- Does Librium (chlordiazepoxide) cause side effects?
- What are the important side effects of Librium (chlordiazepoxide)?
- Librium (chlordiazepoxide) side effects list for healthcare professionals
- Does Librium (chlordiazepoxide) cause addiction or withdrawal symptoms?
- What drugs interact with Librium (chlordiazepoxide)?
Does Librium (chlordiazepoxide) cause side effects?
Librium (chlordiazepoxide) is a long-acting benzodiazepine used to manage symptoms associated with anxiety disorders. Librium has anti-anxiety, sedative, appetite-stimulating, and weak pain-relieving properties.
The exact mechanism of how Librium provides therapeutic benefits is not yet understood. However, current understanding of benzodiazepines indicates that they enhance or increase the activity of GABA, an inhibitory neurotransmitter, a chemical that cells in the brain use to suppress the activity of other cells.
Common side effects of Librium include
- impaired muscle control,
- skin problems,
- fluid retention (edema),
- minor menstrual irregularities,
- movement disorders, and
- decreased sexual desire.
Serious side effects of Librium include
- blood disorders,
- yellowing skin and eyes (jaundice), and
- liver dysfunction.
Drug interactions of Librium include drugs that inhibit cytochrome P450 3A4 enzymes, because they reduce the metabolism of Librium and have the potential for causing side effects.
- Examples of CYP3A4 inhibitors include
- anti-retroviral protease inhibitors,
- cimetidine, and
- Additionally, inducers of the CYP 3A4 enzymes may increase the activity of these enzymes and cause blood levels of Librium to decrease.
- Examples of CYP3A4 inducers include
- phenytoin, and
- St. John's wort.
- Librium has depressant effects on the central nervous system.
- Medications that have similar activity may increase the risk for drowsiness, respiratory depression, and other CNS depressant effects.
- Co-administration with alcohol, kava-kava, other benzodiazepines, and opiates should generally be avoided.
Due to the risk of potential harm to the fetus, use of Librium during pregnancy is not recommended.
Librium is thought to be excreted into breast milk. Due to the lack of conclusive safety data, use in breastfeeding mothers is not recommended.
What are the important side effects of Librium (chlordiazepoxide)?
Reported side effects include:
- Impaired muscle control (ataxia)
- Skin problems
- Minor menstrual irregularities
- Movement disorders
- Decreased desire for sexual activity (decreased libido).
Serious side effects that have been reported are:
- Blood disorders
- Liver dysfunction
Librium (chlordiazepoxide) side effects list for healthcare professionals
- The necessity of discontinuing therapy because of undesirable effects has been rare.
- Drowsiness, ataxia and confusion have been reported in some patients particularly the elderly and debilitated. While these effects can be avoided in almost all instances by proper dosage adjustment, they have occasionally been observed at the lower dosage ranges. In a few instances syncope has been reported.
- Other adverse reactions reported during therapy include isolated instances of
- Such side effects have been infrequent, and are generally controlled with reduction of dosage. Changes in EEG patterns (low-voltage fast activity) have been observed in patients during and after Librium (chlordiazepoxide) treatment.
- Blood dyscrasias (including agranulocytosis), jaundice and hepatic dysfunction have occasionally been reported during therapy.
- When Librium (chlordiazepoxide) treatment is protracted, periodic blood counts and liver function tests are advisable.
Does Librium (chlordiazepoxide) cause addiction or withdrawal symptoms?
- Chlordiazepoxide hydrochloride capsules are classified by the Drug Enforcement Administration as a Schedule IV controlled substance.
- Withdrawal symptoms, similar in character to those noted with barbiturates and alcohol (convulsions, tremor, abdominal and muscle cramps, vomiting and sweating), have occurred following abrupt discontinuance of chlordiazepoxide.
- The more severe withdrawal symptoms have usually been limited to those patients who had received excessive doses over an extended period of time.
- Generally milder withdrawal symptoms (eg, dysphoria and insomnia) have been reported following abrupt discontinuance of benzodiazepines taken continuously at therapeutic levels for several months.
- Consequently, after extended therapy, abrupt discontinuation should generally be avoided and a gradual dosage tapering schedule followed.
- Addiction-prone individuals (such as drug addicts or alcoholics) should be under careful surveillance when receiving chlordiazepoxide or, other, psychotropic agents because of the predisposition of such patients to habituation and dependence.
Librium (chlordiazepoxide) is a long-acting benzodiazepine used to manage symptoms associated with anxiety disorders. Common side effects of Librium include drowsiness, impaired muscle control, confusion, dizziness, skin problems, fluid retention (edema), minor menstrual irregularities, nausea, constipation, movement disorders, and decreased sexual desire. Due to the risk of potential harm to the fetus, use of Librium during pregnancy is not recommended. Librium is thought to be excreted into breast milk. Due to the lack of conclusive safety data, use in breastfeeding mothers is not recommended.
Multimedia: Slideshows, Images & Quizzes
A Visual Guide to Generalized Anxiety Disorder
Learn about generalized anxiety disorder (GAD). See if your worries are normal or something more by learning about symptoms,...
Anxiety, Stress, Worry, and Your Body
What is the definition of anxiety, stress, and worry? Find treatments to relieve stress, eliminate worry, and combat anxiety as...
Anxiety & Panic Disorders: Risk Factors for Anxiety
Do you feel anxious? Many things could make it more likely. Learn more, including what you can do if you feel anxious.
Related Disease Conditions
Second Source article from WebMD
Anxiety is a feeling of apprehension and fear characterized by symptoms such as trouble concentrating, headaches, sleep problems, and irritability. Anxiety disorders are serious medical illnesses that affect approximately 19 million American adults. Treatment for anxiety may incorporate medications and psychotherapy.
What Happens During an Anxiety Attack?
Anxiety can occur during everyday life, it could be fleeting or it could persist and build. But if you have an anxiety disorder, you may feel your anxiety or panic overwhelm you with intense anxiety and fear.
Separation anxiety disorder is a common childhood anxiety disorder that has many causes. Infants, children, older kids and adults can suffer from symptoms of separation anxiety disorder. Common separation anxiety treatment methods include therapy and medications. Factors that contribute to how quickly or successfully a child moves past separation anxiety by preschool age include how well the parent and child reunite, the skills the child and adult have at coping with the separation, and how well the adult responds to the infant's separation issues. For example, children of anxious parents tend to be anxious children.
What Are the Six Types of Anxiety Disorders?
Anxiety disorders cause worry, fear and panic as an irrational response to mundane situations. The six main types are generalized anxiety disorder, panic disorder, social anxiety, separation anxiety, trauma-related disorders and phobias.
Holiday Depression, Anxiety, and Stress
Though the holidays are a fun time for most, for others, they're a sad, lonely and anxiety-filled time. Get tips on how to avoid depression and stress during the holiday season.
What Does Anxiety Do to Your Body?
It increases a person’s chances of suffering from other medical conditions, such as heart diseases, raised blood pressure, high cholesterol obesity, depression and diabetes. In short term, anxiety may cause sleep disturbances and poor work performance.
What Symptoms Are Caused by Anxiety?
It's normal to feel stressed or worried about things that happen in our everyday lives. However, people who experience anxiety disorders often feel heightened fear or worry about common situations.
Treatment & Diagnosis
Medications & Supplements
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Professional side effects, drug interactions, and addiction sections courtesy of the U.S. Food and Drug Administration.