss and other symptoms. Ulcers are treated with lifestyle modification and medications.
How Do I Get Rid of the Stomach Flu?
The medical treatment for stomach flu is based on maintaining adequate hydration and body sodium-potassium levels. The treatment for stomach flu initially consists of self-care measures such as drinking fluids, replacing lost electrolytes, resting, eating a bland diet and seeking medical attention if you need to.
Treatment & Diagnosis
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Medications & Supplements
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.