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- Does Librium (chlordiazepoxide) cause side effects?
- What are the important side effects of Librium (chlordiazepoxide)?
- Librium (chlordiazepoxide) side effects list for healthcare professionals
- Does Librium (chlordiazepoxide) cause addiction or withdrawal symptoms?
- What drugs interact with Librium (chlordiazepoxide)?
Does Librium (chlordiazepoxide) cause side effects?
Librium (chlordiazepoxide) is a long-acting benzodiazepine used to manage symptoms associated with anxiety disorders. Librium has anti-anxiety, sedative, appetite-stimulating, and weak pain-relieving properties.
The exact mechanism of how Librium provides therapeutic benefits is not yet understood. However, current understanding of benzodiazepines indicates that they enhance or increase the activity of GABA, an inhibitory neurotransmitter, a chemical that cells in the brain use to suppress the activity of other cells.
Common side effects of Librium include
- impaired muscle control,
- skin problems,
- fluid retention (edema),
- minor menstrual irregularities,
- movement disorders, and
- decreased sexual desire.
Serious side effects of Librium include
- Examples of CYP3A4 inhibitors include
- Additionally, inducers of the CYP 3A4 enzymes may increase the activity of these enzymes and cause blood levels of Librium to decrease.
- Examples of CYP3A4 inducers include
- Librium has depressant effects on the central nervous system.
- Medications that have similar activity may increase the risk for drowsiness, respiratory depression, and other CNS depressant effects.
- Co-administration with alcohol, kava-kava, other benzodiazepines, and opiates should generally be avoided.
Due to the risk of potential harm to the fetus, use of Librium during pregnancy is not recommended.
What are the important side effects of Librium (chlordiazepoxide)?
Reported side effects include:
- Impaired muscle control (ataxia)
- Skin problems
- Minor menstrual irregularities
- Movement disorders
- Decreased desire for sexual activity (decreased libido).
Serious side effects that have been reported are:
- Blood disorders
- Liver dysfunction
Librium (chlordiazepoxide) side effects list for healthcare professionals
- The necessity of discontinuing therapy because of undesirable effects has been rare.
- Drowsiness, ataxia and confusion have been reported in some patients particularly the elderly and debilitated. While these effects can be avoided in almost all instances by proper dosage adjustment, they have occasionally been observed at the lower dosage ranges. In a few instances syncope has been reported.
- Other adverse reactions reported during therapy include isolated instances of
- Such side effects have been infrequent, and are generally controlled with reduction of dosage. Changes in EEG patterns (low-voltage fast activity) have been observed in patients during and after Librium (chlordiazepoxide) treatment.
- Blood dyscrasias (including agranulocytosis), jaundice and hepatic dysfunction have occasionally been reported during therapy.
- When Librium (chlordiazepoxide) treatment is protracted, periodic blood counts and liver function tests are advisable.
Does Librium (chlordiazepoxide) cause addiction or withdrawal symptoms?
- Chlordiazepoxide hydrochloride capsules are classified by the Drug Enforcement Administration as a Schedule IV controlled substance.
- Withdrawal symptoms, similar in character to those noted with barbiturates and alcohol (convulsions, tremor, abdominal and muscle cramps, vomiting and sweating), have occurred following abrupt discontinuance of chlordiazepoxide.
- The more severe withdrawal symptoms have usually been limited to those patients who had received excessive doses over an extended period of time.
- Generally milder withdrawal symptoms (eg, dysphoria and insomnia) have been reported following abrupt discontinuance of benzodiazepines taken continuously at therapeutic levels for several months.
- Consequently, after extended therapy, abrupt discontinuation should generally be avoided and a gradual dosage tapering schedule followed.
- Addiction-prone individuals (such as drug addicts or alcoholics) should be under careful surveillance when receiving chlordiazepoxide or, other, psychotropic agents because of the predisposition of such patients to habituation and dependence.
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Treatment & Diagnosis
Medications & Supplements
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Professional side effects, drug interactions, and addiction sections courtesy of the U.S. Food and Drug Administration.